Abstract: A wireless, web based system for monitoring patient drug compliance includes a plastic container that holds a wireless device, the patient's drugs, and a cpu programmable remotely and automatically from normal computer input by health care providers and pharmacists to control the functioning of the wireless transceiver and a variety of sound, vibration, light and readable screen for reminders and to provide drug related information. A sensor detects and wirelessly reports the opening of the medicine container in real time to remind the patient, when noncompliance occurs, on the patient's portable device and also telephones or pages. the patient as additional reminders. The web site program analyzes models and interprets the data to provide important drug non-compliance information to healthcare professionals.

Abstract: A process is provided for preparing an oral fast-melt composition of a selective cyclooxygenase-2 inhibitory drug, the process comprising (a) a step of wet granulating the drug together with a binding agent comprising a saccharide of high moldability, and (b) a step of blending with the drug a saccharide of low moldability, wherein the above steps (a) and (b) occur in any order or simultaneously to result in formation of granules. The process optionally incorporates means to inhibit agglomeration of the drug, for example addition of a wetting agent. Optionally the process further comprises (c) a step of blending the granules with at least one of a lubricant, a sweetening agent and a flavoring agent to form a tableting blend, and (d) a step of compressing the tableting blend to form oral fast-melt tablets. Also provided is a composition prepared by such a process.