Patents by Inventor Jay A. Markwalder

Jay A. Markwalder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 6-Substituted pyrazolo [3,4-d] pyrimidin-4-ones useful as cyclin dependent kinase inhibitors
    Publication number: 20040248905
    Abstract: This invention relates to 6-substituted pyrazolo[3,4-d]pyrimidin-4-ones useful as cyclin dependant kinase (cdk) inhibitors, pharmaceutical compositions comprising the same and methods for using these compounds for treating cancer and proliferative diseases.
    Type: Application
    Filed: July 14, 2004
    Publication date: December 9, 2004
    Inventors: Jay A Markwalder, Steven P Seitz, Susan R Sherk
  • 6-substituted pyrazolo[3,4-d]pyrimidin-4-ones useful as cyclin dependent kinase inhibitors
    Patent number: 6559152
    Abstract: The present invention relates to the synthesis of a novel class of pyrazolo[3,4-d]pyrimidin-4-ones of formula (I), alternatively represented by the tautomer (II): that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cyclin dependent kinase 1-8 and their regulatory subunits know as cyclins A-H, K, N, and T. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.
    Type: Grant
    Filed: February 27, 2001
    Date of Patent: May 6, 2003
    Assignee: DuPont Pharmaceuticals Company
    Inventors: Jay A. Markwalder, Steven P. Seitz, Susan R. Sherk
  • 6-substituted pyrazolo [3,4-d] pyrimidin-4-ones useful as cyclin dependent kinase inhibitors
    Patent number: 6531477
    Abstract: The present invention relates to the synthesis of a novel class of pyrazolo[3,4-d]pyrimidin-4-ones of formula (I), alternatively represented by the tautomer (II): that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cyclin dependent kinase 1-8 and their regulatory subunits know as cyclins A-H, K, N, and T. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.
    Type: Grant
    Filed: October 12, 1999
    Date of Patent: March 11, 2003
    Assignee: DuPont Pharmaceuticals Company
    Inventors: Jay A. Markwalder, Steven P. Seitz, Susan R. Sherk
  • 6-Substituted pyrazolo[3,4-d] pyrimidin-4-ones useful as cyclin dependent kinase inhibitors
    Publication number: 20020013328
    Abstract: The present invention relates to the synthesis of a novel class of pyrazolo[3,4-d]pyrimidin-4-ones of formula (I), alternatively represented by the tautomer (II): 1
    Type: Application
    Filed: February 27, 2001
    Publication date: January 31, 2002
    Inventors: Jay A. Markwalder, Steven P. Seitz, Susan R. Sherk
  • Angiotensin II receptor blocking tertiary amides
    Patent number: 5260325
    Abstract: Novel substituted tertiary amides of formula (I), which are useful as angiotensin II antagonists, are disclosed: ##STR1##
    Type: Grant
    Filed: August 19, 1991
    Date of Patent: November 9, 1993
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Jay A. Markwalder, Richard S. Pottorf