Patents by Inventor Rainer Ludwig Knaus
Rainer Ludwig Knaus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11963979Abstract: An in vitro expansion process for rapid expansion of antigen specific T cells, such as allogeneic antigen specific T cells comprising the steps culturing in a gas permeable vessel a population of PBMCs (such as allogeneic PBMCs) in the presence of antigen, for example a peptide or peptide mix relevant to a target antigen(s), in the presence of an exogenous cytokine characterized in that the expansion to provide the desired population of T cells is 14 days or less, for example 9, 10, 11 or 12 days, such as 10 days. The disclosure also extends to T cell populations generated by and obtained from the method and the use of same in therapy.Type: GrantFiled: June 22, 2018Date of Patent: April 23, 2024Assignees: AlloVir, Inc., Baylor College of Medicine, Wilson Wolf Manufacturing CorporationInventors: Rainer Ludwig Knaus, Katy Rebecca Newton, Juan Vera, Ann Leen, Cliona Rooney, John R. Wilson
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Publication number: 20220152111Abstract: An in vitro expansion process for rapid expansion of antigen specific T cells, such as allogeneic antigen specific cells comprising the steps culturing in a gas permeable vessel a population of PBMCs (such as allogeneic PBMCs) in the presence of antigen, for example a peptide or peptide mix relevant to a target antigen(s), in the presence of an exogenous cytokine characterized in that the expansion to provide the desired population of T cells is 14 days or less, for example 9, 10, 11 or 12 days, such as 10 days. The disclosure also extends to T cell populations generated by and obtained from the method and the use of same in therapy.Type: ApplicationFiled: January 27, 2022Publication date: May 19, 2022Inventors: Rainer Ludwig KNAUS, Katy Rebecca NEWTON, Juan VERA, Ann LEEN, Cliona ROONEY, John R. WILSON
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Patent number: 11155784Abstract: The present disclosure relates to a novel process for expanding T cells, such as autologous T cells, cell populations therefrom, pharmaceutical compositions comprising the said cell populations and use of the cells and compositions for treatment, particular the treatment or prophylaxis of virus infection and/or cancer, for example in immune compromised or immune competent human patients.Type: GrantFiled: August 29, 2018Date of Patent: October 26, 2021Assignees: Baylor College of Medicine, Cell Medica Inc.Inventors: Cliona M Rooney, Rainer Ludwig Knaus
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Patent number: 10351824Abstract: The present disclosure relates to a novel process for expanding T cells, such as autologous T cells, cell populations therefrom, pharmaceutical compositions comprising the said cell populations and use of the cells and compositions for treatment, particular the treatment or prophylaxis of virus infection and/or cancer, for example in immune compromised or immune competent human patients.Type: GrantFiled: April 23, 2012Date of Patent: July 16, 2019Assignees: Cell Medica Limited, Baylor College of MedicineInventors: Cliona M. Rooney, Ann M. Leen, Juan F. Vera, Minhtran V. Ngo, Rainer Ludwig Knaus
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Publication number: 20190134092Abstract: An in vitro expansion process for rapid expansion of antigen specific T cells, such as allogeneic antigen specific T cells comprising the steps culturing in a gas permeable vessel a population of PBMCs (such as allogeneic PBMCs) in the presence of antigen, for example a peptide or peptide mix relevant to a target antigen(s), in the presence of an exogenous cytokine characterized in that the expansion to provide the desired population of T cells is 14 days or less, for example 9, 10, 11 or 12 days, such as 10 days. The disclosure also extends to T cell populations generated by and obtained from the method and the use of same in therapy.Type: ApplicationFiled: June 22, 2018Publication date: May 9, 2019Inventors: Rainer Ludwig KNAUS, Katy Rebecca NEWTON
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Patent number: 10221391Abstract: A closed system suitable for the aseptic culturing of therapeutic cells. The present system facilitates the aseptic manufacturing of cells for use in therapy, without the need for a clean-room environment because no open processing steps are required.Type: GrantFiled: March 18, 2016Date of Patent: March 5, 2019Assignee: CELL MEDICA LIMITEDInventors: Rainer Ludwig Knaus, Gavin Holms, Katy Rebecca Newton, Tina Lesley Crombie, Andrew Roy MacLeod Provan
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Publication number: 20160201021Abstract: A closed system suitable for the aseptic culturing of therapeutic cells. The present system facilitates the aseptic manufacturing of cells for use in therapy, without the need for a clean-room environment because no open processing steps are required.Type: ApplicationFiled: March 18, 2016Publication date: July 14, 2016Inventors: Rainer Ludwig KNAUS, Gavin HOLMS, Katy Rebecca NEWTON, Tina Lesley CROMBIE, Andrew Roy MacLeod PROVAN
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Patent number: 9315774Abstract: A closed system suitable for the aseptic culturing therapeutic cells comprises a vessel comprising: a gas permeable portion suitable for supporting cell growth and allowing delivery of gases to the cells during culturing, a vent comprising a conduit having an exterior orifice and an interior orifice spaced apart therefrom, the vent extending from the exterior of the system into the internal volume of the vessel and terminating therein with the interior orifice, wherein the interior orifice is arranged such that during filling and emptying of liquid medium it is not susceptible to blockage by liquid, the exterior orifice is adapted to connect to an aseptic filter thereby allowing passage of gases through the filter into the vessel or out of the vessel, as required to achieve the entry and exit of fluids and cells into the vessel, a port or ports adapted to allow introduction of fluids and cells aseptically into the vessel, and a port or ports adapted to allow fluids to exit the system without exposing the systType: GrantFiled: October 19, 2012Date of Patent: April 19, 2016Assignee: Cell Medica LimitedInventors: Rainer Ludwig Knaus, Gavin Holms, Katy Rebecca Newton, Tina Lesley Crombie, Andrew Roy MacLeod Provan
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Publication number: 20150044258Abstract: An in vitro expansion process for rapid expansion of antigen specific T cells, such as allogeneic antigen specific T cells comprising the steps culturing in a gas permeable vessel a population of PBMCs (such as allogeneic PBMCs) in the presence of antigen, for example a peptide or peptide mix relevant to a target antigen(s), in the presence of an exogenous cytokine characterized in that the expansion to provide the desired population of T cells is 14 days or less, for example 9, 10, 11 or 12 days, such as 10 days. The disclosure also extends to T cell populations generated by and obtained from the method and the use of same in therapy.Type: ApplicationFiled: December 12, 2012Publication date: February 12, 2015Inventors: Rainer Ludwig Knaus, Katy Rebecca Newton
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Publication number: 20150017723Abstract: The present disclosure relates to a novel process for expanding T cells, such as autologous T cells, cell populations therefrom, pharmaceutical compositions comprising the said cell populations and use of the cells and compositions for treatment, particular the treatment or prophylaxis of virus infection and/or cancer, for example in immune compromised or immune competent human patients.Type: ApplicationFiled: April 23, 2012Publication date: January 15, 2015Inventors: Cliona M. Rooney, Ann M. Leen, Juan F. Vera, Minhtran V. Ngo, Rainer Ludwig Knaus
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Publication number: 20140273077Abstract: A closed system suitable for the aseptic culturing therapeutic cells comprises a vessel comprising: a gas permeable portion suitable for supporting cell growth and allowing delivery of gases to the cells during culturing, a vent comprising a conduit having an exterior orifice and an interior orifice spaced apart therefrom, the vent extending from the exterior of the system into the internal volume of the vessel and terminating therein with the interior orifice, wherein the interior orifice is arranged such that during filling and emptying of liquid medium it is not susceptible to blockage by liquid, the exterior orifice is adapted to connect to an aseptic filter thereby allowing passage of gases through the filter into the vessel or out of the vessel, as required to achieve the entry and exit of fluids and cells into the vessel, a port or ports adapted to allow introduction of fluids and cells aseptically into the vessel, and a port or ports adapted to allow fluids to exit the system without exposing the systType: ApplicationFiled: October 19, 2012Publication date: September 18, 2014Inventors: Rainer Ludwig Knaus, Gavin Holms, Katy Rebecca Newton, Tina Lesley Crombie, Andrew Roy MacLeod Provan
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Patent number: D820996Type: GrantFiled: March 14, 2014Date of Patent: June 19, 2018Assignee: CELL MEDICA LIMITEDInventors: Rainer Ludwig Knaus, Gavin Holms, Katy Rebecca Newton, Tina Lesley Crombie, Andrew Roy MacLeod Provan