Patents by Inventor John M. Roubie

John M. Roubie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cyclohexanone extraction of 3-hydroxymethylcephalosporins
    Patent number: 5801241
    Abstract: The cephalosporin intermediates, desacetyl 7-glutaryl ACA and desacetyl cephalosporin D, are obtained in the form of a concentrated aqueous solution from an aqueous solution containing said intermediates in less concentrated form by solvent extraction using cyclohexanone followed by back-extraction into water. The concentrated aqueous solution of intermediate is in a form which can be used for economical production of 7-ACA using known procedures.
    Type: Grant
    Filed: July 18, 1997
    Date of Patent: September 1, 1998
    Assignee: Bristol-Myers Squibb Company
    Inventors: Gary M. F. Lim, John M. Roubie, Vicki H. Audia
  • Syn-isomer of thiazolyl intermediate and process for the preparation thereof
    Patent number: 5698703
    Abstract: The present invention provides a stable, crystalline syn-isomer of 2-(2-aminothiazol-4-yl)-2-methoxyimino acetyl chloride hydrochloride substantially free of the anti-isomer and a process for the preparation thereof which may be used in an acylation process for the preparation of useful broad-spectrum antibiotics.
    Type: Grant
    Filed: April 25, 1994
    Date of Patent: December 16, 1997
    Assignee: Bristol-Myers Squibb Company
    Inventors: Gary M. F. Lim, John M. Roubie
  • Process for the preparation of a cephalosporin antibiotic
    Patent number: 5594129
    Abstract: The present invention provides an anhydrous acylation process for the preparation of antibiotic, cefepime dihydrochloride hydrate which is substantially free of the anti-isomer and the .DELTA..sup.2 isomer comprising the N-acylation of a silylated derivative of 7-amino-3-[(1-methyl-1-pyrrolidinio)-methyl]ceph-3-em-4-carboxylate with the syn-isomer of 2-(2-aminothiazol-4-yl)-2-methoxyimino acetyl chloride hydrochloride.
    Type: Grant
    Filed: December 19, 1994
    Date of Patent: January 14, 1997
    Assignee: Bristol-Myers Squibb Company
    Inventors: Gary M. F. Lim, John M. Roubie, Elizabeth A. Garofalo
  • Process for preparing cephalosporin intermediates
    Patent number: 5594131
    Abstract: The present invention provides a process for the preparation of stable, crystalline cephalosporin intermediates of the formula ##STR1## wherein X is HI, HCl or H.sub.2 SO.sub.4 which are substantially free of the .DELTA..sup.2 isomer, and which are convertible into broad-spectrum cephalosporin antibiotics.
    Type: Grant
    Filed: February 2, 1995
    Date of Patent: January 14, 1997
    Assignee: Bristol-Myers Squibb COmpany
    Inventors: Gary M. F. Lim, John M. Roubie
  • Preparation of a cephalosporin antibiotic using the syn-isomer of a thiazolyl intermediate
    Patent number: 5594130
    Abstract: The present invention provides an aqueous acylation process for the preparation of antibiotic, cefepime dihydrochloride hydrate which is substantially free of the anti-isomer and the .DELTA..sup.2 isomer comprising the N-acylation of 7-amino-3-[(1-methyl-1-pyrrolidinio)-methyl]ceph-3-em-4-carboxylate with the syn-isomer of 2-(2-aminothiazol-4-yl)-2-methoxyimino acetyl chloride hydrochloride.
    Type: Grant
    Filed: February 2, 1995
    Date of Patent: January 14, 1997
    Assignee: Bristol-Myers Squibb Company
    Inventors: Gary M. F. Lim, John M. Roubie