Abstract: The invention relates to the field of medicine and medicinal chemistry, more in particular to the design, manufacture and use of anti-cancer drugs that can be activated by an external stimulus that can be applied in a spatiotemporal fashion. Provided herein is a compound having the chemical structure or a pharmaceutically acceptable salt thereof.

Abstract: The present invention relates to electrospun fibres containing: i) a first and a second hydrophilic fibre-forming polymer that is soluble in a hydrophilic solvent, ii) a bioadhesive substance that is slightly soluble in said hydrophilic solvent, iv) a drug substance, wherein the first hydrophilic polymer has a solubility in water at 37° C. that is at least 10 times greater than the solubility in water at 37° C. of the second hydrophilic fibre-forming polymer, and wherein the bioadhesive substance is present in solid form.

Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express novel recombinant genes encoding steviol biosynthetic enzymes and UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol or steviol glycosides, e.g., rubusoside or Rebaudioside A, which can be used as natural sweeteners in food products and dietary supplements.

Abstract: The present invention relates to electrospun fibers comprising i) a hydrophilic polymer that is soluble in a first solvent, ii) a bioadhesive substance that is slightly soluble in said first solvent, iii) optionally, a drug substance.

Abstract: The present invention relates to a topical spray composition comprising a biologically active vitamin D derivative or analogue and a corticosteroid, and its use in the treatment of dermal diseases and conditions.

Abstract: This present invention relates to a method for making a two-layered product (3) comprising a hydrophilic first material (1) made from electrospun fibers connected to a hydrophobic second material (2) made from electrospun fibers, and wherein said first material (1) contains a drug substance, characterized in that —said method comprises using a press (5) comprising a first surface (100) and a second surface (200), and wherein said second surface (200) has a temperature being higher than the temperature of said first surface (100), —said first (1) and second material (2) being arranged in a layered combination between the first (100) and second surface (200) of the press (5), wherein a pressure is provided towards said layered combination from said first (100) and second surface (200) of said press (5), and whereby said first material (1) comes into contact with said first surface (100) of said press (5), —wherein the combination of pressure between the first (100) and second surface (200) and the temperature o

Abstract: The present invention relates to electrospun fibres containing: i) a first and a second hydrophilic fibre-forming polymer that is soluble in a hydrophilic solvent, ii) a bioadhesive substance that is slightly soluble in said hydrophilic solvent, iv) a drug substance, wherein the first hydrophilic polymer has a solubility in water at 37° C. that is at least 10 times greater than the solubility in water at 37° C. of the second hydrophilic fibre-forming polymer, and wherein the bioadhesive substance is present in solid form.

Abstract: The present invention relates to electrospun fibers comprising i) a hydrophilic polymer that is soluble in a first solvent, ii) a bioadhesive substance that is slightly soluble in said first solvent, iii) optionally, a drug substance.

Abstract: A method and a device for increasing the perception of acoustic events, particularly for increasing musical sensitivity. As high a correlation as possible between heard and felt perceptions can be achieved by the conversion of the musical signal into vibrations on the skin, the local impact distribution of the filtered musical signals, the emphasis of the dominant musical signals by expanding the extent of the impact, the transfer of the signal portions in the non-feelable range into the feelable range, and the variable base spectrum adapting to the current musical spectrum.

Abstract: The present invention relates to electrospun fibers comprising i) a hydrophilic polymer that is soluble in a first solvent, ii) a bioadhesive substance that is slightly soluble in said first solvent, iii) optionally, a drug substance.

Abstract: The invention relates to the field of medicine and medicinal chemistry, more in particular to the design, manufacture and use of anti-cancer drugs that can be activated by an external stimulus that can be applied in a spatiotemporal fashion. Provided herein is a compound having the chemical structure or a pharmaceutically acceptable salt thereof.

Abstract: The present invention relates to a method for preparing electrospun fibers, the method comprising v) dissolving a fiber-forming hydrophilic polymer in an alcohol selected from C1-C3 alcohols, vi) dissolving a bioadhesive substance in water, wherein the bioadhesive substance has a solubility in water of 3 g/100 ml or more at 25° C. or g/100 ml or more at 25° C., and wherein the bioadhesive substance has a solubility in an alcohol selected from C1-C3 alcohols of 0.5 g/100 nil 10 or less at 25° C. or 0.1 g/100 ml or less at 25° C., vii) adding under stirring the resulting solution from ii) to the resulting solution from i), whereby the bioadhesive substance precipitates and a homogeneous suspension is formed, wherein the bioadhesive substance is suspended as particles, and viii) electrospinning the homogeneous suspension to obtain hydrophilic fibers.

Abstract: A method and a device for increasing the perception of acoustic events, particularly for increasing musical sensitivity. As high a correlation as possible between heard and felt perceptions can be achieved by the conversion of the musical signal into vibrations on the skin, the local impact distribution of the filtered musical signals, the emphasis of the dominant musical signals by expanding the extent of the impact, the transfer of the signal portions in the non-feelable range into the feelable range, and the variable base spectrum adapting to the current musical spectrum.

Abstract: The present invention relates to a topical spray composition comprising a biologically active vitamin D derivative or analogue and a corticosteroid, and its use in the treatment of dermal diseases and conditions.

Abstract: The present invention relates to a topical spray composition comprising a biologically active vitamin D derivative or analogue and a corticosteroid, and its use in the treatment of dermal diseases and conditions.

Abstract: The present invention relates to a topical spray composition comprising a biologically active vitamin D derivative or analogue and a corticosteroid, and its use in the treatment of dermal diseases and conditions.

Abstract: A Pharmaceutical Spray Composition Comprising a Vitamin D Analogue and a Corticosteroid The present invention relates to a topical spray composition comprising a biologically active vitamin D derivative or analogue and a corticosteroid, and its use in the treatment of dermal diseases and conditions.

Abstract: The present invention relates to a topical spray composition comprising a biologically active vitamin D derivative or analogue and a corticosteroid, and its use in the treatment of dermal diseases and conditions.

Abstract: The present invention relates to a topical spray composition comprising a biologically active vitamin D derivative or analogue and a corticosteroid, and its use in the treatment of dermal diseases and conditions.

Abstract: A Pharmaceutical Spray Composition Comprising a Vitamin D Analogue and a Corticosteroid The present invention relates to a topical spray composition comprising a biologically active vitamin D derivative or analogue and a corticosteroid, and its use in the treatment of dermal diseases and conditions.