Patents by Inventor Galen W. Radebaugh
Galen W. Radebaugh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5462747Abstract: A pharmaceutical sustained release homogeneous tablet or homogeneous tablet layer is formed by making a wet granulation using povidone (PVP) in alcohol as the granulating fluid which is mixed with a pharmaceutical active, ethylcellulose, a wicking agent, e.g. microcrystalline cellulose, an erosion promoter, e.g. pregelatinized starch, then drying and milling the granulation and blending with a dry powdered erosion promotor, wicking agent, lubricant, e.g. magnesium stearate and glidant, e.g. silicon dioxide, and compressing the resultant granulation, which upon administration results in a long-lasting slow and relatively regular incremental release of the pharmaceutical active, and multi-layered pharmaceutical active tablets comprising immediate release and/or sustained release layers.Type: GrantFiled: January 17, 1995Date of Patent: October 31, 1995Assignee: McNeil-PPC, Inc.Inventors: Galen W. Radebaugh, Thomas N. Julian, Robert Glinecke
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Patent number: 5424301Abstract: Solid compositions of certain cholinergic compounds are stabilized in starch. Especially compositions of corn starch combined or mixed with the 0-substituted-1,2,5,6-tetrahydro-3-pyridine oxime ether, CI-979 HCl, a cognition activator, have been found stable in a heated environment of up to 60.degree. C. over 17 days such that no losses were detected by HPLC analysis. A solid peroral pharmaceutical formulation for the treatment of cognitive disorders is based on the bicomponent composition of active ingredient and stabilizer using appropriate amounts of other excipients or components known in the formulation art.Type: GrantFiled: February 1, 1993Date of Patent: June 13, 1995Assignee: Warner-Lambert CompanyInventors: Hua-Pin Huang, Scott C. Wootton, Thomas N. Julian, Galen W. Radebaugh, Mahdi B. Fawzi
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Patent number: 5362860Abstract: A solid composition for stabilizing the dosage of cognition activator CI-979 HCl by formation of a complex with cyclic polydextrose. In particular, compositions with HP.beta.CD have been found to stabilize CI-979 HCl even in the presence of other excipients such as sodium carbonate. Pharmaceutical formulations for the treatment of cognitive disorders in humans are based on the stabilizing composition of CI-979 HCl and cyclic polydextrose, including appropriate amounts of other excipients or components as known in the formulation art.Type: GrantFiled: February 1, 1993Date of Patent: November 8, 1994Assignee: Warner-Lambert CompanyInventors: Hua-Pin Huang, Scott C. Wootton, Thomas N. Julian, Galen W. Radebaugh, Mahdi B. Fawzi
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Patent number: 5290794Abstract: Calcium lactate antibacterial complexes in parenteral dosage forms are provided that are relatively free from tissue irritation following injection, comprising a quinolone or naphthyridine.Type: GrantFiled: October 27, 1992Date of Patent: March 1, 1994Assignee: Warner Lambert Co.Inventors: Surendra C. Mehta, Hua-Pin Huang, Galen W. Radebaugh, Mahdi B. Fawzi
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Patent number: 5200193Abstract: A pharmaceutical sustained release homogeneous tablet or homogeneous tablet layer is formed by making a wet granulation using povidone (PVP) in alcohol as the granulating fluid which is mixed with a pharmaceutical active, ethylcellulose, a wicking agent, e.g. microcrystalline cellulose, an erosion promoter, e.g. pregelatinized starch, then drying and milling the granulation and blending with a dry powdered erosion promotor, wicking agent, lubricant, e.g. magnesium stearate and glidant, e.g. silicon dioxide, and compressing the resultant granulation, which upon administration results in a long-lasting slow and relatively regular incremental release of the pharmaceutical active, and multi-layered pharmaceutical active tablets comprising immediate release and/or sustained release layers.Type: GrantFiled: October 22, 1990Date of Patent: April 6, 1993Assignee: McNeilab, Inc.Inventors: Galen W. Radebaugh, Thomas N. Julian, Robert Glinecke
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Patent number: 5073380Abstract: A pharmaceutical sustained release tablet or tablet layer is formed by making a wet granulation, using povidone (PVP) in water or alcohol-water as the granulating fluid which is mixed with a pharmaceutical active, hydroxyethyl cellulose, a wicking agent e.g. microcrystalline cellulose, then drying and milling the granulation and blending with dry powdered smoothness enhancer, e.g. povidone, erosion promoter, e.g. pregelatinized starch, additional wicking agent, lubricant e.g. magnesium stearate and glidant e.g. silicon dioxide, and compressing the resultant granulation into a tablet with a smooth outer surface, which tablet provides, upon administration, a slow release of the pharmaceutical active.Type: GrantFiled: July 9, 1990Date of Patent: December 17, 1991Assignee: McNeil-PPC, Inc.Inventors: Suresh R. Babu, Robert Glinecke, John L. Murtha, Galen W. Radebaugh
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Patent number: 5004613Abstract: A pharmaceutical sustained release tablet or tablet layer is formed by making a wet granulation, using povidone (PVP) in water or alcohol-water as the granulating fluid which is mixed with a pharmaceutical active, hydroxyethyl cellulose, a wicking agent e.g. microcrystalline cellulose, then drying and milling the granulation and blending with dry powdered erosion promotor, e.g. pregelantinized starch, additional wicking agent, lubricant e.g. magnesium stearate and glidant e.g. silicon dioxide, and compressing the resultant granulation, which upon administration results in a slow release of the pharmaceutical active.Type: GrantFiled: August 11, 1989Date of Patent: April 2, 1991Assignee: McNeil-PPC, Inc.Inventors: Galen W. Radebaugh, John L. Murtha, Robert Glinecke
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Patent number: 4968509Abstract: An acetaminophen-sustained release tablet or tablet layer is formed by making a wet granulation, using Povidone (PVP) in water or alcohol-water as the granulating fluid which is mixed with acetaminophen, hydroxyethyl cellulose, a wicking agent e.g. microcrystalline cellulose, then drying and milling the granulation and blending with dry powdered erosion promoter, e.g. pregelatinized starch, wicking agent, lubricant e.g. magnesium stearate and glidant e.g. silicon dioxide, and compressing the resultant granulation, which upon administration results in a slow release of the acetaminophen.Type: GrantFiled: January 19, 1989Date of Patent: November 6, 1990Assignee: McNeilab, Inc.Inventors: Galen W. Radebaugh, John L. Murtha, Robert Glinecke
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Patent number: 4851226Abstract: Chewable medicament tablets are made from coated granules of medicament wherein the coating on said granules comprises a blend of cellulose acetate or cellulose acetate butyrate and polyvinyl pyrrolidone.Type: GrantFiled: June 30, 1988Date of Patent: July 25, 1989Assignee: McNeil Consumer Products CompanyInventors: Thomas N. Julian, Galen W. Radebaugh
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Patent number: 4820522Abstract: An acetaminophen-sustained release tablet or tablet layer is formed by making a wet granulation, using Povidone (PVP) in water or alcohol-water as the granulating fluid which is mixed with acetaminophen, hydroxyethyl cellulose, a wicking agent e.g. microcrystalline cellulose, then drying and milling the granulation and blending with dry powdered erosion promoter, e.g. pregelatinized starch, wicking agent, lubricant e.g. magnesium stearate and glidant e.g. silicon dioxide, and compressing the resultant granulation, which upon administration results in a slow release of the acetaminophen.Type: GrantFiled: July 27, 1987Date of Patent: April 11, 1989Assignee: McNeilab, Inc.Inventors: Galen W. Radebaugh, John L. Murtha, Robert Glinecke
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Patent number: 4806359Abstract: An ibuprofen-sustained release tablet or tablet layer is formed by making a wet granulation using providone (PVP) in alcohol as the granulating fluid which is mixed with ibuprofen, ethylcellulose, a wicking agent e.g. microcrystalline cellulose, an erosion promoter e.g. pregelatinized starch, then drying and milling the granulation and blending with dry powdered erosion promotor, wicking agent, lubricant e.g. magnesium stearate and glidant e.g. silicon dioxide, and compressing the resultant granulation, which upon administration results in a long-lasting slow and relatively regular incremental release of the ibuprofen.Type: GrantFiled: April 22, 1987Date of Patent: February 21, 1989Assignee: McNeilab, Inc.Inventors: Galen W. Radebaugh, Robert Glinecke, Thomas N. Julian