Abstract: This application is directed to methods which allow for encapsulation of an array of biological materials under physiological conditions that are relevant given a biological context and the compositions made using those methods. These reconstituted biological materials encompass: a) purified proteins that can bind to the lipid membranes inside and outside of vesicles based on the electrostatic charge; b) purified cytosolic proteins that position themselves in the lumen of the vesicles, c) mammalian cell extracts with an array of cytosolic protein content, among other contents and d) small biological molecules such as DNA and RNA as well as fluorescent dyes/probes. These vesicles can be used to simulate cells in drug discovery methods as well as useful in administering drugs and other compositions to cells in vitro and in vivo.

Abstract: Described are conjugates of nucleic acid nanotubes and cells by linking the nanotubes to a cell surface moiety. Devices, kits, systems, and methods comprising the nanotube cell conjugates are also described.

Abstract: This application is directed to methods which allow for encapsulation of an array of biological materials under physiological conditions that are relevant given a biological context and the compositions made using those methods. These reconstituted biological materials encompass: a) purified proteins that can bind to the lipid membranes inside and outside of vesicles based on the electrostatic charge; b) purified cytosolic proteins that position themselves in the lumen of the vesicles, c) mammalian cell extracts with an array of cytosolic protein content, among other contents and d) small biological molecules such as DNA and RNA as well as fluorescent dyes/probes. These vesicles can be used to simulate cells in drug discovery methods as well as useful in administering drugs and other compositions to cells in vitro and in vivo.

Abstract: A BOM of a product which is used at a plurality of sites is acquired from a BOM input unit. With respect to each component configuration in the BOM, specifications with variations in past demand at or above a given level are accepted as variation specification information. On the basis of the variation specification information, the component specification to be segmented is extracted from the BOM and a BOM to be changed is generated. On the basis of the BOM to be changed, the component configuration of the BOM is segmented and reconfigured, a changed BOM is generated, and the changed BOM is outputted.

Abstract: The objective of the present invention is to provide, in the case of recreating a procurement plan, a technology which can create a procurement plan appropriate for the situation even without a skilled operator. A procurement plan creation device according to the present invention has predefined definitions for second constraint conditions in which constraint conditions related to a procurement plan have been relaxed, and creates a plurality of second procurement plans according to combinations of the second constraint conditions and presents the plurality of second procurement plans to an operator (see FIG. 15).

Abstract: A device for supporting goods delivery schedule coordination includes: a storage unit retaining information of a delivery schedule and transportation lead time; a computation unit having a transportation lead-time converting unit which calculates the shipment date in the delivery schedule and stores that as an updated delivery schedule; an output unit which outputs by a screen the information of the updated delivery schedule based on two types of timing of arrival-date basis and shipment-date basis; and a control unit having a schedule-coordination-information receiving unit which receives information of the delivery schedule requested to be coordinated and stores that as a coordination-requested schedule. The computation unit further has a schedule-coordinatable-period calculating unit which stores the delivery schedule included in the coordinatable period as a coordinatable period. The output unit distinguishably displays a range about the coordinatable period.

Abstract: A compound represented by the general formula (I) or a salt thereof, wherein R represents a group represented by the following formula (A), (B) or (C) wherein R1 and R2 independently represent a C1-6 alkyl group, R3 represents an amino group, a mono(C1-6 alkyl)amino group, a di(C1-6 alkyl)amino group or a C1-6 alkoxy group and X-represents an anion, and n represents an integer of 2 to 5. The compound or a salt is useful as a ligand of inositol-1,4,5-trisphosphate (IP3) receptor.