Patents by Inventor Michael MacPhee

Michael MacPhee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Succinate forms and compositions of Bruton's tyrosine kinase inhibitors
    Patent number: 11174243
    Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
    Type: Grant
    Filed: January 6, 2017
    Date of Patent: November 16, 2021
    Assignees: Sunesis Pharmaceuticals, Inc., Biogen MA Inc.
    Inventors: J. Michael Macphee, Linda L. Neuman
  • CRYSTALLINE FORMS OF 3-((1R,5S,9r)-9-ETHOXY-3-AZABICYCLO[3.3.1]NONAN-9-YL)-BENZAMIDE AND SALT FORMS THEREOF
    Publication number: 20210238177
    Abstract: This disclosure provides crystalline forms of a ? receptor agonist, and methods of making and using these forms.
    Type: Application
    Filed: February 3, 2021
    Publication date: August 5, 2021
    Applicant: Alkermes, Inc.
    Inventors: J. Michael MacPhee, David Robert Webster, Mark David Tawa, Lisa Ferreira
  • SUCCINATE FORMS AND COMPOSITIONS OF BRUTON'S TYROSINE KINASE INHIBITORS
    Publication number: 20210032218
    Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
    Type: Application
    Filed: January 6, 2017
    Publication date: February 4, 2021
    Inventors: J. Michael MACPHEE, Linda L. NEUMAN
  • Inhibitors of Bruton's tyrosine kinase
    Patent number: 10189817
    Abstract: The present invention provides a compound, solid forms, and compositions thereof, which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same. The present invention also provides methods of making provided compound and solid forms.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: January 29, 2019
    Assignee: BIOGEN MA INC.
    Inventors: Brian T. Hopkins, Xiongwei Cai, Timothy R. Chan, Patrick Conlon, Michael Humora, Tracy J. Jenkins, J. Michael Macphee, Xianglin Shi, Ross A. Miller, Andrew Thompson
  • INHIBITORS OF BRUTON'S TYROSINE KINASE
    Publication number: 20180291001
    Abstract: The present invention provides a compound, solid forms, and compositions thereof, which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same. The present invention also provides methods of making provided compound and solid forms.
    Type: Application
    Filed: January 19, 2018
    Publication date: October 11, 2018
    Inventors: Brian T. Hopkins, Xiongwei Cai, Timothy R. Chan, Patrick Conlon, Michael Humora, Tracy J. Jenkins, J. Michael Macphee, Xianglin Shi, Ross A. Miller, Andrew Thompson
  • FORMS AND COMPOSITIONS OF BIARYL INHIBITORS OF BRUTON'S TYROSINE KINASE
    Publication number: 20180282310
    Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
    Type: Application
    Filed: June 10, 2016
    Publication date: October 4, 2018
    Inventors: J. Michael MacPhee, Michael Humora
  • ADIPATE FORMS AND COMPOSITIONS OF BIARYL INHIBITORS OF BRUTON'S TYROSINE KINASE
    Publication number: 20180179189
    Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
    Type: Application
    Filed: June 10, 2016
    Publication date: June 28, 2018
    Inventors: J. Michael MacPhee, Robbie Chen, Steven Ferguson, Lloyd Franklin, Tamera L. Mack
  • INHIBITORS OF BRUTON'S TYROSINE KINASE
    Publication number: 20170114039
    Abstract: The present invention provides a compound, solid forms, and compositions thereof, which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same. The present invention also provides methods of making provided compound and solid forms.
    Type: Application
    Filed: May 27, 2016
    Publication date: April 27, 2017
    Inventors: Brian T. Hopkins, Xiongwei Cai, Timothy R. Chan, Patrick Conlon, Michael Humora, Tracy J. Jenkins, J. Michael Macphee, Xianglin Shi, Ross A. Miller, Andrew Thompson
  • METHODS AND SYSTEMS FOR ANALYZING SOLIDS
    Publication number: 20090091740
    Abstract: Methods and systems for the analysis of solid materials are disclosed. The present invention comprises x-ray and Raman analytical techniques and systems which facilitate the rapid characterization of a plurality of solid samples.
    Type: Application
    Filed: April 14, 2005
    Publication date: April 9, 2009
    Applicant: TransForm Pharmaceuticals, Inc.
    Inventors: Nathan Kane, Michael MacPhee, Mark Oliveira
  • NOVEL CRYSTALLINE FORMS OF CONAZOLES AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20090088443
    Abstract: The invention provides novel soluble conazole crystalline forms (e.g. itraconazole, posaconazole and saperconazole) that include salts, co-crystals and related solvates useful as pharmaceuticals. The invention also provides pharmaceutical compositions comprising, and processes for making, these conazole crystalline forms. Methods of using such compositions for the treatment or prevention of systemic and local fungal, yeast, and dermatophyte infections are also provided.
    Type: Application
    Filed: September 19, 2008
    Publication date: April 2, 2009
    Inventors: Julius Remenar, Michael MacPhee, Matthew Peterson, Sherry Morissette, Orn Almarsson
  • Crystalline forms of conazoles and methods of making and using the same
    Patent number: 7446107
    Abstract: The invention provides novel soluble conazole crystalline forms (e.g. itraconazole, posaconazole and saperconazole) that include salts, co-crystals and related solvates useful as pharmaceuticals. The invention also provides pharmaceutical compositions comprising, and processes for making, these conazole crystalline forms. Methods of using such compositions for the treatment or prevention of systemic and local fungal, yeast, and dermatophyte infections are also provided.
    Type: Grant
    Filed: August 26, 2004
    Date of Patent: November 4, 2008
    Assignee: Transform Pharmaceuticals, Inc.
    Inventors: Julius Remenar, Michael MacPhee, Matthew Peterson, Sherry Morissette, Orn Almarsson
  • Sertraline compositions
    Patent number: 7186863
    Abstract: An acid salt of sertraline, wherein the acid is citric acid, fumaric acid, malic acid, maleic acid, malonic acid, phosphoric acid, succinic acid, sulfuric acid, L-tartaric acid, HBr, acetic acid, benzoic acid, benzenesulfonic acid, ethanesulfonic acid, lactic acid, methanesulfonic acid or toluenesulfonic acid. Similarly, a solvate of sertraline HCl, wherein the solvent is methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, t-butanol, acetic acid, ethyl acetate, or propylene glycol.
    Type: Grant
    Filed: May 21, 2004
    Date of Patent: March 6, 2007
    Assignee: TransForm Pharmaceuticals, Inc.
    Inventors: Julius Remenar, Michael MacPhee, Matthew Lynn Peterson, Mark Tawa
  • CIS-itraconazole crystalline forms and related processes, pharmaceutical compositions and methods
    Patent number: 7078526
    Abstract: The invention provides novel soluble conazole crystalline forms (e.g. itraconazole, posaconazole and saperconazole) that include salts, co-crystals and related solvates useful as pharmaceuticals. The invention also provides pharmaceutical compositions comprising, and processes for making, these conazole crystalline forms. Methods of using such compositions for the treatment or prevention of systemic and local fungal, yeast, and dermatophyte infections are also provided.
    Type: Grant
    Filed: May 30, 2003
    Date of Patent: July 18, 2006
    Assignee: TransForm Pharmaceuticals, Inc.
    Inventors: Jules Remenar, Michael MacPhee, Matthew Lynn Peterson, Sherry Lynn Morissette, Orn Almarsson
  • Novel crystalline forms of conazoles and methods of making and using the same
    Publication number: 20050070551
    Abstract: The invention provides novel soluble conazole crystalline forms (e.g. itraconazole, posaconazole and saperconazole) that include salts, co-crystals and related solvates useful as pharmaceuticals. The invention also provides pharmaceutical compositions comprising, and processes for making, these conazole crystalline forms. Methods of using such compositions for the treatment or prevention of systemic and local fungal, yeast, and dermatophyte infections are also provided.
    Type: Application
    Filed: August 26, 2004
    Publication date: March 31, 2005
    Inventors: Julius Remenar, Michael MacPhee, Matthew Peterson, Sherry Morissette, Orn Almarsson
  • Sertraline compositions
    Publication number: 20050014829
    Abstract: An acid salt of sertraline, wherein the acid is citric acid, fumaric acid, malic acid, maleic acid, malonic acid, phosphoric acid, succinic acid, sulfuric acid, L-tartaric acid, HBr, acetic acid, benzoic acid, benzenesulfonic acid, ethanesulfonic acid, lactic acid, methanesulfonic acid or toluenesulfonic acid. Similarly, a solvate of sertraline HCl, wherein the solvent is methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, t-butanol, acetic acid, ethyl acetate, or propylene glycol.
    Type: Application
    Filed: May 21, 2004
    Publication date: January 20, 2005
    Inventors: Julius Remenar, Michael MacPhee, Matthew Peterson, Mark Tawa
  • Novel conazole crystalline forms and related processes, pharmaceutical compositions and methods
    Publication number: 20040019211
    Abstract: The invention provides novel soluble conazole crystalline forms (e.g. itraconazole, posaconazole and saperconazole) that include salts, co-crystals and related solvates useful as pharmaceuticals. The invention also provides pharmaceutical compositions comprising, and processes for making, these conazole crystalline forms. Methods of using such compositions for the treatment or prevention of systemic and local fungal, yeast, and dermatophyte infections are also provided.
    Type: Application
    Filed: May 30, 2003
    Publication date: January 29, 2004
    Applicant: Transform Pharmaceuticals, Inc.
    Inventors: Jules Remenar, Michael MacPhee, Matthew Lynn Peterson, Sherry Lynn Morissette, Orn Almarsson
  • Cheesecake in a cone
    Patent number: D442762
    Type: Grant
    Filed: August 10, 2000
    Date of Patent: May 29, 2001
    Inventor: Michael MacPhee
  • Cheesecake in a cone
    Patent number: D434204
    Type: Grant
    Filed: January 19, 2000
    Date of Patent: November 28, 2000
    Inventor: Michael MacPhee