Patents by Inventor Maria Filomena Andrade De Freitas
Maria Filomena Andrade De Freitas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11077060Abstract: A biocomposite powder comprising 20-95% (w/w) chitin-glucan complex (CGC), and up to 50% (w/w) mannose-containing polysaccharides, wherein the biocomposite powder has a bulk density of 0.5 to 1.0 g/cm3, and wherein greater than 60% (w/w) of the particles of the biocomposite powder have a size below 212 ?m.Type: GrantFiled: May 19, 2015Date of Patent: August 3, 2021Assignee: PHARMA73, S. A.Inventors: Maria Filomena Andrade De Freitas, Fernando Miguel Da Silva Cruz, Maria D'Ascensão Carvalho Fernandes de Miranda Reis, Inês Da Silva Farinha
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Patent number: 10793648Abstract: The presently disclosed subject matter concerns a microbial biopolymer comprising fucose in its composition. This biopolymer consists of a polysaccharide comprising fucose, which represents at least 10% of its composition. This fucose-containing polysaccharide also contains non-sugar components, namely, acyl group substituents. This disclosed subject matter also concerns the process for the production of the biopolymer, which is obtained cultivation of the bacterium Enterobacter A47 (DSM 23139), using glycerol or glycerol-rich mixtures as carbon sources. The fucose-containing biopolymer of the presently disclosed subject matter may be used in several industrial applications (e.g. pharmaceutical, cosmetics and agro-food industries) and in the treatment of industrial wastes (e.g. oil and metal recovery).Type: GrantFiled: April 17, 2017Date of Patent: October 6, 2020Assignee: 73100—SETENTA E TRES MIL E CEM, LDA.Inventors: Maria D'Ascencao Carvalho Fernandes De Miranda Reis, Rui Manuel Freitas Oliveira, Maria Filomena Andrade De Freitas, Vitor Manuel Delgado Alves
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Patent number: 9861700Abstract: The present invention concerns a natural biocomposite powder prepared from the biomass of yeast Pichia pastoris, comprising chitin-glucan complex (CGC) and mannose-containing polysaccharides. In a second aspect, the invention concerns the method of preparation of the natural biocomposite powder. The invention also concerns the method to obtain Pichia pastoris biomass with increased CGC content, as well as increased chitin to glucan content in the CGC. Finally, the invention concerns the use of the natural biocomposite powder, prepared from the cell wall of yeast Pichia pastoris by the method according to the invention, as excipient in the pharmaceutical, cosmetics or food industries.Type: GrantFiled: March 15, 2013Date of Patent: January 9, 2018Assignee: Pharma73, S.A.Inventors: Maria Filomena Andrade De Freitas, Christophe François Aimé Roca, Fernando Miguel Da Silva Cruz, Maria D'Ascensão Carvalho Fernandes De Miranda Reis, Inês Da Silva Farinha, Bárbara Ferreira Chagas, Rui Manuel Freitas Oliveira
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Publication number: 20170349672Abstract: The presently disclosed subject matter concerns a microbial biopolymer comprising fucose in its composition. This biopolymer consists of a polysaccharide comprising fucose, which represents at least 10% of its composition. This fucose-containing polysaccharide also contains non-sugar components, namely, acyl group substituents. This disclosed subject matter also concerns the process for the production of the biopolymer, which is obtained cultivation of the bacterium Enterobacter A47 (DSM 23139), using glycerol or glycerol-rich mixtures as carbon sources. The fucose-containing biopolymer of the presently disclosed subject matter may be used in several industrial applications (e.g. pharmaceutical, cosmetics and agro-food industries) and in the treatment of industrial wastes (e.g. oil and metal recovery).Type: ApplicationFiled: April 17, 2017Publication date: December 7, 2017Applicant: 73100- SETENTA E TRES MIL E CEM, LDA.Inventors: Maria D'Ascencao Carvalho Fernandes De Miranda Reis, Rui Manuel Freitas Oliveira, Maria Filomena Andrade De Freitas, Vitor Manuel Delgado Alves
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Patent number: 9624313Abstract: The presently disclosed subject matter concerns a microbial biopolymer comprising fucose in its composition. This biopolymer consists of a polysaccharide comprising fucose, which represents at least 10% of its composition. This fucose-containing polysaccharide also contains non-sugar components, namely, acyl group substituents. This disclosed subject matter also concerns the process for the production of the biopolymer, which is obtained cultivation of the bacterium Enterobacter A47 (DSM 23139), using glycerol or glycerol-rich mixtures as carbon sources. The fucose-containing biopolymer of the presently disclosed subject matter may be used in several industrial applications (e.g. pharmaceutical, cosmetics and agro-food industries) and in the treatment of industrial wastes (e.g. oil and metal recovery).Type: GrantFiled: May 12, 2014Date of Patent: April 18, 2017Assignee: 73100-Setenta E Tres Mil E Cem, LDAInventors: Maria D'Ascencao Carvalho Fernandes De Miranda Reis, Rui Manuel Freitas Oliveira, Maria Filomena Andrade De Freitas, Vitor Manuel Delgado Alves
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Publication number: 20170079917Abstract: A biocomposite powder comprising 20-95% (w/w) chitin-glucan complex (CGC), and up to 50% (w/w) mannose-containing polysaccharides, wherein the biocomposite powder has a bulk density of 0.5 to 1.0 g/cm3, and wherein greater than 60% (w/w) of the particles of the biocomposite powder have a size below 212 ?m.Type: ApplicationFiled: May 19, 2015Publication date: March 23, 2017Applicant: PHARMA73, S.A.Inventors: Maria Filomena Andrade De Freitas, Fernando Miguel Da Silva Cruz, Maria D'Ascensão Carvalho Fernandes de Miranda Reis, Inês Da Silva Farinha
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Patent number: 9428591Abstract: This invention concerns a biopolymer consisting of a polysaccharide composed of galactose (50-90%), glucose (1-25%), mannose (1-25%) and rhamnose (0.5-20%), which may additionally contain, in trace amounts, xylose, fucose, ribose, arabinose and/or fructose. The galactose-rich polymer also contains non-saccharide components, namely, acyl groups. This invention also concerns a process for the production of the galactose-rich polymer, by microbial fermentation using glycerol or glycerol-rich substrates as carbon source, and recovery of the polymer from the culture broth. From the process for the production of the galactose-rich polymer results the co-production of intracellular biopolymers, namely, polyhydroxyalkanoates.Type: GrantFiled: March 5, 2014Date of Patent: August 30, 2016Assignee: 73100-Setenta E Tres Mil & Cem, LDA.Inventors: Maria d'Ascencao Carvalho Fernandes De Miranda Reis, Rui Manuel Freitas Oliveira, Cristina Paula Pereira Da Cunha Rodrigues Oliveira, Maria Filomena Andrade De Freitas, Victor Manuel Delgado Alves, Joana Oliveira Pais
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Publication number: 20140378556Abstract: The presently disclosed subject matter concerns a microbial biopolymer comprising fucose in its composition. This biopolymer consists of a polysaccharide comprising fucose, which represents at least 10% of its composition. This fucose-containing polysaccharide also contains non-sugar components, namely, acyl group substituents. This disclosed subject matter also concerns the process for the production of the biopolymer, which is obtained cultivation of the bacterium Enterobacter A47 (DSM 23139), using glycerol or glycerol-rich mixtures as carbon sources. The fucose-containing biopolymer of the presently disclosed subject matter may be used in several industrial applications (e.g. pharmaceutical, cosmetics and agro-food industries) and in the treatment of industrial wastes (e.g. oil and metal recovery).Type: ApplicationFiled: May 12, 2014Publication date: December 25, 2014Applicant: 73100- SETENTA E TRES MIL E CEM, LDA.Inventors: Maria D'Ascencao Carvalho Fernandes De Miranda Reis, Rui Manuel Freitas Oliveira, Maria Filomena Andrade De Freitas, Vitor Manuel Delgado Alves
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Publication number: 20140190367Abstract: This invention concerns a biopolymer consisting of a polysaccharide composed of galactose (50-90%), glucose (1-25%), mannose (1-25%) and rhamnose (0.5-20%), which may additionally contain, in trace amounts, xylose, fucose, ribose, arabinose and/or fructose. The galactose-rich polymer also contains non-saccharide components, namely, acyl groups. This invention also concerns a process for the production of the galactose-rich polymer, by microbial fermentation using glycerol or glycerol-rich substrates as carbon source, and recovery of the polymer from the culture broth. From the process for the production of the galactose-rich polymer results the co-production of intracellular biopolymers, namely, polyhydroxyalkanoates.Type: ApplicationFiled: March 5, 2014Publication date: July 10, 2014Applicant: 73100- SETENTA E TRES MIL E CEM, LDA.Inventors: Maria d'Ascencao Carvalho Fernandes De Miranda Reis, Rui Manuel Freitas Oliveira, Cristina Paula Pereira Da Cunha Rodrigues Oliveira, Maria Filomena Andrade De Freitas, Victor Manuel Delgado Alves, Joana Oliveira Pais
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Patent number: 8748123Abstract: The presently disclosed subject matter concerns a microbial biopolymer comprising fucose in its composition. This biopolymer consists of a polysaccharide comprising fucose, which represents at least 10% of its composition. This fucose-containing polysaccharide also contains non-sugar components, namely, acyl group substituents. This disclosed subject matter also concerns the process for the production of the biopolymer, which is obtained cultivation of the bacterium Enterobacter A47 (DSM 23139), using glycerol or glycerol-rich mixtures as carbon sources. The fucose-containing biopolymer of the presently disclosed subject matter may be used in several industrial applications (e.g. pharmaceutical, cosmetics and agro-food industries) and in the treatment of industrial wastes (e.g. oil and metal recovery).Type: GrantFiled: December 15, 2010Date of Patent: June 10, 2014Assignee: 73100-Setenta e Tres Mil e Cem, Lda.Inventors: Maria D'Ascensão Carvalho Fernandes De Miranda Reis, Rui Manuel Freitas Oliveira, Maria Filomena Andrade De Freitas, Vítor Manuel Delgado Alves
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Publication number: 20140120584Abstract: This invention concerns a process for the co-production of glucosamine polymers (chitin, chitosan or any of its derivatives) and polymers containing glucose, mannose and/or galactose, by the high cell density fermentation of the yeast Pichia pastoris in a bioreactor under aerobic conditions, preferably using glycerol byproduct from the biodiesel industry as carbon source. Pure glycerol, pure methanol, glycerol-rich or methanol rich mixtures may also be used as carbon sources. The present invention also concerns P. pastoris fermentation process duly optimized for attaining high cell densities and high cell wall chitin content, as well as polymers containing glucose, mannose and/or galactose.Type: ApplicationFiled: December 20, 2013Publication date: May 1, 2014Applicant: 73100 SETENTA E TRES MIL E CEM, LDAInventors: Maria d'Ascencao Carvalho Fernandes De Miranda Reis, Rui Manuel Freitas Oliveira, Maria Filomena Andrade De Freitas, Barbara Ferreira Chagas, Ana Luisa Braga Da Cruz, Antonio Eduardo Pio Barbosa Pereira Da Cunha, Joao Jose Vazao Mano Clemente
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Patent number: 8679796Abstract: This invention concerns a biopolymer consisting of a polysaccharide composed of galactose (50-90%), glucose (1-25%), mannose (1-25%) and rhamnose (0.5-20%), which may additionally contain, in trace amounts, xylose, fucose, ribose, arabinose and/or fructose. The galactose-rich polymer also contains non-saccharide components, namely, acyl groups. This invention also concerns a process for the production of the galactose-rich polymer, by microbial fermentation using glycerol or glycerol-rich substrates as carbon source, and recovery of the polymer from the culture broth. From the process for the production of the galactose-rich polymer results the co-production of intracellular biopolymers, namely, polyhydroxyalkanoates.Type: GrantFiled: April 9, 2008Date of Patent: March 25, 2014Assignee: 73100-Setenta e Tres Mil e Cem, Lda.Inventors: Maria D'ascenção Carvalho Fernandes De Miranda Reis, Rui Manuel Freitas Oliveira, Cristina Paula Pereira Da Cunha Rodrigues Oliveira, Maria Filomena Andrade De Freitas, Victor Manuel Delgado Alves, Joana Oliveira Pais
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Patent number: 8614070Abstract: The presently disclosed subject matter concerns a process for the co-production of glucosamine polymers (chitin, chitosan or any of its derivatives) and polymers containing glucose, mannose and/or galactose, by the high cell density fermentation of the yeast Pichia pastoris in a bioreactor under aerobic conditions. The process can include the use of glycerol byproduct from the biodiesel industry as carbon source. Pure glycerol, pure methanol, glycerol-rich or methanol rich mixtures may also be used as carbon sources. The P. pastoris fermentation process can be duly optimized for attaining high cell densities and high cell wall chitin content. The disclosed subject matter also concerns polymers containing glucose, mannose and/or galactose.Type: GrantFiled: July 22, 2009Date of Patent: December 24, 2013Assignee: 73100-Setenta E Tres Mil E CEM, LDAInventors: Maria d'Ascenção Carvalho Fernandes De Miranda Reis, Rui Manuel Freitas Oliveira, Maria Filomena Andrade De Freitas, Bárbara Ferreira Chagas, Ana Luísa Braga Da Cruz, António Eduardo Pio Barbosa Pereira Da Cunha, João José Vazão Mano Clemente
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Publication number: 20130251806Abstract: The present invention concerns a natural biocomposite powder prepared from the biomass of yeast Pichia pastoris, comprising chitin-glucan complex (CGC) and mannose-containing polysaccharides. In a second aspect, the invention concerns the method of preparation of the natural biocomposite powder. The invention also concerns the method to obtain Pichia pastoris biomass with increased CGC content, as well as increased chitin to glucan content in the CGC. Finally, the invention concerns the use of the natural biocomposite powder, prepared from the cell wall of yeast Pichia pastoris by the method according to the invention, as excipient in the pharmaceutical, cosmetics or food industries.Type: ApplicationFiled: March 15, 2013Publication date: September 26, 2013Applicant: Pharma73, S.A.Inventors: Maria Filomena ANDRADE DE FREITAS, Christophe François AIMÉ Roca, Fernando Miguel DA SILVA CRUZ, Maria D'ASCENSÃO CARVALHO FERNANDES DE MIRANDA REIS, Inês DA SILVA FARINHA, Bárbara FERREIRA CHAGAS, Rui Manuel FREITAS OLIVEIRA
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Publication number: 20110159288Abstract: The presently disclosed subject matter concerns a microbial biopolymer comprising fucose in its composition. This biopolymer consists of a polysaccharide comprising fucose, which represents at least 10% of its composition. This fucose-containing polysaccharide also contains non-sugar components, namely, acyl group substituents. This disclosed subject matter also concerns the process for the production of the biopolymer, which is obtained cultivation of the bacterium Enterobacter A47 (DSM 23139), using glycerol or glycerol-rich mixtures as carbon sources. The fucose-containing biopolymer of the presently disclosed subject matter may be used in several industrial applications (e.g. pharmaceutical, cosmetics and agro-food industries) and in the treatment of industrial wastes (e.g. oil and metal recovery).Type: ApplicationFiled: December 15, 2010Publication date: June 30, 2011Inventors: Maria D' Ascensão Carvalho Fernandes De Miranda Reis, Rui Manuel Freitas Oliveira, Maria Filomena Andrade De Freitas, Vítor Manuel Delgado Alves
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Publication number: 20110159546Abstract: The presently disclosed subject matter concerns a process for the co-production of glucosamine polymers (chitin, chitosan or any of its derivatives) and polymers containing glucose, mannose and/or galactose, by the high cell density fermentation of the yeast Pichia pastoris in a bioreactor under aerobic conditions. The process can include the use of glycerol byproduct from the biodiesel industry as carbon source. Pure glycerol, pure methanol, glycerol-rich or methanol rich mixtures may also be used as carbon sources. The P. pastoris fermentation process can be duly optimized for attaining high cell densities and high cell wall chitin content. The disclosed subject matter also concerns polymers containing glucose, mannose and/or galactose.Type: ApplicationFiled: July 22, 2009Publication date: June 30, 2011Inventors: Maria d' Ascenção Carvalho Fernandes De Miranda Reis, Rui Manuel Freitas Oliveira, Maria Filomena Andrade De Freitas, Bárbara Ferreira Chagas, Ana Luísa Braga Da Cruz, António Eduardo Pio Barbosa Pereira Da Cunha, João José Vazão Mano Clemente
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Publication number: 20100113765Abstract: This invention concerns a biopolymer consisting of a polysaccharide composed of galactose (50-90%), glucose (1-25%), mannose (1-25%) and rhamnose (0.5-20%), which may additionally contain, in trace amounts, xylose, fucose, ribose, arabinose and/or fructose. The galactose-rich polymer also contains non-saccharide components, namely, acyl groups. This invention also concerns a process for the production of the galactose-rich polymer, by microbial fermentation using glycerol or glycerol-rich substrates as carbon source, and recovery of the polymer from the culture broth. From the process for the production of the galactose-rich polymer results the co-production of intracellular biopolymers, namely, polyhydroxyalkanoates.Type: ApplicationFiled: April 9, 2008Publication date: May 6, 2010Inventors: Maria D'ascencão Carvalho Fernandes De Miranda Reis, Rui Manuel Freitas Oliveira, Cristina Paula Pereira Da Cunha Rodrigues Oliveira, Maria Filomena Andrade De Freitas, Victor Manuel Delgado Alves, Joana Oliveira Pais