Patents by Inventor Frederik C. Gronvald

Frederik C. Gronvald has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Piperidine derivatives
    Patent number: 5478845
    Abstract: Piperidine derivatives of formula ##STR1## wherein A is straight or branched alkyl, alkoxy-alkyl, or alkenyl; X is O or NH; Y is O, S, NH, NCN, or N-alkyl; R.sup.1 is 6-fluoro-1,2-benzisoxazol-3-yl, 6-fluoro-1H-indazol-3-yl, or 6-fluoro-1-methyl-1H-indazol-3-yl; R.sup.2 is alkyl or phenyl; and R.sup.3 is phenyl optionally substituted, or R.sup.3 is ##STR2## wherein Z represents a 5- or 6-membered heterocyclic ring; or R.sup.2 and R.sup.3 together with the nitrogen atom form a fused heterocyclic ring system; or pharmaceutically acceptable salts thereof are useful in the treatment of indications related to the CNS-system, cardiovascular system or to gastrointestinal disorders.
    Type: Grant
    Filed: May 23, 1994
    Date of Patent: December 26, 1995
    Assignee: Novo Nordisk A/S
    Inventors: John B. Hansen, Frederik C. Gronvald, John P. Mogensen
  • Antipsychotic piperidine derivatives
    Patent number: 5378714
    Abstract: The present invention relates to therapeutically active piperidine derivatives, of formula 1 ##STR1## wherein, R.sup.1, R.sup.2, A, X and Y are as defined in the specification. The compounds are useful in the treatment of indications related to the CNS-system, cardiovascular system or to gastrointestinal disorders.
    Type: Grant
    Filed: November 19, 1992
    Date of Patent: January 3, 1995
    Assignee: Novo Nordisk A/S
    Inventors: John B. Hansen, Lone Jeppesen, Frederik C. Gronvald
  • Benzothienopyrazinedione compounds and their preparation and use
    Patent number: 5182279
    Abstract: Novel [1]benzothieno[2,3-b]pyrazine-2,3(1H,4H)-diones or tautomeric forms thereof of the general formula (I) ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently represent hydrogen, halogen, alkyl, alkoxy or trifluoromethyl.The compounds are useful for treating a central nervous system ailment associated with the NMDA receptor-associated glycine site.
    Type: Grant
    Filed: April 18, 1991
    Date of Patent: January 26, 1993
    Assignee: Novo Nordisk A/S
    Inventors: Anker S. Jorgensen, Carsten E. Stidsen, Peter Faarup, Frederik C. Gronvald, Flemming E. Nielsen
  • N-(butenyl substituted) azaheterocyclic carboxylic acids
    Patent number: 5010090
    Abstract: 1-Aminobut-3-en derivatives having optionally substituted furanyl, thienyl, pyridyl and/or pyrrolyl in the 4-position and 3-carboxypiperidin-1-yl, 3-carboxytetrahydropyrid-1-yl or 3 carboxymethylpyrrolidin-1-yl in the 1-position potentiate GABA-ergic neurotransmission.
    Type: Grant
    Filed: October 7, 1988
    Date of Patent: April 23, 1991
    Assignee: Novo Nordisk A/S.
    Inventors: Frederik C. Gronvald, Claus Braestrup
  • Use of peptides as medicaments and certain novel peptides
    Patent number: 4598065
    Abstract: Certain peptides containing the glucagon.sub.1-21 peptide chain His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Al a-Gln-Asp, usable as a medicament or a diagnostic; the peptide exerts a spasmolytic effect and an inhibitory effect on gastric acid secretion similar to glucagon with not more than a negligible metabolic effect. Some of the glucagon fragments are novel compounds.
    Type: Grant
    Filed: June 30, 1981
    Date of Patent: July 1, 1986
    Assignee: Novo Industri A/S
    Inventors: Behrend F. Lundt, Karin D. Jorgensen, Nils L. Johansen, Frederik C. Gronvald, Erik K. Frandsen, Alister J. Moody, Jan Markussen