Patents by Inventor Lawrence Hamann

Lawrence Hamann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bicyclic modulators of androgen receptor function
    Patent number: 7772267
    Abstract: There are provided compounds according to formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia. Also provided are pharmaceutical compositions containing such compounds and processes for preparing some of the compounds of the invention. Other embodiments are also disclosed.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: August 10, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: Chong-qing Sun, Lawrence Hamann, David Augeri, Yingzhi Bi, Jeffrey Robl, Yan-Ting Huang, Tammy Wang, Alexandra Holubec, Ligaya Simpkins, James C. Sutton, James J. Li
  • Bicyclic compounds as modulators of androgen receptor function and method
    Patent number: 7732480
    Abstract: There are disclosed bicyclic compounds according to formula I, pharmaceutical compositions containing such compounds and methods of using such compounds in the treatment of androgen receptor-associated conditions, such as age-related diseases, for example sarcopenia, wherein R1, R2, R5, X and n are defined herein.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: June 8, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: James J. Li, Lawrence Hamann, Haixia Wang
  • Bicyclic compounds as modulators of androgen receptor function and method
    Patent number: 7696241
    Abstract: The present invention relates to bicyclic compounds according to formula I, pharmaceutical compositions containing such compounds and methods of using such compounds in the treatment of androgen receptor-associated conditions, such as age-related diseases, for example sarcopenia, wherein R1, R2, R5, X and n are defined herein.
    Type: Grant
    Filed: March 2, 2005
    Date of Patent: April 13, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: James J. Li, Lawrence Hamann, Haixia Wang
  • Bicyclic modulators of androgen receptor function
    Patent number: 7625923
    Abstract: The present invention relates to bicyclic compounds according to formula I, pharmaceutical compositions containing such compounds and methods of using such compounds in the treatment of androgen receptor-associated conditions, such as age-related diseases, for example sarcopenia, wherein R1, R2, R5, X, Y and n are defined herein.
    Type: Grant
    Filed: March 2, 2005
    Date of Patent: December 1, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Alexandra Nirschl, James C. Sutton, Lawrence Hamann, Tammy Wang, Yan Zou, Chongqing Sun
  • Bicyclic modulators of androgen receptor function
    Patent number: 7405234
    Abstract: The invention provides compounds according to formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia. Also provided are pharmaceutical compositions containing such compounds and processes for preparing some of the compounds of the invention.
    Type: Grant
    Filed: February 17, 2004
    Date of Patent: July 29, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: Chong-Qing Sun, Lawrence Hamann, David Augeri, Yingzhi Bi, Jeffrey Robl, Yan-Ting Huang, Tammy Wang, Alexandra Holubec, Ligaya Simpkins, James C. Sutton, James J. Li
  • Bicyclic compounds as modulators of androgen receptor function and method
    Patent number: 7388027
    Abstract: The present invention relates to bicyclic compounds according to formula I, pharmaceutical compositions containing such compounds and methods of using such compounds in the treatment of androgen receptor-associated conditions, such as age-related diseases, for example sarcopenia, wherein R1, R2, R2? R5, G, n and W are defined herein.
    Type: Grant
    Filed: March 2, 2005
    Date of Patent: June 17, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: James J. Li, Lawrence Hamann, David Augeri, Yingzhi Bi
  • OPEN-CHAIN PROLYL UREA-RELATED MODULATORS OF ANDROGEN RECEPTOR FUNCTION
    Publication number: 20080108691
    Abstract: There are provided nuclear hormone receptor modulating compounds of formula I wherein R1, R2, R3, X, Y, n and G are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia, and also provided are pharmaceutical compositions containing such compounds. Other embodiments are also disclosed.
    Type: Application
    Filed: October 31, 2007
    Publication date: May 8, 2008
    Applicant: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Lawrence Hamann, David Augeri, Mark Manfredi
  • BICYCLIC MODULATORS OF ANDROGEN RECEPTOR FUNCTION
    Publication number: 20080108649
    Abstract: There are provided compounds according to formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia. Also provided are pharmaceutical compositions containing such compounds and processes for preparing some of the compounds of the invention. Other embodiments are also disclosed.
    Type: Application
    Filed: October 31, 2007
    Publication date: May 8, 2008
    Applicant: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Chong-Qing Sun, Lawrence Hamann, David Augeri, Yingzhi Bi, Jeffrey Robl, Yan-Ting Huang, Tammy Wang, Alexandra Holubec, Ligaya Simpkins, James Sutton, James Li
  • Novel Bicyclic Compounds As Modulators of Androgen Receptor Function And Method
    Publication number: 20080096954
    Abstract: There are disclosed bicyclic compounds according to formula I, pharmaceutical compositions containing such compounds and methods of using such compounds in the treatment of androgen receptor-associated conditions, such as age-related diseases, for example sarcopenia, wherein R1, R2, R5, X and n are defined herein.
    Type: Application
    Filed: October 31, 2007
    Publication date: April 24, 2008
    Applicant: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: James Li, Lawrence Hamann, Haixia Wang
  • Novel bicyclic compounds as modulators of androgen receptor function and method
    Publication number: 20070004717
    Abstract: The present invention relates to bicyclic compounds according to formula I, pharmaceutical compositions containing such compounds and methods of using such compounds in the treatment of androgen receptor-associated conditions, such as age-related diseases, for example sarcopenia, wherein R1, R2, R5, X and n are defined herein.
    Type: Application
    Filed: March 2, 2005
    Publication date: January 4, 2007
    Inventors: James Li, Lawrence Hamann, Haixia Wang
  • Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors
    Publication number: 20060287357
    Abstract: Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrogenase type I inhibitor therapy. These novel compounds have the structure: or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein W, L, R3, R3a, R3b and R4 are defined herein.
    Type: Application
    Filed: June 7, 2006
    Publication date: December 21, 2006
    Inventors: James Li, Lawrence Hamann, Haixia Wang, Zheming Ruan, Christopher Cooper, Jun Li, Jeffrey Robl
  • Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors
    Publication number: 20060281750
    Abstract: Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrogenase type I inhibitor therapy. These novel compounds have the structure: W-L-Z ??(I) or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein W, L and Z are defined herein.
    Type: Application
    Filed: June 7, 2006
    Publication date: December 14, 2006
    Inventors: James Li, Lawrence Hamann, Haixia Wang
  • Pyrrolopyridine-based inhibitors of dipeptidyl peptidase IV and methods
    Publication number: 20060264457
    Abstract: Compounds are provided having the formula (I) wherein R, X, Y, Z, A and n are as defined herein, which are inhibitors of dipeptidyl peptidase IV and thus are useful in treating diabetes and related diseases.
    Type: Application
    Filed: May 9, 2006
    Publication date: November 23, 2006
    Inventors: Pratik Devasthale, Wei Wang, Lawrence Hamann, Stephen O'Connor, John Fevig
  • Inhibitors of 11-beta hydroxysteroid dehydrogenase type I
    Publication number: 20060235028
    Abstract: Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrogenase type I inhibitor therapy. These novel compounds have the structure: or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein G, L, Q, Z, R6, R7, and R8 are defined herein.
    Type: Application
    Filed: April 12, 2006
    Publication date: October 19, 2006
    Inventors: James Li, Lawrence Hamann, Zheming Ruan, Christopher Cooper, Shung Wu, Ligaya Simpkins, Haixia Wang, Akbar Nayeem, Stanley Krystek
  • Azolopyrimidine-based inhibitors of dipeptidyl peptidase IV and methods
    Publication number: 20060178377
    Abstract: Compounds are provided having the formula (I) wherein R, X, Y, A and n are as defined herein.
    Type: Application
    Filed: December 21, 2005
    Publication date: August 10, 2006
    Inventors: Wei Meng, Lawrence Hamann, Robert Brigance
  • Pyrimidine-based inhibitors of dipeptidyl peptidase IV and methods
    Publication number: 20060142576
    Abstract: Compounds are provided having the formula (I) wherein R, B, X and Y are as defined herein.
    Type: Application
    Filed: December 21, 2005
    Publication date: June 29, 2006
    Inventors: Wei Meng, Lawrence Hamann, Robert Brigance
  • Bicyclic modulators of androgen receptor function
    Patent number: 6992102
    Abstract: The invention provides compounds of the formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia, and also provided are pharmaceutical compositions containing such compounds.
    Type: Grant
    Filed: October 14, 2003
    Date of Patent: January 31, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Lawrence Hamann, David Augeri, Chongqing Sun, Jeffrey A. Robl, Mark E. Salvati, Tammy Wang
  • Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods
    Publication number: 20050239839
    Abstract: Compounds are provided having the formula (I) wherein: n is 0, 1 or 2; m is 0, 1 or 2; the sum of n+m less then or equal to 2; the dashed bonds forming a cyclopropyl ring can only be present when Y is CH; X is H or CN; Y is CH, CH2, CHF, CF2, O, S, SO, or SO2; and A is adamantyl. Further provided are methods of using such compounds for the treatment of diabetes and related diseases, and to pharmaceutical compositions containing such compounds.
    Type: Application
    Filed: June 9, 2005
    Publication date: October 27, 2005
    Inventors: Lawrence Hamann, Ashish Khanna, Mark Kirby, David Magnin, Ligaya Simpkins, James Sutton, Jeffrey Robl
  • Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods
    Publication number: 20050228021
    Abstract: Compounds are provided having the formula (I) wherein: n is 0, 1 or 2; m is 0, 1 or 2; the sum of n+m less then or equal to 2; the dashed bonds forming a cyclopropyl ring can only be present when Y is CH; X is H or CN; Y is CH, CH2, CHF, CF2, O, S, SO, or SO2; and A is adamantyl. Further provided are methods of using such compounds for the treatment of diabetes and related diseases, and to pharmaceutical compositions containing such compounds.
    Type: Application
    Filed: June 9, 2005
    Publication date: October 13, 2005
    Inventors: Lawrence Hamann, Ashish Khanna, Mark Kirby, David Magnin, Ligaya Simpkins, James Sutton, Jeffrey Robl
  • Bicyclic modulators of androgen receptor function
    Publication number: 20050197359
    Abstract: The present invention relates to bicyclic compounds according to formula I, pharmaceutical compositions containing such compounds and methods of using such compounds in the treatment of androgen receptor-associated conditions, such as age-related diseases, for example sarcopenia, wherein R1, R2, R5, X, Y and n are defined herein.
    Type: Application
    Filed: March 2, 2005
    Publication date: September 8, 2005
    Inventors: Alexandra Nirschl, James Sutton, Lawrence Hamann, Tammy Wang, Yan Zou, Chongqing Sun