Patents by Inventor Niven Rajin Narain

Niven Rajin Narain has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240062844
    Abstract: Described herein is a discovery Platform Technology for analyzing a biological system or process (e.g.
    Type: Application
    Filed: March 23, 2023
    Publication date: February 22, 2024
    Inventors: Niven Rajin Narain, Rangaprasad Sarangarajan, Vivek K. Vishnudas
  • Publication number: 20230302022
    Abstract: The invention provides methods and pharmaceutical compositions for preventing or mitigating chemotherapy-induced alopecia (CIA). The pharmaceutical compositions of the invention comprise an effective amount of a vitamin D compound in a topical formulation. The invention has broad applications in chemotherapies that induce alopecia, for example taxane based chemotherapy for cervical cancer, endometrial cancer, ovarian cancer, fallopian tube cancer, primary peritoneal carcinoma, soft tissue sarcoma, or bone sarcoma. The pharmaceutical compositions of the invention can be advantageously administered before and/or concurrent with the chemotherapy.
    Type: Application
    Filed: November 4, 2022
    Publication date: September 28, 2023
    Inventors: Rangaprasad Sarangarajan, Joaquin J. Jimenez, Niven Rajin Narain
  • Publication number: 20230285272
    Abstract: The invention provides regimens and methods for the treatment of cancer comprising continuous infusion of coenzyme Q10. The coenzyme Q10 may be administered as a monotherapy, or in combination with an additional agent, such as an anticancer agent, a chemotherapeutic agent, or an anti-angiogenic agent. The coenzyme Q10 may be administered at two or more different rates.
    Type: Application
    Filed: October 10, 2022
    Publication date: September 14, 2023
    Inventors: Niven Rajin Narain, Rangaprasad Sarangarajan, Thomas Mitchell Gray, John Patrick McCook, Joaquin J. Jimenez
  • Publication number: 20230274799
    Abstract: Disclosed herein are methods and systems for identifying one or more potential biomarkers for a clinical outcome related to administration of an agent. The method includes processing molecular profile data for a plurality of subjects where the molecular profile data includes data obtained before, during and/or after administration of an agent to the plurality of subjects. The method also includes processing clinical records data for the subjects, where the clinical records data includes clinical outcome data, integrating the processed molecular profile data and the processed clinical records data for the subjects and storing in a database as merged data, selecting two or more subsets of the merged data using one or more criteria based on the clinical records data to generate two or more selected data sets, and analyzing one or more of the selected data sets to identify one or more potential biomarkers for a clinical outcome related to administration of the agent.
    Type: Application
    Filed: September 26, 2022
    Publication date: August 31, 2023
    Inventors: Niven Rajin Narain, Viatcheslav R. Akmaev, Leonardo Rodrigues, Gregory Mark Miller
  • Patent number: 11734593
    Abstract: Systems, methods, and computer-readable medium are provided for healthcare analysis. Data corresponding to a plurality of patients is received. The data is parsed to generate normalized data for a plurality of variables, with normalized data generated for more than one variable for each patient. A causal relationship network model is generated relating the plurality of variables based on the generated normalized data using a Bayesian network algorithm. The causal relationship network model includes variables related to a plurality of medical conditions or medical drugs. In another aspect, a selection of a medical condition or drug is received. A sub-network is determined from a causal relationship network model. The sub-network includes one or more variables associated with the selected medical condition or drug. One or more predictors for the selected medical condition or drug are identified.
    Type: Grant
    Filed: October 3, 2019
    Date of Patent: August 22, 2023
    Assignee: BPGBio, Inc.
    Inventors: Niven Rajin Narain, Viatcheslav R. Akmaev, Vijetha Vemulapalli
  • Patent number: 11694765
    Abstract: Described herein is a discovery Platform Technology for analyzing a drug-induced toxicity condition, such as cardiotoxicity via model building.
    Type: Grant
    Filed: November 5, 2018
    Date of Patent: July 4, 2023
    Assignee: Berg LLC
    Inventors: Niven Rajin Narain, Rangaprasad Sarangarajan, Vivek K. Vishnudas
  • Publication number: 20230165809
    Abstract: Disclosed herein are formulations suitable for parenteral administration of certain hydrophobic active agents such as Coenzyme Q10. Methods of preparing the same and methods of treatment of oncological disorders using the same are also provided herein. The formulations comprise an aqueous solution; a hydrophobic active agent dispersed to form a colloidal nano-dispersion of particles; and at least one of a dispersion stabilizing agent and an opsonization reducer wherein the colloidal nano-dispersion of the active agent is dispersed into nano-dispersion particles having a mean size of less than 200-nm. Methods of preparing the parenteral formulations comprise dispersing the hydrophobic active agent by high pressure homogenization by (1) adding hydrophobic active agent to a 65° C. bath of water and mixing to form a hydrophobic active agent/water mixture; (2) adding a dispersion stabilizing agent to the hydrophobic active agent/water mixture and mix at 65° C.
    Type: Application
    Filed: June 9, 2022
    Publication date: June 1, 2023
    Inventors: Niven Rajin Narain, John Patrick McCook
  • Publication number: 20230149292
    Abstract: Topical formulations of CoQ10 reduce the rate of tumor growth in an animal subject. In the experiments described herein, CoQ10 was shown to increase the rate of apoptosis in a culture of skin cancer cells but not normal cells. Moreover, treatment of tumor-bearing animals with a topical formulation of CoQ10 was shown to dramatically reduce the rate of tumor growth in the animals.
    Type: Application
    Filed: April 4, 2022
    Publication date: May 18, 2023
    Applicant: University of Miami
    Inventors: Sung Lan Hsia, Niven Rajin Narain, Jie Li, Kathryn J. Russell, Karrune V. Woan, Indushekhar Persaud
  • Publication number: 20230147697
    Abstract: The present disclosure provides compositions suitable for delivering lipophilic bioactive agents. The compositions may be utilized to treat numerous diseases and conditions that would benefit from the application of a lipophilic bioactive agent.
    Type: Application
    Filed: June 23, 2022
    Publication date: May 11, 2023
    Inventors: John Patrick McCook, Indushekhar Persaud, Niven Rajin Narain
  • Publication number: 20230142060
    Abstract: The present invention is directed, in part, to methods of treating Epidermolysis Bullosa (EB) in a subject in need thereof, comprising topical administration of a pharmaceutical composition comprising a therapeutically effective amount of a of Coenzyme Q10 (CoQ10) to the subject.
    Type: Application
    Filed: July 13, 2022
    Publication date: May 11, 2023
    Inventors: Niven Rajin Narain, Rangaprasad Sarangarajan, Michael Andrew Kiebish
  • Publication number: 20230059578
    Abstract: The present invention relates to protein markers for ER-positive-like and ER-negative-like breast cancer. Methods for differentiating ER-positive-like and ER-negative-like breast cancer in a subject having breast cancer are provided, such methods including the detection of levels of a variety of biomarkers for ER-positive-like and ER-negative-like breast cancer. Compositions in the form of kits and panels of reagents for detecting the biomarkers of the invention are also provided.
    Type: Application
    Filed: April 6, 2022
    Publication date: February 23, 2023
    Inventors: Michael Andrew Kiebish, Albert John Kovatich, Punit Shah, Niven Rajin Narain, Rangaprasad Sarangarajan, Guisong Wang, Jeffery A. Hooke, Jamie Leigh Campbell, Mary Lou Cutler, Craig D. Shriver, Hai Hu
  • Patent number: 11456054
    Abstract: Described herein is a discovery Platform Technology for analyzing a biological system or process (e.g., a disease condition, such as cancer) via model building.
    Type: Grant
    Filed: January 3, 2018
    Date of Patent: September 27, 2022
    Assignee: Berg LLC
    Inventors: Niven Rajin Narain, Rangaprasad Sarangarajan, Vivek K. Vishnudas
  • Patent number: 11452699
    Abstract: The invention provides methods and compositions for treatment of a subject with a central nervous system (CNS) tumor comprising administration of Coenzyme Q10 (CoQ10), particularly when the subject exhibits at least one CNS abnormality as a result of the tumor.
    Type: Grant
    Filed: June 18, 2019
    Date of Patent: September 27, 2022
    Assignee: Berg LLC
    Inventors: Joaquin J. Jimenez, Niven Rajin Narain, Rangaprasad Sarangarajan, John Patrick McCook
  • Patent number: 11419830
    Abstract: The present invention is directed, in part, to methods of treating Epidermolysis Bullosa (EB) in a subject in need thereof, comprising topical administration of a pharmaceutical composition comprising a therapeutically effective amount of a of Coenzyme Q10 (CoQ10) to the subject.
    Type: Grant
    Filed: May 16, 2018
    Date of Patent: August 23, 2022
    Assignee: Berg LLC
    Inventors: Niven Rajin Narain, Rangaprasad Sarangarajan, Michael Andrew Kiebish
  • Patent number: 11400058
    Abstract: Disclosed herein are formulations suitable for parenteral administration of certain hydrophobic active agents such as Coenzyme Q10. Methods of preparing the same and methods of treatment of oncological disorders using the same are also provided herein. The formulations comprise an aqueous solution; a hydrophobic active agent dispersed to form a colloidal nano-dispersion of particles; and at least one of a dispersion stabilizing agent and an opsonization reducer wherein the colloidal nano-dispersion of the active agent is dispersed into nano-dispersion particles having a mean size of less than 200-nm. Methods of preparing the parenteral formulations comprise dispersing the hydrophobic active agent by high pressure homogenization by (1) adding hydrophobic active agent to a 65° C. bath of water and mixing to form a hydrophobic active agent/water mixture; (2) adding a dispersion stabilizing agent to the hydrophobic active agent/water mixture and mix at 65° C.
    Type: Grant
    Filed: March 11, 2011
    Date of Patent: August 2, 2022
    Assignee: Berg LLC
    Inventors: Niven Rajin Narain, John Patrick McCook
  • Publication number: 20220202741
    Abstract: The invention provides methods and compositions for treatment of a subject with a glioma that has failed treatment with temozolomide (TMZ) comprising administration of a composition comprising a Coenzyme Q10 compound to the subject. The invention also provides a method of treating a cancer that exhibits increased Complex II activity in a subject comprising administration of a composition comprising a Coenzyme Q10 compound to the subject.
    Type: Application
    Filed: January 10, 2022
    Publication date: June 30, 2022
    Inventors: Niven Rajin Narain, Rangaprasad Sarangarajan, Vivek K. Vishnudas, Anne R. Diers, Stephane Gesta
  • Publication number: 20220137070
    Abstract: Methods for treatment and diagnosis of pervasive developmental disorders in humans are described.
    Type: Application
    Filed: June 11, 2021
    Publication date: May 5, 2022
    Inventors: Niven Rajin Narain, Paula Patricia Narain
  • Patent number: 11305016
    Abstract: The invention provides methods and pharmaceutical compositions for preventing or treating alopecia, such as chemotherapy-induced alopecia (CIA). The pharmaceutical compositions of the invention comprises an effective amount of a vitamin D compound in a formulation that topically delivers the vitamin D compound to the epidermis layer but substantially avoids the dermis layer. In chemotherapy patients, the pharmaceutical compositions of the invention can be administered either before or concurrent with the chemotherapy medication.
    Type: Grant
    Filed: January 16, 2018
    Date of Patent: April 19, 2022
    Assignee: Berg LLC
    Inventors: Joaquin J. Jimenez, Niven Rajin Narain, John Patrick McCook
  • Patent number: 11298313
    Abstract: The invention provides regimens and methods for the treatment of cancer comprising continuous infusion of coenzyme Q10. The coenzyme Q10 may be administered as a monotherapy, or in combination with an additional agent, such as an anticancer agent, a chemotherapeutic agent, or an anti-angiogenic agent. The coenzyme Q10 may be administered at two or more different rates.
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: April 12, 2022
    Assignee: Berg LLC
    Inventors: Niven Rajin Narain, Rangaprasad Sarangarajan, Thomas Mitchell Gray, John Patrick McCook, Joaquin J. Jimenez
  • Publication number: 20220107322
    Abstract: Methods for diagnosing the presence of prostate cancer in a subject are provided, such methods including the detection of levels of a variety of biomarkers diagnostic of prostate cancer. The invention also provides methods of treating prostate cancer by administering a biomarker or an agent that modulates a biomarker of prostate cancer. Compositions in the form of kits and panels of reagents for detecting the biomarkers of the invention are also provided.
    Type: Application
    Filed: June 9, 2021
    Publication date: April 7, 2022
    Inventors: Michael Andrew Kiebish, Niven Rajin Narain, Rangaprasad Sarangarajan, Viatcheslav R. Akmaev, Leonardo Rodrigues, Yezhou Sun, Shiv Srivastava, Albert Dobi