Publication number: 20240174690
Abstract: The present invention encompasses compounds of formula (I) wherein R1a, R1b, R2a, R2b, Z, R3 to R5, A, p, U, V and W have the meanings given in the claims and specification, their use as inhibitors of KRAS, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.
Type:
Application
Filed:
May 9, 2023
Publication date:
May 30, 2024
Inventors:
Joachim BROEKER, Jason ABBOTT, Jianwen CUI, Stephen W. FESIK, Julian FUCHS, Andreas GOLLNER, Lorenz HERDEIS, Tim HODGES, Andrew LITTLE, Andreas MANTOULIDIS, Jason PHAN, Juergen RAMHARTER, Dhruba SARKAR, Christian Alan Paul SMETHURST, Kevin SOKOL, Heinz STADTMUELLER, Qi SUN, Matthias TREU, Alex WATERSON, Birgit WILDING, Tobias WUNBERG
Publication number: 20240171821
Abstract: Provided are an interaction method and apparatus in a live streaming room, and a device and a storage medium. The method comprises: in response to a trigger operation for a preset duet entry on a live streaming room page, jumping from the live streaming room page to a camera capture page, wherein a host portrait cutout corresponding to the live streaming room page is displayed on the camera capture page and a capture control is provided on the camera capture page acquiring multimedia information captured by a camera, in response to a trigger operation for the capture control on the camera capture page, wherein the multimedia information comprises an image or a video; and synthesizing the multimedia information with the host portrait cutout to obtain a duet multimedia product.
Type:
Application
Filed:
March 14, 2022
Publication date:
May 23, 2024
Inventors:
Ling YANG, Manting WANG, Sijing WANG, Ji LIU, Feifei TANG, Xiaoben WANG, Man ZHANG, Zaiyou RUAN, Yuna HU, Zihao CHEN, Siqin LIU, Chen ZHONG, Suyao ZHANG, Yichao WU, Changhua HE, Zenan LI, Yibin CHEN, Jialuo ZHANG, Ping LI, Xinyue GONG, Jialong ZHAO, Fanglu ZHONG, Pingfei FU, Yingzhao SUN, Syenny NA, Qi FAN, Yehua LYU, Jiacheng LIU, Lin ZHOU, Fukang HONG, Xiangzeng MENG, Qian Li, Qi ZHAO, Hui Li
Publication number: 20240140957
Abstract: Provided herein are Bridged Compounds having the following structures: wherein R1a, R1b, R1c, R1d, R2a, R2b, R2c, R2d, R3a, R3b, R3c, R3d, R4, R5, R6, R7, R8, m1, m2, m3, n2, n3, n4, q, X1, X2, Y1, Y2, L1 and ring A are as defined herein, compositions comprising an effective amount of a Bridged Compound, and methods for treating or preventing various diseases, e.g., pancreatic cancer, or a condition treatable or preventable by inhibition of the function of KRAS protein. In another aspect, a Bridged Compound is useful for treating or preventing a condition treatable or preventable by inhibition of the function of KRAS protein with G12D mutation. In another aspect, a Bridged Compound is useful for treating or preventing a condition treatable or preventable by inhibition of a RAS/MAPK pathway.
Type:
Application
Filed:
January 7, 2022
Publication date:
May 2, 2024
Inventors:
Qi JI, Chao YU, Ce WANG, Hanzi sun, Hao YUAN, Zhiwei WANG