Patents by Inventor Winston A. Vadino
Winston A. Vadino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11179377Abstract: Provided are pharmaceutical compositions useful for the treatment and/or prevention of a disorder, such as addiction. For example, pharmaceutical compositions are provided that comprise a first active pharmaceutical component (e.g., metyrapone) and a second active pharmaceutical component (e.g., oxazepam). The compositions may be constructed in such a manner as to limit the physical contact between the first and second active pharmaceutical components, thus preventing any degradation of the active pharmaceutical components resulting form interaction between the two components. The compositions may include at least one pharmaceutically acceptable excipient. Also provided are methods of making the compositions as well as kits containing materials to provide the compositions.Type: GrantFiled: March 12, 2018Date of Patent: November 23, 2021Assignee: Embera NeuroTherapeutics, Inc.Inventors: Julie Straub, Muralikrishna Duvvuri, Parag M. Ved, Bruce Rehlaender, Jay Breaux, Winston A. Vadino, Kripanath Borah, Carol Gloff
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Publication number: 20200054615Abstract: Provided are pharmaceutical compositions useful for the treatment and/or prevention of a disorder, such as addiction. For example, pharmaceutical compositions are provided that comprise a first active pharmaceutical component (e.g., metyrapone) and a second active pharmaceutical component (e.g., oxazepam). The compositions may be constructed in such a manner as to limit the physical contact between the first and second active pharmaceutical components, thus preventing any degradation of the active pharmaceutical components resulting form interaction between the two components. The compositions may include at least one pharmaceutically acceptable excipient. Also provided are methods of making the compositions as well as kits containing materials to provide the compositions.Type: ApplicationFiled: March 12, 2018Publication date: February 20, 2020Inventors: Julie Straub, Muralikrishna Duvvuri, Parag M. Ved, Bruce Rehlaender, Jay Breaux, Winston A. Vadino, Kripanath Borah, Carol Gloff
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Patent number: 6337090Abstract: An orally administrable solid dosage form containing a compacted ribavirin composition having an advantageously high tap density of at least 0.6 g/mL as well as surprisingly rapid disintegration and dissolution rates and wherein the ribavirin is substantially free of polymorphic forms of ribavirin and a process for making such solid dosage forms are disclosed.Type: GrantFiled: November 13, 2000Date of Patent: January 8, 2002Assignee: Schering CorporationInventors: Stephen M. Liebowitz, Elliot I. Stupak, Imtiaz A. Chaudry, Winston A. Vadino, Frank E. Bowen
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Patent number: 6335032Abstract: An orally administrable solid dosage form containing a compacted ribavirin composition having an advantageously high tap density of at least 0.6 g/mL as well as surprisingly rapid disintegration and dissolution rates and wherein the ribavirin is substantially free of polymorphic forms of ribavirin is disclosed.Type: GrantFiled: March 6, 2000Date of Patent: January 1, 2002Assignee: Schering CorporationInventors: Stephen M. Liebowitz, Elliot I. Stupak, Imtiaz A. Chaudry, Winston A. Vadino, Frank E. Bowen
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Patent number: 6051252Abstract: An orally administrable solid dosage form containing a compacted ribavirin composition having an advantageously high tap density of at least 0.6 g/mL as well as surprisingly rapid disintegration and dissolution rates and wherein the ribavirin is subsantially free of polymorphic forms of ribavirin is disclosed.Type: GrantFiled: May 7, 1999Date of Patent: April 18, 2000Assignee: Schering CorporationInventors: Stephen M. Liebowitz, Elliot I. Stupak, Imtiaz A. Chaudry, Winston A. Vadino, Frank E. Bowen
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Patent number: 5972381Abstract: A pharmaceutical composition in the form of a substantially amorphous solid solution comprising an antifungal compound of the formula I: ##STR1## wherein: X is F; and R.sub.1 is ##STR2## or an ester or ether of said compound of Formula I; and a soluble or insoluble polymer such as: povidone or crospovidone, wherein the ratio of said compound to said polymer is about 1:3 to about 1:6 is disclosed.Type: GrantFiled: June 25, 1997Date of Patent: October 26, 1999Assignee: Schering CorporationInventors: Surendra A. Sangekar, Ping I. Lee, Winston A. Vadino
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Patent number: 5916594Abstract: A process of making an orally administrable solid dosage form containing a compacted ribavirin composition having an advantageously high tap density of at least 0.6 g/mL as well as surprisingly rapid disintegration and dissolution rates and wherein the ribavirin is substantially free of polymorphic forms of ribavirin as determined is disclosed.Type: GrantFiled: December 22, 1997Date of Patent: June 29, 1999Assignee: Schering CorporationInventors: Stephen M. Liebowitz, Elliot I. Stupak, Imtiaz A. Chaudry, Winston A. Vadino, Frank E. Bowen
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Patent number: 5914128Abstract: An orally administrable solid dosage form containing a compacted ribavirin composition having an advantageously high tap density of at least 0.6 g/mL as well as surprisingly rapid disintegration and dissolution rates and wherein the ribavirin is substantially free of polymorphic forms of ribavirin is disclosed.Type: GrantFiled: December 22, 1997Date of Patent: June 22, 1999Assignee: Schering CorporationInventors: Stephen M. Liebowitz, Elliot I. Stupak, Imtiaz A. Chaudry, Winston A. Vadino, Frank E. Bowen
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Patent number: 5846971Abstract: A pharmaceutical composition comprising:i) substantially inert beads; wherein said beads are coated withii) an antifungal agent which is (-)-(2R-cis)-4-?4-?4-?4-??-5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-tr iazol-1-ylmethyl)furan-3-yl!methoxy!phenyl!-1-piperazinyl!phenyl!-2,4-dihyd ro-2-?(S)-1-ethyl-2(S)-hydroxypropyl!-3H-1,2,4-triazol-3-one;iii) a binder to enables the antifungal compound to adhere to said beads.The composition enables the antifungal compound, which has very low water solubility, to have enhanced bioavailability in mammals, such as humans.Type: GrantFiled: June 20, 1997Date of Patent: December 8, 1998Assignee: Schering CorporationInventors: Surendra A. Sangekar, Winston A. Vadino, Ping I. Lee
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Patent number: 5834472Abstract: A pharmaceutical composition comprising:i) an antifungal agent which is (-)-(2R-cis)-4-?4-?4-?4-??-5-(2,4-difluorophenyl)-tetrahydro-5-(1H-1,2,4-t riazol-1-ylmethyl)furan-3-yl!methoxy!phenyl!-1-piperazinyl!phenyl!-2,4-dihy dro-2-?(S)-1-ethyl-2(S)-hydroxypropyl!-3H-1,2,4-triazol-3-one;ii) at least one non-ionic surfactant; andiii) a diluent.The composition enables the antifungal compound, which has very low water solubility, to have enhanced bioavailability in mammals, such as humans.Type: GrantFiled: May 21, 1997Date of Patent: November 10, 1998Assignee: Schering CorporationInventors: Surendra A. Sangekar, Winston A. Vadino, Ping I. Lee
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Patent number: 5100675Abstract: Pharmaceutical compositions for use in the treatment of cough/cold symptoms comprising loratadine, ibuprofen and pseudoephedrine are disclosed.Type: GrantFiled: November 13, 1990Date of Patent: March 31, 1992Assignee: Schering CorporationInventors: Wing-Kee P. Cho, Winston A. Vadino, Imtiaz A. Chaudry
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Patent number: 5000962Abstract: A long acting diltiazem formulation is disclosed that comprises more than 35 percent by weight of a swellable hydrophilic polymer.Release rate is also controlled by the application of diffusion controlled membrane to the matrix tablet containing swellable hydrophilic polymers. The diffusion rate through the membrane depends upon the composition or ratio of hydrophilic to hydrophobic coating agent.Type: GrantFiled: August 25, 1989Date of Patent: March 19, 1991Assignee: Schering CorporationInventors: Surendra Sangekar, Winston A. Vadino, Eugenio A. Cefali
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Patent number: 4992277Abstract: An immediate release diltiazem tablet is disclosed that exhibits an unexpectedly rapid bioavailability profile when the active ingredient is diltiazem.Type: GrantFiled: August 25, 1989Date of Patent: February 12, 1991Assignee: Schering CorporationInventors: Surendra Sangekar, Winston A. Vadino, Eugenio A. Cefali
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Patent number: 4990535Abstract: Pharmaceutical compositions for use in the treatment of cough/cold symptoms comprising loratadine, ibuprofen and pseudoephedrine are disclosed.Type: GrantFiled: May 3, 1989Date of Patent: February 5, 1991Assignee: Schering CorporationInventors: Wing-Kee P. Cho, Winston A. Vadino, Imtiaz A. Chaudry
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Patent number: 4940580Abstract: A sustained release dosage form of labetalol hydrochloride is disclosed comprising the active ingredient in a polymeric matrix of hydroxypropylmethylcellulose and polyvinylpyrrolidone and a pharmaceutically acceptable organic acid.Type: GrantFiled: February 2, 1989Date of Patent: July 10, 1990Assignee: Schering CorporationInventors: Surendra Sangekar, Winston A. Vadino
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Patent number: 4777050Abstract: The invention relates to a controlled release dosage form comprising three actives: acetaminophen, pseudoephedrine and dexbrompheniramine.Type: GrantFiled: March 23, 1987Date of Patent: October 11, 1988Assignee: Schering CorporationInventor: Winston A. Vadino
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Patent number: 4695591Abstract: Controlled release solid dosage forms comprising less than about one-third of the total dosage form weight of hydroxypropylmethylcellulose USP 2910 are disclosed.Type: GrantFiled: November 22, 1985Date of Patent: September 22, 1987Assignee: Schering CorporationInventors: Gayda Hanna, Winston A. Vadino
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Patent number: 4657757Abstract: The invention relates to a controlled release dosage form comprising three actives: acetaminophen, pseudoephedrine sulfate and dexbrompheniramine maleate.Type: GrantFiled: December 4, 1985Date of Patent: April 14, 1987Assignee: Schering CorporationInventors: Gayda Hanna, Winston A. Vadino
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Patent number: 4601894Abstract: The invention relates to a controlled release dosage form comprising three actives: acetaminophen, psueudoephedrine sulfate and dexbrompheniramine maleate.Type: GrantFiled: March 29, 1985Date of Patent: July 22, 1986Assignee: Schering CorporationInventors: Gayda Hanna, Winston A. Vadino