Patents by Inventor Joseph E. Payne

Joseph E. Payne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ionizable cationic lipid for RNA delivery
    Patent number: 9850202
    Abstract: What is described is a compound wherein R1 and R2 are the same or different, each a linear or branched alkyl with 1-9 carbons, or an alkenyl or alkynyl with 2 to 11 carbons; L1 and L2 are the same or different, each a linear alkyl having 3 to 18 carbons; X1 and X3 are —CO—O—; X3 is S or O; L3 is a lower alkyl; R3 is a lower alkyl; and R4 and R5 are the same or different, each a lower alkyl; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: December 26, 2017
    Assignee: Arcturus Therapeutics, Inc.
    Inventors: Joseph E. Payne, Padmanabh Chivukula
  • Aromatic ionizable cationic lipid
    Patent number: 9834510
    Abstract: What is described is a compound of formula I wherein X is an ethene, or an unsubstituted or substituted arene or heteroarene; Y is a bond, an ethene, or an unsubstituted or substituted arene or heteroarene; Z is S or O; L is a linear or branched alkylene of 1 to 6 carbons; R1 and R2 are independently a linear or branched alkyl or alkenyl of 1 to 18 carbons; R3 and R4 are independently a linear or branched alkyl of 1 to 6 carbons; n is 0 to 6; and m, p, q, and r are independently 1-18; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 29, 2016
    Date of Patent: December 5, 2017
    Assignee: Arcturus Therapeutics, Inc.
    Inventors: Joseph E. Payne, Padmanabh Chivukula, Steven P. Tanis
  • IONIZABLE CATIONIC LIPID FOR RNA DELIVERY
    Publication number: 20170267631
    Abstract: What is described is a compound of formula I wherein R1 is a linear alkyl, alkenyl, or alkynyl of 2 to 12 carbons, or a branched alkyl with 12 to 20 carbons, R2 is a branched alkyl with 12 to 20 carbons, L1 and L2 are independently a linear alkylene with 1-18 carbons or alkenylene with 2-18 carbons, X is S or O, L3 is a bond or an alkylene with 1 to 6 carbons, R3 is an alkylene with 1 to 6 carbons, and R4 and R5 are the same or different, each a linear or branched alkyl with 1 to 6 carbons.
    Type: Application
    Filed: June 5, 2017
    Publication date: September 21, 2017
    Inventors: Joseph E. Payne, Padmanabh Chivukula
  • Aromatic Ionizable Cationic Lipid
    Publication number: 20170190661
    Abstract: What is described is a compound of formula I wherein X is an ethene, or an unsubstituted or substituted arene or heteroarene; Y is a bond, an ethene, or an unsubstituted or substituted arene or heteroarene; Z is S or O; L is a linear or branched alkylene of 1 to 6 carbons; R1 and R2 are independently a linear or branched alkyl or alkenyl of 1 to 18 carbons; R3 and R4 are independently a linear or branched alkyl of 1 to 6 carbons; n is 0 to 6; and m, p, q, and r are independently 1-18; or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: December 29, 2016
    Publication date: July 6, 2017
    Inventors: Joseph E. Payne, Padmanabh Chivukula, Steven P. Tanis
  • METHOD FOR TREATING FIBROSIS USING SIRNA AND A RETINOID-LIPID DRUG CARRIER
    Publication number: 20170175115
    Abstract: What is described is a method for treating a fibrotic disease by administering a pharmaceutical composition comprising a drug carrier, which comprises a lipid and a retinoid, and a double-stranded nucleic acid molecule, which comprises an antisense sequence to mRNA encoding human hsp47.
    Type: Application
    Filed: September 30, 2016
    Publication date: June 22, 2017
    Inventors: Yoshiro Niitsu, Victor Knopov, Joseph E. Payne, Richard P. Witte, Mohammad Ahmadian, Loren A. Perelman, Violetta Akopian, Yasunobu Tanaka, Elena Feinstein, Sharon Avkin-Nahum, Hagar Kalinski, Igor Mett, Kenjiro Minomi, Wenbin Ying, Yun Liu
  • Ionizable cationic lipid for RNA delivery
    Patent number: 9670152
    Abstract: What is described is a compound of formula I wherein R is a linear alkyl of 1 to 12 carbons, or a linear alkenyl or alkynyl of 2 to 12 carbons; L is a linear alkylene or alkenylene of 5 to 18 carbons; X is —CO—O— or —O—CO—; Y is S or O; R1 is a linear or branched alkylene consisting of 1 to 6 carbons; and R2 and R3 are the same or different, consisting of a hydrogen or a linear or branched alkyl consisting of 1 to 6 carbons; and n is 1-6; or a salt, a solvate, or a pharmaceutical formulation thereof.
    Type: Grant
    Filed: November 9, 2016
    Date of Patent: June 6, 2017
    Assignee: Arcturus Therapeutics, Inc.
    Inventors: Joseph E. Payne, Padmanabh Chivukula
  • LIPID PARTICLES WITH CATIONIC LIPIDS FOR RNA DELIVERY
    Publication number: 20170152223
    Abstract: What is described is a lipid particle comprising the compound of formula I wherein R1 consists of alkyl, alkenyl, alkynyl, or cholesteryl; R2 consists of alkyl or alkenyl; L1 consists of alkyl, alkylene or alkenyl; X1 consists of —O—(CO)— or —(CO)—O; X2 consists of S or O; L2 consists of a bond or alkylene; R3 consists of alkylene; and R4 and R5 are the same or different, each consisting of alkyl; or a pharmaceutical preparation thereof.
    Type: Application
    Filed: February 9, 2017
    Publication date: June 1, 2017
    Inventors: Joseph E. Payne, Padmanabh Chivukula
  • IONIZABLE CATIONIC LIPID FOR RNA DELIVERY
    Publication number: 20170144967
    Abstract: What is described is a compound wherein R1 and R2 are the same or different, each a linear or branched alkyl with 1-9 carbons, or an alkenyl or alkynyl with 2 to 11 carbons; L1 and L2 are the same or different, each a linear alkyl having 3 to 18 carbons; X1 and X3 are —CO—O—; X3 is S or O; L3 is a lower alkyl; R3 is a lower alkyl; and R4 and R5 are the same or different, each a lower alkyl; or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: February 2, 2017
    Publication date: May 25, 2017
    Inventors: Joseph E. Payne, Padmanabh Chivukula
  • IONIZABLE CATIONIC LIPID FOR RNA DELIVERY
    Publication number: 20170114010
    Abstract: What is described is a compound of formula III or IV wherein R1 is a branched alkyl with 12 to 20 carbons; R2 is a linear alkyl with 5 to 10 carbons or a branched alkyl with 12 to 20 carbons; L1 and L2 are each a bond or a linear alkylene having 1 to 3 carbon atoms, when L3 is a bond; L1 and L2 are each a linear alkylene or alkenylene 5 to 18 carbon atoms, when L3 is an alkylene of 5 to 18 carbons; X is S or O; R3 is of a lower alkyl; and R4 and R5 are the same or different, each a lower alkyl; or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: January 6, 2017
    Publication date: April 27, 2017
    Inventors: Joseph E. Payne, Padmanabh Chivukula
  • IONIZABLE CATIONIC LIPID FOR RNA DELIVERY
    Publication number: 20170101370
    Abstract: What is described is a compound of formula I wherein R is a linear alkyl of 1 to 12 carbons, or a linear alkenyl or alkynyl of 2 to 12 carbons; L is a linear alkylene or alkenylene of 5 to 18 carbons; X is —CO—O— or —O—CO—; Y is S or O; R1 is a linear or branched alkylene consisting of 1 to 6 carbons; and R2 and R3 are the same or different, consisting of a hydrogen or a linear or branched alkyl consisting of 1 to 6 carbons; and n is 1-6; or a salt, a solvate, or a pharmaceutical formulation thereof.
    Type: Application
    Filed: November 9, 2016
    Publication date: April 13, 2017
    Inventors: Joseph E. Payne, Padmanabh Chivukula
  • RETINOID-LIPID DRUG CARRIER
    Publication number: 20170081663
    Abstract: What is described is a pharmaceutical composition for treating a fibrotic disease comprising a drug carrier, which comprises a lipid and a retinoid, and a double-stranded nucleic acid molecule, which comprises an antisense sequence to mRNA encoding human hsp47.
    Type: Application
    Filed: October 3, 2016
    Publication date: March 23, 2017
    Inventors: Yoshiro Niitsu, Victor Knopov, Joseph E. Payne, Richard P. Witte, Mohammad Ahmadian, Loren A. Perelman, Violetta Akopian, Yasunobu Tanaka, Elena Feinstein, Sharon Avkin-Nahum, Hagar Kalinski, Igor Mett, Kenjiro Minomi, Wenbin Ying, Yun Liu, Zheng Hou, John A. Gaudette, Priya Karmali, Sridhar C. Nagarajan
  • Ionizable cationic lipid for RNA delivery
    Patent number: 9593077
    Abstract: What is described is a compound of formula (1) wherein R1 and R2 are the same or different, each a linear or branched alkyl with 1-9 carbons, or an alkenyl or alkynyl with 2 to 11 carbon atoms; L1 and L2 are the same or different, each a linear alkyl having 5 to 18 carbon atoms, or form a heterocycle with N; X1 is a bond, or is —CO—O— whereby L2-CO—O—R2 is formed; X2 is S or O; L3 is a bond or a lower alkyl, or form a heterocycle with N; R3 is a lower alkyl; and R4 and R5 are the same or different, each a lower alkyl; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: November 18, 2014
    Date of Patent: March 14, 2017
    Assignee: Arcturus Therapeutics, Inc.
    Inventors: Joseph E. Payne, Padmanabh Chivukula
  • Lipid particles with asymmetric cationic lipids for RNA delivery
    Patent number: 9580711
    Abstract: What is described is a lipid particle comprising the compound of formula I wherein R1 consists of alkyl, alkenyl, alkynyl, or cholesteryl; R2 consists of alkyl or alkenyl; L1 consists of alkyl, alkylene or alkenyl; X1 consists of —O—(CO)— or —(CO)—O—; X2 consists of S or O; L2 consists of a bond or alkylene; R3 consists of alkylene; and R4 and R5 are the same or different, each consisting of alkyl; or a pharmaceutical preparation thereof.
    Type: Grant
    Filed: May 4, 2016
    Date of Patent: February 28, 2017
    Assignee: Arcturus Therapeutics, Inc.
    Inventors: Joseph E. Payne, Padmanabh Chivukula, David Webb
  • Ionizable cationic lipid for RNA delivery
    Patent number: 9567296
    Abstract: What are described are compounds of formula II. The compound of formula II consists of a compound in which R1 and R2 are both a linear alkyl consisting of 1 to 12 carbons, an alkenyl or alkynyl consisting of 2 to 12 carbons; L1 and L2 both consist of a linear alkylene or alkenylene consisting of 5 to 18 carbons; X is S; L3 consists of a bond; R3 consists of a linear or branched alkylene consisting of 1 to 6 carbons; and R4 and R5 are the same or different, each consisting of hydrogen or a linear or branched alkyl consisting of 1 to 6 carbons; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: May 8, 2015
    Date of Patent: February 14, 2017
    Assignee: Arcturus Therapeutics, Inc.
    Inventors: Joseph E. Payne, Padmanabh Chivukula
  • MultiLigand Agent for Drug Delivery
    Publication number: 20170028074
    Abstract: Described herein is a compound having the structure of formula I, II, or III, wherein R comprises a double stranded RNA molecule, and L1, L2, and L3 independently for each occurrence comprise a ligand selected from the group consisting of a carbohydrate, a cholesteryl, or a peptide; a pharmaceutically accepted salt or pharmaceutical composition thereof; and a method of making the compound.
    Type: Application
    Filed: July 29, 2016
    Publication date: February 2, 2017
    Inventors: Joseph E. Payne, Padmanabh Chivukula, Steven P. Tanis
  • COMPOUNDS FOR TARGETING DRUG DELIVERY AND ENHANCING siRNA ACTIVITY
    Publication number: 20170000893
    Abstract: Here described are compounds consisting of the structure (targeting molecule)m-linker-(targeting molecule)n, wherein the targeting molecule is a retinoid or a fat soluble vitamin having a specific receptor on the target cell; wherein m and n are independently 0, 1, 2 or 3; and wherein the linker comprises a polyethylene glycol (PEG) or PEG-like molecule, as well as compositions and pharmaceutical formulations including these compounds which are useful for the targeting and delivery of therapeutic agents; and methods of using these compositions and pharmaceutical formulations.
    Type: Application
    Filed: June 8, 2016
    Publication date: January 5, 2017
    Inventors: Yoshiro Niitsu, Joseph E. Payne, John A. Gaudette, Zheng Hou, Victor Knopov, Richard P. Witte, Mohammad Ahmadian, Loren A. Perelman, Yasunobu Tanaka, Violetta Akopian
  • COMPOUNDS FOR TARGETING DRUG DELIVERY AND ENHANCING siRNA ACTIVITY
    Publication number: 20170001950
    Abstract: Here described are compounds consisting of the structure (targeting molecule)m-linker-(targeting molecule)n, wherein the targeting molecule is a retinoid or a fat soluble vitamin having a specific receptor on the target cell; wherein m and n are independently 0, 1, 2 or 3; and wherein the linker comprises a polyethylene glycol (PEG) or PEG-like molecule, as well as compositions and pharmaceutical formulations including these compounds which are useful for the targeting and delivery of therapeutic agents; and methods of using these compositions and pharmaceutical formulations.
    Type: Application
    Filed: June 8, 2016
    Publication date: January 5, 2017
    Inventors: Yoshiro Niitsu, Joseph E. Payne, John A. Gaudette, Zheng Hou, Victor Knopov, Richard P. Witte, Mohammad Ahmadian, Loren A. Perelman, Yasunobu Tanaka, Violetta Akopian
  • Method for treating fibrosis using siRNA and a retinoid-lipid drug carrier
    Patent number: 9456984
    Abstract: What is described is a method for treating a fibrotic disease by administering a pharmaceutical composition comprising a drug carrier, which comprises a lipid and a retinoid, and a double-stranded nucleic acid molecule, which comprises an antisense sequence to mRNA encoding human hsp47.
    Type: Grant
    Filed: June 2, 2014
    Date of Patent: October 4, 2016
    Assignee: Nitto Denko Corporation
    Inventors: Yoshiro Niitsu, Victor Knopov, Joseph E. Payne, Richard P. Witte, Mohammad Ahmadian, Loren A. Perelman, Violetta Akopian, Yasunobu Tanaka, Elena Feinstein, Sharon Avkin-Nahum, Hagar Kalinski, Igor Mett, Kenjiro Minomi, Wenbin Ying, Yun Liu
  • LIPID PARTICLES WITH ASYMMETRIC CATIONIC LIPIDS FOR RNA DELIVERY
    Publication number: 20160244761
    Abstract: What is described is a lipid particle comprising the compound of formula I wherein R1 consists of alkyl, alkenyl, alkynyl, or cholesteryl; R2 consists of alkyl or alkenyl; L1 consists of alkyl, alkylene or alkenyl; X1 consists of —O—(CO)— or —(CO)—O—; X2 consists of S or O; L2 consists of a bond or alkylene; R3 consists of alkylene; and R4 and R5 are the same or different, each consisting of alkyl; or a pharmaceutical preparation thereof.
    Type: Application
    Filed: May 4, 2016
    Publication date: August 25, 2016
    Inventors: Joseph E. Payne, Padmanabh Chivukula, David Webb
  • Compounds for targeting drug delivery and enhancing siRNA activity
    Patent number: 9393315
    Abstract: Here described are compounds consisting of the structure (targeting molecule)m-linker-(targeting molecule)n, wherein the targeting molecule is a retinoid or a fat soluble vitamin having a specific receptor on the target cell; wherein m and n are independently 0, 1, 2 or 3; and wherein the linker comprises a polyethylene glycol (PEG) or PEG-like molecule, as well as compositions and pharmaceutical formulations including these compounds which are useful for the targeting and delivery of therapeutic agents; and methods of using these compositions and pharmaceutical formulations.
    Type: Grant
    Filed: June 8, 2012
    Date of Patent: July 19, 2016
    Assignee: Nitto Denko Corporation
    Inventors: Yoshiro Niitsu, Joseph E. Payne, John A. Gaudette, Zheng Hou, Victor Knopov, Richard P. Witte, Mohammad Ahmadian, Loren A. Perelman, Yasunobu Tanaka, Violetta Akopian