Patents by Inventor Hosheng Tu

Hosheng Tu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nanoparticles for protein drug delivery
    Patent number: 8283317
    Abstract: The invention discloses particulate complexes composed of chitosan, poly-glutamic acid, and at least one bioactive agent, wherein equal moles of the positively charged chitosan and the negatively charged poly-glutamic acid substrate form an electrostatic network enabling improved loading the bioactive agent.
    Type: Grant
    Filed: May 7, 2012
    Date of Patent: October 9, 2012
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Zi-Xian Liao, Shu-Fen Peng, Hosheng Tu
  • OCULAR SYSTEM WITH ANCHORING IMPLANT AND THERAPEUTIC AGENT
    Publication number: 20120253258
    Abstract: Ocular implants, delivery devices and methods for treating ocular disorders are disclosed. One method involves inserting an implant on one side of an eye. The implant has an anchor on a distal end portion and an outlet opening that is disposed proximal of the anchor. The implant is advanced across the eye to the other side of the eye. The anchor is inserted into eye tissue on the other side of the eye. A therapeutic agent is eluted using the implant.
    Type: Application
    Filed: February 17, 2012
    Publication date: October 4, 2012
    Applicant: DOSE MEDICAL CORPORATION
    Inventors: Hosheng Tu, Jason Artof, David Haffner
  • Pharmaceutical composition of nanoparticles
    Patent number: 8257740
    Abstract: The invention discloses a composition of chitosan-shelled nanoparticles and methods of manufacturing. The chitosan-shelled nanoparticles are characterized with a positive surface charge and enhanced epithelial ermeability for oral drug delivery.
    Type: Grant
    Filed: August 15, 2011
    Date of Patent: September 4, 2012
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Kiran Sonaje, Ho-Ngoc Nguyen, Hosheng Tu
  • PHARMACEUTICAL COMPOSITION OF NANOPARTICLES
    Publication number: 20120207845
    Abstract: The invention relates to a method for treating disorders or diseases of a tight junction comprising delivering a pharmaceutical composition of nanoparticles to the tight junction, wherein the nanoparticles consist of positively charged chitosan, a negatively charged substrate, optionally a zero-charge compound, and at least one bioactive agent for treating said disorders or diseases of the tight junction of an animal subject.
    Type: Application
    Filed: April 23, 2012
    Publication date: August 16, 2012
    Inventors: Hsing-Wen Sung, Kiran Sonaje, Ho-Ngoc Nguyen, Er-Yuan Chuang, Hosheng Tu
  • Pharmaceutical composition of nanoparticles
    Patent number: 8236281
    Abstract: The invention relates to a pharmaceutical composition of nanoparticles, wherein the nanoparticles comprise positively charged chitosan, a negatively charged substrate, optionally a zero-charge compound, and at least one bioactive agent for treating diabetes of an animal subject.
    Type: Grant
    Filed: April 17, 2012
    Date of Patent: August 7, 2012
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Kiran Sonaje, Hosheng Tu
  • Pharmaceutical composition of nanoparticles
    Patent number: 8236752
    Abstract: The invention relates to a method for treating disorders or diseases of a tight junction comprising delivering a pharmaceutical composition of nanoparticles to the tight junction, wherein the nanoparticles consist of positively charged chitosan, a negatively charged substrate, optionally a zero-charge compound, and at least one bioactive agent for treating said disorders or diseases of the tight junction of an animal subject.
    Type: Grant
    Filed: April 23, 2012
    Date of Patent: August 7, 2012
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Kiran Sonaje, Ho-Ngoc Nguyen, Er-Yuan Chuang, Hosheng Tu
  • Pharmaceutical composition of nanoparticles
    Patent number: 8226928
    Abstract: The invention discloses nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent, wherein the bioactive agent may include mitofusin 1, mitofusin 2, and/or anti-diabetic compounds.
    Type: Grant
    Filed: March 29, 2012
    Date of Patent: July 24, 2012
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Kiran Sonaje, Ho-Ngoc Nguyen, Ha Giang Thi Nguyen, Fang Yi Su, Er-Yuan Chuang, Hosheng Tu
  • Intragastric balloon system and therapeutic processes and products
    Patent number: 8226602
    Abstract: A gastric space filler device for treating obesity in a patient by reducing the stomach volume features at least one inflatable space filler with drag delivery and stimulation features and includes therapeutic devices and anchoring apparatus enabling tracking, visualization and optimized management of inter-balloon connecting sections, drug reservoirs and pumping systems along with related improvements.
    Type: Grant
    Filed: March 30, 2007
    Date of Patent: July 24, 2012
    Assignee: ReShape Medical, Inc.
    Inventors: Rodolfo C. Quijana, Andrew H. Cragg, Hosheng Tu, Stephen A. Sosnowski, George Wallace
  • Composition of imaging nanoparticles
    Patent number: 8221795
    Abstract: The invention relates to a method of managing a tumor of an animal subject comprising imaging the tumor by delivering a dosage of imaging nanoparticles to the tumor site, the imaging nanoparticles consisting of positively charged chitosan, optionally a zero-charge substance or bioactive agent, and a negatively charged substrate having gadolinium (Gd) chelated to the negatively charged substrate.
    Type: Grant
    Filed: December 8, 2011
    Date of Patent: July 17, 2012
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Kiran Sonaje, Ho-Ngoc Nguyen, Er-Yuan Chuang, Hosheng Tu
  • Cardiac valve leaflet attachment device and methods thereof
    Patent number: 8216230
    Abstract: A medical device system comprising a guide catheter and a leaflet fastening applicator, the guide catheter having suitable dimensions for deployment and insertion percutaneously into a human heart in a vicinity of a heart valve, the leaflet fastening applicator having a size allowing insertion through the guide catheter and being capable of holding portions of opposing heart valve leaflets, wherein the fastening applicator comprises a pair of grasping-electrodes adapted for holding and engaging the portions of opposing heart valve leaflets together and for applying energy to fasten the portions, in which heart valve leaflets can be captured and securely fastened, thereby improving coaptation of the leaflets and improving competence of the valve.
    Type: Grant
    Filed: April 4, 2011
    Date of Patent: July 10, 2012
    Assignee: Evalve, Inc.
    Inventors: Wallace Neil Hauck, Samuel Victor Lichtenstein, Hosheng Tu
  • Pharmaceutical composition of nanoparticles
    Patent number: 8202839
    Abstract: The invention discloses a pharmaceutical composition of bioactive nanoparticles composed of chitosan, poly-glutamic acid, and a bioactive agent for oral delivery. The chitosan-based nanoparticles are characterized with a positive surface charge and enhanced permeability for oral drug delivery.
    Type: Grant
    Filed: January 7, 2012
    Date of Patent: June 19, 2012
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Kiran Sonaje, Ho-Ngoc Nguyen, Er-Yuan Chuang, Hosheng Tu
  • Pharmaceutical composition of nanoparticles for protein drug delivery
    Patent number: 8202508
    Abstract: The invention discloses a pharmaceutical composition of bioactive nanoparticles composed of chitosan, poly-glutamic acid, and a bioactive agent for oral delivery. The chitosan-based nanoparticles are characterized with a positive surface charge and enhanced permeability for oral drug delivery.
    Type: Grant
    Filed: February 13, 2012
    Date of Patent: June 19, 2012
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Kiran Sonaje, Ho-Ngoc Nguyen, Er-Yuan Chuang, Hosheng Tu
  • Pharmaceutical composition of nanoparticles
    Patent number: 8198246
    Abstract: The invention discloses a pharmaceutical composition of liposome nanoparticles for lodging in a target tissue cell in situ of an animal subject, the nanoparticles comprising at least one thermal triggered phase-transition compound as a targeting drug delivery system for physical cancer therapy.
    Type: Grant
    Filed: December 3, 2010
    Date of Patent: June 12, 2012
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Hosheng Tu
  • Pharmaceutical composition of nanoparticles
    Patent number: 8192718
    Abstract: The invention relates to a method for treating disorders or diseases of a tight junction comprising delivering a pharmaceutical composition of nanoparticles to the tight junction, wherein the nanoparticles consist of positively charged chitosan, a negatively charged substrate, optionally a zero-charge compound, and at least one bioactive agent for treating said disorders or diseases of the tight junction of an animal subject.
    Type: Grant
    Filed: December 7, 2011
    Date of Patent: June 5, 2012
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Kiran Sonaje, Ho-Ngoc Nguyen, Er-Yuan Chuang, Hosheng Tu
  • Pharmaceutical composition of nanoparticles
    Patent number: 8187571
    Abstract: The invention discloses a pharmaceutical composition of nanoparticles, wherein each nanoparticle comprises N-palmitoyl chitosan that is conjugated with at least two different moieties, the moieties including a donor moiety and an acceptor moiety having a distance of 10 nm or less enabling Förster resonance energy transfer.
    Type: Grant
    Filed: December 22, 2010
    Date of Patent: May 29, 2012
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Patent number: 8187570
    Abstract: The invention discloses particulate complexes composed of chitosan, poly-glutamic acid, and at least one bioactive agent, wherein equal moles of the positively charged chitosan and the negatively charged poly-glutamic acid substrate form an electrostatic network enabling improved loading the bioactive agent.
    Type: Grant
    Filed: January 23, 2012
    Date of Patent: May 29, 2012
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Zi-Xian Liao, Shu-Fen Peng, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Patent number: 8188042
    Abstract: The invention discloses bioactive nanoparticles composed of chitosan, poly-glutamic acid, and diethylenetriaminepentaacetic acid for use in radionuclide decorporation during radiological emergency. The chitosan-based nanoparticles are characterized with a positive surface charge and enhanced permeability for oral drug delivery.
    Type: Grant
    Filed: October 21, 2009
    Date of Patent: May 29, 2012
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Hosheng Tu
  • PHARMACEUTICAL COMPOSITION OF PEPTIDE DRUG AND ENZYME-INHIBITION COMPOUNDS
    Publication number: 20120121701
    Abstract: The invention relates to a method of co-administering a peptide or protein drug with an enzyme-resistant PGA-complexone compound orally so to mitigate enzyme attack in the gastrointestinal tract of an animal subject.
    Type: Application
    Filed: December 13, 2011
    Publication date: May 17, 2012
    Inventors: Hsing-Wen Sung, Kiran Sonaje, Hosheng Tu
  • Pharmaceutical composition of peptide drug and enzyme-inhibition compounds
    Patent number: 8173106
    Abstract: The invention relates to a method of co-administering a peptide or protein drug with an enzyme-resistant PGA-complexone compound orally so to mitigate enzyme attack in the gastrointestinal tract of an animal subject.
    Type: Grant
    Filed: December 13, 2011
    Date of Patent: May 8, 2012
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Kiran Sonaje, Hosheng Tu
  • COMBINED TREATMENT FOR CATARACT AND GLAUCOMA TREATMENT
    Publication number: 20120109040
    Abstract: A method is provided for treatment of cataract in combination with a glaucoma procedure while maintaining the intraocular pressure by permitting aqueous to flow out of an anterior chamber of the eye through a surgically stented pathway. A trabecular stent is adapted for implantation within the trabecular meshwork of an eye such that intraocular liquid flows controllably from the anterior chamber of the eye to Schlemm's canal, bypassing the trabecular meshwork. Depending upon the specific treatment contemplated, pharmaceuticals may be utilized in conjunction with the trabecular stent enabling post-cataract healing processes.
    Type: Application
    Filed: May 27, 2011
    Publication date: May 3, 2012
    Applicant: GLAUKOS CORPORATION
    Inventors: Gregory T. Smedley, David Haffner, Barbara Niksch, Hosheng Tu, Thomas W. Burns