Abstract: A composition for curing proliferative skin diseases containing 4-carbamoyl-1-.beta.-D-ribofuranosyl-imidazolium 5-olate (mizoribine) as an active ingredient. It has a potent activity of inhibiting the growth of keratinocytes and an improved effect of curing psoriasis, so that it is useful for curing proliferative skin diseases. Further it has only an extremely reduced toxicity, is highly safe, and can be administered for long and perorally.

Abstract: A compound of the formula [I] and pharmaceutically acceptable salts thereof; and a synthetic intermediate represented by the formula [II] and pharmaceutically acceptable salts thereof, ##STR1## wherein R 1 is hydrogen or lower alkyl;R 2 is hydrogen or a protective group of thiol;R 3 is hydroxy, a remainder of ester group or a remainder of amido group;A is straight or branched lower alkylene, andthe sulfur atom in the side chain may be directly join with --CO-- to conform a thiolactone ring.The compounds of this invention have excellent thymulin-like activities and are expected to be useful for treatment of various immune disorders such as immunodeficiency and autoimmune diseases.

Abstract: A preparation containing an absorption promoter selected from N-acyl amino acid derivatives or N-acyl peptide derivatives represented by the formula: R-CO-A (R is an aliphatic hydrocarbon group, an aromatic hydrocarbon group or an aryl-substituted lower hydrocarbon group which may optionally be substituted, and A is an amino acid residue or a peptide residue), preferably in the presence of a salt at a concentation exhibiting higher osmotic pressure than isotonic sodium chloride solution, and a medicine is found to promote absorption of the medicine through a gastrointestinal organ such as the colon and rectum, and through the vagina.

Abstract: Stable oral preparations of 16-membered ring macrolide antibiotics such as SF-837, josamycin, 3"-propionyljosamycin, by incorporating stabilizers showing pH 3-10 in an aqueous medium, such as glycine, and dissolution accelerators showing pH 2.5-4 in an aqueous medium such as citric acid or tartaric acid. Coating such dissolution accelerators with a film-forming substance is useful to enhance the stability of the oral preparation of such antibiotics.

Abstract: An insecticidal composition which contains microcapsules whose core substance is made of 20-85% by weight of an insecticidal ingredient of diazinon or chlorpyrifos and 50% or less by weight of a diluent and wall material made of 10-30% by weight of polycathionic water-soluble nitrogen-containing compound and 10% by weight or less of a hardener. The microcapsules may be mixed with coagulation-preventing agent of non-ionic surfactant and water-soluble thickener and then may be shaped into granules.

Abstract: A preparation containing an absorption promoter selected from specific classes of water-soluble macromolecular compounds having chelating activity, preferably in the presence of a salt at a concentration such that the composition exhibits higher osmotic pressure than isotonic sodium chloride solution, and a medicine is found to promote absorption of the medicine through a gastrointestinal organ such as the colon, rectum, or vagina.

Abstract: Selective adsorbents are prepared by dispersing powdery adsorbents in a composition for forming a crosslinked high molecular weight polymer, then dispersing in fine droplets the dispersion in a vehicle and performing crosslinking reaction to form a crosslinked polymer. The fine powders of adsorbents are enclosed within the crosslinked polymer and dispersed in three-dimensional spaces. Hydroxyl group containing polymeric substance and crosslinking agent or a monomer mixture of ethylenically unsaturated monomer and crosslinking monomer is used in said composition. The selective adsorbents can be useful in separation or purification of various organic compounds.

Abstract: A cellulose microcapsule having absorbing capacity, consisting of outer semipermeable barrier layer of cellulose and absorbent powders dispersed within inner cellulose gel matrix is prepared by dispersing adsorbent powders in a solution of cellulose dissolved in a solvent which is not adversely affected by the adsorbing capacity of adsorbent powders and capable of dissolving cellulose, then forming the dispersion into droplets and finally precipitating cellulose on the droplets. It is excellent in resistance to chemicals such as acids, alkalis or organic solvents and is useful for various purposes.

Abstract: A novel cellulose microcapsule having adsorbing capacity, consisting of outer semipermeable barrier layer of cellulose and adsorbent powders dispersed within inner cellulose gel matrix, is prepared by ester hydrolysis of a precursor microcapsule consisting of cellulose ester derivative and adsorbent powders. It is excellent in resistance to chemicals such as acids, alkalis or organic solvents and is useful for various purposes.

Abstract: 7-Amino-cephem compounds are produced from 7-substituted-cephem compounds by the enzymatic action of microorganisms Comamonas sp. SY-77-1 FERM-P 2410 or Pseudomonas ovalis ATCC 950.

Abstract: Encapsulated medicaments are prepared by dissolving a wall material for capsules in at least one organic solvent poorly miscible with water which has a boiling point of less than 100.degree.C., a vapor pressure higher than that of water and a dielectric constant of less than about 10, dissolving or dispersing in the resulting solution a medicament which is insoluble or slightly soluble in water, dispersing the resulting solution or dispersion to the form of fine drops in a liquid vehicle comprising an aqueous solution of a hydrophilic colloid or surface active agent, and then removing the organic solvent by evaporation.

Abstract: Selective adsorbing particles are prepared by dispersing activated charcoal in a hydrophilic solvent solution of a polymer capable of forming a semi-permeable film in a coagulating medium and then adding the dispersion dropwise into a coagulating bath. The selective adsorbing particles have adsorption capacity substantially the same as that of untreated activated charcoal. Separation of organic compounds is performed by a method wherein a solution containing a mixture of adsorptive organic compounds and non-adsorptive compounds is contacted with the selective adsorbing particles. The method is suitable for separation or purification of various organic compounds such as antibiotics, dyestuffs, nucleic acids, preteins or enzymes.

Abstract: A novel molecular sieving particle containing adsorbent powders dispersed in matrix of micro-porous polymer gels is prepared by dispersing adsorbent powders into a polymeric material solution dissolved in a solvent, then emulsifying the thus prepared dispersion into a vehicle having a boiling point higher than that of the solvent and finally removing the solvent by evaporation. This molecular sieving particle has excellent molecular sieving effect as well as excellent adsorption capacity, and applicable in various applications.

Abstract: Microcapsules are made by (a.) dispersing or dissolving a core substance in a film-forming polymer solution, (b.) emulsifying in fine droplets the resulting dispersion or solution in a vehicle which is poorly miscible with the solvent of the polymer solution and which doesn't dissolve said polymer to prepare an emulsion, and (c.) adding to the emulsion a non-solvent for the polymer wherein the non-solvent is miscible with the solvent, poorly miscible with the vehicle, and does not dissolve the polymer, whereby the solvent is removed by being absorbed by non-solvent emulsion droplets to precipitate the polymer film around the core substance.