Abstract: The present invention provides compounds of Formula (Ia): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.

Abstract: The present invention relates to a method for preparing a bone graft substitute using bovine bone, and more particularly to a method for preparing a safe bone graft substitute which does not have the risk of infection with bovine spongiform encephalopathy, the method comprising treating bovine bone with sodium hypochlorite and treating the treated bone at a high temperature of more than 600° C. The bone graft substitute does not cause an immune response, because it is prepared by effectively removing lipids and organic substances from bovine bone having a structure very similar to that of the human bone. Also, it has excellent osteoconductivity, and is free of prion, and thus it does not have the risk of infection with bovine spongiform encephalopathy. According to the disclosed invention, the bone graft substitute having such advantages can be prepared in a simple manner.

Abstract: A radio frequency (RF) receiver and a method of receiving an RF signal are provided. The RF receiver includes a low-noise amplifying unit which amplifies a received signal while restricting out-of-band interference of the received signal, a sampling unit which performs sampling to convert the amplified signal to a discrete time domain signal, a frequency translation unit which down-converts the discrete time domain signal into a frequency band that enables the discrete time domain signal to be converted into a digital signal and restricts interference from a frequency within an aliasing band according to a sampling frequency, an anti-aliasing filtering unit which prevents aliasing from the down-converted signal, a clock unit which provides the sampling unit, the frequency translation unit, and the anti-aliasing filtering unit with sampling frequencies, and an analog-digital-converter which converts the converted signal into the digital signal.

Abstract: A discrete time filter includes a plurality of sampling cells and a first dummy sampling cell. Each of the sampling cells performs a current mode sampling operation based on current input to an input terminal in response to a corresponding one of a plurality of sampling clock signals and is reset in response to a corresponding one of the plurality of sampling clock signals and a first dummy sampling clocks. The first dummy sampling cell alternately performs with the first sampling cell the current mode sampling operation based on current input to the input terminal in response to the first dummy sampling clock signal and is alternately reset with the first sampling cell in response to the first sampling clock signal.

Abstract: A compound of formula I wherein R1, R2, R3, R4 and R5 are described herein.

Abstract: A compound of formula I wherein R1, R2, R3, R4 and R5 are described herein.

Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective Factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.

Abstract: A variable inductor is provided, which includes a first lead having both ends to receive a pair of difference signals, a second lead having both ends to receive a pair of the difference signals, and a switch selectively supplying a pair of the difference signals to the second lead by turning on/off according to a control signal. Accordingly, a variable inductor can be implemented that is compact and maximizes the variation rate of inductance.