Abstract: An improved process for obtaining at least one bis-benzyl isoquinoline alkaloid from botanical material involves contacting the botanical material with a supercritical fluid having as a major component one or more aliphatic hydrocarbon compounds, such as alkanes, alkenes, cyclic aliphatic hydrocarbons, or a combination of these compounds.

Abstract: A self-emulsifying drug delivery system to improve dissolution, stability, and bioavailability of drug compounds of dronabinol or other cannabinoids. The drug compound(s) are dissolved in an oily medium (e.g. triglycerides and/or mixed glycerides and/or free fatty acids containing medium and/or long chain saturated, mono-unsaturated, and/or poly-unsaturated free fatty acids) together with at least one surfactant. The surfactant promotes self-emulsification, thereby promoting targeted chylomicron delivery and optimal bioavailability to a mammalian intestinal lumen. A dosage form can optionally include co-solvents, anti-oxidants, viscosity modifying agents, cytochrome P450 metabolic inhibitors, P-GP efflux inhibitors, and amphiphilic/non-amphiphilic solutes to induce semi-solid formation for targeted release rates.

Abstract: Disclosed is an extended or controlled release dosage form of citalopram or its related forms and other newer antidepressants for oral administration to treat chronic patients suffering from depression and to minimize the side effects associated with the current drug treatment.

Abstract: Disclosed is a pharmaceutical formulation for the stabilization and sustained delivery of an active pharmaceutical ingredient, such as the antidepressant, bupropion.

Abstract: Disclosed are pharmaceutical formulations for the ophthalmic delivery of tetrahydrocannabinol.

Abstract: Disclosed is a sublingual pharmaceutical formulation containing tetrahydrocannabinol and certain excipients. Also disclosed is how to make and use the formulation.

Abstract: Disclosed is an injectable pharmaceutical formulation containing tetrahydrocannabinol and certain excipients. Also disclosed is how to make and use the formulation.

Abstract: Disclosed are compositions for the delivery of therapeutic agents and methods of using these compositions.

Abstract: A drug delivery device for delivery of a drug to the lungs of a user includes a tubular housing having a mouth a mouthpiece, a heat source, and a middle section between the mouthpiece and the heat source. The middle section has an chamber containing a plurality of inert inorganic particles which have a drug adsorbed as a coating thereon. The heat source, the plurality of inert inorganic particles in the middle section and the mouthpiece are fluidly connected through an interior passageway of the tubular housing and the distal end section is fluidly connected to outside air. When a user applies suction to the mouthpiece, air from the outside is drawn into the heat source by suction and is heated, and the heated air is drawn into the chamber of the middle section to heat, volatilize and desorb the drug from the inert particles. The volatilized and desorbed drug is then drawn from the chamber of the middle section into the mouthpiece and then into the mouth and lungs of the user.

Abstract: The present application features methods and articles of manufacture for alleviating acute symptoms of nicotine withdrawal and as an aid in smoking cessation. The invention features lobeline held in sublingual tablets for administration to the sublingual and nasal mucosa.