Patents by Inventor Michael R. Hoy
Michael R. Hoy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240117339Abstract: The disclosure relates to barcoded polymer nanoparticles for in vivo screening and for in vivo therapeutic delivery, and methods therefor. More particularly, the invention relates to polymer nanoparticles, such as reversible addition-fragmentation chain transfer (RAFT) polymer compositions, associated with polynucleotide barcodes, for therapeutic delivery, and for high throughput in vivo screening of drug delivery nanoparticles.Type: ApplicationFiled: September 27, 2023Publication date: April 11, 2024Inventors: Anthony D. DUONG, Danielle J. HUK, Cherry GUPTA, Kenneth R. SIMS, Jr., Michael S. KOERIS, Zachary R. SHANK, Ashlee J. COLBERT, Andrea D. MCCUE, Emma K. SCHMITZ, Caleb T. HILLRICH, Shannon D. MILLER, Joanna L. HOY
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Publication number: 20240067960Abstract: The invention relates to barcoded nucleic acid nanostructure delivery compositions for in vivo screening for subsequent use in vivo therapeutic delivery, and methods therefor. More particularly, the invention relates to nucleic acid nanostructure delivery compositions, such as DNA origami structures, associated with barcodes for high throughput in vivo screening of the nucleic acid nanostructure delivery compositions for subsequent use in drug delivery, and methods therefor.Type: ApplicationFiled: June 9, 2023Publication date: February 29, 2024Inventors: Cherry GUPTA, Anthony D. DUONG, Danielle J. HUK, Kenneth R. SIMS, JR., Michael S. KOERIS, Miguel D. PEDROZO, Nickolas R. ANDRIOFF, Zachary R. SHANK, Ashlee J. COLBERT, Andrea D. MCCUE, Emma K. SCHMITZ, Caleb T. HILLRICH, Shannon D. MILLER, Joanna L. HOY, Natalie HOFFMAN
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Patent number: 6387411Abstract: A method for preparing sterol/stanol and sterol/stanol ester compositions with improved dispersibility is provided by co-melting the sterol/stanol and/or sterol/stanol ester with highly branched hydrocarbons and then grinding the resulting product. A method for preparing the compounds is also disclosed. The ground compound is suitable for formulating into orally administered products suitable for control of blood serum cholesterol.Type: GrantFiled: April 4, 2001Date of Patent: May 14, 2002Assignee: McNeil-PPC, Inc.Inventors: Richard D. Bruce, Brid Burruano, Michael R. Hoy, Nicholas R. Paquette
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Publication number: 20010012521Abstract: A method for preparing sterol/stanol and sterol/stanol ester compositions with improved dispersibility is provided by co-melting the sterol/stanol and/or sterol/stanol ester with highly branched hydrocarbons and then grinding the resulting product. A method for preparing the compounds is also disclosed. The ground compound is suitable for formulating into orally administered products suitable for control of blood serum cholesterol.Type: ApplicationFiled: April 4, 2001Publication date: August 9, 2001Inventors: Richard D. Bruce, Brid Burruano, Michael R. Hoy, Nicholas R. Paquette
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Patent number: 6242001Abstract: A method for preparing sterol/stanol and sterol/stanol ester compositions with improved dispersibility is provided by co-melting the sterol/stanol and/or sterol/stanol ester with highly branched hydrocarbons and then grinding the resulting product. A method for preparing the compounds is also disclosed. The ground compound is suitable for formulating into orally administered products suitable for control of blood serum cholesterol.Type: GrantFiled: November 30, 1998Date of Patent: June 5, 2001Assignee: McNeil-PPC, Inc.Inventors: Richard D. Bruce, Brid Burruano, Michael R. Hoy, Nicholas R. Paquette
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Patent number: 6110502Abstract: A method for preparing .beta.-sitosterol is disclosed which provides the sterol in a readily consumable form. The method includes the spray drying of the .beta.-sitosterol in a mixed micelle formulation. The product is provided in a convenient form that can be provided to food or drinks or incorporated into solid and suspension dosage forms.Type: GrantFiled: February 19, 1998Date of Patent: August 29, 2000Assignee: McNeil-PPC, Inc.Inventors: Brid Burruano, Richard D. Bruce, Michael R. Hoy
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Patent number: 6054144Abstract: A method for preparing .beta.-sitosterol, oryzanol, esters of both of these compounds and related compounds are disclosed which provides the sterol in a readily consumable form. The method includes the spray drying of the .beta.-sitosterol in a mixed micelle formulation. The product is provided in a convenient form that can be provided to food or drinks or incorporated into solid and suspension dosage forms.Type: GrantFiled: November 4, 1998Date of Patent: April 25, 2000Assignee: McNeil-PPC, Inc.Inventors: Brid Burruano, Richard D. Bruce, Michael R. Hoy, John D. Higgins, III
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Patent number: 6024980Abstract: The present invention relates to a dosage form containing a common enclosure of polymeric material. The enclosure contains multiple phases of semi-solid fill materials containing active ingredients.Type: GrantFiled: June 28, 1996Date of Patent: February 15, 2000Assignee: McNeil-PPC, Inc.Inventor: Michael R. Hoy
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Patent number: 5980944Abstract: A solid oral dosage form for the treatment of gastrointestinal disorders comprising a therapeutically effective amount of a pharmaceutical suitable for the treatment of gastric disorders selected from the group consisting of granules of diphenoxylate, loperamide, loperamide-N-oxide, pharmaceutically acceptable salts thereof and combinations thereof; and a therapeutically effective amount of simethicone wherein the pharmaceutical and simethicone are separated by a barrier coat on the granules which is substantially impermeable to simethicone.Type: GrantFiled: November 25, 1997Date of Patent: November 9, 1999Assignee: McNeil-PPC, Inc.Inventors: Charles A. Stevens, Michael R. Hoy, Edward J. Roche
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Patent number: 5919481Abstract: The present invention relates to a substantially translucent, semi-solid fill material for a soft gelatin capsule containing a therapeutically effective amount of a pharmaceutical dissolved or suspended in the semi-solid. The semi-solid is sufficiently viscous so that it cannot be readily expelled at room temperature from the capsule with a syringe.Type: GrantFiled: June 28, 1996Date of Patent: July 6, 1999Assignee: NcNeil-PPC, Inc.Inventors: Sharon L. Cody, Brid T. Devlin, John Dubek, Michael R. Hoy
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Patent number: 5916590Abstract: The present invention relates to a substantially translucent, gel fill material for a soft gelatin capsule containing a therapeutically effective amount of a pharmaceutical dissolved or suspended in the gel. The gel is sufficiently viscous so that it cannot be expelled at room temperature from the capsule with a syringe.Type: GrantFiled: September 25, 1996Date of Patent: June 29, 1999Assignee: McNeil-PPC, Inc.Inventors: Sharon L. Cody, Michael R. Hoy, Edward J. Roche, Eric J. Walter
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Patent number: 5908636Abstract: The present invention relates to a semi-solid fill material for a soft gelatin capsule containing a therapeutically effective amount of an antiflatulent. The semi-solid is sufficiently viscous so that it cannot be expelled readily at room temperature from the capsule with a syringe.Type: GrantFiled: June 28, 1996Date of Patent: June 1, 1999Assignee: McNeil-PPC, Inc.Inventors: Brid T. Devlin, Michael R. Hoy
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Patent number: 5840337Abstract: The present invention relates to gelling liquid polyethylene glycol at room temperature with calcium acetate.Type: GrantFiled: June 13, 1997Date of Patent: November 24, 1998Assignee: McNeil-PPC, Inc.Inventors: Sharon L. Cody, Michael R. Hoy, Eric J. Walter
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Patent number: 5807568Abstract: The present invention is directed to flurbiprofen-containing compositions for topical administration comprising about 0.5 to 10% flurbiprofen; about 10 to 80% of a lower alcohol; about 0 to 25% of a glycol; about 0 to 5% of a gelling agent; an amount of a pH adjusting agent sufficient to adjust the pH of the composition to a range of from about 2 to less than 4.5; and water in an amount sufficient to make up the balance of the composition, and methods for delivering flurbiprofen-containing compositions through the skin.Type: GrantFiled: November 8, 1996Date of Patent: September 15, 1998Assignee: McNeil-PPC, Inc.Inventors: Sharon L. Cody, Richard D. Fegley, Michael R. Hoy
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Patent number: 5716641Abstract: A solid oral dosage form for the treatment of gastrointestinal disorders comprising a therapeutically effective amount of a pharmaceutical suitable for the treatment of gastric disorders selected from the group consisting of cimetidine, ranitidine, famotidine, diphenoxylate, loperamide, loperamide-N-oxide, pharmaceutically acceptable salts thereof and combinations thereof; and a therapeutically effective amount of simethicone wherein the pharmaceutical and simethicone are separated by a barrier which is substantially impermeable to simethicone.Type: GrantFiled: March 20, 1996Date of Patent: February 10, 1998Assignee: McNeil-PPC, Inc.Inventors: Charles A. Stevens, Michael R. Hoy, Edward J. Roche
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Patent number: 5679376Abstract: A solid oral dosage form for the treatment of gastrointestinal disorders comprising a therapeutically effective amount of a pharmaceutical suitable for the treatment of gastric disorders selected from the group consisting of cimetidine, ranitidine, famotidine, diphenoxylate, loperamide, loperamide-N-oxide, pharmaceutically acceptable salts thereof and combinations thereof; and a therapeutically effective amount of simethicone wherein the pharmaceutical and simethicone are separated by a barrier which is substantially impermeable to simethicone.Type: GrantFiled: May 31, 1995Date of Patent: October 21, 1997Assignee: McNeil-PPC, Inc.Inventors: Charles A. Stevens, Michael R. Hoy, Edward J. Roche
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Patent number: 5660859Abstract: The present invention relates to gelling liquid polyethylene glycol at room temperature with calcium acetate.Type: GrantFiled: December 29, 1994Date of Patent: August 26, 1997Assignee: McNeil-PPC, Inc.Inventors: Sharon L. Cody, Michael R. Hoy, Eric J. Walter
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Patent number: 5599577Abstract: A method of making solid oral dosage form for the treatment of gastrointestinal disorders comprising a therapeutically effective amount of a pharmaceutical suitable for the treatment of gastric disorders selected from the group consisting of cimetidine, ranitidine, famotidine, diphenoxylate, loperamide, loperamide-N-oxide, pharmaceutically acceptable salts thereof and combinations thereof; and a therapeutically effective amount of simethicone wherein the pharmaceutical and simethicone are separated by a barrier. The barrier is formed by coating with a polymer impermeable to simethicone.Type: GrantFiled: May 31, 1995Date of Patent: February 4, 1997Assignee: McNeil-PPC, Inc.Inventors: Charles A. Stevens, Michael R. Hoy, Edward J. Roche
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Patent number: 5489436Abstract: Chewable tablets are made from a coated medicament wherein the coating comprises a mixture of dimethylaminoethyl methacrylate and neutral methacrylic acid ester and a cellulose ester, e.g. cellulose acetate, cellulose acetate butyrate, cellulose triacetate or a combination thereof and optionally polyvinyl pyrrolidone, and a process for making such tablets and a method of providing taste masking and sustained releasing of medicaments utilizing such coatings.Type: GrantFiled: December 13, 1993Date of Patent: February 6, 1996Assignee: McNeil-PPC, Inc.Inventors: Michael R. Hoy, Edward J. Roche