Patents by Inventor Milton L. Hoefle

Milton L. Hoefle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fenamate 1,3,4-thiadiazoles and 1,3,4-oxadiazoles as antiinflammatory agents
    Patent number: 5462952
    Abstract: The present invention is novel compounds which are 1,3,4-thiadiazoles and 1,3,4-oxadiazoles, and pharamaceutically acceptable acid addition or base salts thereof having activity as inhibitors of singly or together 5-lipoxygenase and cyclooxygenase, and pharmaceutical compositions or methods of use therefor.
    Type: Grant
    Filed: September 8, 1993
    Date of Patent: October 31, 1995
    Assignee: Warner-Lambert Company
    Inventors: Diane H. Boschelli, David T. Connor, Milton L. Hoefle
  • Triazole derivatives of fenamates as antiinflammatory agents
    Patent number: 5066668
    Abstract: The present invention is novel compounds which are 1,2,4-triazoles, derivatives of fenamates and pharmaceutically acceptable additions and base salts thereof, pharmaceutical compositions and methods of use therefor. The nvention compounds are now found to have activity as inhibitors of 5-lipoxygenase and/or cyclooxygenase providing treatment of conditions advantageously affected by such inhibition including inflammation, arthritis, pain, fever, and the like.
    Type: Grant
    Filed: April 3, 1990
    Date of Patent: November 19, 1991
    Assignee: Warner-Lambert Co.
    Inventors: Diane H. Boschelli, David T. Connor, Daniel L. Flynn, Jagadish C. Sircar, Milton L. Hoefle
  • Novel N-(substituted-phenyl)-5-(substituted-2,5-dimethylphenoxy)-2,2-dimethylp entanamides
    Patent number: 4975456
    Abstract: Novel N-(substituted-phenyl)-5-(substituted-2,5-dimethylphenoxy)-2,2- dimethylpentanamides which are useful in preventing the intestinal absorption of cholesterol and also increasing high-density lipoprotein (HDL) cholesterol, as well as novel pharmaceutical compositions and methods of use, as well as processes for their manufacture are herein described.
    Type: Grant
    Filed: July 13, 1989
    Date of Patent: December 4, 1990
    Assignee: Warner-Lambert Company
    Inventors: Paul L. Creger, Milton L. Hoefle, Ann Holmes
  • Triazole derivatives of fenamates as antiinflammatory agents
    Patent number: 4962119
    Abstract: The present invention is novel compounds which are 1,2,4-triazoles, derivatives of fenamates and pharmaceutically acceptable additions and base salts thereof, pharmaceutical compositions and methods of use thereof. The invention compounds are now found to have activity as inhibitors of 5-lipoxygenase and/or cyclooxygenase providing treatment of conditions advantageously affected by such inhibition including inflammation, arthritis, pain, fever, and the like.
    Type: Grant
    Filed: June 9, 1989
    Date of Patent: October 9, 1990
    Assignee: Warner-Lambert Company
    Inventors: Diane H. Boschelli, David T. Connor, Daniel L. Flynn, Jagadish C. Sircar, Milton L. Hoefle
  • Novel N-(substituted-phenyl)-5-(substituted-2,5-dimethylphenoxy)-2,2-dimethylp entanamides
    Patent number: 4882357
    Abstract: Novel N-(substituted-phenyl)-5-(substituted-2,5-dimethylphenoxy)-2,2-dimethylpen tan amides which are useful in preventing the intestinal absorption of cholesterol and also increasing high-density lipoprotein (HDL) cholesterol, as well as novel pharmaceutical compositions and methods of use, as well as processes for their manufacture are herein described.
    Type: Grant
    Filed: July 15, 1988
    Date of Patent: November 21, 1989
    Assignee: Warner-Lambert Company
    Inventors: Paul L. Creger, Milton L. Hoefle, Ann Holmes
  • Substituted amide inhibitors of cholesterol absorption
    Patent number: 4824843
    Abstract: Novel N-(substituted-phenyl)-5-(2,5-dimethylphenoxy)-2,2-dimethylpentanamides which are useful in preventing the intestinal absorption of cholesterol, as well as novel pharmaceutical compositions and methods of use, as well as processes for their manufacture are herein described.
    Type: Grant
    Filed: June 25, 1987
    Date of Patent: April 25, 1989
    Assignee: Warner-Lambert Company
    Inventors: Milton L. Hoefle, Robert F. Meyer
  • Substituted anilides of oleic, linoleic, or linolenic acid as inhibitors of acyl-coa:cholesterol acyltransferase
    Patent number: 4751026
    Abstract: Certain trisubstituted anilides of oleic, linoleic, and linolenic acid are potent inhibitors of the enzyme acyl-CoA:cholesterol acyltransferase and are thus useful agents for inhibiting the intestinal absorption of cholesterol.
    Type: Grant
    Filed: January 16, 1987
    Date of Patent: June 14, 1988
    Assignee: Warner-Lambert Company
    Inventors: Milton L. Hoefle, Ann Holmes
  • Treating fungal infections with substituted-(6-(tetrahydro-4-hydroxy-2-oxo-2H-pyran-2-yl)ethyl)- or ethenyl)pyrazoles
    Patent number: 4751229
    Abstract: A method of treating fungal infections in mammals employing 1,3,5-trisubstituted-4- (4-hydroxy-2-oxo-pyran-6-yl)pyrazoles is disclosed.
    Type: Grant
    Filed: July 9, 1987
    Date of Patent: June 14, 1988
    Assignee: Warner-Lambert Company
    Inventors: Carl L. Heifetz, Milton L. Hoefle, Bruce D. Roth, Drago R. Sliskovic, Michael W. Wilson
  • Saturated fatty acid amides as inhibitors of acyl-coa:cholesterol acyltransferase
    Patent number: 4743605
    Abstract: Certain substituted amides of saturated fatty acids are potent inhibitors of the enzyme acyl-CoA:cholesterol acyltransferase and are thus useful agents for inhibiting the intestinal absorption of cholesterol.
    Type: Grant
    Filed: October 1, 1987
    Date of Patent: May 10, 1988
    Assignee: Warner-Lambert Company
    Inventors: Milton L. Hoefle, Ann Holmes, Bruce D. Roth
  • 4-(substituted-isoindol-2-yl)phenoxy-pentanoic and -heptanoic acids and derivatives as anti-arteriosclerotic agents
    Patent number: 4737512
    Abstract: Novel 4-(substituted-isoindol-2-yl)phenoxy-pentanoic and -heptanoic acids and derivatives which are useful as anti-arteriosclerotic agents are disclosed. The compounds elevate the high density lipoprotein fraction of cholesterol and also lower the low density lipoprotein fraction of cholesterol. Methods for preparing and using the compounds are included.
    Type: Grant
    Filed: October 27, 1986
    Date of Patent: April 12, 1988
    Assignee: Warner-Lambert Company
    Inventor: Milton L. Hoefle
  • Saturated fatty acid amides as inhibitors of acyl-CoA:cholesterol acyltransferase
    Patent number: 4716175
    Abstract: Certain substituted amides of saturated fatty acids are potent inhibitors of the enzyme acyl-CoA:cholesterol acyltransferase and are thus useful agents for inhibiting the intestinal absorption of cholesterol.
    Type: Grant
    Filed: February 24, 1987
    Date of Patent: December 29, 1987
    Assignee: Warner-Lambert Company
    Inventors: Milton L. Hoefle, Ann Holmes, Bruce D. Roth
  • Antiarteriosclerotic substituted benzimidazol-2-yl-and 3H-imidazo[4,5-b]pyridin-2-yl-phenoxy-alkanoic acids and salts and esters thereof
    Patent number: 4714762
    Abstract: Novel substituted benzimidazol-2-yl-phenoxyalkanoic acids, salts and esters thereof and 3H-imidazo[4,5-b]pyridin-2-yl phenoxy-alkanoic acid, salts, and esters which are useful as antiarteriosclerotic agents are disclosed. The compounds elevate the high density lipoprotein fraction of cholesterol and also lower the low density lipoprotein fraction of cholesterol. Methods for preparing and using the compounds are included.
    Type: Grant
    Filed: October 31, 1986
    Date of Patent: December 22, 1987
    Assignee: Warner-Lambert Company
    Inventors: Milton L. Hoefle, Ann Holmes, Charlotte D. Stratton
  • Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis
    Patent number: 4647576
    Abstract: 6-[2-(Substituted-pyrrol-1-yl)alkyl]pyran-2-ones and the corresponding ring-opened hydroxy-acids derived therefrom are potent inhibitors of the enzyme 3-hydroxy-3-methylglutarylcoenzyme A reductase (HMG-CoA reductase), and are thus useful hypolipidemic and hypocholesterolemic agents. Pharmaceutical compositions containing such compounds, and a method of treatment employing such pharmaceutical compositions are also disclosed.
    Type: Grant
    Filed: December 10, 1984
    Date of Patent: March 3, 1987
    Assignee: Warner-Lambert Company
    Inventors: Milton L. Hoefle, Bruce D. Roth, Charlotte D. Stratton
  • N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
    Patent number: 4532342
    Abstract: N-substituted amino acids are described which when coupled with 1,2,3,4-tetrahydroisoquinolines result in substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids as anti-hypertensive agents. The novel intermediates are in turn prepared by reacting an amino acid such as alanine with 2-bromo-4-phenyl butanoic acid or an ester thereof.
    Type: Grant
    Filed: June 8, 1982
    Date of Patent: July 30, 1985
    Assignee: Warner-Lambert Company
    Inventors: Milton L. Hoefle, Sylvestor Klutchko
  • Substituted acyl derivatives of chair form of octahydro-1H-indole-2-carboxylic acids
    Patent number: 4425355
    Abstract: Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acid and the pharmaceutically acceptable salts thereof are produced by acylating a suitably substituted octahydro-1H-indole with a suitably activated substituted carboxylic acid and when desired hydrolyzing the resulting product. The compounds of the invention, their salts and pharmaceutical compositions thereof are useful as antihypertensive agents.
    Type: Grant
    Filed: June 29, 1981
    Date of Patent: January 10, 1984
    Assignee: Warner-Lambert Company
    Inventors: Milton L. Hoefle, George Bobowski
  • Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
    Patent number: 4350704
    Abstract: Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acid and the pharmaceutically acceptable salts thereof are produced by acylating a suitably substituted octahydro-1H-indole with a suitably activated substituted carboxylic acid and when desired hydrolyzing the resulting product. The compounds of the invention, their salts and pharmaceutical compositions thereof are useful as antihypertensive agents.
    Type: Grant
    Filed: February 17, 1981
    Date of Patent: September 21, 1982
    Assignee: Warner-Lambert Company
    Inventors: Milton L. Hoefle, George Bobowski
  • Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
    Patent number: 4344949
    Abstract: Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids and the pharmaceutically acceptable salts thereof are produced by coupling a suitably substituted 1,2,3,4-tetrahydroisoquinoline with a suitably substituted amino acid and when desired hydrolyzing or removing protecting groups of the resulting product. The compounds of the invention, their salts and pharmaceutical compositions thereof are useful as antihypertensive agents.
    Type: Grant
    Filed: February 20, 1981
    Date of Patent: August 17, 1982
    Assignee: Warner-Lambert Company
    Inventors: Milton L. Hoefle, Sylvester Klutchko
  • 2,2-Dimethyl-5-(2,5-dimethylphenoxy)pentyl ester of 3-pyridine carboxylic acid and use as an anti-atherosclerotic agent
    Patent number: 4285951
    Abstract: Certain pyridine derivatives of 1,1-dimethyl-4-(2,5-dimethylphenoxy)butane and their pharmaceutically-acceptable acid-addition salts are disclosed. These compounds increase the high density lipoprotein fraction of cholesterol found in the blood plasma.
    Type: Grant
    Filed: September 7, 1979
    Date of Patent: August 25, 1981
    Assignee: Warner-Lambert Company
    Inventor: Milton L. Hoefle