Abstract: The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.

Abstract: Disclosed are oral care compositions comprising a thickening silica and a fluoride ion source, wherein fluoride is absorbed on the thickening silica and wherein the pH of the composition is below 5.5, as well as to methods of using these compositions. The thickening silica may have a particle size distribution (D95) less than or equal to 7 ?m and a BET surface area of greater than or equal to 150 m2/g.

Abstract: The disclosure relates to a switching element comprising an external part and an internal part, which is axially displaceable in a bore of the external part. At least one radially displaceable locking element is disposed within at least one receptacle of the internal part and includes a flattened portion on a radially outwardly directed end. At least one recess of the external part can be acted upon by a control pressure and the at least one locking element can thereby be radially displaced from the locking position into a release position. At least in a respective locking position, a chamber delimited by the at least one locking element is spatially separated from the at least one recess of the external part by a respective locking section. At least one bypass is designed, which indirectly fluidly connects the at least one recess of the external part and a respective chamber.

Abstract: A system and method for remote monitoring of patient motor functions includes a computing device that uses captured image data depicting a patient's body part and, based on movement information, detects whether a condition may exist that is affecting motor functions. The body part can be a hand that is tracked as the user performs a tapping exercise. The body part can also include the patient's face during speech and also without speech.

Abstract: A virtual agent instructs a responding person to perform specific verbal exercises. Audio and image inputs from the responding person's performance of the exercises are used to identify speech, video, cognitive, and/or respiratory biomarkers, which are then used to evaluate speech motor function and/or neurological health. Contemplated exercises include test aspects of oral motor proficiency, sustained phonation, diadochokinesis, reading speech, spontaneous speech, spirometry, picture description, and emotion elicitation. Metrics from evaluation of the responding person's performance are advantageously produced automatically, and are presented in spreadsheet format.

Abstract: A refrigeration appliance device, in particular a household refrigeration appliance device, which achieves a high level of efficiency, includes an inner compartment, which forms a storage space for articles and which is made up at least of a first inner-compartment part and at least of a second inner-compartment part, which is adjacent to the first inner-compartment part and is formed separately from the first inner-compartment part. At least one prefabricated, in particular at least substantially panel-shaped, thermal insulation element, is fastened on at least one side of the inner compartment directed away from the storage space. A refrigeration appliance and/or freezer having the refrigeration appliance device, a modular system for manufacturing the refrigeration appliance device, and a method for producing the refrigeration appliance device, are also provided.

Abstract: A computer-generated dialog session is customized for a user having a pathology characterized at least in part by a speech pathology. The user's speech is analyzed for spans of speech in which the starts and ends of the spans satisfy predetermined thresholds of time. Customization occurs by altering at least one of the following configurable parameters: (a) a threshold minimum signal strength of speech (dB) to consider as the start of the span of speech; (b) an adjustment factor by which signal strengths of background noise increases between consecutive spans of speech; (c) a threshold between signal strength during the span of speech and signal strength during the span of non-speech; (d) a start speech time threshold; and (e) an end speech time threshold.

Abstract: An armrest console includes an armrest, a fixed gear coupled to a top of a storage compartment in the armrest console, an elevating gear coupled to the armrest; a dampener gear engaged with the elevating gear and the fixed gear, and a gear connector to receive the elevating gear and the dampener gear. When the armrest is rotated about an axis of the elevating gear in a counterclockwise direction to open, the elevating gear is rotated in the counterclockwise direction and the dampener gear is rotated in a clockwise direction and both the elevating gear and the dampener gear are rotated about an axis of the fixed gear, and wherein the elevating gear and the dampener gear are moved up at a height direction when the armrest is rotated to open.

Abstract: A virtual agent converses with a patient or other person to assess one or more psychological or other medical conditions of the other person. The virtual agent uses both semantic and affect content from the person to branch the conversation, and to assess a psychological or other condition of the person. The virtual agent can have artificial intelligence functionalities or can utilize a separate artificial intelligence functionality. A communication agent can be utilized to monitor a telecommunication session with the person, and if appropriate, modify relative bandwidth utilization between the audio and image inputs. The virtual agent/artificial intelligence agent can simultaneously assist multiple virtual agents, who are each conversing with a responding person assessing their psychological or other medical condition(s), in parallel. The contemplated virtual agents can be especially useful in assessing disorder severity in multiple neurological and mental disorders.

Abstract: Disclosed are oral care compositions comprising a thickening silica and a fluoride ion source, wherein fluoride is absorbed on the thickening silica and wherein the pH of the composition is below 5.5, as well as to methods of using these compositions. The thickening silica may have a particle size distribution (D95) less than or equal to 7 ?m and a BET surface area of greater than or equal to 150 m2/g.

Abstract: Inertial lock systems for push-push latch style vehicle drawers or storage bins including an inertia lock to maintain a drawer in a closed position under a g-force. A shaft is rotatably mounted on a drawer housing; an inertia member is mounted on the shaft; and a confining member is mounted on the shaft and disposed opposite to the inertia member. The confining member is configured to move to a position to restrict movement of a rotating latch of the drawer when a g-forced applied to the drawer exceeds a predetermined level.

Abstract: An armrest console includes an armrest, a fixed gear coupled to a top of a storage compartment in the armrest console, an elevating gear coupled to the armrest; a dampener gear engaged with the elevating gear and the fixed gear, and a gear connector to receive the elevating gear and the dampener gear. When the armrest is rotated about an axis of the elevating gear in a counterclockwise direction to open, the elevating gear is rotated in the counterclockwise direction and the dampener gear is rotated in a clockwise direction and both the elevating gear and the dampener gear are rotated about an axis of the fixed gear, and wherein the elevating gear and the dampener gear are moved up at a height direction when the armrest is rotated to open.

Abstract: An air register knob assembly comprises a vane having a first side and a second side opposite the first side; a knob having a main body. The main body is slidably connected to only the first side of the vane.

Abstract: Systems and methods for multi-robot gradient-based adaptive navigation are provided.

Abstract: A fastener is provided to be pre-assembled to a substrate. The fastener comprises a shaft having a first end and a second end opposite the first end, and a thread portion adjacent to the second end; a head disposed on the first end; and a unidirectional retention member between the head and the thread portion. The unidirectional retention member is configured to pass through a mounting hole of the substrate in one direction such that the fastener is retained on the substrate once the unidirectional retention member has passed through the mounting hole.

Abstract: A method and apparatus for determining relationships between objects in a meta-model semantic network is described. A contextual network graph comprising nodes and edges representing semantic objects and semantic relationships is generated from a meta-model of business objects from the meta-model semantic network. The contextual network graph is used to generate a unique identifier for each node and associated edge. The unique identifiers are used to compute information of cost and energy between the nodes. The information is stored in a meta-model semantic network database.

Abstract: The present disclosure describes methods, systems, and computer program products for importing data to a semantic graph. One computer-implemented method includes collecting, at a client, data from an information source; receiving, from a server, a query for information associated with the semantic graph; and sending, in response to the query, the collected data to the server in accordance to a communication protocol, wherein the collected data is imported to the semantic graph.

Abstract: A fastener is provided to be pre-assembled to a substrate. The fastener comprises a shaft having a first end and a second end opposite the first end, and a thread portion adjacent to the second end; a head disposed on the first end; and a unidirectional retention member between the head and the thread portion. The unidirectional retention member is configured to pass through a mounting hole of the substrate in one direction such that the fastener is retained on the substrate once the unidirectional retention member has passed through the mounting hole.

Abstract: A device holder to hold an electronic device is provided. The device holder comprises an upper arc arm; a lower arc arm; and a drive device. The upper arm and the lower arc arms are attached to the drive device and moveably between a non-use position and a use position and the drive device enables a synchronized movement of the upper arc arm and a lower arc arm at opposite directions.

Abstract: An assembly for mounting a door with a vehicle compartment includes an arm coupled with the compartment and with the door and a constant-force spring having a coil coupled with one of the door and the compartment and an end coupled with the other of the door and the compartment such that a contraction of the spring causes the door to move with rotation of the arm.