Patents by Inventor John N. Staniforth
John N. Staniforth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7153538Abstract: A method of coating a pharmaceutical substrate includes the steps of applying an active coating material to a surface of the substrate to form an active coating layer and applying a cover coating material onto the active coating layer to form a cover coating layer. The active coating layer is substantially completely covered by the cover coating layer.Type: GrantFiled: September 26, 2001Date of Patent: December 26, 2006Assignee: Phoqus Pharmaceuticals LimitedInventors: Steven R. Brown, Linda A. Reeves, John N. Staniforth
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Patent number: 7008668Abstract: An apparatus and method for locking a gun. The apparatus includes a dummy round configured for insertion into a firing chamber of a gun, a locking component configured for coupling with the dummy round, and an elongated sleeve rotatably coupled with the locking component. The locking component includes a keyed head positioned within a longitudinal channel of the elongated sleeve. The locking component and elongated sleeve are insertable through the discharge end of a gun's barrel. An actuating mechanism, such as a key is insertable through the channel of the elongated sleeve to engage with the keyed head and rotate the locking mechanism relative to the elongated sleeve. Rotation of the locking mechanism effects a friction lock between the locking mechanism and the dummy round.Type: GrantFiled: November 19, 2001Date of Patent: March 7, 2006Assignee: Phoqus Pharmaceuticals LimitedInventors: John E. Hogan, Trevor Page, Linda Reeves, John N. Staniforth
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Patent number: 6960356Abstract: A pharmaceutical composition in the form of tablets or capsules provides a combination of temporal and spatial control of drug delivery to a patient for effective therapeutic results. The pharmaceutical composition comprises a drug, a gas generating component, a swelling agent, a viscolyzing agent, and optionally a gel forming polymer. The swelling agent belongs to a class of compounds known as superdisintegrants (e.g., cross-linked polyvinylpyrrolidone or sodium carboxymethylcellulose). The viscolyzing agent initially and the gel forming polymer thereafter form a hydrated gel matrix which entraps the gas, causing the tablet or capsule to be retained in the stomach or upper part of the small intestine (spatial control). At the same time, the hydrated gel matrix creates a tortuous diffusion path for the drug resulting in sustained release of the drug (temporal control). A preferred once daily ciprofloxacin formulation comprises 69.9% profloxacin base, 0.34% sodium alginate, 1.103% xanthan gum, 13.Type: GrantFiled: July 2, 1999Date of Patent: November 1, 2005Assignee: Ranbaxy Laboratories LimitedInventors: Naresh Talwar, Himadri Sen, John N. Staniforth
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Patent number: 6936277Abstract: A method of preparing an excipient composition includes forming an aqueous slurry containing a mixture of microcrystalline cellulose in the form of a wet cake and a surfactant, said surfactant being present in an amount from about 0.1% to about 0.5% by weight of the wet-cake microcrystalline cellulose; and drying said slurry to obtain an excipient comprising a plurality of agglomerated particles of microcrystalline cellulose in intimate association with said surfactant. The excipient may be mixed with a therapeutically active agent to form a dosage form. The surfactant provides a hydrophobic boundary at cellulose surfaces, and improves absorptivity of the therapeutically active agent.Type: GrantFiled: May 14, 2002Date of Patent: August 30, 2005Assignee: J. Rettenmaier & Soehne GmbH & Co. KGInventors: John N. Staniforth, Edward A. Hunter, Bob E. Sherwood
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Patent number: 6866867Abstract: The present invention provides an improved process for the preparation of a agglomerated solid dosage form, comprising: (1) preparing an aqueous slurry of (a) microcrystalline cellulose; (b) a microcrystalline cellulose compressibility augmenting agent which (i) physically restricts the proximity of the interface between adjacent cellulose surfaces; (ii) inhibits interactions between adjacent cellulose surfaces, for example, via the creation of a hydrophobic boundary at cellulose surfaces; or (iii) accomplishes both (i) and (ii) above; and (c) an active agent; (2) thereafter drying the resultant aqueous slurry in a manner which inhibits quasi-hornification, thereby obtaining an agglomerated material which is directly compressible into a solid dosage form.Type: GrantFiled: December 13, 2001Date of Patent: March 15, 2005Assignee: J. Rettenmaier & Soehne GmbH + Co. KGInventors: John N. Staniforth, Bob E. Sherwood, Edward A. Hunter, Clifford M. Davidson
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Publication number: 20040265374Abstract: A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0.1% to about 20% silicon dioxide particles, by weight of microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from about 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide. An extra low moisture excipient is provided which exhibits improved compressibility as compared to conventional microcrystalline cellulose, while providing a moisture content of of from about 0.5 to 2.5% LOD, preferably between about 0.5 and about 1.8%, more preferably between 0.8 and 1.5%, and most preferably between about 0.8 and about 1.2%.Type: ApplicationFiled: April 2, 2004Publication date: December 30, 2004Applicant: J. Rettenmaier & Soehne GmbH + Co. KGInventors: John N. Staniforth, Bob E. Sherwood, Edward A. Hunter
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Patent number: 6783768Abstract: Method of coating a substrate which is a belt, sheet, film, or tape, comprising applying an active coating material to the substrate to form an active coating layer, the active coating material comprising biologically active material. The active coating material is applied electrostatically as a powder and, after the active coating material is applied, the active coating material is fused to form an active film layer. The active coating material is removable from the substrate as a wafer comprising the active film layer.Type: GrantFiled: May 13, 1999Date of Patent: August 31, 2004Assignee: Phoqus Pharmaceuticals LimitedInventors: Steven R. Brown, Linda A. Reeves, John N. Staniforth
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Patent number: 6746693Abstract: A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0.1% to about 20% silicon dioxide particles, by weight of microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide. An extra low moisture excipient is provided which exhibits improved compressibility as compared to conventional microcrystalline cellulose, while providing a moisture content of of from about 0.5 to 2.5% LOD, preferably between about 0.5 and about 1.8%, more preferably between 0.8 and 1.5%, and most preferably between about 0.8 and about 1.2%.Type: GrantFiled: October 8, 2002Date of Patent: June 8, 2004Assignee: J. Rettenmaier & Soehne GmbH + Co. KGInventors: John N. Staniforth, Bob E. Sherwood, Edward A. Hunter
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Publication number: 20030147949Abstract: A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0.1% to about 20% silicon dioxide particles, by weight of microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide. An extra low moisture excipient is provided which exhibits improved compressibility as compared to conventional microcrystalline cellulose, while providing a moisture content of of from about 0.5 to 2.5% LOD, preferably between about 0.5 and about 1.8%, more preferably between 0.8 and 1.5%, and most preferably between about 0.8 and about 1.2%.Type: ApplicationFiled: October 8, 2002Publication date: August 7, 2003Inventors: John N. Staniforth, Bob E. Sherwood, Edward A. Hunter
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Publication number: 20030138487Abstract: An apparatus and method for locking a gun. The apparatus includes a dummy round configured for insertion into a firing chamber of a gun, a locking component configured for coupling with the dummy round, and an elongated sleeve rotatably coupled with the locking component. The locking component includes a keyed head positioned within a longitudinal channel of the elongated sleeve. The locking component and elongated sleeve are insertable through the discharge end of a gun's barrel. An actuating mechanism, such as a key is insertable through the channel of the elongated sleeve to engage with the keyed head and rotate the locking mechanism relative to the elongated sleeve. Rotation of the locking mechanism effects a friction lock between the locking mechanism and the dummy round.Type: ApplicationFiled: November 19, 2001Publication date: July 24, 2003Applicant: Phoqus LimitedInventors: John E. Hogan, Trevor Page, Linda Reeves, John N. Staniforth
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Publication number: 20030099702Abstract: A method of preparing an excipient composition includes forming an aqueous slurry containing a mixture of microcrystalline cellulose in the form of a wet cake and a surfactant, said surfactant being present in an amount from about 0.1% to about 0.5% by weight of the wet-cake microcrystalline cellulose; and drying said slurry to obtain an excipient comprising a plurality of agglomerated particles of microcrystalline cellulose in intimate association with said surfactant. The excipient may be mixed with a therapeutically active agent to form a dosage form. The surfactant provides a hydrophobic boundary at cellulose surfaces, and improves absorptivity of the therapeutically active agent.Type: ApplicationFiled: May 14, 2002Publication date: May 29, 2003Applicant: Penwest Pharmaceuticals Co.Inventors: John N. Staniforth, Edward A. Hunter, Bob E. Sherwood
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Publication number: 20020197388Abstract: A method of coating a pharmaceutical substrate includes the steps of applying an active coating material to a surface of the substrate to form an active coating layer and applying a cover coating material onto the active coating layer to form a cover coating layer. The active coating layer is substantially completely covered by the cover coating layer.Type: ApplicationFiled: September 26, 2001Publication date: December 26, 2002Applicant: Phoqus Limited.Inventors: Steven R. Brown, Linda A. Reeves, John N. Staniforth
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Publication number: 20020182259Abstract: The present invention provides an improved process for the preparation of a agglomerated solid dosage form, comprising: (1) preparing an aqueous slurry of (a) microcrystalline cellulose; (b) a microcrystalline cellulose compressibility augmenting agent which (i) physically restricts the proximity of the interface between adjacent cellulose surfaces; (ii) inhibits interactions between adjacent cellulose surfaces, for example, via the creation of a hydrophobic boundary at cellulose surfaces; or (iii) accomplishes both (i) and (ii) above; and (c) an active agent; (2) thereafter drying the resultant aqueous slurry in a manner which inhibits quasi-hornification, thereby obtaining an agglomerated material which is directly compressible into a solid dosage form.Type: ApplicationFiled: December 13, 2001Publication date: December 5, 2002Inventors: John N. Staniforth, Bob E. Sherwood, Edward A. Hunter, Clifford M. Davidson
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Patent number: 6471994Abstract: A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0.1% to about 20% silicon dioxide particles, by weight of microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from about 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide. An extra low moisture excipient is provided which exhibits improved compressibility as compared to conventional microcrystalline cellulose, while providing a moisture content of from about 0.5 to 2.5% LOD, preferably between about 0.5 and about 1.8%, more preferably between 0.8 and 1.5%, and most preferably between about 0.8 and about 1.2 %.Type: GrantFiled: August 27, 1999Date of Patent: October 29, 2002Assignee: Edward Mendell Co., Inc.Inventors: John N. Staniforth, Bob E. Sherwood, Edward A. Hunter
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Publication number: 20020090345Abstract: Controlled release powder insufflation formulations are disclosed. The powder formulation includes cohesive composites of particles containing a medicament and a controlled release carrier which preferably includes one or more polysaccharide gums of natural origin.Type: ApplicationFiled: January 14, 2002Publication date: July 11, 2002Applicant: Penwest Pharmaceuticals Co.Inventors: Anand Baichwal, John N. Staniforth
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Patent number: 6406738Abstract: A method of coating a substrate which is a core for a pharmaceutical dosage form, which comprises electrostatically applying to a surface of the core a powder material comprising active material, the coating material applied constituting a dosage of active material, wherein the powder material includes composite particles, each composite particle comprising two or more components having different physical and/or chemical properties.Type: GrantFiled: November 10, 1997Date of Patent: June 18, 2002Assignee: Phoqus LimitedInventors: John E. Hogan, Trevor Page, Linda Reeves, John N. Staniforth
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Patent number: 6395303Abstract: The present invention provides an improved process for the preparation of a agglomerated solid dosage form, comprising preparing an aqueous slurry of microcrystalline cellulose and a microcrystalline cellulose compressibility augmenting agent and an active agent. The augmenting agent is capable of physically restricting the proximity of the interface between adjacent cellulose surfaces and/or inhibiting interactions between adjacent cellulose surfaces, for example, via the creation of a hydrophobic boundary at cellulose surfaces. The resulting aqueous slurry is dried in a manner which inhibits quasi-hornification, thereby obtaining an agglomerated material which is directly compressible into a solid dosage form.Type: GrantFiled: June 4, 1997Date of Patent: May 28, 2002Assignee: Edward Mendell Co., Inc.Inventors: John N. Staniforth, Bob E. Sherwood, Edward A. Hunter, Clifford M. Davidson
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Patent number: 6387394Abstract: Controlled release powder insufflation formulations are disclosed. The powder formulation includes cohesive composites of particles containing a medicament and a controlled release carrier which preferably includes one or more polysaccharide gums of natural origin.Type: GrantFiled: July 26, 1999Date of Patent: May 14, 2002Assignee: Penwest Pharmaceuticals Co.Inventors: Anand Baichwal, John N. Staniforth
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Patent number: 6261601Abstract: A pharmaceutical composition in the form of tablets or capsules provides a combination of temporal and spatial control of drug delivery to a patient for effective therapeutic results. The pharmaceutical composition comprises a drug, a gas generating component, a swelling agent, a viscolyzing agent, and optionally a gel forming polymer. The swelling agent belongs to a class of compounds known as superdisintegrants (e.g., cross-linked polyvinylpyrrolidone or sodium carboxymethylcellulose). The viscolyzing agent initially and the gel forming polymer thereafter form a hydrated gel matrix which entraps the gas, causing the tablet or capsule to be retained in the stomach or upper part of the small intestine (spatial control). At the same time, the hydrated gel matrix creates a tortuous diffusion path for the drug, resulting in sustained release of the drug (temporal control). A preferred once daily ciprofloxacin formulation comprises 69.9% ciprofloxacin base, 0.34% sodium alginate, 1.03% xanthan gum, 13.Type: GrantFiled: September 14, 1998Date of Patent: July 17, 2001Assignee: Ranbaxy Laboratories LimitedInventors: Naresh Talwar, Himadri Sen, John N. Staniforth
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Patent number: 6106865Abstract: A composition, comprising (a) microcrystalline cellulose; and (b) a compressibility augmenting agent which (i) physically restricts the proximity of the interface between adjacent cellulose surfaces; or (ii) inhibits interactions between adjacent cellulose surfaces; or (iii) accomplishes both (i) and (ii) above, is disclosed. The composition is in the form of agglomerated particles of microcrystalline cellulose and the compressibility augmenting agent in intimate association with each other.Type: GrantFiled: March 10, 1998Date of Patent: August 22, 2000Assignee: Edward Mendell Co., Inc.Inventors: John N. Staniforth, Edward A. Hunter, Bob E. Sherwood