Abstract: Provided are methods for treatment of Fabry disease in a patient having renal impairment. Certain methods comprise administering to the patient about 100 mg to about 300 mg free base equivalent of migalastat or salt thereof at a frequency of greater than once every other day, such as once every four or seven days. Certain methods comprise measuring lyso-Gb3 and/or migalastat in one or more plasma samples from the patient.

Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions is also demonstrated.

Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions is also demonstrated.

Abstract: A subsurface propeller module, using Voith Schneider propeller technology, is provided for use in underwater vehicle dynamic motion control. One or more modules are mounted between nose and body sections of the vehicle such that their axes of rotation coincide with the longitudinal centerline of the vehicle. This enables the module to thrust in any direction normal to the direction of travel. Wiring for power and sensors can be routed through structural conduits connecting the nose section to the main body of the vehicle and supporting the propeller modules. The structural conduits can be shaped to provide support for the nose and body sections, and to have minimal hydrodynamic impact on vehicle forward motion or module thrust. A sealed housing is provided for the motors and control actuators of the propeller modules.

Abstract: The present invention relates to methods, systems, and apparatuses for providing automated vehicle image acquisition, analysis, and reporting. One embodiment of the invention includes a method for providing vehicle damage information to an interested party. The method can include receiving simultaneously captured image data associated with a vehicle. The method can also include comparing at least a portion of the image data with previously stored image data associated with the vehicle. Furthermore, the method can include based at least in part on the comparison of the portion of image data with previously stored image data associated with the vehicle, determining whether damage to the vehicle exists. In addition, the method can include outputting an indicator of whether damage to the vehicle exists.

Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions is also demonstrated.

Abstract: Crusher has a housing with a cylindrical crushing chamber defined by a tubular wall. Opposed side plates are secured to respective ends of the wall. A drive shaft rotates impact tools within the chamber. An intake aperture and a discharge aperture are in communication with the chamber. An inlet door, having an inner face with a curvature of similar radius to the cylindrical chamber, may be pivoted over the intake aperture such that the inner face is flush with the inner surface of the chamber, whereby impact tools strike and remove material adhering to the inner face. An arcuately shaped screen, having a curvature of similar radius to the cylindrical chamber, may be pivoted over the discharge aperture such that the screen is flush with the inner surface of the chamber. The screen may be pivoted away from the discharge aperture for the service thereof.

Abstract: This invention presents a sulphurous acid generator which employs a concentric hopper and burn chamber in which the burn chamber is surrounded or substantially surrounded by the hopper. The present invention also employs means for substantially eliminating any discharge plume.

Abstract: A portable, foldable bath device for use on a bed or other support surface, includes: (a) a generally planar, flexible, water impervious bottom wall; (b) at least one flexible, water impervious side wall attached along one of its side edges to the periphery of the bottom wall; and (c) an aperture in one of the walls of the bath device, the aperture being occludable by a closure mechanism; wherein the side wall is convertible from a generally horizontal, planar, folded position adjacent the bottom wall to a generally vertical, erect, open position extending in an upward direction from the generally horizontal bottom wall.

Abstract: The invention provides a device for generating surface plasmas, for ignition of propellants. The invention provides a plurality of sheet fuses with insulating sheets separating each fuse. One of the fuses is complete, while the other fuses have a gap. The fuses are sheets formed into concentric coaxial cylinders. The complete fuse forms the outer most cylinder. The fuses sequentially become a plasma starting from the outer most fuse to the inner most fuse.

Abstract: This disclosure relates to a stabilized plasma injector device specifically adapted to incubate, shape and develop plasma under the influence of an adjustable electromagnetic field to provide ignition and further promote energy coupling between the plasma and a combustible mass. The device includes a pair of shaped coils one of which is evaporated to form the plasma and the other coil provides the electromagnetic force field to influence the characteristic arc symmetry and the energy coupling between the plasma and the surrounding combustible mass.

Abstract: This disclosure relates to a stabilized plasma injector device specifically adapted to incubate, shape and develop plasma under the influence of an adjustable electromagnetic field to provide ignition and further promote energy coupling between the plasma and a combustible mass. The device includes a pair of shaped coils one of which is evaporated to form the plasma and the other coil provides the electromagnetic force field to influence the characteristic arc symmetry and the energy coupling between the plasma and the surrounding combustible mass.

Abstract: A rigidified suspension is provided for a load-carrying vehicle, such as a trailer for a dual use, belly-dumping and end-dumping trailer, of the type having a frame with left and right side beams connected together and to which frame wheels are mounted through a suspension. The rigidified suspension includes left and right suspension rails, which are provided having a forward end and a rearward end and are horizontally disposed inward from and below the left and right side beams of the frame. A rear plate is fastened to said left and right side beams of the frame and extends downward therefrom adjacent to the rearward end of the left and right suspension rails. A connector brace is rigidly fastened to the rear ends of the left and right rails and to the rear plate and thereby between each other and the frame. A forward suspension brace is provided, rigidly fastening the forward ends of the left and right suspension rails to the frame and to each other.

Abstract: This disclosure relates to a stabilized plasma injector device specifically adapted to incubate, shape and develop plasma under the influence of an adjustable electromagnetic field to provide ignition and further promote energy coupling between the plasma and a combustible mass. The device includes a pair of shaped coils one of which is evaporated to form the plasma and the other coil provides the electromagnetic force field to influence the characteristic arc symmetry and the energy coupling between the plasma and the surrounding combustible mass.