Patents by Inventor Fady Malik

Fady Malik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for treating heart failure
    Publication number: 20060173024
    Abstract: Certain substituted benzamide derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
    Type: Application
    Filed: February 14, 2006
    Publication date: August 3, 2006
    Applicant: Cytokinetics, Inc.
    Inventors: Fady Malik, Adam Tomasi, Bainian Feng, Erica Kraynack, Kathleen Elias, Pu-Ping Lu, Whitney Smith, Xiangping Qian, David Morgans
  • Compositions and methods for treating heart failure
    Patent number: 7053094
    Abstract: Certain substituted benzamide derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
    Type: Grant
    Filed: January 20, 2005
    Date of Patent: May 30, 2006
    Assignee: Cytokinetics, Inc.
    Inventors: Fady Malik, Adam Lewis Tomasi, Bainian Feng, Erica Anne Kraynack, Kathleen A. Elias, Pu-Ping Lu, Whitney Walter Smith, Xiangping Qian, David J. Morgans, Jr.
  • Compositions, devices and methods for treating cardiovascular disease
    Publication number: 20050282834
    Abstract: In situ drug-delivering medical devices, materials and associated compounds, pharmaceutical compositions and methods are disclosed for the treatment of diseases of proliferating cells, particularly atherosclerosis and restenosis.
    Type: Application
    Filed: June 7, 2005
    Publication date: December 22, 2005
    Inventors: Fady Malik, Gustave Bergnes
  • Human smooth muscle myosin heavy chain
    Patent number: 6974688
    Abstract: The invention provides novel compositions, methods, and uses of hSMMyHC polypeptides and polynucleotides.
    Type: Grant
    Filed: August 10, 2001
    Date of Patent: December 13, 2005
    Assignee: Cytokinetics, Inc.
    Inventors: Fady Malik, Christophe Beraud, Richard Freedman, Andrew Craven, Roman Sakowicz, James Hartman
  • High throughput sarcomeric assay
    Publication number: 20050266511
    Abstract: The present invention provides high throughput screening systems for identifying compounds that modulate the biological activity of a biochemically functional sarcomere. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
    Type: Application
    Filed: April 7, 2005
    Publication date: December 1, 2005
    Applicant: Cytokinetics, Inc.
    Inventors: James Hartman, Fady Malik, Roman Sakowicz, Jeffrey Finer
  • Compounds, compositions and methods
    Publication number: 20050159416
    Abstract: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
    Type: Application
    Filed: July 14, 2004
    Publication date: July 21, 2005
    Inventors: Bradley Morgan, Kathleen Elias, Erica Kraynack, Pu-Ping Lu, Fady Malik, Alex Muci, Xiangping Qian, Whitney Smith, Todd Tochimoto, Adam Tomasi, David Morgans
  • Compositions and methods for treating heart failure
    Publication number: 20050148638
    Abstract: Certain substituted benzamide derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
    Type: Application
    Filed: January 20, 2005
    Publication date: July 7, 2005
    Applicant: Cytokinetics, Inc.
    Inventors: Fady Malik, Adam Tomasi, Bainian Feng, Erica Kraynack, Kathleen Elias, Pu-Ping Lu, Whitney Smith, Xiangping Qian, David Morgans
  • Compositions and methods for treating heart failure
    Patent number: 6908923
    Abstract: Certain substituted benzamide derivatives of Formula I: selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: June 21, 2005
    Assignee: Cytokinetics, Inc.
    Inventors: Fady Malik, Adam Lewis Tomasi, Bainian Feng, Erica Anne Kraynack, Kathleen A. Elias, Pu-Ping Lu, Whitney Walter Smith, Xiangping Qian, David J. Morgans, Jr.
  • Human smooth muscle myosin heavy chain
    Publication number: 20050130143
    Abstract: The invention provides novel compositions, methods, and uses of hSMMyHC polypeptides and polynucleotides.
    Type: Application
    Filed: August 9, 2002
    Publication date: June 16, 2005
    Applicant: Cytokinetics, Inc
    Inventors: Fady Malik, Christophe Beraud, Richard Freedman, Andrew Craven, Roman Sakowicz, James Hartman
  • Methods for purifying actin
    Patent number: 6759240
    Abstract: Methods for purifying actin are provided. The methods generally involve the addition of a magnesium salt in a sufficient quantity, whereby G-actin polymerizes to form actin paracrystals, which can be recovered as a purified form of actin.
    Type: Grant
    Filed: November 1, 2001
    Date of Patent: July 6, 2004
    Assignee: Cytokinetics, Inc.
    Inventors: James J. Hartman, Fady Malik, Roman Sakowicz, Jeffrey T. Finer
  • Compositions and assays utilizing ADP or phosphate for detecting protein modulators
    Patent number: 6743599
    Abstract: Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obviate the cumbersome steps of using gels or radioactive materials.
    Type: Grant
    Filed: March 25, 2002
    Date of Patent: June 1, 2004
    Assignee: Cytokinetics, Inc.
    Inventors: Jeffrey T. Finer, Fady Malik, Roman Sakowicz, Christopher Shumate, Kenneth Wood
  • High throughput sarcomeric assay
    Publication number: 20030203835
    Abstract: The present invention provides high throughput screening systems for identifying compounds that modulate the biological activity of a biochemically functional sarcomere. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
    Type: Application
    Filed: April 15, 2003
    Publication date: October 30, 2003
    Applicant: Cytokinetics, Inc.
    Inventors: James J. Hartman, Fady Malik, Roman Sakowicz, Jeffrey T. Finer
  • Compositions and methods for treating heart failure
    Publication number: 20030158186
    Abstract: Certain substituted benzamide derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
    Type: Application
    Filed: December 20, 2002
    Publication date: August 21, 2003
    Inventors: Fady Malik, Adam Lewis Tomasi, Bainian Feng, Bradley Paul Morgan, Han-Jie Zhou, Kathleen A. Elias, Pu-Ping Lu, Whitney Walter Smith, Xiangping Qian, David J. Morgans,
  • Compositions and methods for treating heart failure
    Publication number: 20030158233
    Abstract: Certain substituted benzamide derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
    Type: Application
    Filed: December 20, 2002
    Publication date: August 21, 2003
    Inventors: Fady Malik, Adam Lewis Tomasi, Bainian Feng, Erica Anne Kraynack, Kathleen A. Elias, Pu-Ping Lu, Whitney Walter Smith, Xiangping Qian, David J. Morgans,
  • Sarcomere protein composition
    Patent number: 6573061
    Abstract: The present invention provides high throughput screening systems for identifying compounds that modulate the biological activity of a biochemically functional sarcomere. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: June 3, 2003
    Assignee: Cytokinetics, Inc.
    Inventors: James J. Hartman, Fady Malik, Roman Sakowicz, Jeffrey T. Finer
  • Human smooth muscle myosin heavy chain
    Publication number: 20030032018
    Abstract: The invention provides novel compositions, methods, and uses of hSMMyHC polypeptides and polynucleotides.
    Type: Application
    Filed: August 10, 2001
    Publication date: February 13, 2003
    Applicant: Cytokinetics, Inc.
    Inventors: Fady Malik, Christophe Beraud, Richard Freedman, Andrew Craven, Roman Sakowicz, James Hartman
  • High throughput sarcomeric assay
    Patent number: 6509167
    Abstract: The present invention provides high throughput screening systems for identifying compounds that modulate the biological activity of a biochemically functional sarcomere. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: January 21, 2003
    Assignee: Cytokinetics, Inc.
    Inventors: James J. Hartman, Fady Malik, Roman Sakowicz, Jeffrey T. Finer
  • High throughput sarcomeric assay
    Patent number: 6495337
    Abstract: The present invention provides high throughput screening systems for identifying compounds that modulate the biological activity of a biochemically functional sarcomere. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
    Type: Grant
    Filed: March 29, 2000
    Date of Patent: December 17, 2002
    Assignee: Cytokinetics, Inc.
    Inventors: James J. Hartman, Fady Malik, Roman Sakowicz, Jeffrey T. Finer
  • Compositions and assays utilizing ADP or phosphate for detecting protein modulators
    Patent number: 6410254
    Abstract: Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obviate the cumbersome steps of using gels or radioactive materials.
    Type: Grant
    Filed: May 18, 1999
    Date of Patent: June 25, 2002
    Assignee: Cytokinetics
    Inventors: Jeffrey T. Finer, Fady Malik, Roman Sakowicz, Christopher Shumate, Kenneth Wood
  • High throughput sarcomeric assay
    Publication number: 20020022716
    Abstract: The present invention provides high throughput screening systems for identifying compounds that modulate the biological activity of a biochemically functional sarcomere. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
    Type: Application
    Filed: September 26, 2001
    Publication date: February 21, 2002
    Inventors: James J. Hartman, Fady Malik, Roman Sakowicz, Jeffrey T. Finer