Abstract: The invention relates to particular substituted heterocycle fused gamma-carbolines, their prodrugs, in free, solid, pharmaceutically acceptable salt and/or substantially pure form as described herein, pharmaceutical compositions thereof, and methods of use in the treatment of diseases involving the 5-HT2A receptor, the serotonin transporter (SERT), pathways involving the dopamine Di and D2 receptor signaling system, and/or the wopioid receptor.

Abstract: The technology described herein allows a user to bring phone functionality into a virtual world without disrupting the virtual world experience. For example, the technology described herein enables the user to make and receive calls while in the virtual world, access their contacts, and recent call information. The user may also send and receive text communications. This functionality may be enabled by a phone-sharing application running on a Head Mounted Device (“HMD”) interfacing with the wireless telecommunication network that provides service to the user's telephone (e.g., smartphone). The phone-sharing application can communicate with the telecommunication network to provide notice that the user is actively using the HMD (e.g., in a virtual world). Upon receiving the notice, the telecommunication network can associate the user's telephone number with the HMD to cause communications to be routed to the HMD.

Abstract: A refuse vehicle includes multiple systems, each system including a sensor. The refuse vehicle also includes an automated check system. The automated check system includes processing circuitry configured to obtain sensor data from the sensor of each of the multiple systems, determine which of the multiple systems require manual inspection based on the sensor data, and operate a display screen to prompt a technician to manually inspect one or more of the multiple systems.

Abstract: A genetically modified mouse is provided, wherein the mouse expresses an immunoglobulin light chain repertoire characterized by a limited number of light chain variable domains. Mice are provided that express just one or a few immunoglobulin light chain variable domains from a limited repertoire in their germline. Methods for making bispecific antibodies having universal light chains using mice as described herein, including human light chain variable regions, are provided. Methods for making human variable regions suitable for use in multispecific binding proteins, e.g., bispecific antibodies, and host cells are provided. Bispecific antibodies capable of binding first and second antigens are provided, wherein the first and second antigens are separate epitopes of a single protein or separate epitopes on two different proteins are provided.

Abstract: This disclosure relates to SARS-CoV-2 antibodies disclosed herein and specific binding fragments thereof, therapeutic and diagnostic uses, and compositions related thereto. In certain embodiments, this disclosure relates to antibodies disclosed herein and specific binding fragments thereof wherein the antibody or fragment specifically binds to an epitope expressed on a SARS-CoV-2 particle such as the spike protein or receptor binding domain. In certain embodiments, this disclosure relates to treating or preventing a SARS-CoV-2 or related coronavirus infection comprising administering an effective amount of an antibody disclosed herein or specific binding fragments thereof to a subject in need thereof.

Abstract: The disclosure provides methods for the acute treatment of depression and/or anxiety, for the enhancement of mTOR (e.g., mTORC1) signaling, and for the reduction of neuroinflammation, comprising administering to a patient in need thereof, a therapeutically effective amount of a 5-HT2A or 5-HT2A/D2 receptor ligand, e.g. lumateperone.

Abstract: A remote storage digital video recorder (RSDVR) retains multiple copies of media programs so long as the copies are expected to be useful to at least one user. Rather than assigning copies to specific users at the time the program is recorded, copies can be assigned as the users request access to the particular media programs. Copies of unassigned programs can be deleted according to a schedule to reduce disk storage and processing demands on the system. A pool of program copies that are not initially assigned to particular users can be maintained until the user makes a specific request to view the program. This “late assignment” of program copies can substantially reduce the amount of data stored by the RSDVR system without substantially impacting the viewer experience.

Abstract: The present disclosure provides an endoscopic apparatus and associated methods. The apparatus may include a steerable tool having a first flexible tube concentrically nested within a second flexible tube. The apparatus may include an end cap disposed on the steerable tool, an image sensor disposed on the end cap, and one or more light sources disposed on the end cap. The apparatus may be configured for accessing a region within a middle ear cavity of a patient. As such, the apparatus may further include a flexible tube, through which the steerable tool may extend, as well as a pre-curved rigid tube, through which the flexible tube may extend, thus allowing the apparatus to be deployed for middle ear access.

Abstract: Methods, devices and systems are disclosed for inter-app communications between software applications on a mobile communications device. In one aspect, a computer-readable medium on a mobile computing device comprising an inter-application communication data structure to facilitate transitioning and distributing data between software applications in a shared app group for an operating system of the mobile computing device includes a scheme field of the data structure providing a scheme id associated with a target software app to transition to from a source software app, wherein the scheme id is listed on a scheme list stored with the source software app; and a payload field of the data structure providing data and/or an identification where to access data in a shared file system accessible to the software applications in the shared app group, wherein the payload field is encrypted.

Abstract: A blaster for shooting projectiles that includes a housing that defines a housing interior, and a variable velocity barrel assembly positioned in the housing interior. The variable velocity barrel assembly includes a barrel that defines a barrel axis and a barrel interior. The barrel includes an exit opening at a distal end thereof. At least a first opening communicates the barrel interior with an exterior of the barrel. The first opening is defined through a side wall of the barrel. A slider member that includes a cylindrical portion that surrounds the barrel is movable axially along the barrel between a maximum velocity position where the cylindrical portion covers the first opening and a minimum velocity position where the slider member does not cover the first opening.

Abstract: A layer pad (10) comprises a substantially flat sheet (12) having first and second opposite substantially planar faces (14, 16). The layer pad (10) further includes at least one raised formation (18) on at least one of the faces (14, 16).

Abstract: A refuse body adapter includes a sub-frame assembly, a sub-frame adapter, and a spacer. The sub-frame assembly is configured to be coupled to a cargo body. The sub-frame adapter is configured to be coupled to a chassis of a vehicle. The spacer is coupled to both the sub-frame assembly and the sub-frame adapter. The spacer is disposed in a gap formed between the sub-frame assembly and the sub-frame adapter. A thickness of the spacer may be adjusted to accommodate different gap sizes between the sub-frame assembly and the sub-frame adapter.

Abstract: The present disclosure relates to solid oral dosage forms comprising lumateperone, in free, or pharmaceutically acceptable salt form, optionally in combination with one or more additional therapeutic agents, processes for manufacture thereof and methods of use in the treatment or prophylaxis of disease.

Abstract: The present invention relates to use of particular substituted heterocycle fused gamma-carbolines as described herein, in free, pharmaceutically acceptable salt or prodrug form, and pharmaceutical composition comprising the same optionally in combination with one or more agents, for the prophylaxis or treatment of one or more disorders associated with dementia, particularly behavioral or mood disturbances (e.g., agitation/aggression), psychosis, depression and sleep disturbances among others in patients suffering from dementia.

Abstract: An actuation mechanism for use in a vehicle. The actuation mechanism includes one or more motors having an output shaft with a sun gear. At least a portion of the sun gear is drivingly connected to at least a portion of one or more planetary gears. The one or more planetary gears are drivingly connected to at least a portion of a carrier, a fixed non-rotating ring gear and an output gear. The disclosure further relates to a method of operating an actuation mechanism that is drivingly connected to at least a portion of a vehicle parking mechanism. The method includes providing an actuation mechanism, providing a parking mechanism and one or more sensors that are operably configured to collect an amount of data to be analyzed. Based on the data analyzed, one or more failures within the parking mechanism may be determined and an alert may be sent.

Abstract: An apparatus, system and related methods for controlling a pressurized flow from a high or low pressure system. An actuated sand dump system and related methods include a first valve positioned downstream of a high or low pressure system, a second valve positioned downstream of the first valve, a choke positioned between in the first and second valves, a plurality of pressure gauges, and a control unit operable to automatically open and close the first and second valves and the choke in a predetermined sequence, upon initiating the predetermined sequence, and in response to pressure measurements from the plurality of pressure gauges.

Abstract: A system for remotely operating a machine, such as a mine vehicle, includes at least one first emitter for emitting a first signal corresponding to a first zone adjacent to the machine. A transmitter is provided for receiving the first signal emitted by the emitter, the transmitter being adapted for issuing commands for controlling the machine and also indicating the presence of the transmitter in the first zone. A controller is also provided for controlling the machine based on the control signals from the transmitter based on the presence of the transmitter in the first zone. Related methods are also disclosed.

Abstract: A system for detecting and engaging a refuse can includes at least one sensor positioned on a refuse collection vehicle and configured to detect objects on one or more sides of the refuse vehicle, an actuator assembly configured to actuate to engage the refuse can, and a controller configured to detect, using a single-stage object detector, the presence of the refuse can based on first data received from the at least one sensor, determine, based on the first data, a position of the refuse can with respect to the refuse collection vehicle, generate a first trajectory from the refuse collection vehicle to the position of the refuse can, generate a second trajectory for the actuator assembly, and initiate a control action to move at least one of the refuse collection vehicle along the first trajectory or the actuator assembly along the second trajectory to engage the refuse can.

Abstract: An intermittent catheter package including a plurality of components and a catheterization tray configured to facilitate a catheterization procedure. The plurality of components include a urinary catheter fluidly connected to a urine-drainage bag and a sampling-port access device configured to fluidly connect to a urine-sampling port of the urinary catheter or the urine-drainage bag for aseptic collection of one or more urine samples. The catheterization tray includes at least a first compartment, a second compartment, and a third compartment configured to hold the plurality of components. The first compartment is configured to hold the urinary catheter. The second compartment is connected to the first compartment by an intercompartment connection. The second compartment is configured to hold the urine-drainage bag. The third compartment is configured to hold the sampling-port access device. Step-by-step instructions are incorporated into the catheterization tray to facilitate the catheterization procedure.

Abstract: The present disclosure relates to pharmaceutical capsules comprising lumateperone, in free, or pharmaceutically acceptable salt form, optionally in combination with one or more additional therapeutic agents, processes for manufacture thereof and methods of use in the treatment or prophylaxis of disease.