Patents by Inventor Jingwu Duan

Jingwu Duan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Beta-sulfone derivatives as inhibitors of matrix metalloproteinases and/or TNF-alpha converting enzyme (TACE)
    Publication number: 20030212056
    Abstract: The present application describes novel &bgr;-sulfone derivatives of formula I: 1
    Type: Application
    Filed: November 1, 2002
    Publication date: November 13, 2003
    Inventors: Jingwu Duan, Gregory R. Ott
  • Bicyclic lactam derivatives as inhibitors of matrix metalloproteinases and/or TNF-alpha converting enzyme (TACE)
    Publication number: 20030181438
    Abstract: The present application describes novel bicyclic lactam derivatives of formula I: 1
    Type: Application
    Filed: October 16, 2002
    Publication date: September 25, 2003
    Inventors: Carl P. Decicco, Ying Song, Jingwu Duan, Matthew E. Voss
  • Lactam metalloprotease inhibitors
    Patent number: 6620823
    Abstract: The present application describes novel lactams and derivatives thereof of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 4-8 membered cyclic amide comprising 0-3 additional heteroatoms selected from N, O, and S, which are useful as metalloprotease inhibitors.
    Type: Grant
    Filed: July 10, 2001
    Date of Patent: September 16, 2003
    Assignee: Bristol-Myers Squibb Pharme Company
    Inventors: Thomas P Maduskuie, Jingwu Duan, Stephen E Mercer
  • Barbituric acid derivatives as inhibitors of TNF-alpha converting enzyme (TACE) and/or matrix metalloproteinases
    Publication number: 20030166647
    Abstract: The present application describes novel barbituric acid derivatives of formula I: 1
    Type: Application
    Filed: December 17, 2002
    Publication date: September 4, 2003
    Inventors: Jingwu Duan, Zhonghui Lu
  • Lactam metalloprotease inhibitors
    Patent number: 6610731
    Abstract: The present application describes novel lactams and derivatives thereof of formula I: or pharmaceutically acceptable salt forms thereof, wherein rings ring B is a 4-8 membered cyclic amide containing from 0-3 additional heteroatoms selected from N, O, and S, which are useful as metalloprotease inhibitors.
    Type: Grant
    Filed: March 12, 2002
    Date of Patent: August 26, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jingwu Duan, Carl P. Decicco, Zelda R. Wasserman, Thomas P. Maduskuie, Jr.
  • Cyclic sulfone derivatives as inhibitors of matrix metalloproteinases and/or TNF-Alpha converting enzyme (TACE)
    Publication number: 20030149031
    Abstract: The present application describes novel cyclic sulfone derivatives of formula I: 1
    Type: Application
    Filed: October 7, 2002
    Publication date: August 7, 2003
    Inventors: Jingwu Duan, Chu-Biao Xue
  • Cyclic hydroxamic acids as inhibitors of matrix metalloproteinases and/or TNF-alpha converting enzyme (TACE)
    Publication number: 20030139388
    Abstract: The present application describes novel cyclic hydroxamic acids of formula I: 1
    Type: Application
    Filed: September 16, 2002
    Publication date: July 24, 2003
    Inventors: Gregory R. Ott, Xiao-Tao Chen, Jingwu Duan, Zhonghui Lu
  • Novel lactam metalloprotease inhibitors
    Publication number: 20030134827
    Abstract: The present application describes novel lactams and derivatives thereof of formula I: 1
    Type: Application
    Filed: March 12, 2002
    Publication date: July 17, 2003
    Inventors: Jingwu Duan, Carl P. Decicco, Zelda R. Wasserman, Thomas P. Maduskuie
  • Hydantoins and related heterocycles as inhibitors of matrix metalloproteinases and/or TNF-alpha converting enzyme (TACE)
    Publication number: 20030130273
    Abstract: The present application describes novel hydantoin derivatives of formula (I): 1
    Type: Application
    Filed: May 23, 2002
    Publication date: July 10, 2003
    Inventors: James E. Sheppeck, Jingwu Duan, Chu-Biao Xue, Zelda Wasserman
  • Bicyclic hydroxamates as inhibitors of matrix metalloproteinases and/or TNF-alpha converting enzyme (TACE)
    Publication number: 20030130257
    Abstract: The present application describes to novel bicyclic hydroxamates derivatives of formula I: 1
    Type: Application
    Filed: August 15, 2002
    Publication date: July 10, 2003
    Inventors: James E. Sheppeck, Jingwu Duan
  • Spiro-cyclic beta-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-alpha converting enzyme (TACE)
    Publication number: 20030087882
    Abstract: The present application describes novel spiro-cyclic &bgr;-amino acid derivatives of formula I: 1
    Type: Application
    Filed: March 12, 2002
    Publication date: May 8, 2003
    Inventors: Gregory R. Ott, Xiao Tao Chen, Jingwu Duan, Matthew E. Voss
  • Novel amide derivatives as inhibitors of matrix metalloproteinases, TNF-alpha, and aggrecanase
    Publication number: 20030032803
    Abstract: The present application describes novel amides and derivatives thereof of formula 1
    Type: Application
    Filed: February 12, 2002
    Publication date: February 13, 2003
    Inventors: Jingwu Duan, Carl P. Decicco, David J. Nelson, Chu-Biao Xue
  • &bgr;-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-&agr;
    Patent number: 6495565
    Abstract: The present application describes novel &bgr;-amino acid derivatives of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, X, Z, Ua, Xa, Ya, Za, R1, R2, R3, R4, and R4a are defined in the present specification, which are useful as metalloprotease and/or as TNF-&agr; inhibitors.
    Type: Grant
    Filed: March 16, 2001
    Date of Patent: December 17, 2002
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Jingwu Duan, Bryan W. King, Carl Decicco, Thomas P. Maduskuie, Jr., Matthew E. Voss
  • Lactam inhibitors of matrix metalloproteinases, TNF-&agr; and aggrecanase
    Patent number: 6495548
    Abstract: The present application describes novel lactams and derivatives thereof of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 4-8 membered lactam containing from 0-3 additional heteroatoms selected from N, O, and S, which are useful as inhibitors of matrix metalloproteinases, TNF-&agr;, and aggrecanase.
    Type: Grant
    Filed: March 31, 2000
    Date of Patent: December 17, 2002
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventor: Jingwu Duan
  • Cyclic sulfonamide derivatives as metalloproteinase inhibitors
    Patent number: 6455522
    Abstract: The present application describes novel lactams and derivatives thereof of formula I: or pharmaceutically acceptable salt forms thereof, wherein rings ring B is a 4-8 membered cyclic sulfonamide containing from 0-3 additional heteroatoms selected from N, O, and S, which are useful as metalloprotease inhibitors.
    Type: Grant
    Filed: February 10, 1999
    Date of Patent: September 24, 2002
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Jingwu Duan, Lihua Chen, Robert J. Cherney, Carl P. Decicco, Matthew E. Voss
  • Lactam metalloprotease inhibitors
    Patent number: 6403632
    Abstract: The present application describes novel lactams and derivatives thereof of formula I: or pharmaceutically acceptable salt forms thereof, wherein rings ring B is a 4-8 membered cyclic amide containing from 0-3 additional heteroatoms selected from N, O, and S, which are useful as metalloprotease inhibitors.
    Type: Grant
    Filed: March 1, 2000
    Date of Patent: June 11, 2002
    Inventors: Jingwu Duan, Carl P. Decicco, Zelda R. Wasserman, Thomas P. Maduskuie, Jr.
  • Amide derivatives as inhibitors of matrix metalloproteinases, TNF-&agr;, and aggrecanase
    Patent number: 6376665
    Abstract: The present application describes novel amides and derivatives thereof of formula I: or pharmaceutically acceptable salt forms thereof, wherein these compounds are useful as inhibitors of matrix metalloproteinases, TNF-&agr;, and aggrecanase.
    Type: Grant
    Filed: March 31, 2000
    Date of Patent: April 23, 2002
    Inventors: Jingwu Duan, Carl P. Decicco, David J. Nelson, Chu-Biao Xue
  • Novel lactam metalloprotease inhibitors
    Publication number: 20020042398
    Abstract: The present application describes novel lactams and derivatives thereof of formula I: 1
    Type: Application
    Filed: July 10, 2001
    Publication date: April 11, 2002
    Inventors: Thomas P. Maduskuie, Jingwu Duan, Stephen E. Mercer
  • Cyclic beta-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-alpha
    Publication number: 20020016336
    Abstract: The present application describes novel cyclic &bgr;-amino acid derivatives of formula I: 1
    Type: Application
    Filed: March 16, 2001
    Publication date: February 7, 2002
    Inventors: Jingwu Duan, Gregory R. Ott, Lihua Chen, Carl Decicco, Zhonghui Lu, Thomas P. Maduskuie, Matthew E. Voss, Chu-Biao Xue
  • Beta-Amino-Acid derivatives as inhibitors of matrix metalloproteases and TNF-Alpha
    Publication number: 20020013341
    Abstract: The present application describes novel &bgr;-amino acid derivatives of formula I: 1
    Type: Application
    Filed: March 16, 2001
    Publication date: January 31, 2002
    Inventors: Jingwu Duan, Bryan W. King, Carl Decicco, Thomas P. Maduskuie, Matthew E. Voss