Abstract: In various embodiments a computer-implemented method for providing sustainability insights to a user designing an object. The method includes determining a value of a sustainability metric associated with a design of an object; determining a target value for the sustainability metric; determining an amount of progress made towards achieving the target value for the sustainability metric based on the value of the sustainability metric and the target value for the sustainability metric; and displaying, via a graphical user interface (GUI), a visual indication of the amount of progress made towards achieving the target value for the sustainability metric.

Abstract: In various embodiments a computer-implemented method for providing sustainability insights to a user designing an object. The method includes determining a first value of a sustainability metric associated with a design of an object, displaying, via a graphical user interface (GUI), a visual indication of the first value of the sustainability metric, and detecting a change to the design of the object. The method further includes, in response to detecting the change to the design of the object, determining a second value of the sustainability metric and displaying, via the GUI, a visual indication of the second value of the sustainability metric.

Abstract: There is provided a method for the treatment of a patient suffering or recovering from a critical illness using a device comprising a generator configured to produce an electrical stimulation signal and a controller. The controller is connected to the generator and configured to determine the form of the electrical stimulation signal. The method includes producing an electrical stimulation signal from the generator, and determining the form of the electrical stimulation signal using the controller connected to the generator; and transmitting the electrical stimulation signal to an electrode in contact with a tragus of the patient.

Abstract: Methods, systems, and apparatus, including medium-encoded computer program products, for computer aided design of physical structures using generative design processes. A method includes obtaining one or more load cases and one or more design criteria for a modeled object; iteratively modifying a three dimensional shape of the modeled object in accordance with the one or more design criteria and the one or more load cases, the iteratively modifying comprising regulating shape change velocities for an implicit surface representation of the three dimensional shape that exceed a reference velocity, where the reference velocity is set based on a mean and a standard deviation of a shape derivative on the implicit surface; and providing the three dimensional shape of the modeled object for use in manufacturing a physical structure corresponding to the modeled object using one or more computer-controlled manufacturing systems.

Abstract: Methods, systems, and apparatus, including medium-encoded computer program products, for computer aided design of physical structures using generative design processes. A method includes obtaining a design space for a modeled object, one or more design criteria for the modeled object, and one or more in-use load cases; iteratively modifying a generatively designed three dimensional shape of the modeled object in the design space in accordance with the one or more design criteria and the one or more in-use load cases for the physical structure, comprising: performing numerical simulation of the modeled object in accordance the one or more in-use load cases, computing shape change velocities for an implicit surface in a level-set representation of the three dimensional shape, changing the shape change velocities in accordance with a polynomial function, and updating the level-set representation using the shape change velocities to produce an updated version of the three dimensional shape.

Abstract: Methods, systems, and apparatus, including medium-encoded computer program products, for computer aided design of physical structures using generative design processes. A method includes obtaining a design space for a modeled object, one or more design criteria for the modeled object, and one or more in-use load cases; iteratively modifying a generatively designed three dimensional shape of the modeled object in the design space in accordance with the one or more design criteria and the one or more in-use load cases for the physical structure, comprising: performing numerical simulation of the modeled object in accordance the one or more in-use load cases, computing shape change velocities for an implicit surface in a level-set representation of the three dimensional shape, changing the shape change velocities in accordance with a polynomial function, and updating the level-set representation using the shape change velocities to produce an updated version of the three dimensional shape.

Abstract: Systems, methods, and computer readable media are described for modifying or updating a user interface. In some examples, systems, methods, and computer readable media include receiving, via an operator console on an operator system, one or more inputs for a template for a user interface, generating, based on the one or more inputs, the template for the user interface, and generating, based on the template, a plurality of designs for the user interface, wherein each design in the plurality of designs is associated with an interface profile.

Abstract: According to embodiments of the disclosure, an image capture control system is provided, the image capture control system comprising circuitry configured to: receive image data of an imaging environment from an image capture device; identify a selection of a first imaging zone of a plurality of pre-configured imaging zones within the imaging environment as an active imaging zone; control the image capture device based on the identification of the active imaging zone to capture image data of the active imaging zone; and perform processing on the captured image data of the active imaging zone based on the active imaging zone which has been selected.

Abstract: An apparatus for inspecting a tip shroud includes a frame having top and bottom surfaces. A first stop is connected to the bottom surface to contact a first side surface of the tip shroud, and a second stop is in sliding engagement with the frame to contact a second side surface of the tip shroud. A method for inspecting a tip shroud includes placing an apparatus against the tip shroud, wherein the apparatus has a first stop connected to a frame and a second stop in sliding engagement with the frame. The method further includes engaging the first stop with a first side surface of the tip shroud and sliding the second stop with respect to the frame until the second stop contacts a second side surface of the tip shroud.

Abstract: A transaction terminal system for a card-based purchase communicates with a host system to provide dynamic currency conversion. The transaction terminal system can select one of a number of different rate request messages according to various local factors in order to obtain a currency conversion rate for dynamic currency conversion.

Abstract: A payment terminal system for a card-based purchase can automatically determine a purchase that is potentially entitled to a tax refund from a billing currency for the payment card indicated in a purchase approval response message in response to payment authorisation request transmitted by the payment terminal system. Tax refund records are allocated. The tax refund records make reference to one or more reference currencies.

Abstract: The present invention relates to delayed release coated cores comprising an active substance in their core and a polymer coating comprising at least one or more ammonio methacrylate copolymer, characterized in that the core comprises at least a surfactant; to monolithic or multiparticulate pharmaceutical dosage forms comprising such delayed release coated cores and to their method of manufacture.

Abstract: The invention concerns a novel formulation for prolonged release of an active principle having a pH-dependent solubility. The inventive formulation comprises a matrix support based on hydrophilic polymer containing a specific dose of active principle, and further comprises one or more acidifying agents in the form of an acid salt of an organic acid.

Abstract: The present invention relates to timed dual release dosage forms of short acting hypnotics or salts thereof adapted to release the short acting hypnotic over a predetermined time period, according to a profile of dissolution characterized in that it comprises two release pulses, the first being immediate (lasting up to 30 minutes) and the second being delayed by a fixed time (this fixed time being between 50 and 200 minutes).

Abstract: A substance dispensing device is disclosed having a body that defines a chamber for receiving a substance capsule. The capsule is operable to dispense substance therefrom and has an outlet through which substance is dispensed. The body has two relatively movable parts that are moved relatively apart from a rest position to condition the device for use. A closure member associated with the movable part obstructs the outlet when the movable parts are in the rest position.

Abstract: The invention relates to a solid pharmaceutical composition for oral administration of amisulpride, which comprises at least one coated amisulpride particle and at least one pharmaceutically acceptable excipient suitable for an orodispersible administration of the composition.

Abstract: A sustained-release pharmaceutical formulation containing mizolastine, a core formed of a sustained-release table containing mizolastine combined with a fatty matrix and an organic acid, the tablet being coated.

Abstract: The invention concerns a pharmaceutical composition with gastric residence and controlled release, characterized in that it comprises two or three layers and contains (a) an active principle associated with a excipient modifying its release; (b) a system generating carbon dioxide in a swelling polymer hydrophilic matrix; (a) and (b) capable of being included in a common layer or in separate layers.

Abstract: Timed dual release dosage forms of short acting hypnotics or salts thereof adapted to release the short acting hypnotic over a predetermined time period according to a profile of dissolution comprising two release pulses, the first being immediate and the second being delayed by a fixed time after administration.

Abstract: A tamper evident packaging system including a tag (10) attachable to a package comprising a substantially oxygen impermeable upper barrier layer (12a), a reactive intermediate layer (14) including a reactive material changeable between an un-reacted condition in the absence of oxygen and a reacted condition in the presence of oxygen to produce a visible colour change, and a lower layer (12b) which can be a substantially oxygen impermeable lower barrier layer or an integral part of the package.