Patents by Inventor Paul M. Hwang

Paul M. Hwang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for assessing atherosclerosis by measuring expression of FOS or DUSP1 in monocytes
    Patent number: 7998682
    Abstract: A non-invasive method for the diagnosis of atherosclerosis is provided. In one example, the method includes assaying the expression of FOS, DUSP1, or both FOS and DUSP1 in monocytes or a cell fraction thereof, or in plasma, serum or peripheral blood from the subject. An increase the expression of FOS, DUSP1, or both FOS and DUSP1 in monocytes in the sample as compared to a control indicates that the subject has atherosclerosis. A method is also provided for determining if a pharmaceutical agent is effective for treatment of atherosclerosis in a subject. The method includes assaying the expression of FOS, DUSP1, or both FOS and DUSP1 in a monocytes treated with the pharmaceutical agent, wherein a decrease the expression of FOS, DUSP1, or both FOS and DUSP1 in monocytes in the sample as compared to a control indicates that the pharmaceutical agent is effective for the treatment of atherosclerosis. The monocytes can be contacted with the agent in vivo or in vitro.
    Type: Grant
    Filed: September 2, 2005
    Date of Patent: August 16, 2011
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Paul M. Hwang, Willmar D. Patino, Omar Y. Mian, Ju-Gyeong Kang, Satoaki Matoba
  • Therapeutic composition and delivery system for administering drug
    Publication number: 20040062799
    Abstract: A therapeutic composition comprising a drug and a polyitol, a dosage form comprising the therapeutic composition, and the method of using the therapeutic composition and the dosage form are disclosed for an indicated therapy.
    Type: Application
    Filed: September 12, 2003
    Publication date: April 1, 2004
    Inventors: Atul D. Ayer, Michael A. Desjardin, Paul M. Hwang, Clark P. Allphin
  • Therapeutic dosage form for delivering oxybutynin
    Publication number: 20020160045
    Abstract: A dosage form, a therapeutic composition, and the use thereof is disclosed for administering a therapeutic agent accompanied by a pharmaceutically acceptable means administered for an indicated therapy.
    Type: Application
    Filed: June 4, 2002
    Publication date: October 31, 2002
    Inventors: Michael A. Desjardin, Paul M. Hwang, Halle Treanor
  • Dosage form for administering prescribed dose
    Publication number: 20010038855
    Abstract: A dosage form, a therapeutic composition, and the use thereof is disclosed for administering a therapeutic agent accompanied by a pharmaceutically acceptable means administered for an indicated therapy.
    Type: Application
    Filed: July 13, 2001
    Publication date: November 8, 2001
    Inventors: Michael A. Desjardin, Paul M. Hwang, Halle Treanor
  • Analgesic tablet compositions
    Patent number: 6284274
    Abstract: An opiate analgesic composition and a non-opiate analgesic composition are disclosed for delivering an analgesic in either embodiment to a patient in need of relief from pain. The analgesics are present optionally with a nonionic surfactant and with an osmotic composition comprising a carbonate or bicarbonate for delivering the opiate analgesic and non-opiate analgesic from a dosage form.
    Type: Grant
    Filed: March 3, 2000
    Date of Patent: September 4, 2001
    Assignee: Alza Corporation
    Inventors: Sonya Merrill, Atul D. Ayer, Paul M. Hwang, Anthony L. Kuczynski, Nils W. Ahlgren, Deborah J. Johnson
  • Controlled release tablet compositions
    Patent number: 6077538
    Abstract: An opiate analgesic composition and a non-opiate analgesic composition are disclosed for delivering an analgesic in either embodiment to a patient in need of relief from pain. The analgesics are present optionally with a nonionic surfactant and with an osmotic composition comprising a carbonate or bicarbonate for delivering the opiate analgesic and non-opiate analgesic from a dosage form.
    Type: Grant
    Filed: June 15, 1999
    Date of Patent: June 20, 2000
    Assignee: Alza Corporation
    Inventors: Sonya Merrill, Atul D. Ayer, Paul M. Hwang, Anthony L. Kuczynski, Nils W. Ahlgren, Deborah J. Johnson
  • Compositions containing opiate analgesics
    Patent number: 5948787
    Abstract: An opiate analgesic composition and a non-opiate analgesic composition are disclosed for delivering an analgesic in either embodiment to a patient in need of relief from pain. The analgesics are present optionally with a nonionic surfactant and with an osmotic composition comprising a carbonate or bicarbonate for delivering the opiate analgesic and non-opiate analgesic from a dosage form.
    Type: Grant
    Filed: February 28, 1997
    Date of Patent: September 7, 1999
    Assignee: Alza Corporation
    Inventors: Sonya Merrill, Atul D. Ayer, Paul M. Hwang, Anthony L. Kuczynski, Nils W. Ahlgren, Deborah J. Johnson