Patents by Inventor Thomas Christoph

Thomas Christoph has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted Tetrahydropyrrolopyrazine Compounds and the Use Thereof in Pharmaceutical Compositions
    Publication number: 20090258880
    Abstract: Substituted tetrahydropyrrolopyrazine compounds corresponding to formula I a process for producing such compounds; and a method of using such compounds to treat or inhibit various disorders or disease states including pain, depression and anxiety.
    Type: Application
    Filed: April 17, 2009
    Publication date: October 15, 2009
    Applicant: Gruenenthal GmbH
    Inventors: Beatrix MERLA, Thomas Christoph, Stefan Oberboersch, Klaus Schiene, Gregor Bahrenberg, Robert Frank, Sven Kuehnert, Wolfgang Schroeder
  • Method of Inhibiting Polyneuropathic Pain with 3-(2-Dimethylaminomethylcyclohexyl) Phenol
    Publication number: 20090197960
    Abstract: A method of using 3-(2-dimethylaminomethylcyclohexyl)phenol or a pharmaceutically acceptable salt thereof as an active pharmaceutical ingredient for treating or inhibiting polyneuropathic pain, in particular in diabetic polyneuropathy.
    Type: Application
    Filed: February 2, 2009
    Publication date: August 6, 2009
    Applicant: Gruenenthal GmbH
    Inventor: Thomas CHRISTOPH
  • Vanilloid Receptor Ligands, Pharmaceutical Compositions Containing Them, Process for Making Them, and Use Thereof for Treating Pain and Other Conditions
    Publication number: 20090156590
    Abstract: Vanilloid receptor ligand compounds corresponding to formula I: pharmaceutical compositions containing such compounds, a process for producing such compounds, and methods of using such compounds for treating or inhibiting pain and various other disorders or conditions.
    Type: Application
    Filed: April 15, 2008
    Publication date: June 18, 2009
    Applicant: Gruenenthal GmbH
    Inventors: Robert FRANK, Gregor BAHRENBERG, Thomas CHRISTOPH, Klaus SCHIENE, Jean DE VRY, Derek SAUNDERS, Bernd SUNDERMANN, Jeewoo LEE
  • Vanilloid receptor ligands, pharmaceutical compositions containing them, process for making them and use thereof for treating pain and other conditions
    Publication number: 20080275044
    Abstract: Compounds corresponding to formula I: which act as vanilloid receptor ligands, pharmaceutical compositions containing such compounds, a process for the producing such compounds, and the use thereof to treat or inhibit pain and/or various other disorders or conditions.
    Type: Application
    Filed: April 11, 2008
    Publication date: November 6, 2008
    Applicant: Gruenenthal GmbH
    Inventors: Robert Frank, Gregor Bahrenberg, Thomas Christoph, Klaus Schiene, Jean De Vry, Derek Saunders, Bernd Sundermann, Jeewoo Lee
  • Use of 1-Phenyl-3-Dimethylamino-propane Compounds for Treating Neuropathic Pain
    Publication number: 20080269326
    Abstract: Use of 1-phenyl-3-dimethylaminopropane compounds for the production of medicaments for treating neuropathic pain, preferably polyneuropathic pain, also preferably diabetic neuropathic pain, more preferably diabetic peripheral neuropathic pain, and furthermore preferably for treating diabetic peripheral neuropathy.
    Type: Application
    Filed: March 11, 2008
    Publication date: October 30, 2008
    Applicant: GRUENENTHAL GmbH
    Inventors: Thomas Christoph, Elmar Friderichs, Babette-Yvonne Koegel
  • Vanilloid receptor ligand compounds, pharmaceutical compositions containing them, a method of producing them and the use thereof to treat pain and various other conditions
    Publication number: 20080269289
    Abstract: Compounds corresponding to formula I: which act as vanilloid receptor ligands, pharmaceutical composition s containing such compounds, a method for producing the compounds, and the use of such compounds to treat pain and various other conditions.
    Type: Application
    Filed: April 11, 2008
    Publication date: October 30, 2008
    Applicant: Gruenenthal GmbH
    Inventors: Robert Frank, Gregor Bahrenberg, Thomas Christoph, Klaus Schiene, Jean De Vry, Derek Saunders, Jeewoo Lee
  • Vanilloid Receptor Ligands, Pharmaceutical Compositions Containing Them, Process For Making Them, and Use Thereof For Treating Pain and Other Conditions
    Publication number: 20080262039
    Abstract: Vanilloid receptor ligand compounds corresponding to formula I: a process for producing such compounds, pharmaceutical compositions containing them, and the use of such compounds to treat pain and various other vanilloid receptor mediated conditions.
    Type: Application
    Filed: April 15, 2008
    Publication date: October 23, 2008
    Applicant: Gruenenthal GmbH
    Inventors: Robert FRANK, Gregor Bahrenberg, Thomas Christoph, Klaus Schiene, Jean De Vry, Derek Saunders, Michael Przewosny, Bernd Sundermann, Jewoo Lee
  • Substituted Sulfonamide Compounds
    Publication number: 20080249128
    Abstract: Substituted sulfonamide compounds with bradykinin receptor (B1R) modulating activity; processes for the preparation thereof, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat or inhibit pain and/or other disorders and/or disease states.
    Type: Application
    Filed: October 16, 2007
    Publication date: October 9, 2008
    Applicant: GRUENENTHAL GmbH
    Inventors: Stefan OBERBOERSCH, Melanie Reich, Stefan Schunk, Sabine Hees, Ruth Jostock, Michael Engels, Achim Kless, Thomas Christoph, Klaus Schiene, Tieno Germann, Edward Bijsterveld
  • Substituted bicyclic imidazo-3-ylamine compounds
    Patent number: 7420056
    Abstract: Substituted bicyclic imidazo-3-yl-amine compounds are provided, as well as processes for the production thereof and pharmaceutical formulations containing these compounds. The use of these compounds for the production of pharmaceutical formulations and related methods of treatment are also provided.
    Type: Grant
    Filed: March 14, 2007
    Date of Patent: September 2, 2008
    Assignee: Gruenenthal GmbH
    Inventors: Sven Kuehnert, Stefan Oberboersch, Corinna Sundermann, Michael Haurand, Ruth Jostock, Klaus Schiene, Thomas Tzschentke, Thomas Christoph, Dagmar Kaulartz, Saskia Zemolka
  • Substituted Tetrahydropyrrolopyrazine Compounds and the Use Thereof in the Treatment and/or Inhibition of Pain
    Publication number: 20080167315
    Abstract: Substituted tetrahydropyrrolopyrazine compounds corresponding to the formula I: processes for their preparation, pharmaceutical compositions comprising these compounds and the use of these compounds for the treatment and/or inhibition of pain and other disorders or disease states at least partly mediated by KCNQ2/3 K+ channels.
    Type: Application
    Filed: October 17, 2007
    Publication date: July 10, 2008
    Applicant: GRUENENTHAL GmbH
    Inventors: Beatrix Merla, Thomas Christoph, Stefan Oberboersch, Klaus Schiene, Gregor Bahrenberg, Robert Frank, Sven Kuehnert, Wolfgang Schroeder
  • SUBSTITUTED SULFONAMIDE COMPOUNDS
    Publication number: 20080153843
    Abstract: Substituted sulfonamide derivatives, a process for their preparation, pharmaceutical compositions containing these compounds, and to the use of substituted sulfonamide derivatives in the treatment or inhibition of pain and/or various disorders or disease states.
    Type: Application
    Filed: September 28, 2007
    Publication date: June 26, 2008
    Applicant: Gruenenthal GmbH
    Inventors: Stefan OBERBOERSCH, Melanie REICH, Stefan SCHUNK, Sabine HEES, Ruth JOSTOCK, Michael Franz-Martin ENGELS, Achim KLESS, Thomas CHRISTOPH, Klaus SCHIENE, Tieno GERMANN, Edward BIJSTERVELD
  • Mixed ORL1/mu-agonists for the treatment of pain
    Publication number: 20080125475
    Abstract: The invention relates to the use of compounds which exhibit an affinity for the ?-opioid receptor of at least 100 nM (Ki value, human) and an affinity for the ORL-1 receptor, wherein the ratio between the affinities ORL1/? defined as 1/[Ki(ORL1)/Ki(?)] is from 0.1 to 30, for the treatment of pain.
    Type: Application
    Filed: September 28, 2007
    Publication date: May 29, 2008
    Applicant: GRUNENTHAL GMBH
    Inventors: KLAUS LINZ, Babette-Yvonne Kogel, Wolfgang Schroder, Thomas Christoph, Jean De Vry, Elmar Friderichs
  • Compositions and methods for the treatment of urinary incontinence
    Patent number: 7361690
    Abstract: A method for treating increased uninary urgency or urinary incontinence, comprising administering an effective amount of a compound corresponding to formula I It has been surprisingly discovered that the methods of the present invention are effective for treating increased urinary urgency or urinary incontinence. Also disclosed are methods of treatment using related pharmaceutical compositions.
    Type: Grant
    Filed: November 2, 2004
    Date of Patent: April 22, 2008
    Assignee: Gruenenthal GmbH
    Inventors: Thomas Christoph, Elmar Friderichs
  • SUBSTITUTED BICYCLIC IMIDAZO-3-YLAMINE COMPOUNDS
    Publication number: 20070155965
    Abstract: Substituted bicyclic imidazo-3-yl-amine compounds are provided, as well as processes for the production thereof and pharmaceutical formulations containing these compounds. The use of these compounds for the production of pharmaceutical formulations and related methods of treatment are also provided.
    Type: Application
    Filed: March 14, 2007
    Publication date: July 5, 2007
    Applicant: Gruenenthal GmbH.
    Inventors: SVEN KUHNERT, Stefan Oberborsch, Corinna Sundermann, Michael Haurand, Ruth Jostock, Klaus Schiene, Thomas Tzschentke, Thomas Christoph, Dagmar Kaulartz, Saskia Zemolka
  • VGLUT-specific dsRNA compounds
    Publication number: 20070117771
    Abstract: VGLUT-specific dsRNAs capable of triggering the phenomenon of RNA interference, host cells containing theses dsRNAs, and pharmaceutical compositions containing these dsRNAs, in particular for the treatment of pain and other diseases associated with VGLUT family members.
    Type: Application
    Filed: September 11, 2006
    Publication date: May 24, 2007
    Applicant: Gruenenthal GmbH
    Inventors: Clemens Gillen, Gregor Bahrenberg, Thomas Christoph, Eberhard Weihe, Martin Schaefer, Florian Bender
  • NOVEL VANILLOID RECEPTOR LIGANDS AND USE THEREOF FOR THE PRODUCTION OF PHARMACEUTICAL PREPARATIONS
    Publication number: 20070105861
    Abstract: The present invention relates to novel vanilloid receptor ligands, to a process for the production thereof, to pharmaceutical preparations containing these compounds and to the use of these compounds for the production of pharmaceutical preparations.
    Type: Application
    Filed: October 19, 2006
    Publication date: May 10, 2007
    Applicant: GRUENENTHAL GMBH
    Inventors: Jeewoo Lee, Hyung Ryu, Robert Frank, Gregor Bahrenberg, Jean De Vry, Thomas Christoph, Derek Saunders, Klaus Schiene, Bernd Sundermann
  • Pharmaceutical compositions containing aryl or heteroaryl azolylcarbinol compounds
    Publication number: 20060194860
    Abstract: Pharmaceutical formulations are provided and comprise compounds corresponding to formula I, wherein R1, R2, R3 and R4 have the meanings given in the description. Related methods of treating or inhibiting pain and other conditions or disorders are also provided.
    Type: Application
    Filed: January 31, 2006
    Publication date: August 31, 2006
    Applicant: GRUENENTHAL GMBH
    Inventors: Clemens Gillen, Thomas Christoph, Klaus Schiene, Derek Saunders, Hagen-Heinrich Hennies, Carsten Griebel
  • Use of weak opioids and mixed opioid agonists/antagonists for treatment of urinary incontinence
    Patent number: 7008939
    Abstract: A pharmaceutical composition for the treatment of an increased urge to urinate or urinary incontinence, comprising an effective amount of at least a compound selected from the group consisting of codeine, dihydrocodeine, dextropropoxyphene, meptazinol and tilidine. Also disclosed are methods of treatment using the pharmaceutical compositions and preferred dosages for the treatment methods.
    Type: Grant
    Filed: May 30, 2003
    Date of Patent: March 7, 2006
    Assignee: Gruenenthal GmbH
    Inventor: Thomas Christoph
  • Metabolites of 1-dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol and their use in the treatment of urinary incontinence
    Publication number: 20050137145
    Abstract: 1-phenyl-3-dimethylamino-propane compounds for producing a drug for treating urinary urgency or urinary incontinence and corresponding drugs and methods of treating or alleviating urinary urgency or urinary incontinence.
    Type: Application
    Filed: November 30, 2004
    Publication date: June 23, 2005
    Applicant: Gruenenthal GmbH
    Inventors: Burkhard Kurth, Joerg Holenz, Helmut Buschmann, Oswald Zimmer, Thomas Christoph
  • Use of 6-dimethylaminomethyl-1-phenyl-cyclohexane compounds for treatment of urinary incontinence
    Patent number: 6908944
    Abstract: A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of formula I: It has been surprisingly discovered that the pharmaceutical composition of the present invention is effective for the treatment of increased urge to urinate or urinary incontinence. Also disclosed are methods of treatment using the pharmaceutical compositions.
    Type: Grant
    Filed: May 30, 2003
    Date of Patent: June 21, 2005
    Assignee: Gruenenthal GmbH
    Inventors: Thomas Christoph, Elmar Friderichs