Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: A blowout preventer comprises a pair of ram assemblies which are mounted on diametrically opposite sides of a BOP housing. A cylinder-ram is slidably received within each ram assembly and includes a cylindrical cavity. A back plate couples with the outer end of the cylinder-ram and a piston head is positioned in the cavity, forming first and second piston chambers. Hydraulic pressure in the first and second piston chambers forces the cylinder ram from an open position to a closed position, thereby sealing the BOP bore.

Abstract: A blowout preventer comprises a pair of ram assemblies which are mounted on diametrically opposite sides of a BOP housing. A cylinder-ram is slidably received within each ram assembly and includes a cylindrical cavity. A back plate couples with the outer end of the cylinder-ram and a piston head is positioned in the cavity, forming first and second piston chambers. Hydraulic pressure in the first and second piston chambers forces the cylinder ram from an open position to a closed position, thereby sealing the BOP bore.

Abstract: An apparatus adapted for removing a plug (12) from a subsea Christmas tree (10) is disclosed which includes a housing (84), a distal end of the apparatus that is adapted to engage the plug (12) and a fluid passage (83) formed in the housing (84) for use in directing a stream of fluid toward the plug (12) to remove debris (90) from above the plug (12). Also disclosed is a method for removing debris (90) from a subsea Christmas tree (10) including connecting a marine riser and a blowout preventer (BOP) (60) to a subsea Christmas tree (10), lowering a plug removal tool (80) through the marine riser to the Christmas tree (10), the plug removal tool (80) having a fluid passage (83) formed therein, and forcing a fluid down the marine riser and through the fluid passage (83) in the plug removal tool (80) to wash out debris (90) in the Christmas tree (10).

Abstract: Nucleic acid sequences, particularly DNA sequences, coding for all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, expression vectors containing the DNA sequences, host cells containing the expression vectors, and methods utilizing these materials. The invention also concerns polypeptide molecules comprising all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, and methods for producing these polypeptide molecules. The invention additionally concerns novel methods for preventing, stabilizing or causing regression of atherosclerosis and therapeutic agents having such activity. The invention concerns further novel methods for lowering serum liquid levels and therapeutic agents having such activity.

Abstract: Compounds are provided which inhibit microsomal triglyceride transfer protein and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases. The compounds have the structure ##STR1## wherein R.sup.1 to R.sup.7, Q, X and Y are as defined herein.

Abstract: Compounds are provided which inhibit microsomal triglyceride transfer protein and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases. The compounds have the structure ##STR1## wherein R.sup.1 to R.sup.7, Q, X and Y are as defined herein.

Abstract: Compounds are provided which inhibit microsomal triglyceride transfer protein and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases. The compounds have the structure ##STR1## wherein R.sup.1 to R.sup.7, Q, X and Y are as defined herein.

Abstract: Nucleic acid sequences, particularly DNA sequences, coding for all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, expression vectors containing the DNA sequences, host cells containing the expression vectors, and methods utilizing these materials. The invention also concerns polypeptide molecules comprising all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, and methods for producing these polypeptide molecules. The invention additionally concerns novel methods for preventing, stabilizing or causing regression of atherosclerosis and therapeutic agents having such activity. The invention concerns further novel methods for lowering serum liquid levels and therapeutic agents having such activity.

Abstract: A valve arrangement having an insert assembly (11) receivable in a receptacle (10). The insert assembly includes valve elements for controlling fluid flow through the valve. These include a gate (40) and chamber valve seat members (52, 53). The insert is constructed so that it can be removed from and located in the receptacle. When located in the receptacle and in operation the gate is urged against one of the seat members so that a seal is formed between the seat and gate and between the seat and receptacle body. The gate (40) can be an expandable gate.

Abstract: A fluid operated tool 30 (FIG. 4) for use in replacing a body clamped between facing platens has an open ended tubular member 31, through which the body can pass, that carries outwardly thereof, and axially extending, coplaner support arms 33, 34 at the end of which are hydraulic piston and cylinder arrangements 35, 36 for inserting between the platens to overcome the clamping force on the body, permitting it to be removed and replaced by way of the tubular member 31. The tool may be used subsea with a submersible to handle it and provide hydraulic power.

Abstract: An improved clamp connector for securing ends of tubular members together in tight sealed relationship and including a pair of semicircular segments having lips to engage the opposite sides of abutting projections on the tubular members, a pressure responsive actuator to preload the segments on the projections, connecting studs between the segments which are loaded by the actuator and blocks of a preselected size to be positioned in supporting relationship to the actuator in its preload position to maintain such preload on the segments and studs after the fluid pressure on the actuator is released. A pressure responsive portion of the blocks allows their quick and positive release when desired.

Abstract: A valve mounting for securing a valve body between two spaced apart mounting members having hydraulic studs which are elongated by pressure for release of the clamping engagement of the valve body for its quick and easy installation and removal. A preferred form of the present invention includes the application of a plurality of valve modules connected to the exterior of an elongate block manifold body through the use of hydraulic studs to control the flow into one of the longitudinal passages extending through the manifold body.

Abstract: Method and apparatus for establishing a seal across the annulus between two concentric rigid members to seal the annulus against large fluid pressures. A specially formed seal ring, advantageously of low carbon steel in the annealed state, is preliminarily inserted into the annular space between two concentrically opposed surfaces, then forced further into that annular space to force the sealing ring, with accompanying plastic deformation of a portion of the ring, into sealing engagement with both of the concentrically opposed surfaces.

Abstract: In well installations subjected to high internal fluid pressures, hangers for long casing strings are supported independently in the upright bore of a wellhead body or other support member without requiring that the hangers be stacked one atop another or that the bore diameter be stepped to provide an upwardly exposed shoulder for each hanger. All hangers save the lowermost hanger are supported by an annular support member engaged in a groove in the wellhead body, with no load being transferred from an upper hanger to a lower hanger.

Abstract: 1-(4-Pyrimidinyloxy)-3-(hetarylalkylamino)-2-propanols are cardiovascular agents having a range of vasodilator and adrenergic beta-receptor blocking activities making these compounds useful anti-hypertensive agents. Preferred compounds bear a hydrazino or hydrazono substituent in the 2- position of the pyrimidine ring.

Abstract: A self-levelling underwater structure receivable on an upright support implanted in the floor of a body of water and including a hollow unit fitting over the upright support and having a pivot device thereon engaging the upright support so that the hollow unit gravitates to a level position, and a securing assembly for securing the hollow unit to the upright support in the levelled position. A locking assembly is also provided to prevent relative axial movement of the hollow unit and the upright support once the structure is levelled.

Abstract: A connector for coupling a plurality of flowlines in a catenary bundle in fluid-flow relationship with a plurality of wellheads supported on a submerged buoyant support. The connector comprises a first member that is rigidly coupled to the submerged support, has a plurality of conduits extending therefrom to the wellheads, and has an open-ended member with a rotational orientation member therein; and a second member that is coupled to the end of the flowline bundle, is receivable on the first member and has an elongated stinger thereon receivable in the annular open-ended member on the first connector member. The stinger has a second orientation member for mating with the orientation member in the open-ended member. Run from the surface through the open-ended member and attached to the end of the stinger is a hauling wireline used to bring the first and second connector members into engagement, at which time they are rotationally oriented and locked together.

Abstract: A flowline receiving and guiding unit characterized by having a generally tubular base member adapted to be landed upon the upper end portion of an upright support, typically a pile, secured in the floor of a body of water. The unit includes an elongated curved tubular structure, typically of J-tube configuration, so positioned that when the unit has been landed the upper end of the curved tubular structure is upright and occupies a predetermined position relative to the pile.

Abstract: In installation of a flowline and connection thereof to an underwater installation equipped with guide lines extending from the installation to an operational base at the surface of the body of water, a pile or other upright support is first installed in a predetermined location adjacent the underwater installation, and all operations necessary to install the flowline and connect the flowline to the underwater installation are then carried out with the aid of the guide lines and employing apparatus installed on the pile.