Abstract: A method for controlling or reversing the alcohol intake in the non-alcohol dependent individual both before or during their alcohol imbibing. This is accomplished by self-administering a spray directed into sensitive mucosal vein endings of the individual. There are at least three technologies to accomplish the above noted task. The first one is a nasal spray which is directed into the nasal passage. The second spray is directed into the mouth of the individual so that the medication can be absorbed by the buccal mucosal membrane in the mouth of the individual. The third medicated spray technology is pulmonary inhaler aerosolization which is absorbed in the tissues of the lung. All of the above noted sprays by-pass the liver and the intestines. The medication, Flumazenil, is the medication used in any of these sprays to accomplish the desired effect.

Abstract: A method of preventing a relapse in the abstinent substance abuse dependent person. The method involves the use of the medication of Flumazenil in a nasal spray device and to teach the person to self-administer the medication by spraying the medication into the nasal passage whenever the need and the urge to relapse arises, thereby preventing relapse.

Abstract: A method of preventing a relapse in the abstinent substance dependent person. The method involves the use of the medication Flumazenil in a spray delivery device and to teach the person to self-administer the medication by spraying the medication into either the nasal passage, the buccal mucosol membranes or the pulmonary membranes, whenever the need and the urge to relapse arises, thereby preventing relapse.

Abstract: Neuro-degenerative diseases such as Alzheimer's Disease with circulating molecules that pass through the Blood Brain Barrier which can generate a monoclonal antibodies specific to the offending circulating molecules are treated with an external blood cleansing system utilizing the monoclonal antibodies to extract the offending molecules.

Abstract: A novel class of substances of N-acyl-prolyldipeptides, which possess psychotropic activity and particularly facilitate learning and memory are described. The N-acyl-prolyldipeptides of the invention have the formula: ##STR1## wherein R.sup.1 =(C.sub.4 -C.sub.5) alkyl, cycloalkyl, aralkyl, or aryl; R.sup.2 =H.sub.1 (C.sub.1 -C.sub.4) alkyl, carbamidoalkyl, or carbalkoxyalkyl; R.sup.3 =NH.sub.2, NH(alkyl), N(alkyl).sub.2, OH, or alkoxy; and n=0-3, preferably 0-2.

Abstract: 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine derivatives having the formula (Formula I) ##STR1## and therapeutically acceptable acid addition salts thereof (Formula I.HX), wherein: R.sup.1 =hydrogen or acyl groups; and R.sup.2 =hydrogen or substituted aminomethyl groups. Said compounds and their acid addition salts have psychotropic activity, particularly anxiolytic activity.

Abstract: The craving for cocaine and use of cocaine among users may be reduced by administration of valproic acid. Cocaine-usage is effectively treated with valproic acid administration.

Abstract: The craving for cocaine and use of cocaine among users may be reduced by administration of carbamazepine. Cocaine-usage is effectively treated with the carbamazepine administration.