Abstract: A glucocerebroside compound, a pharmaceutical composition thereof, and the use of the glucocerebroside compound and the pharmaceutical composition thereof in the preparation of drugs for preventing or treating immune-related diseases.

Abstract: Provided are a series of crocins compounds and related pharmacological applications thereof in prevention and treatment of Alzheimer's disease. The series of crocins compounds are obtained by taking the Chinese herb, namely Gardenia jasminoides Ellis, as a raw material and separating same by means of various methods. The compounds playing a role in preventing oxidative injury caused by hydrogen peroxide (H2O2) and excitatory amino acid injury caused by L-glutamic acid are screened out by in-vitro cell experiments. The results show that the crocins compounds have good effect in preventing cell injury caused by H2O2 and L-glutamic acid. The compounds have good effect in preventing and treating Alzheimer's disease due to the fact that significant rise of oxidative stress and excitatory amino acid is a key factor for nerve injury in Alzheimer's disease, and have broad development and application prospect.

Abstract: The present invention relates to dicaffeoyl spermidine derivative glycosides, a preparation method and a use thereof. The biological activity experiments show that the dicaffeoyl spermidine derivative glycosides of the present invention have anti-oxidative activity and antiviral activity, and their activity are even better than that of a positive control drug, thus can be used as an antioxidant for the prevention and/or treatment of neurodegenerative diseases such as Senile dementia, and as an antiviral agent for the prevention and/or treatment of viral infections.

Abstract: A composition, and a crocins active site extracted from Gardenia jasminoides Ellis, mainly comprising the following ingredients: crocetin di-?-D-gentiobioside, crocetin-?-D-glucopyranosyl-?-D-gentiobioside, crocetin di-?-D-glucopyranoside, 13Z-crocetin di-?-D-gentiobioside, neocrocin B, crocetin mono-?-D-gentiobioside, 13Z-crocetin-8-O-?-D-gentiobioside, 13Z-crocetin-8?-O-?-D-gentiobioside, and crocetin mono-?-D-glucopyranoside. Pharmacological experiment results show that the crocins active site can effectively improve learning and memory injuries in mice induced by scopolamine and amyloid ? protein.

Abstract: The present invention relates to dicaffeoyl spermidine cyclized derivatives and a preparation method and use thereof. Biological activity experiments show that the dicaffeoyl spermidine cyclized derivatives of the present invention have anti-Senile dementia activity and antioxidant activity, and their activity are even better than that of a positive control drug, thus suitable for the prevention and treatment of neurodegenerative diseases such as Senile dementia.

Abstract: The present invention relates to dicaffeoyl spermidine derivative glycosides, a preparation method and a use thereof. The biological activity experiments show that the dicaffeoyl spermidine derivative glycosides of the present invention have anti-oxidative activity and antiviral activity, and their activity are even better than that of a positive control drug, thus can be used as an antioxidant for the prevention and/or treatment of neurodegenerative diseases such as Senile dementia, and as an antiviral agent for the prevention and/or treatment of viral infections.

Abstract: Provided are a series of crocins compounds and related pharmacological applications thereof in prevention and treatment of Alzheimer's disease. The series of crocins compounds are obtained by taking the Chinese herb, namely Gardenia jasminoides Ellis, as a raw material and separating same by means of various methods. The compounds playing a role in preventing oxidative injury caused by hydrogen peroxide (H2O2) and excitatory amino acid injury caused by L-glutamic acid are screened out by in-vitro cell experiments. The results show that the crocins compounds have good effect in preventing cell injury caused by H2O2 and L-glutamic acid. The compounds have good effect in preventing and treating Alzheimer's disease due to the fact that significant rise of oxidative stress and excitatory amino acid is a key factor for nerve injury in Alzheimer's disease, and have broad development and application prospect.

Abstract: A composition, and a crocins active site extracted from Gardenia jasminoides Ellis, mainly comprising the following ingredients: crocetin di-?-D-gentiobioside, crocetin-?-D-glucopyranosyl-?-D-gentiobioside, crocetin di-?-D-glucopyranoside, 13Z-crocetin di-?-D-gentiobioside, neocrocin B, crocetin mono-?-D-gentiobioside, 13Z-crocetin-8-O-?-D-gentiobioside, 13Z-crocetin-8?-O-?-D-gentiobioside, and crocetin mono-?-D-glucopyranoside. Pharmacological experiment results show that the crocins active site can effectively improve learning and memory injuries in mice induced by scopolamine and amyloid ? protein.

Abstract: The present invention relates to dicaffeoyl spermidine cyclized derivatives and a preparation method and use thereof. Biological activity experiments show that the dicaffeoyl spermidine cyclized derivatives of the present invention have anti-Senile dementia activity and antioxidant activity, and their activity are even better than that of a positive control drug, thus suitable for the prevention and treatment of neurodegenerative diseases such as Senile dementia.

Abstract: The present invention relates to a steroidal saponins compound, and the preparation and application in curing cardiovascular diseases, such as miocardial infarction, etc. The chemical structure of the steroidal saponins compound is as (I) or (II): wherein, R1=?-D-glucose; R2=straight or bifurcate sugar chains; R3?H or CH3. In this invention, by various ways of separation, the steroidal saponins compound with chemical structure of (I) or (II) could be extracted, synthesized or semi-synthesized process from traditional Chinese medicine and natural products. Oral dosage drug or non-oral dosage drug was produced by the single steroidal saponins compound or the mixture of these compounds in vary ratio, the drug can be used to prevention and cure the diseases miocardial infarction, coronary artery disease, heart angina, arrhythmia, blood losing of cardiac muscle, hypertension, hyperlipaemia and ropy blood, etc.

Abstract: The present invention provides a novel diterpene compounds with antineoplastic activities. The novel diterpene compounds of the present invention are represented by the general formula (I). R1 to R6 in the formula represent an aliphatic group, or a radical represented by the general formula RCO—, wherein R represents an aliphatic, an aromatic or a heteroaromatic group. The compounds of the present invention may be prepared by extracting roots of Euphorbia kansui L. with an organic solvent such as chloroform, ethyl acetate and butanol. These extracted compounds may be used as starting materials for the preparation of the compounds represented by the general formula (I). The compounds of the present invention have antineoplastic activities, and therefore, useful as antineoplastic agents.

Abstract: The present invention provides a novel diterpene compounds with antineoplastic activities. The novel diterpene compounds of the present invention are represented by the general formula (I). R1 to R6 in the formula represent an aliphatic group, or a radical represented by the general formula RCO—, wherein R represents an aliphatic, an aromatic or a heteroaromatic group. The compounds of the present invention may be prepared by extracting roots of Euphorbia kansui L. with an organic solvent such as chloroform, ethyl acetate and butanol. These extracted compounds may be used as starting materials for the preparation of the compounds represented by the general formula (I). The compounds of the present invention have antineoplastic activities, and therefore, useful as antineoplastic agents.