Abstract: A complexation process between a cyclodextrin and active pharmaceutical ingredients is disclosed, and comprises a process for preparing a complex of at least one cyclodextrin and at least one active pharmaceutical ingredient comprising the steps of a. Preparing a first solution (solution A) comprising at least one cyclodextrin and at least one solvent; b. Preparing a second solution (solution B) comprising at least one dissolved, partially dissolved or suspended API; c. Mixing said solution A and solution B by means of a microfludization system to produce a solution and/or suspension of at least one of said complex; d. Isolating said solution and/or suspension and/or optionally drying it; and e. Optionally collecting a powdered form of the complex. The described process has high throughput with higher yields of complexation in less time than prior art methods.

Abstract: A complexation process between a cyclodextrin and active pharmaceutical ingredients is disclosed, and comprises a process for preparing a complex of at least one cyclodextrin and at least one active pharmaceutical ingredient comprising the steps of a. Preparing a first solution (solution A) comprising at least one cyclodextrin and at least one solvent; b. Preparing a second solution (solution B) comprising at least one dissolved, partially dissolved or suspended API; c. Mixing said solution A and solution B by means of a microfludization system to produce a solution and/or suspension of at least one of said complex; d. Isolating said solution and/or suspension and/or optionally drying it; and e. Optionally collecting a powdered form of the complex. The described process has high throughput with higher yields of complexation in less time than prior art methods.

Abstract: A process for manufacturing a can with a polygonal cross-section and a can with a polygonal cross-section, the process comprising the steps of milling the cylindrical lateral wall of a tubular body (10), providing said wall with a plurality of circumferential ribs (20) which are continuous and axially spaced from each other and defined by a certain degree of radial plastic deformation of the respective circumferential region of the cylindrical lateral wall of the tubular body (10); expanding the formed tubular body (10), deforming it, in order to define longitudinal edges (12) in whose region the circumferential ribs (20) are eliminated; and double-seaming a bottom and an upper wall of the can to the tubular body (10). This process defines a can having any polygonal cross-section and circumferential ribs (20) on the lateral wall thereof, between the longitudinal edges (12).