Patents by Inventor Xinhua Qian

Xinhua Qian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing tetrahydrocarbazole carboxamide compound
    Patent number: 11591314
    Abstract: Disclosed is a process for preparing Compound 8: comprising the step of reacting Compound of 7: wherein R is C1-8 alkyl or benzyl in the presence of a base. Also disclosed are intermediates and processes for preparing the intermediates.
    Type: Grant
    Filed: November 23, 2020
    Date of Patent: February 28, 2023
    Assignee: Bristol-Myers Squibb Company
    Inventors: Ronald Carrasquillo, Peng Geng, Eric C. Huang, Kishta Katipally, Andrew Lee, Boguslaw Mudryk, Xinhua Qian, Thomas M. Razler, Jianji Wang, Carolyn S. Wei, Steven R. Wisniewski, Ye Zhu
  • PROCESS FOR PREPARING TETRAHYDROCARBAZOLE CARBOXAMIDE COMPOUND
    Publication number: 20210078980
    Abstract: Disclosed is a process for preparing Compound 8: comprising the step of reacting Compound of 7: wherein R is C1-8 alkyl or benzyl in the presence of a base. Also disclosed are intermediates and processes for preparing the intermediates.
    Type: Application
    Filed: November 23, 2020
    Publication date: March 18, 2021
    Inventors: Ronald Carrasquillo, Peng Geng, Eric C. Huang, Kishta Katipally, Andrew Lee, Boguslaw Mudryk, Xinhua Qian, Thomas M. Razler, Jianji Wang, Carolyn S. Wei, Steven R. Wisniewski, Ye Zhu
  • Process for preparing tetrahydrocarbazole carboxamide compound
    Patent number: 10875843
    Abstract: Disclosed is a process for preparing Compound 8: (8) comprising the step of reacting Compound of 7: (7) wherein R is C1-8 alkyl or benzyl in the presence of a base. Also disclosed are intermediates and processes for preparing the intermediates.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: December 29, 2020
    Assignee: Bristol-Myers Squibb Company
    Inventors: Ronald Carrasquillo, Peng Geng, Eric C. Huang, Kishta Katipally, Andrew Lee, Boguslaw Mudryk, Xinhua Qian, Thomas M. Razler, Jianji Wang, Carolyn S. Wei, Steven R. Wisniewski, Ye Zhu
  • PROCESS FOR PREPARING TETRAHYDROCARBAZOLE CARBOXAMIDE COMPOUND
    Publication number: 20200109133
    Abstract: Disclosed is a process for preparing Compound 8: (8) comprising the step of reacting Compound of 7: (7) wherein R is C1-8 alkyl or benzyl in the presence of a base. Also disclosed are intermediates and processes for preparing the intermediates.
    Type: Application
    Filed: December 19, 2017
    Publication date: April 9, 2020
    Inventors: Ronald Carrasquillo, Peng Geng, Eric C. Huang, Kishta Katipally, Andrew Lee, Boguslaw M. Mudryk, Xinhua Qian, Thomas M. Razler, Jianji Wang, Carolyn S. Wei, Steven R. Wisniewski, Ye Zhu
  • Process for the preparation of 4-(8-(2-chlorophenoxy)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)bicyclo[2.2.1]heptan-1-ol and novel intermediates therefor
    Patent number: 9580420
    Abstract: A process is provided for preparing 4-(8-(2-chlorophenoxy)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)bicyclo[2.2.1]heptan-1-ol and novel intermediates used in the process. The compound is a 11-beta hydroxysteroid dehydrogenase type I inhibitor which exhibits activity in the treatment of various metabolic diseases.
    Type: Grant
    Filed: August 4, 2015
    Date of Patent: February 28, 2017
    Assignee: Bristol-Meyers Squibb Company
    Inventors: Xinhua Qian, Keming Zhu, Joerg Deerberg, Wendy Wangying Yang, Kana Yamamoto, Matthew R. Hickey
  • PROCESS FOR THE PREPARATION OF 4-(8-(2-CHLOROPHENOXY)-[1,2,4]TRIAZOLO[4,3-A]PYRIDIN-3-YL)BICYCLO[2.2.1]HEPTAN-1-OL AND NOVEL INTERMEDIATES THEREFOR
    Publication number: 20160039813
    Abstract: A process is provided for preparing 4-(8-(2-chlorophenoxy)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)bicyclo[2.2.1]heptan-1-ol and novel intermediates used in the process. The compound is a 11-beta hydroxysteroid dehydrogenase type I inhibitor which exhibits activity in the treatment of various metabolic diseases.
    Type: Application
    Filed: August 4, 2015
    Publication date: February 11, 2016
    Inventors: Xinhua Qian, Keming Zhu, Joerg Deerberg, Wendy Wangying Yang, Kana Yamamoto, Matthew R. Hickey
  • Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors
    Patent number: 8119658
    Abstract: Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrogenase type I inhibitor therapy. These novel compounds of formula I: or stereoisomers or pharmaceutically acceptable salts thereof, wherein G, Q, X, Y, R3, R3a, and R3b are defined herein.
    Type: Grant
    Filed: September 9, 2008
    Date of Patent: February 21, 2012
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jun Li, Jeffrey A. Robl, James J. Li, Lawrence J. Kennedy, Haixia Wang, Jie Jack Li, Xinhua Qian, Rajendra P. Deshpande, Laxma R. Kolla, Reginald O. Cann, Chenkou Wei, Michael Galella
  • Intermediates in the preparation of entecavir via carbon-silicon oxidation
    Patent number: 7968555
    Abstract: Processes for preparing entecavir and novel intermediates thereof using carbon-silicon oxidation.
    Type: Grant
    Filed: July 22, 2010
    Date of Patent: June 28, 2011
    Assignee: Bristol-Myers Squibb Company
    Inventors: Maotang X. Zhou, Emily A. Reiff, Purushotham Vemishetti, Yadagiri R. Pendri, Ambarish K. Singh, Siva Josyula Prasad, Ulhas P. Dhokte, Xinhua Qian, Pia Mountford, Kerry B. Hartung, Helen Sailes
  • Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein
    Patent number: 7968718
    Abstract: A process is provided for preparing triazole substituted azaindoleoxoacetic piperazine derivative. Novel intermediates produced in the above process, and novel N-1 and amorphous forms of a 1,2,3-triazole substituted azaindoloxoacetic piperazine derivatives and processes for producing such novel forms are also provided.
    Type: Grant
    Filed: August 27, 2009
    Date of Patent: June 28, 2011
    Assignee: Bristol-Myers Squibb Company
    Inventors: Nachimuthu Soundararajan, Yuping Qiu, Wenhao Hu, David R. Kronenthal, Pierre Sirard, Jean Lajeunesse, Robert Droghini, Ramakrishnan Chidambaram, Xinhua Qian, Kenneth J. Natalie, Shawn K. Pack, Nathan Reising, Erqing Tang, Michael G. Fakes, Qi Gao, Feng Qian, Blisse J. Vakkalagadda, Chiajen Lai, Shan-Ming Kuang
  • Process for the Preparation of Entecavir and Novel Intermediates Thereof Via Carbon-Silicon Oxidation
    Publication number: 20100286089
    Abstract: Processes for preparing entecavir and novel intermediates thereof using carbon-silicon oxidation.
    Type: Application
    Filed: July 22, 2010
    Publication date: November 11, 2010
    Inventors: Maotang X. Zhou, Emily A. Reiff, Purushotham Vemishetti, Yadagiri R. Pendri, Ambarish K. Singh, Siva Josyula Prasad, Ulhas P. Dhokte, Xinhua Qian, Pia Mountford, Kerry B. Hartung, Helen Sailes
  • Process for preparation of entecavir and novel intermediates thereof via carbon-silicon oxidation
    Patent number: 7786300
    Abstract: Processes for preparing entecavir and novel intermediates thereof using carbon-silicon oxidation.
    Type: Grant
    Filed: February 4, 2009
    Date of Patent: August 31, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: Maotang X. Zhou, Emily A. Reiff, Purushotham Vemishetti, Yadagiri R. Pendri, Ambarish K. Singh, Siva Josyula Prasad, Ulhas P. Dhokte, Xinhua Qian, Pia Mountford, Kerry B. Hartung, Helen Sailes
  • PROCESS FOR PREPARING TRIAZOLE SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES AND NOVEL SALT FORMS PRODUCED THEREIN
    Publication number: 20100076191
    Abstract: A process is provided for preparing triazole substituted azaindoleoxoacetic piperazine derivative. Novel intermediates produced in the above process, and novel N-1 and amorphous forms of a 1,2,3-triazole substituted azaindoloxoacetic piperazine derivatives and processes for producing such novel forms are also provided.
    Type: Application
    Filed: August 27, 2009
    Publication date: March 25, 2010
    Inventors: NACHIMUTHU SOUNDARARAJAN, Yuping Qiu, Wenhao Hu, David R. Kronenthal, Pierre Sirard, Jean Lajeunesse, Robert Droghini, Ramakrishnan Chidambaram, Xinhua Qian, Kenneth J. Natalie, Shawn K. Pack, Nathan Reising, Erqing Tang, Michael G. Fakes, Qi Gao, Feng Qian, Blisse J. Vakkalagadda, Chiajen Lai, Shan-Ming Kuang
  • Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein
    Patent number: 7601715
    Abstract: A process is provided for preparing triazole substituted azaindoleoxoacetic piperazine derivative. Novel intermediates produced in the above process, and novel N-1 and amorphous forms of a 1,2,3-triazole substituted azaindoloxoacetic piperazine derivatives and processes for producing such novel forms are also provided.
    Type: Grant
    Filed: June 19, 2006
    Date of Patent: October 13, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Nachimuthu Soundararajan, Yuping Qiu, Wenhao Hu, David R. Kronenthal, Pierre Sirard, Jean Lajeunesse, Robert Droghini, Ramakrishnan Chidambaram, Xinhua Qian, Kenneth J. Natalie, Shawn K. Pack, Nathan Reising, Erqing Tang, Michael G. Fakes, Qi Gao, Feng Qian, Blisse J. Vakkalagadda, Chiajen Lai, Shan-Ming Kuang
  • Process for Preparation of Entecavir and Novel Intermediates Thereof Via Carbon-Silicon Oxidation
    Publication number: 20090143578
    Abstract: Processes for preparing entecavir and novel intermediates thereof using carbon-silicon oxidation.
    Type: Application
    Filed: February 4, 2009
    Publication date: June 4, 2009
    Inventors: Maotang X. Zhou, Emily A. Reiff, Purushotham Vemishetti, Yadagiri R. Pendri, Ambarish K. Singh, Siva Josyula Prasad, Ulhas P. Dhokte, Xinhua Qian, Pia Mountford, Kerry B. Hartung, Helen Sailes
  • TRIAZOLOPYRIDINE 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS
    Publication number: 20090093516
    Abstract: Novel compounds are provided which are 11 -beta-hydroxysteroid dehydrogenase type I inhibitors. 11-beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrogenase type I inhibitor therapy. These novel compounds of formula I: or stereoisomers or pharmaceutically acceptable salts thereof, wherein G, Q, X, Y, R3, R3a, and R3b are defined herein.
    Type: Application
    Filed: September 9, 2008
    Publication date: April 9, 2009
    Inventors: Jun Li, Jeffrey A. Robl, James J. Li, Lawrence J. Kennedy, Haixia Wang, Jie Jack Li, Xinhua Qian, Rajendra P. Deshpande, Laxma R. Kolla, Reginald O. Cann, Chenkou Wei, Michael Galella
  • Process for the preparation of entecavir and novel intermediates thereof via carbon-silicon oxidation
    Patent number: 7511139
    Abstract: Processes for preparing entecavir and novel intermediates thereof using carbon-silicon oxidation.
    Type: Grant
    Filed: June 2, 2005
    Date of Patent: March 31, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Maotang X. Zhou, Emily A. Reiff, Purushotham Vemishetti, Yadagiri R. Pendri, Ambarish K. Singh, Siva Josyula Prasad, Ulhas P. Dhokte, Xinhua Qian, Pia Mountford, Kerry B. Hartung, Helen Sailes
  • SUBSTITUTED ACID DERIVATIVES USEFUL AS ANTIDIABETIC AND ANTIOBESITY AGENTS AND METHOD
    Publication number: 20080009534
    Abstract: Compounds are provided which have the structure of Formula (I): wherein R is hydrogen or C1-C4 alkyl; and each of R1 and R2 is independently hydrogen, C1-C4 alkyl, halo or C1-C4 alkoxy, and salts thereof, which compounds are useful as antidiabetic, hypolipidemic, and antiobesity agents.
    Type: Application
    Filed: July 5, 2007
    Publication date: January 10, 2008
    Inventors: Peter Cheng, Sean Chen, Xinhua Qian, Rajendra Deshpande, Erqing Tang
  • Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein
    Publication number: 20060293304
    Abstract: A process is provided for preparing triazole substituted azaindoleoxoacetic piperazine derivative. Novel intermediates produced in the above process, and novel N-1 and amorphous forms of a 1,2,3-triazole substituted azaindoloxoacetic piperazine derivatives and processes for producing such novel forms are also provided.
    Type: Application
    Filed: June 19, 2006
    Publication date: December 28, 2006
    Inventors: Nachimuthu Soundararajan, Yuping Qiu, Wenhao Hu, David Kronenthal, Pierre Sirard, Jean Lajeunesse, Robert Droghini, Ramakrishnan Chidambaram, Xinhua Qian, Kenneth Natalie, Shawn Pack, Nathan Reising, Erqing Tang, Michael Fakes, Qi Gao, Feng Qian, Blisse Vakkalagadda, Chiajen Lai, Shan-Ming Kuang
  • Process for the preparation of entecavir and novel intermediates thereof via carbon-silicon oxidation
    Publication number: 20050272932
    Abstract: Processes for preparing entecavir and novel intermediates thereof using carbon-silicon oxidation.
    Type: Application
    Filed: June 2, 2005
    Publication date: December 8, 2005
    Inventors: Maotang Zhou, Emily Reiff, Purushotham Vemishetti, Yadagiri Pendri, Ambarish Singh, Siva Prasad, Ulhas Dhokte, Xinhua Qian, Pia Mountford, Kerry Hartung, Helen Sailes
  • Process for preparing chiral diol sulfones and dihydroxy acid HMG CoA reductase inhibitors
    Publication number: 20050124641
    Abstract: A process is provided for preparing chiral diol sulfones of the structure where R3 is preferably where R4a is preferably aryl such as phenyl, and R1a is preferably alkyl such as t-butyl, which are intermediates used in preparing HMG CoA reductase inhibitors.
    Type: Application
    Filed: January 20, 2005
    Publication date: June 9, 2005
    Inventors: Paul Brodfuehrer, Thomas Sattleberg, Joydeep Kant, Xinhua Qian