Abstract: The present invention relates to: an indole derivative, which is a novel cell mitosis inhibitor; a stereoisomer thereof or a pharmaceutically acceptable salt thereof; a use thereof as a therapeutic agent; a composition containing the same and a treatment method using the composition; and a preparation method therefor. According to the present invention, the indole derivative, the stereoisomer thereof or the pharmaceutically acceptable salt thereof, inhibits the tubulin polymerization during mitosis so as to induce apoptosis, and has an excellent anti-cancer effect also in cancer cells having multiple drug resistance.

Abstract: The invention features modified alphavirus or flavivirus virus-like particles (VLPs). The invention provides methods, compositions, and kits featuring the modified VLPs. The invention also features methods for enhancing production of modified VLPs for use in the prevention or treatment of alphavirus and flavivirus-mediated diseases. The invention also provides methods for delivering agents to a cell using the modified VLPs.

Abstract: Compounds and methods for their preparation and use as therapeutic or prophylactic agents, for example for treatment of cancer, bacterial or viral diseases by targeting Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1).

Abstract: The present invention relates generally to systems for measuring pH. In particular, the present invention relates to a continuous flow system having one or more solid state pH sensors positioned within a fluid pathway of the system to provide continuous pH measurement.

Abstract: A traverse mechanism for measuring flow characteristics in a fluid flow path is provided. The traverse mechanism includes a rotating member configured to rotate 360 degrees about an axis in a circumferential direction. The traverse mechanism also includes a probe coupled to the rotating member. The probe extends in a radial direction relative to the axis through a portion the rotating member into the fluid flow path. Rotation of the rotating member enables the probe to map or measure one or more flow characteristic in the fluid flow path 360 degrees about the axis in the circumferential direction.

Abstract: Solid-state electrodes comprising Redox Active Surface Areas for use in analyte sensing devices and various product platform devices.

Abstract: Some examples relate to detecting network link failure. In an example, a determination may be made at a first network device on a network regarding an average round-trip delay time (RTD) between the first network device and a second network device over a given time interval during a given period of time. Then, for the given time interval, a keepalive packet may be sent from the first network device to the second network device at the average RTD of the given time interval for a keepalive time. In response to a determination, by the first network device that there is no acknowledgement of the keepalive packet from the second network device during the keepalive time, a network link between the first network device and the second network device may be identified as failed.

Abstract: The disclosure relates in some aspects to forbidden area procedures and connection release management for a user terminal (UT). Forbidden area-related procedures include, for example, using a special paging area code (PAC) in conjunction with a forbidden area, defining a location reporting threshold for a UT based on the proximity of the UT to a forbidden area, or using a default paging area code if a service restriction for a UT has ended. Connection release management includes, for example, a UT sending a request to cause the release of a Radio Connection that the UT no longer needs, or a UT sending a Location Indication (e.g., including a flag requesting release of a connection) to release the connection used for location reporting when a UT is done sending the location information and is going to go back to idle mode.

Abstract: In some examples, a non-transitory machine-readable storage medium having stored thereon machine-readable instructions to cause a computing processor to track a Layer 2 (L2) bit indicating a L2 connectedness between a first user anchor controller (UAC) corresponding to a client device and a second UAC acting as a standby UAC for the first UAC in a controller cluster, and reassign a third UAC to be the standby UAC for the first UAC in response to the L2 bit indicating that the first UAC is not connected to the second UAC in the same L2 network, wherein the first UAC is in the same L2 network as the third UAC.

Abstract: Systems and methods are provided for dynamic power allocation of a first maximum uplink power and a second maximum uplink power, wherein the first maximum uplink power is used by a first transmitter to communicate with a first access point and the second maximum uplink power is used by a second transmitter to communicate with a second access point (dual connectivity). Historical data for a sector and one or more wireless communication devices is collected and analyzed to determine the modification of the first maximum uplink power and the second maximum uplink power.

Abstract: The disclosure relates in some aspects to managing paging area information for a user terminal (UT) and connection signaling. In some aspects, paging area information is provided for an idle UT by defining a default paging area code (PAC) that is known by the network and the UT. In some aspects, paging area information is communicated via connection signaling. In some aspects, connection signaling may be used to force a UT to invoke an update procedure (e.g., a reconnection).

Abstract: Particular embodiments described herein provide for an electronic device that can be configured to include a fan where the fan blades are decoupled from the center shaft. The fan can include a center shaft, a motor coil support, motor coils coupled to the motor coil support, a rotator coupled to the center shaft, and fan blades coupled to the rotator, where rotation of the fan blades is decoupled from the center shaft by the rotator. A blade support can be coupled to the rotator, where the blade support couples the fan blades to the rotator and magnets can be coupled to the blade support. In an example, the rotator can include an inner, an outer race, and bearings.

Abstract: An example of a system may include a controller to monitor network parameters in a wireless local area network (WLAN), the controller may include a processing resource and a memory resource including instructions executable by the processing resource to analyze network parameters in the WLAN over a period of time, determine a threshold for the network parameters, determine a plurality of time intervals based on an upgrade to be applied to the WLAN, identify when the network parameters of the WLAN are below the determined threshold, and initiate the upgrade to the WLAN when the network parameters are below the determined threshold where the upgrade is performed during one of the plurality of time intervals.

Abstract: A latch described herein comprises a ratchet movable between a primary closed position, a secondary closed position and an open position. The ratchet is biased towards the open position for facilitating travel of a striker in a fishmouth of the latch to the secondary closed position. The latch includes a pawl movable between a primary locking position, a secondary locking position and an unlocking position. The pawl is biased towards the primary locking position and has a pawl locking surface for holding the ratchet in the primary closed position and the secondary closed position. The latch includes a lift lever biased towards the open position for moving the striker in the fishmouth away from the secondary closed position and towards the open position when the pawl is in the unlocking position. The striker is further from the primary position when in the open position compared to the secondary closed position.

Abstract: In an example, an access point includes a first and second Ethernet port, a processing resource and a memory resource storing machine readable instructions. The machine readable instructions may be to cause the processing resource to create a first communication channel between the access point and a first network zone using the first Ethernet port and to create a second communication channel between the access point and a second network zone using the second Ethernet port. The first and second network zones may be independently configured with respective first and second zone controllers and the first and second communication channels may exist simultaneously.

Abstract: An example of a system may include a processing resource and a computing device comprising instructions executable by the processing resource to determine an interval based on an amount of time to upgrade a network; determine a series of time windows based on the interval; analyze data traffic in the network over the series of time windows; identify a subset of the series of time windows that are sequential and non-overlapping; and select a particular time window from the subset of the series of time windows to perform an upgrade of the network based on the analyzed data traffic.

Abstract: A method of assessing uterine parameters via a apparatus including a processor includes determining, by the processor, at least one uterine parameter based on one or more ultrasound images of a uterus of a subject, the one or more ultrasound images being obtained on predefined days within an IVF cycle of the subject, tracking, by the processor, a change in the at least one uterine parameter, and predicting, by the processor, success of embryo implantation based on the change in the at least one uterine parameter.

Abstract: An example of a system may include a processing resource and a computing device comprising instructions executable by the processing resource to assign a first radio, operable in a frequency band, of an access point (AP) to a prioritized data zone utilizing the AP; and assign a second radio, operable in the frequency band, of the AP to a plurality of non-prioritized data zones utilizing the AP.

Abstract: Disclosed is a system for detecting security threats in a local network. A security analytics system collects data about entities in the local network. The raw data can be filtered to extract data fields from the raw data that are relevant to detecting security threats in the local network. The filtered data can be converted into structured data that formats the information in the filtered data. The structured data may be formatted based on a set of schema, and can be used to generate a set of features. The security analytics system can use the generated features to build machine-learned models of the behavior of entities in the local network. The security analytics system can use the machine-learned models to generate threat scores representing the likelihood a security threat is present. The security analytics system can provide an indication of the security threat to a user.

Abstract: Some examples relate to detecting network link failure. In an example, a determination may be made at a first network device on a network regarding an average round-trip delay time (RTD) between the first network device and a second network device over a given time interval during a given period of time. Then, for the given time interval, a keepalive packet may be sent from the first network device to the second network device at the average RTD of the given time interval for a keepalive time. In response to a determination, by the first network device that there is no acknowledgement of the keepalive packet from the second network device during the keepalive time, a network link between the first network device and the second network device may be identified as failed.