Patents by Inventor Thomas G. Gant

Thomas G. Gant has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMIDAZOLE MODULATORS OF MUSCARINIC ACETYLCHOLINE RECEPTOR M3
    Publication number: 20110091459
    Abstract: The present invention relates to new imidazole modulators of M3 muscarinic acetylcholine receptor activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: December 11, 2009
    Publication date: April 21, 2011
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Thomas G. Gant, Manouchehr M. Shahbaz
  • NAPTHYLENE INHIBITORS OF CYCLOOXYGENASE
    Publication number: 20110054020
    Abstract: The present invention relates to new napthylene inhibitors of cyclooxygenase activity, pharmaceutical compositions thereof, and methods of use thereof
    Type: Application
    Filed: May 4, 2010
    Publication date: March 3, 2011
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Tadimeti Rao, Chengzhi Zhang, Thomas G. Gant, Sepehr Sarshar
  • Preparation and utility of opioid analgesics
    Patent number: 7872013
    Abstract: The present disclosure is directed to modulators of opiate- and/or NMDA receptors and pharmaceutically acceptable salts and prodrugs thereof, the chemical synthesis thereof, and the use of such compounds for the treatment and/or management of pain, anxiety, neurodegeneration, drug dependence, coughing, muscular tension, and/or glaucoma and any other condition in which it is beneficial to modulate an opiate- and/or NMDA receptor.
    Type: Grant
    Filed: August 16, 2007
    Date of Patent: January 18, 2011
    Assignee: Auspex Pharmaceuticals, Inc.
    Inventors: Thomas G. Gant, Sepehr Sarshar
  • Substituted thiophenes
    Patent number: 7863308
    Abstract: Disclosed herein are substituted pyrimidine-based endothelin modulators of Formula I, processes of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Grant
    Filed: April 10, 2008
    Date of Patent: January 4, 2011
    Assignee: Auspex Pharmaceuticals, Inc.
    Inventors: Thomas G. Gant, Sepehr Sarshar
  • CYCLOBUTANEMETHANAMINE INHIBITORS OF MONOAMINE REUPTAKE
    Publication number: 20100311710
    Abstract: The present invention relates to new cyclobutanemethanamine inhibitors of monoamine reuptake, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: December 4, 2009
    Publication date: December 9, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Thomas G. Gant, Sepehr Sarshar, Manouchehr M. Shahbaz
  • 1-METHYLPYRAZOLE MODULATORS OF SUBSTANCE P, CALCITONIN GENE-RELATED PEPTIDE, ADRENERGIC RECEPTOR, AND/OR 5-HT RECEPTOR
    Publication number: 20100291151
    Abstract: The present invention relates to new 1-methylpyrazole modulators of substance P release, calcitonin gene-related peptide activity, adrenergic receptor activity, and/or 5-HT receptor activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: April 21, 2010
    Publication date: November 18, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Thomas G. Gant, Sepehr Sarshar
  • PROP-2-YN-1-AMINE INHIBITORS OF MONOAMINE OXIDASE TYPE B
    Publication number: 20100286124
    Abstract: The present invention relates to new prop-2-yn-1-amine inhibitors of monoamine oxidase type B activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: April 9, 2010
    Publication date: November 11, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Thomas G. Gant, Sepehr Sarshar
  • SUBSTITUTED THIOPHENES
    Publication number: 20100280086
    Abstract: Disclosed herein are substituted pyrimidine-based endothelin modulators of Formula I, processes of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: July 14, 2010
    Publication date: November 4, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Thomas G. Gant, Sepehr Sarshar
  • THIENOBENZODIAZEPINE MODULATORS OF D1 RECEPTOR, D2 RECEPTOR, AND/OR 5-HT2 RECEPTOR
    Publication number: 20100266711
    Abstract: The present invention relates to new thienobenzodiazepine modulators of D1 receptors, D2 receptors, and/or 5-HT2 receptors, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: September 24, 2009
    Publication date: October 21, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Thomas G. Gant, Sepehr Sarshar
  • SUBSTITUTED PDE5 INHIBITORS
    Publication number: 20100234388
    Abstract: Provided herein are substituted PDE5 inhibitors of Formula (1), and processes of preparation and pharmaceutical compositions thereof. Also provided are methods of their use for the treatment and/or management of hypertension, erectile dysfunction, and/or the inability to maintain improved erectile function. The compounds are deuterated tadalafil derivatives.
    Type: Application
    Filed: June 8, 2007
    Publication date: September 16, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Thomas G. Gant, Sepehr Sarshar
  • Isothiazole derivatives useful as anticancer agents
    Patent number: 7790902
    Abstract: The present invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein X1, R1, R2 and R3 are as defined herein. The invention also relates to pharmaceutical compositions containing the above compounds and to methods treating hyperproliferative disorders in mammals by administering the above compounds.
    Type: Grant
    Filed: July 29, 2008
    Date of Patent: September 7, 2010
    Assignees: Pfizer, Inc., OSI Pharmaceuticals, Inc.
    Inventors: Eric R. Larson, Mark C. Noe, Thomas G. Gant
  • SUBSTITUTED PHENETHYLAMINES
    Publication number: 20100222257
    Abstract: Disclosed herein are substituted phenethylamine alpha adrenergic receptor modulators of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: May 17, 2010
    Publication date: September 2, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Thomas G. Gant, Sepehr Sarshar
  • Preparation and utility of substituted imidazopyridine compounds with hypnotic effects
    Patent number: 7772248
    Abstract: The present disclosure is directed to modulators of GABAA receptors and pharmaceutically acceptable salts and prodrugs thereof, the chemical synthesis thereof, and the medical use of such compounds for the treatment and/or management of sleep disorders and/or for providing a patient in need with a hypnotic, anxiolytic or anti-convulsive effect are described.
    Type: Grant
    Filed: May 30, 2007
    Date of Patent: August 10, 2010
    Assignee: Auspex Pharmaceuticals, Inc.
    Inventors: Thomas G. Gant, Sepehr Sarshar
  • Substituted amino alcohols
    Patent number: 7767860
    Abstract: Disclosed herein are substituted amino alcohol anti-mycobacterial agents and/or chelation therapy agents of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Grant
    Filed: September 3, 2008
    Date of Patent: August 3, 2010
    Assignee: Auspex Pharmaceuticals, Inc
    Inventors: Thomas G. Gant, Sepehr Sarshar
  • SUBSTITUTED HYDROXYPHENYLAMINE COMPOUNDS
    Publication number: 20100172916
    Abstract: The present invention relates to new substituted hydroxyphenylamine based modulators of hormone and/or pigment levels, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: November 9, 2009
    Publication date: July 8, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Thomas G. Gant, Craig Hodulik, Soon Woo
  • DIBENZO[b,e][1,4]DIAZEPINE MODULATORS OF DOPAMINE RECEPTORS, SEROTONIN RECEPTORS, ADRENERGIC RECEPTORS, ACETYLCHOLINE RECEPTORS, AND/OR HISTAMINE RECEPTORS
    Publication number: 20100166887
    Abstract: The present invention relates to new dibenzo[b,e][1,4]diazepine modulators of dopamine receptors, serotonin receptors, adrenergic receptors, acetylcholine receptors, and/or histamine receptors, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: October 21, 2009
    Publication date: July 1, 2010
    Applicant: Auspex Pharmaceuticals, Inc.
    Inventors: Thomas G. Gant, Sepehr Sarshar
  • ETHOXYPHENYLMETHYL INHIBITORS OF SGLT2
    Publication number: 20100167988
    Abstract: The present invention relates to new ethoxyphenylmethyl modulators of SGLT2, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: October 22, 2009
    Publication date: July 1, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Thomas G. Gant, Manouchehr M. Shahbaz
  • 7,8,10,10A-TETRAHYDRO-6H-BENZO[C]CHROMEN-9(6AH)-ONE MODULATORS OF CANNABINOID RECEPTORS
    Publication number: 20100168086
    Abstract: The present invention relates to new 7,8,10,10a-tetrahydro-6H-benzo[c]chromen-9(6aH)-one modulators of cannabinoid receptors, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: September 23, 2009
    Publication date: July 1, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Thomas G. Gant, Manoucherhr M. Shahbaz
  • ISOPROPOXYPHENYLMETHYL INHIBITORS OF SGLT2
    Publication number: 20100167989
    Abstract: The present invention relates to new isopropoxyphenylmethyl inhibitors of SGLT2, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: October 23, 2009
    Publication date: July 1, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventor: Thomas G. Gant
  • Substituted phenethylamines
    Patent number: 7745665
    Abstract: Disclosed herein are substituted phenethylamine alpha adrenergic receptor modulators of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Grant
    Filed: June 3, 2008
    Date of Patent: June 29, 2010
    Assignee: Auspex Pharmaceuticals, Inc.
    Inventors: Thomas G. Gant, Sepehr Sarshar