Patents by Inventor Parijat Bhatnagar
Parijat Bhatnagar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240115610Abstract: An example antigen test device comprises a genetically engineered diagnostic cell comprising an exogenous polynucleotide sequence including a receptor element that encodes a chimeric antigen receptor (CAR) comprising an extracellular antigen binding domain operably linked to a transmembrane domain, and an intracellular signaling domain that recognizes an antigen on a surface of a pathogen-infected cell from a sample or on a surface of a virus particle associated with a pathogen from the sample, an actuator element that encodes a transcription factor binding site, and an effector element that encodes a detectable reporter protein, wherein, in response to the antigen binding domain of the CAR binding to the antigen, the genetically engineered diagnostic cell is configured to activate and to synthesize the detectable reporter protein.Type: ApplicationFiled: June 13, 2023Publication date: April 11, 2024Applicant: SRI InternationalInventors: Parijat BHATNAGAR, Marvin A. SSEMADAALI
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Publication number: 20240101632Abstract: An example genetically engineered electrically-stimulated (ES) cell comprises an exogenous polynucleotide sequence that includes an electrical-sensor element, an actuator element, and an effector element. The electrical-sensor element encodes a voltage-gated calcium ion channel (CaV), wherein the CaV is configured to transition from a closed state to an open state in response to stimulation. The actuator element encodes a transcription factor binding site that upregulates synthesis of an effector protein. The effector element encodes the effector protein, wherein, in response to the transition of the CaV to the open state, the genetically engineered ES effector cell is configured to activate and, to synthesize and secrete the effector protein.Type: ApplicationFiled: January 27, 2022Publication date: March 28, 2024Applicant: SRI InternationalInventors: Parijat BHATNAGAR, Sherri NEWMYER
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Publication number: 20230398215Abstract: An example genetically engineered natural killer (NK) cell comprises an exogenous polynucleotide sequence that includes a receptor element, an actuator element, and an effector element. The receptor element encodes a chimeric antigen receptor (CAR) comprising an extracellular antigen binding domain operably linked to a transmembrane domain, and an intracellular signaling domain, wherein the extracellular antigen binding domain recognizes a surface antigen of a target cell. The actuator element encodes a transcription factor binding site that upregulates synthesis of an effector protein. The effector element encodes the effector protein operably linked to a signal peptide, wherein, in response to the antigen binding domain of the CAR binding to the antigen of the target cell, the engineered NK cell is configured to activate and, to synthesize and secrete the effector protein.Type: ApplicationFiled: October 28, 2021Publication date: December 14, 2023Applicant: SRI InternationalInventor: Parijat Bhatnagar
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Patent number: 11672829Abstract: An example genetically engineered effector cell comprises an exogenous polynucleotide sequence that includes a receptor element, an actuator element, and an effector element. The receptor element encodes a chimeric antigen receptor (CAR) comprising an extracellular antigen binding domain operably linked to a transmembrane domain, and an intracellular signaling domain, wherein the extracellular antigen binding domain recognizes an antigen on a surface of a Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-infected cell. The actuator element encodes a transcription factor binding site that upregulates synthesis of an antiviral protein. The effector element encodes the antiviral protein operably linked to a signal peptide, wherein, in response to the antigen binding domain of the CAR binding to the antigen of SARS-CoV-2-infected cell, the engineered effector cell is configured to activate and, to synthesize and secrete the antiviral protein.Type: GrantFiled: January 27, 2022Date of Patent: June 13, 2023Assignee: SRI InternationalInventors: Parijat Bhatnagar, Marvin A. Ssemadaali
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Publication number: 20220143093Abstract: An example genetically engineered effector cell comprises an exogenous polynucleotide sequence that includes a receptor element, an actuator element, and an effector element. The receptor element encodes a chimeric antigen receptor (CAR) comprising an extracellular antigen binding domain operably linked to a transmembrane domain, and an intracellular signaling domain, wherein the extracellular antigen binding domain recognizes an antigen on a surface of a Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-infected cell. The actuator element encodes a transcription factor binding site that upregulates synthesis of an antiviral protein. The effector element encodes the antiviral protein operably linked to a signal peptide, wherein, in response to the antigen binding domain of the CAR binding to the antigen of SARS-CoV-2-infected cell, the engineered effector cell is configured to activate and, to synthesize and secrete the antiviral protein.Type: ApplicationFiled: January 27, 2022Publication date: May 12, 2022Applicant: SRI InternationalInventors: Parijat BHATNAGAR, Marvin A. SSEMADAALI
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Patent number: 9289786Abstract: Multiplexed electrospray deposition apparatus capable of delivering picoliter volumes of one or more substances is disclosed. The apparatus may include a unitary planar dispenser etched from a silicon wafer through microfabrication or micromachining technology. The apparatus may be used as a deposition tool for making protein microarrays in a noncontact mode. Upon application of potential difference in the range of 7-9 kV, the substances may be dispensed directly, not through a collimating mask, onto a substrate with microhydrogel features functionalized with an anchoring agent.Type: GrantFiled: October 22, 2012Date of Patent: March 22, 2016Assignee: Cornell UniversityInventors: Parijat Bhatnagar, Harold G. Craighead
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Publication number: 20130045335Abstract: Multiplexed electrospray deposition apparatus capable of delivering picoliter volumes of one or more substances is disclosed. The apparatus may include a unitary planar dispenser etched from a silicon wafer through microfabrication or micromachining technology. The apparatus may be used as a deposition tool for making protein microarrays in a noncontact mode. Upon application of potential difference in the range of 7-9 kV, the substances may be dispensed directly, not through a collimating mask, onto a substrate with microhydrogel features functionalized with an anchoring agent.Type: ApplicationFiled: October 22, 2012Publication date: February 21, 2013Applicant: Cornell UniveristyInventors: Parijat Bhatnagar, Harold G. Craighead
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Patent number: 8293337Abstract: Multiplexed electrospray deposition apparatus capable of delivering picoliter volumes of one or more substances is disclosed. The apparatus may include a unitary planar dispenser etched from a silicon wafer through microfabrication or micromachining technology. The apparatus may be used as a deposition tool for making protein microarrays in a noncontact mode. Upon application of potential difference in the range of 7-9 kV, the substances may be dispensed directly, not through a collimating mask, onto a substrate with microhydrogel features functionalized with an anchoring agent.Type: GrantFiled: June 23, 2009Date of Patent: October 23, 2012Assignee: Cornell UniversityInventors: Parijat Bhatnagar, Harold G. Craighead
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Publication number: 20090317558Abstract: Multiplexed electrospray deposition apparatus capable of delivering picoliter volumes of one or more substances is disclosed. The apparatus may include a unitary planar dispenser etched from a silicon wafer through microfabrication or micromachining technology. The apparatus may be used as a deposition tool for making protein microarrays in a noncontact mode. Upon application of potential difference in the range of 7-9 kV, the substances may be dispensed directly, not through a collimating mask, onto a substrate with microhydrogel features functionalized with an anchoring agent.Type: ApplicationFiled: June 23, 2009Publication date: December 24, 2009Applicant: Cornell UniversityInventors: Parijat Bhatnagar, Harold G. Craighead
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Publication number: 20040175934Abstract: A method for forming an interconnect structure in a semiconductor device includes defining a first insulator layer on a substrate and defining a via in the first insulator layer, thereby exposing a portion of the substrate. A sacrificial material is deposited over the first insulator layer and within the via, the sacrificial material being deposited at a thickness so as to also form a second insulator layer. A metallization line trench is defined in the second insulator layer, the trench being aligned over the via. Then, the sacrificial material is removed from the via opening, thereby allowing the via and the trench to be filled with a conductive material by dual damascene processing, wherein the formation of the trench and the removal of the sacrificial material from the via is implemented through a single etching operation.Type: ApplicationFiled: March 4, 2003Publication date: September 9, 2004Applicant: International Business Machines CorporationInventors: William G. America, Parijat Bhatnagar, Eugene J. O'Sullivan, Richard S. Wise
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Patent number: 6482298Abstract: An electroplating bath includes two electrolytes that are separated by a low ionic mobility barrier substance. Electroplating substrates can be transferred between the two electrolytes, through the barrier substance. Successive layers can be deposited by alternately electroplating in the two electrolytes. The substrate need not be brought through an air-liquid interface in transferring it between the two electrolytes. More than one anode can be provided in each electrolyte for depositing alloy film layers. A dummy electrode can be provided in each electrolyte to be used in lieu of the substrate in order to change concentrations of compounds in each electrolyte so that sharp compositional transitions between successive layers deposited on the substrate can be obtained.Type: GrantFiled: September 27, 2000Date of Patent: November 19, 2002Assignee: International Business Machines CorporationInventor: Parijat Bhatnagar
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Patent number: 6344124Abstract: A compositionally modulated material electroplated film is deposited by using at least two source metal anodes in an electroplating apparatus, and changing at least one contact area between an anode an electrolyte. In order to obtain sharp boundaries between successive layers of the film, voltage can be switched from an electroplating substrate to a dummy electrode immediately before the contact area is changed, in order to allow the electrolyte to equilibrate at a new set of solute concentrations, before electroplating on the substrate is recommenced.Type: GrantFiled: September 27, 2000Date of Patent: February 5, 2002Assignee: International Business Machines CorporationInventor: Parijat Bhatnagar
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Patent number: 6344123Abstract: A compositionally modulated material electroplated film is deposited by using at least two source metal anodes in an electroplating apparatus, and changing at least one power setting of an electroplating power supply. In order to obtain sharp boundaries between successive layers of the film, voltage can be switched from an electroplating substrate to a dummy electrode immediately before the power setting is changed, in order to allow the electrolyte to equilibrate at a new set of solute concentrations, before electroplating on the substrate is recommenced.Type: GrantFiled: September 27, 2000Date of Patent: February 5, 2002Assignee: International Business Machines CorporationInventor: Parijat Bhatnagar