Abstract: The disclosure discloses small molecule-nanobody conjugate inducers of proximity (SNACIP) and preparation methods and use thereof, and belongs to the technical field of cell regulation. Chemical inducers of proximity (CIPs) induce dimerization between proteins to regulate biological progresses. However, the CIP has the disadvantages of difficulties in directly regulating endogenous proteins without ligand binding sites, background activity interference of endogenous proteins, difficulties in use for drug development, etc. The SNACIP disclosed herein includes a nanobody targeting moiety, a small molecule binding motif, an intracellular delivery moiety and a linker. In the disclosure, a cRGT general inducer has the advantages of easy cell penetration, rapidity, reversibility, thorough regulation, and dose-dependence; a cRTC-type inducer can specifically regulate an intrinsically disordered protein in the cell; and a bivalent nanobody CTTC inducer is suitable for use in vivo.

Abstract: An electric unmanned aerial vehicle includes a position sensor configured to obtain first coordinate information of a present position of the electric unmanned aerial vehicle in real-time, a memory configured to store second coordinate information of a preset position of the electric unmanned aerial vehicle, and a controller in communication with the position sensor and the memory. The controller is configured to calculate, based on the first coordinate information and the second coordinate information, safety electricity amount information of the electric unmanned aerial vehicle; select, based on the safety electricity amount information and a present remaining electricity amount of the electric unmanned aerial vehicle, a safety protection command from a plurality of safety protection commands; and control the electric unmanned aerial vehicle to perform the selected safety protection command.

Abstract: Systems and methods are described to extract desired audio from an apparatus to be worn on a user's wrist. The apparatus includes a wrist wearable device, configured to be worn on the user's wrist. The wrist wearable device includes a first microphone. The first microphone has a first response pattern. The first microphone is coupled to the wrist wearable device. The first microphone is positioned on the wrist wearable device to receive a voice signal from a user when the wrist wearable device is on the user's wrist.

Abstract: The present disclosure describes various improved methods for imaging at least one target in a sample, including methods employing an adapter strand oligonucleotide and a bridge strand oligonucleotide. Some methods also employ bouncer oligonucleotides and/or blocker oligonucleotides. Some methods also use two partial docking strands to detect proximity of the partial docking strands to each other.

Abstract: A driving supporting apparatus comprising a first sensor that detects an object present outside of a vehicle based on a reflection of a radio wave that the first sensor radiates, a second sensor that detects a boundary structural object positioned at a boundary between a road area on which the vehicle can travel and an area other than the road area, and a control unit configured to perform a pre-crash control to avoid a collision between the vehicle and a recognized object that is the object detected by the first sensor. The control unit is configured to make a possibility that the pre-crash control is performed when a far-side position condition to be satisfied when the recognized object is located at a far side of the boundary structural object with respect to the vehicle is satisfied lower than when the far-side position condition is not satisfied.

Abstract: A method, computer program, and computer system are provided for load forecasting. Datasets corresponding to source machine learning models and a target domain base model are identified. A set of forecasting models corresponding to the identified datasets are learned. An ensemble model is determined from the learned set of forecasting models based on gradient boosting. An available resource is allocated based on the ensemble model.

Abstract: A tracking target position estimation unit and a tracking target search unit that searches for a tracking target are included. The tracking target search unit calculates one or more search routes connecting a current position of the mobile device and a position where the tracking target can exist, generates a search route list in which the calculated one or more search routes are arranged from the top in order of proximity to a tracking target estimated position, and selects a search route in order from the top of the generated search route list, and moves the mobile device according to the selected search route to search for the tracking target. It is determined whether or not the tracking target has been detected based on an image captured by a camera mounted on the mobile device, and in a case where the tracking target has been detected, tracking processing is resumed.

Abstract: The disclosure provides chemical compounds possessing therapeutic and/or protective properties against oxidative damage. Methods of making such therapeutic and/or protective compounds and associated compositions are also provided, as are methods for their use, which include protecting cells from oxidative damage and/or inhibiting production of ROS in a cell or subject, as well as preventing or reducing the extent of tissue damage caused by an ischemic event in a subject at elevated risk of such an event.

Abstract: A driver assistance device includes a one or more processors. The one or more processors is configured to determine whether a pedal misapplication determination condition is satisfied, and output, when the one or more processors determines that the pedal misapplication determination condition is satisfied, at least one of a warning display and warning audio directly instructing a driver to release the pedal that is depressed at a point in time of outputting.

Abstract: The present invention relates to a big data evaluation method and system. The method comprises steps of: determining evaluated data, reference data and different statistical indexes for data evaluation according to a preset experimental requirement; performing comparative calculation according to the evaluated data, the reference data and the statistical indexes to obtain corresponding numerical values of the statistical indexes; normalizing the numerical values of the statistical indexes to obtain normalized data; establishing a multi-dimensional spatial coordinate system according to the normalized data, and determining a distance value between the preset evaluation data and the reference data according to the multi-dimensional spatial coordinate system; and judging the comprehensive simulation capability of the evaluated data according to the distance value.

Abstract: A movement adjustment system based on heart rates and rating of perceived exertion (RPE) feedbacks of different users is provided, including: a user client, a heart rate monitoring device, a server, and a doctor client. The user client includes an RPE self-rating module, an RPE data acquisition module, a user-side video movement display module, and a user-side data storage module. The heart rate monitoring device includes an exercise data acquisition module. The server includes a data input module, a core processor, and a video movement library. The doctor client includes a doctor-side video movement display module, a video movement sending module, and a doctor-side data storage module. The above system according to the present disclosure adjusts, based on objective heart rate feedbacks during exercise and subjective RPE feedbacks after the exercise of different users, movements of next exercise of a patient.

Abstract: A movement adjustment system based on heart rates and rating of perceived exertion (RPE) feedbacks of different users is provided, including: a user client, a heart rate monitoring device, a server, and a doctor client. The user client includes an RPE self-rating module, an RPE data acquisition module, a user-side video movement display module, and a user-side data storage module. The heart rate monitoring device includes an exercise data acquisition module. The server includes a data input module, a core processor, and a video movement library. The doctor client includes a doctor-side video movement display module, a video movement sending module, and a doctor-side data storage module. The above system according to the present disclosure adjusts, based on objective heart rate feedbacks during exercise and subjective RPE feedbacks after the exercise of different users, movements of next exercise of a patient.

Abstract: An electronic apparatus includes: a first body including a first side and a second side arranged opposite to each other, and including a first input/output device disposed at the first side; a second body including a third side and a fourth side arranged opposite to each other, and including a second input/output device disposed at the third side; and a connector disposed at the first side and the fourth side. The second body rotates relative to the first body through the connector. During rotation of the second body, orientations of the first side and the third side substantially satisfy a same condition. The electronic apparatus includes a first attitude and a second attitude, which are switchable through the rotation of the second body. The second body does not block the first input/output device when the electronic apparatus is in the first attitude and the second attitude.

Abstract: An apparatus distributing communication load over a plurality of communication cells may select action centers from random cell reselection values, based on a standard deviation of an internet protocol (IP) throughout over the plurality of communication cells; input a first vector indicating a communication state of a communication system and a second vector indicating the standard deviation of the IP throughout of the plurality of communication cells, to a neural network to output a sum of the action centers and offsets as cell reselection parameters; and transmit the cell reselection parameters to the communication system to enable a base station of the communication system to perform a cell reselection based on the cell reselection parameters.

Abstract: Compounds are provided as chemokine inhibitors having the structure:

Abstract: A method for providing access to objects associated with a particular client in a cloud storage system is disclosed. The method includes the steps of establishing a connection with a user, providing a client namespace associated with the client to the user, where the client namespace represents objects stored on the cloud storage system and objects stored on a private storage system apart from the cloud storage system, receiving a request from the user to access an object stored on the private storage system, and providing information to the user to facilitate access to the object stored on the private storage system by said user. Other systems and methods are also disclosed. Important advantages of the present invention are facilitated by separating the logic for user access (control plane) from the actual storage (Storage plane). Private file system access can still be managed from the cloud, while keeping the client data private.

Abstract: Provided herein, in some aspects, are methods of imaging molecules without a microscope or other specialized equipment, referred to herein as “microscope-free imaging (MFI).” Herein, “molecular instruments” (e.g., DNA-based and protein-based molecules) are used, instead of microscopes, in a “bottom-up” approach for inspecting molecular targets.

Abstract: A computer-implemented technique performs machine learning that bypasses the traditional design of loss functions. The technique includes receiving plural instances of gradient objective information. Each of the plural instances includes a particular combination of plural gradient elements. The technique produces plural sets of machine-trained parameter values using the plural respective instances of gradient objective information. The technique performs this operation based on the plural instances of gradient objective information as given, without calculating the plural instances of gradient objective information using loss functions. The technique then measures performance of the plural sets of machine-trained parameter values in an application system. Based on the measured performance, the technique provides output information that identifies a particular set of machine-trained parameter values that satisfies a prescribed test.

Abstract: The present disclosure relates to an apparatus and method for automatically adjusting an exercise prescription based on an exercise heart rate. The apparatus includes: a heart rate detection device, configured to detect a resting heart rate and a user's real-time exercise heart rate; an exercise movement library, configured to store various exercise instruction video and audio, and provide movement guidance for the user; an exercise guidance module, configured to retrieve and display movement video and audio from the exercise movement library to the user; and a central processing unit (CPU), configured to acquire the resting heart rate and the user's real-time exercise heart rate, calculate an effective exercise target heart rate range based on the resting heart rate, determine whether the real-time exercise heart rate falls within the effective exercise target heart rate range.

Abstract: The present disclosure relates to an apparatus for differentially calculating target heart rates of different users, including: a user client, including a health data acquisition module, a medication data acquisition module, and a user-side target heart rate display module; a heart rate detection device, worn on a user and including an exercise test data acquisition module; a server, including a data input module and a core processor; and a doctor client, including a data sending module and a doctor-side target heart rate display module.