Patents by Inventor Timothy E. McKnight
Timothy E. McKnight has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230400436Abstract: A gas sensing device comprising a layer of guest-free cryptophane A molecules on a substrate capable of detecting a molecular level change in mass, viscosity, or stress due to absorption of gas molecules into the cryptophane A molecules, wherein the cryptophane A molecules have the following structure: wherein R1, R2, R3, R4, R5, and R6 are independently selected from methyl and ethyl groups. Also described herein is a method for manufacturing the gas sensing device, particularly a step of sublimating cryptophane A molecules onto a suitable substrate. Also described herein is a method of detecting one or more gases in a space by placing a gas sensing device, as described above, in the space, wherein the gas sensing device transmits detection signals to an external electronic device that performs an analysis of the detection signals.Type: ApplicationFiled: June 12, 2023Publication date: December 14, 2023Inventors: Ilja Popovs, Benjamin LaRiviere, Aleksandr Ivanov, Robert J. Warmack, Timothy E. Mcknight, Tolga Aytug, Timothy J. Mcintyre
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Patent number: 11584919Abstract: A capsule composition comprising: (a) a polyester shell having a thickness of no more than 20 microns, and (b) a solution containing a visual and/or olfactory indicator, wherein the solution is encapsulated by the polyester shell. Also described herein is a method for detecting alpha particle radiation, in which: (i) the capsule composition is placed in contact with an esterase in a location where the presence of alpha particle radiation is being determined; (ii) waiting a period of time for the esterase to degrade the polyester shells, wherein the period of time is insufficient for the esterase to cause leakage of the solution in the absence of alpha particle radiation but is sufficient for alpha particle radiation, if present, to cause leakage from the capsule composition; and (iii) observing whether leakage has occurred at the end of the period of time to determine whether alpha particle radiation is present.Type: GrantFiled: January 21, 2020Date of Patent: February 21, 2023Assignee: UT-Battelle, LLCInventors: Timothy E. McKnight, David E. Graham, Robert F. Standaert, Linda A. Lewis, Samuel A. Lewis
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Publication number: 20200231951Abstract: A capsule composition comprising: (a) a polyester shell having a thickness of no more than 20 microns, and (b) a solution containing a visual and/or olfactory indicator, wherein the solution is encapsulated by the polyester shell. Also described herein is a method for detecting alpha particle radiation, in which: (i) the capsule composition is placed in contact with an esterase in a location where the presence of alpha particle radiation is being determined; (ii) waiting a period of time for the esterase to degrade the polyester shells, wherein the period of time is insufficient for the esterase to cause leakage of the solution in the absence of alpha particle radiation but is sufficient for alpha particle radiation, if present, to cause leakage from the capsule composition; and (iii) observing whether leakage has occurred at the end of the period of time to determine whether alpha particle radiation is present.Type: ApplicationFiled: January 21, 2020Publication date: July 23, 2020Inventors: Timothy E. McKnight, David E. GRAHAM, Robert F. Standaert, Linda A. LEWIS, Samuel A. Lewis
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Patent number: 9523132Abstract: The present invention relates to a rapid, highly fieldable, nearly reagentless diagnostic to identify active RNA viral replication in a live, infected cells, and more particularly in leukocytes and tissue samples (including biopsies and nasal swabs) using an array of a plurality of vertically-aligned nanostructures that impale the cells and introduce a DNA reporter construct that is expressed and amplified in the presence of active viral replication.Type: GrantFiled: March 14, 2014Date of Patent: December 20, 2016Assignee: UT-Battelle, LLCInventor: Timothy E. McKnight
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Patent number: 9333067Abstract: Valve implant systems positionable within a flow passage, the systems having an inlet, an outlet, and a remotely activatable valve between the inlet and outlet, with the valves being operable to provide intermittent occlusion of the flow path. A remote field is applied to provide thermal or magnetic activation of the valves.Type: GrantFiled: February 11, 2014Date of Patent: May 10, 2016Assignee: UT-BATTELLE, LLCInventors: Timothy E. McKnight, Anthony Johnson, Kenneth J. Moise, Milton Nance Ericson, Justin S. Baba, John B. Wilgen, Boyd Mccutchen Evans
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Patent number: 8993327Abstract: Systems and methods are described for parallel macromolecular delivery and biochemical/electrochemical interface to whole cells employing carbon nanostructures including nanofibers and nanotubes. A method includes providing a first material on at least a first portion of a first surface of a first tip of a first elongated carbon nanostructure; providing a second material on at least a second portion of a second surface of a second tip of a second elongated carbon nanostructure, the second elongated carbon nanostructure coupled to, and substantially parallel to, the first elongated carbon nanostructure; and penetrating a boundary of a biological sample with at least one member selected from the group consisting of the first tip and the second tip.Type: GrantFiled: April 7, 2003Date of Patent: March 31, 2015Assignee: UT-Battelle, LLCInventors: Timothy E. McKnight, Anatoli V. Melechko, Guy D. Griffin, Michael A. Guillorn, Vladimir L. Merkulov, Michael L. Simpson
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Publication number: 20140329308Abstract: A method of immobilizing matter for imaging that includes providing an array of nanofibers and directing matter to the array of the nanofibers. The matter is immobilized when contacting at least three nanofibers of the array of nanofibers simultaneously. Adjacent nanofibers in the array of nanofibers may be separated by a pitch as great as 100 microns. The immobilized matter on the array of nanofibers may then be imaged. In some examples, the matter may be cell matter, such as protoplasts.Type: ApplicationFiled: July 23, 2014Publication date: November 6, 2014Applicant: UT-BATTELLE, LLCInventors: Timothy E. McKnight, Udaya C. Kalluri, Anatoli V. Melechko
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Publication number: 20140272943Abstract: The present invention relates to a rapid, highly fieldable, nearly reagentless diagnostic to identify active RNA viral replication in a live, infected cells, and more particularly in leukocytes and tissue samples (including biopsies and nasal swabs) using an array of a plurality of vertically-aligned nanostructures that impale the cells and introduce a DNA reporter construct that is expressed and amplified in the presence of active viral replication.Type: ApplicationFiled: March 14, 2014Publication date: September 18, 2014Applicant: UT-Battelle, LLCInventor: Timothy E. McKnight
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Patent number: 8815780Abstract: A method of immobilizing matter for imaging that includes providing an array of nanofibers and directing matter to the array of the nanofibers. The matter is immobilized when contacting at least three nanofibers of the array of nanofibers simultaneously. Adjacent nanofibers in the array of nanofibers may be separated by a pitch as great as 100 microns. The immobilized matter on the array of nanofibers may then be imaged. In some examples, the matter may be cell matter, such as protoplasts.Type: GrantFiled: February 9, 2012Date of Patent: August 26, 2014Assignee: UT-Battelle, LLCInventors: Timothy E. McKnight, Udaya C. Kalluri, Anatoli V. Melechko
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Publication number: 20140163693Abstract: Valve implant systems positionable within a flow passage, the systems having an inlet, an outlet, and a remotely activatable valve between the inlet and outlet, with the valves being operable to provide intermittent occlusion of the flow path. A remote field is applied to provide thermal or magnetic activation of the valves.Type: ApplicationFiled: February 11, 2014Publication date: June 12, 2014Applicant: UT-BATTELLE, LLCInventors: Timothy E. McKnight, Anthony Johnson, Kenneth J. Moise, Milton Nance Ericson, Justin S. Baba, John B. Wilgen, Boyd Mccutchen Evans
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Patent number: 8657883Abstract: Valve implant systems positionable within a flow passage, the systems having an inlet, an outlet, and a remotely activatable valve between the inlet and outlet, with the valves being operable to provide intermittent occlusion of the flow path. A remote field is applied to provide thermal or magnetic activation of the valves.Type: GrantFiled: March 23, 2010Date of Patent: February 25, 2014Assignee: UT-Battelle, LLCInventors: Timothy E. McKnight, Anthony Johnson, Kenneth J. Moise, Jr., Milton Nance Ericson, Justin S. Baba, John B. Wilgen, Boyd McCutchen Evans, III
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Publication number: 20130210649Abstract: A method of immobilizing matter for imaging that includes providing an array of nanofibers and directing matter to the array of the nanofibers. The matter is immobilized when contacting at least three nanofibers of the array of nanofibers simultaneously. Adjacent nanofibers in the array of nanofibers may be separated by a pitch as great as 100 microns. The immobilized matter on the array of nanofibers may then be imaged. In some examples, the matter may be cell matter, such as protoplasts.Type: ApplicationFiled: February 9, 2012Publication date: August 15, 2013Applicant: UT-BATTELLE, LLCInventors: Timothy E. McKnight, Udaya C. Kalluri, Anatoli V. Melechko
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Patent number: 8343766Abstract: A method for the transient transformation of a living biological cell having an intact cell membrane defining an intracellular domain, and an apparatus for the transient transformation of biological cells. The method and apparatus include introducing a compartmentalized extracellular component fixedly attached to a cellular penetrant structure to the intracellular domain of the cell, wherein the cell is fixed in a predetermined location and wherein the component is expressed within in the cell while being retained within the compartment and wherein the compartment restricts the mobility and interactions of the component within the cell and prevents transference of the component to the cell.Type: GrantFiled: November 28, 2011Date of Patent: January 1, 2013Assignee: UT-Battle, LLCInventors: Timothy E. McKnight, Anatoli V. Melechko, Michael L. Simpson
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Patent number: 8142877Abstract: Methods, manufactures, machines and compositions are described for nanotransfer and nanoreplication using deterministically grown sacrificial nanotemplates. An apparatus, includes a substrate and a nanoconduit material coupled to a surface of the substrate. The substrate defines an aperture and the nanoconduit material defines a nanoconduit that is i) contiguous with the aperture and ii) aligned substantially non-parallel to a plane defined by the surface of the substrate.Type: GrantFiled: November 13, 2007Date of Patent: March 27, 2012Assignee: UT-Battelle, LLCInventors: Anatoli V. Melechko, Timothy E. McKnight, Michael A. Guillorn, Bojan Ilic, Vladimir I. Merkulov, Mitchel J. Doktycz, Douglas H. Lowndes, Michael L. Simpson
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Publication number: 20120070895Abstract: A method for the transient transformation of a living biological cell having an intact cell membrane defining an intracellular domain, and an apparatus for the transient transformation of biological cells. The method and apparatus include introducing a compartmentalized extracellular component fixedly attached to a cellular penetrant structure to the intracellular domain of the cell, wherein the cell is fixed in a predetermined location and wherein the component is expressed within in the cell while being retained within the compartment and wherein the compartment restricts the mobility and interactions of the component within the cell and prevents transference of the component to the cell.Type: ApplicationFiled: November 28, 2011Publication date: March 22, 2012Applicant: UT-Battelle, LLCInventors: Timothy E. McKnight, Anatoli V. Melechko, Michael L. Simpson
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Patent number: 8101388Abstract: The present invention in one embodiment provides a method for extracting molecular material including providing a probe comprising a penetration portion having a nanoscale surface for penetrating a biological compartment, a receptor present on the penetrating portion of the probe, wherein the receptor has an affinity for a target molecular material from the biological compartment; inserting the probe into the biological compartment, the receptor present on the penetrating portion of the probe engages the target molecular material; and extracting the probe and the target molecular material engaged to the inserting portion of the probe from the biological compartment.Type: GrantFiled: September 28, 2007Date of Patent: January 24, 2012Assignee: UT-Battelle, LLCInventors: Timothy E. McKnight, Anatoli V. Melechko, Michael L. Simpson
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Patent number: 8076124Abstract: A method for the transient transformation of a living biological cell having an intact cell membrane defining an intracellular domain, and an apparatus for the transient transformation of biological cells. The method and apparatus include introducing a compartmentalized extracellular component fixedly attached to a cellular penetrant structure to the intracellular domain of the cell, wherein the cell is fixed in a predetermined location and wherein the component is expressed within in the cell while being retained within the compartment and wherein the compartment restricts the mobility and interactions of the component within the cell and prevents transference of the component to the cell.Type: GrantFiled: January 17, 2007Date of Patent: December 13, 2011Assignee: UT-Battelle, LLCInventors: Timothy E. McKnight, Anatoli V. Melechko, Michael L. Simpson
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Patent number: 8003220Abstract: Methods, manufactures, machines and compositions are described for nanotransfer and nanoreplication using deterministically grown sacrificial nanotemplates. An apparatus, includes a substrate and a nanoreplicant structure coupled to a surface of the substrate.Type: GrantFiled: November 13, 2007Date of Patent: August 23, 2011Assignee: UT-Battelle, LLCInventors: Anatoli V. Melechko, Timothy E. McKnight, Michael A. Guillorn, Bojan Ilic, Vladimir I. Merkulov, Mitchel J. Doktycz, Douglas H. Lowndes, Michael L. Simpson
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Patent number: 7943196Abstract: Methods, manufactures, machines and compositions are described for nanotransfer and nanoreplication using deterministically grown sacrificial nanotemplates. A method includes depositing a catalyst particle on a surface of a substrate to define a deterministically located position; growing an aligned elongated nanostructure on the substrate, an end of the aligned elongated nanostructure coupled to the substrate at the deterministically located position; coating the aligned elongated nanostructure with a conduit material; removing a portion of the conduit material to expose the catalyst particle; removing the catalyst particle; and removing the elongated nanostructure to define a nanoconduit.Type: GrantFiled: November 14, 2005Date of Patent: May 17, 2011Assignee: UT-Battelle, LLCInventors: Anatoli V. Melechko, Timothy E. McKnight, Michael A. Guillorn, Bojan Ilic, Vladimir I. Merkulov, Mitchel J. Doktycz, Douglas H. Lowndes, Michael L. Simpson
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Publication number: 20100241241Abstract: Valve implant systems positionable within a flow passage, the systems having an inlet, an outlet, and a remotely activatable valve between the inlet and outlet, with the valves being operable to provide intermittent occlusion of the flow path. A remote field is applied to provide thermal or magnetic activation of the valves.Type: ApplicationFiled: March 23, 2010Publication date: September 23, 2010Applicants: UT-BATTELLE, LLC, BAYLOR COLLEGE OF MEDICINEInventors: Timothy E. McKnight, Anthony Johnson, Kenneth J. Moise, JR., Milton Nance Ericson, Justin S. Baba, John B. Wilgen, Boyd Mccutchen Evans, III