Abstract: A data processing system implements detecting that a first user device associated with a first user has added a first sponsored content item to a host electronic document by adding a first reference to the first sponsored content item to the host electronic document. The first sponsored content item is stored separately in a memory of a cloud-based service from the host electronic document. The data processing system further implements determining that the first user has permission to share the first sponsored content item with other users of the cloud-based service, generating sponsor information to associate the sponsored content item with the host electronic document to permit users having access to the host electronic document to access the sponsored content item, and storing the sponsor information in a sponsored access datastore.

Abstract: Provided herein, in certain embodiments, are programmable nucleases, guide nucleic acids, and complexes thereof. Certain programmable nucleases provided herein comprise a RuvC domain. Also provided herein are nucleic acids encoding said programmable nucleases and guide nucleic acids. Also provided herein are methods of genome editing, methods of regulating gene expression, and methods of detecting nucleic acids with said programmable nucleases and guide nucleic acids.

Abstract: A method of forming an implant includes positioning a first mesh component of the implant within a second mesh component of the implant to form an implant assembly. The implant assembly is manipulated to join the first mesh component with the second mesh component.

Abstract: Provided herein, in certain embodiments, are programmable nucleases, guide nucleic acids, and complexes thereof. Certain programmable nucleases provided herein comprise a RuvC domain. Also provided herein are nucleic acids encoding said programmable nucleases and guide nucleic acids. Also provided herein are methods of genome editing, methods of regulating gene expression, and methods of detecting nucleic acids with said programmable nucleases and guide nucleic acids.

Abstract: A surgical device includes a substrate and a first coating that covers at least a portion of the substrate. The first coating includes a first polymer. The first coating having antibiotics dispersed in the first polymer such that the first polymer releases the antibiotics as the first polymer degrades. A second coating covers at least a portion of the first coating. The second coating includes a second polymer. The second polymer includes an alginate. The second coating has a hemostatic agent dispersed in the second polymer such that the second polymer releases the hemostatic agent as the second polymer degrades. The hemostatic agent is selected from epinephrine, tranexamic acid, chitosan and oxidized regenerated cellulose. In some embodiments, systems and methods are disclosed.

Abstract: A surgical device includes a substrate and a first coating that covers at least a portion of the substrate. The first coating includes a first polymer. The first coating having antibiotics dispersed in the first polymer such that the first polymer releases the antibiotics as the first polymer degrades. A second coating covers at least a portion of the first coating. The second coating includes a second polymer. The second coating has ellagic acid dispersed in the second polymer such that the second polymer releases the ellagic acid as the second polymer degrades. In some embodiments, systems and methods are disclosed.

Abstract: A surgical system including an implantable medical device having a size and shape. The surgical device having a substrate and a coating that covers at least a portion of the substrate. The coating includes a polymer, collagen, glycerin and a hemostatic agent. The polymer is selected from the group of polyhydroxybutyrate, polyglycerol sebacate and adducts of polyglycerol sebacate. The substrate including a first piece and a second piece that is joined with the first piece. The first piece and the second piece forming a pocket having a cavity and an opening that is in communication with the cavity. The device being pre-formed such that a size and shape of the cavity conforms to the size and shape of the implantable medical device.

Abstract: A surgical device configured to surround an implantable medical device that includes a collagen membrane and a coating embedded in the membrane The coating including at least one active pharmaceutical ingredient.

Abstract: A surgical system including an implantable medical device having a size and shape. The surgical device having a substrate and a coating that covers at least a portion of the substrate. The coating including collagen, glycerin and a hemostatic agent. The substrate including a first piece and a second piece that is joined with the first piece. The first piece and the second piece forming a pocket having a cavity and an opening that is in communication with the cavity. The device being pre-formed such that a size and shape of the cavity conforms to the size and shape of the implantable medical device.

Abstract: A package for a surgical implant includes a body having a side wall including opposite top and bottom ends. The body includes a bottom wall coupled to the bottom end. The body includes a flange extending outwardly from the top end. Inner surfaces of the walls define a cavity. The top end defines an opening that is in communication with the cavity. An insert extends from the bottom wall such that the insert is positioned in the cavity. A lid is configured to be coupled to the flange such that the lid covers the opening. Devices, kits and systems are disclosed.

Abstract: A cable assembly having a connector and a cable having a fiber connector, wherein the connector contains a circuit for converting electrical signals to optical signals for transmitting video or high data rate data, and the connector has an interface to connect with the fiber connector of the cable, so that the cable and the connector can be separated for making each of the connector and the cable as a standalone component.

Abstract: A surgical instrument includes a body extending along a longitudinal axis between opposite proximal and distal end surfaces. The distal end surface includes a first cavity and a second cavity. The first cavity includes a first light bulb disposed therein. The second cavity includes a second light bulb disposed therein. A shaft includes opposite proximal and distal ends. The proximal end is coupled to the body. A blade is coupled to the distal end. The first light bulb is an ultraviolet (UV) light bulb and the second light bulb is configured to emit visible light. Systems and methods of use are disclosed.

Abstract: Provided herein are substituted imidazo[1,2-a]pyridin-2-ylamine compounds, for example, of formula (A), and pharmaceutical compositions thereof; and methods of their use for treating, preventing, or ameliorating one or more symptoms of a Janus kinase-mediated disease.

Abstract: A cable assembly includes a cable and a connector, wherein the connector of the cable assembly includes laser diodes for transmitting optical signals to optical fiber wires of the cable for transferring data received from an external device and a light-emitting diode (LED) for emitting a visible light to a plastic fiber wire of the cable so that a user can use the visible light for different purposes. In addition, the connector of the cable assembly is capable of conforming to a standard HDMI connector or integrated with an earphone.

Abstract: An adaptor having a first HDMI interface for connecting with a first external device to receive data therefrom and a second interface for connecting with an HDMI connector of a cable assembly, wherein the cable assembly comprises a cable connected to the HDMI connector and the cable comprises at least one fiber wire, wherein the adaptor comprise at least one processor and a wireless device, wherein the at least one processor is capable of communicating with a second external device via a wireless connection between the wireless device and the second external device to perform operations associated with the transmission of the at least one fiber wire or said data received from first external device.

Abstract: A technique of motion estimation in video compression is described, the technique including: determining, in one or more reference frames of a video picture, the best full-pixel motion vector F for a block in a current frame of the video picture, wherein m and n are signed numbers and integer multiples of the distance between two adjacent full-pixels; selecting the best half-pixel motion vector candidates from a set of half-pixel motion vectors based on the best full-pixel motion vector; determining the best half-pixel motion vector H; selecting the best quarter-pixel motion vector candidates from a set of quarter-pixel motion vectors based on the best full-pixel motion vector and the best half-pixel motion vector; determining the best quarter-pixel motion vector Q; and determining the best motion vector for the block as BMV.

Abstract: Provided herein are substituted imidazo[1,2-a]pyridin-2-ylamine compounds, for example, of formula (A), and pharmaceutical compositions thereof; and methods of their use for treating, preventing, or ameliorating one or more symptoms of a Janus kinase-mediated disease.

Abstract: A cable assembly having a connector and a cable having a fiber connector, wherein the connector contains a circuit for converting electrical signals to optical signals for transmitting video or high data rate data, and the connector has an interface to connect with the fiber connector of the cable, so that the cable and the connector can be separated for making each of the connector and the cable as a standalone component.

Abstract: A voltage detection circuit for a charge pump is disclosed. The voltage detection circuit includes a sampling circuit and a latch circuit. The sampling circuit is configured to sample a supply voltage and provide the latch circuit with a sampled voltage. The latch circuit is configured to detect the sampled voltage and latch a result of the detection. And the latch circuit is connected to a voltage regulation circuit which is configured to regulate a charge-pump cascade structure in the charge pump based on the result of the detection so as to maintain an output voltage of the charge pump stable.

Abstract: A voltage detection circuit for a charge pump is disclosed. The voltage detection circuit includes a sampling circuit and a latch circuit. The sampling circuit is configured to sample a supply voltage and provide the latch circuit with a sampled voltage. The latch circuit is configured to detect the sampled voltage and latch a result of the detection. And the latch circuit is connected to a voltage regulation circuit which is configured to regulate a charge-pump cascade structure in the charge pump based on the result of the detection so as to maintain an output voltage of the charge pump stable.