Abstract: The present invention provides compounds of Formula I: or pharmaceutically acceptable salts thereof, as well as their compositions and methods of use, that inhibit the activity of Janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.

Abstract: Detecting fine-grained similarity in image includes determining a core area of a search image by generating an image salient map from a plurality of layers of the search image and determining a connected area based on the image salient map. Feature descriptors are generated from the core area of the search image. A plurality of capsule vectors are generated from different ones of a plurality of keypoints of the feature descriptors. Capsule vectors of the search image are compared with capsule vectors of each image of the dataset to generate a top-K matrix. Similarity scores for the top-K matrix are calculated. One or more image of the dataset having fine-grained similarity with the search image are selected based a bundled similarity score for each image of the dataset. The bundled similarity score is a summation of the similarity scores of the image.

Abstract: This application relates to compounds of Formula I: or pharmaceutically acceptable salts thereof, which are inhibitors of TAM kinases which are useful for the treatment of disorders such as cancer.

Abstract: One or more systems, devices, computer program products and/or computer-implemented methods of use provided herein relate to detecting a closed ring in a three-dimensional (3D) point cloud via cycle basis. A system can comprise a memory configured to store computer executable components; and a processor configured to execute the computer executable components stored in the memory, wherein the computer executable components can comprise a filtering component that can filter a first undirected graph of a three-dimensional (3D) point cloud, by eliminating one or more edges of the first undirected graph that are longer than an adaptive threshold, wherein filtering the first undirected graph can produce a second undirected graph; and a detection component that can detect a minimum cycle basis of the second undirected graph to determine a cycle path that can traverse an irregular annular shape that is represented by the 3D point cloud.

Abstract: The invention provides a bacterial cellulose-based biosensor, including bacterial cellulose (BC) and a cell presenting a cellulose-binding module CBM2a on the surface. The cell is attached to BC through CBM2a. The cell expresses CBM2a by using pETDuet-tac as a vector. The pETDuet-tac is obtained by replacing two T7 promoters on the vector pETDuet by tac promoters, that is, an upstream first tac promoter and a downstream second tac promoter. The pETDuet-tac includes a gene encoding a fluorescent protein downstream of the first tac promoter and a gene encoding CBM2a presented on the surface downstream of the second tac promoter. By the BC-based biosensor, efficient and specific immobilization of cells on the BC matrix is enabled, the biological activity of cells is maintained, the fluorescence signal output is enhanced, and sufficient pores are provided for the entry and exit of a detected substance, thereby significantly improving the detection sensitivity.

Abstract: Provided is an anesthetic composition for locally administering a local anesthetic agent to a subject in need thereof. The anesthetic composition has a lipid based complex prepared by hydrating a lipid cake containing a local anesthetic agent and a lipid mixture with an aqueous buffer solution at a pH higher than 5.5. Also provided is a method to prepare an anesthetic composition using a simpler and more robust for large-scale manufacture and for providing a high molar ratio of local anesthetic agent to phospholipid content as compared to the prior art. This anesthetic composition has a prolonged duration of efficacy adapted to drug delivery.

Abstract: Embodiments of the disclosure provide an information processing method, an information processing apparatus, and a storage medium. The method includes: obtaining source data; encoding sub-data in the source data based on a target word feature vector to obtain hidden feature vectors corresponding to the sub-data, the target word feature vector representing a sentiment feature standard; obtaining a word feature vector corresponding to the source data based on the hidden feature vectors corresponding to the sub-data; and inputting the word feature vector into a preset sentiment classification network to obtain a result of sentiment polarity prediction of the source data. According to the embodiments of the disclosure, the accuracy of sentiment polarity prediction may be improved.

Abstract: A method for capturing a sound source includes: capturing a space where a microphone array is located to generate an image by a camera, wherein the microphone array is configured to receive a sound generated by the sound source and generate a sound source coordinate of the sound source relative to the microphone array; searching for a sub-image belonging to the microphone array within the images by a computing device connected to the camera; calculating a microphone coordinate of the microphone array relative to the camera by the computing device according to the sub-image; calculating a required control parameter by the computing device at least according to the sound source coordinate and the microphone coordinate; adjusting a capturing direction by the camera to capture the sound source at least according to the required control parameter.

Abstract: An elongate fuel element is described that has a silicon carbide cladding enclosing a fuel, such as UO2, wherein the fuel is dimensioned relative to the cladding to define gaps at each lateral end of the enclosure sufficiently large such that upon swelling in use, the fuel does not increase the strain on the cladding beyond the limits of the claddings strain tolerance. The lateral gaps at the ends of the fuel allow lateral expansion during swelling that reduces the strain on the cladding.

Abstract: The present invention relates to an aqueous lubricant composition for lubricating moving parts in a mechanical system, comprising at least water, glycerol; and hypericin. It also relates to the use of this aqueous lubricant composition for lubricating moving parts in a mechanical system, in particular in a vehicle propulsion system.

Abstract: The present invention provides compounds of Formula I: or pharmaceutically acceptable salts thereof, as well as their compositions and methods of use, that inhibit the activity of Janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.

Abstract: The present invention provides tricyclic fused thiophene derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.

Abstract: A food processing apparatus is provided that includes: a housing structure, a food container structure which is disposed in the housing structure, and an image capturing module, which is located on the food container structure and includes a shell, an image capturing assembly and an air curtain assembly. The shell includes an optical channel which includes a lower opening end, an upper opening end and a wall surface disposed between the lower opening end and the upper opening end. The lower opening end faces the food container structure, the image capturing assembly is disposed at the upper opening end, and the air curtain assembly is disposed on the wall surface. In this way, the air curtain assembly can blow away or block the oil fumes after the food is heated, so that the image capturing module can observe the food processing clearly without being affected by the oil fumes.

Abstract: A cloud-edge collaborative processing system includes: an edge computing system, an ICU diagnosis and treatment device, a service terminal device, and a cloud platform. The edge computing system collects multi-source heterogeneous medical data output from the ICU diagnosis and treatment devices and performs preprocessing, stores preprocessed data into an edge database, and connects to the cloud platform for data transmission and business interaction. The cloud platform connects to a plurality of edge computing systems to perform computation and processing of massive data. The medical-staff handheld terminals and the data terminals of wards are used to issue service instructions to the cloud platform to obtain the required third-party-business services.

Abstract: The present invention provides heterocyclylamine derivatives of Formula I: wherein the variables are defined herein, that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.

Abstract: Disclosed are a method and system for generating a data analysis report of a multi-parameter monitoring device. The method includes: receiving, by an application server, multi-parameter data transmitted in real time by the multi-parameter monitoring device, and storing the received multi-parameter data in a database server; the application server receiving a report generation instruction transmitted by a client, the instruction including a client identifier used for indicating a permission of the client; if the permission is a first mode permission, transmitting the multi-parameter data to the client, to allow the client to process the multi-parameter data, so as to generate a multi-parameter analysis report and a report attachment; and if the permission is a second mode permission, the application server processing the multi-parameter data to generate the multi-parameter analysis report and the report attachment, and transmitting the multi-parameter analysis report and the report attachment to the client.

Abstract: An automatic scoring method, performed by a processing device, includes: obtaining a current test paper image, wherein a hand-writing script on the current test paper image has a script color; determining whether the script color is a designated color; determining whether a database stores a reference text string if the script color is not the designated color; aligning the current test paper image with a reference test paper image corresponding to the reference text string and using reference coordinates to compare the current test paper image with the current test paper image to output a test score when the database stores the reference text string; and identifying the hand-writing script to store an identification result as the reference text string and storing position coordinates of the hand-writing script on the current test paper image as the reference coordinates if the script color is the designated color.

Abstract: The present invention provides methods of treating arthritis. A sustained release composition comprising liposomes and one or more therapeutic agent or a pharmaceutically acceptable salt thereof is administered to a subject in need thereof. The liposomes may be in an aqueous suspension. The sustained release composition can be administered intraarticularly.

Abstract: A system for monitoring a helium compressor and a magnetic resonance imaging device may include photoelectric converter configured to monitor a status current of a helium compressor; a dry contact signal converter having a dry contact switch and a signal converter. The dry contact switch may include a first pair of switch contacts connected to an output of the photoelectric converter and a second pair of switch contacts connected to an output voltage of the helium compressor. The signal converter may be configured to collect an action signal of the dry contact switch, and convert corresponding fault information into a network signal and send the same to a network server. Personnel may be notified of the fault information in a preset communication mode using a preset communication address.

Abstract: Provided herein are benzimidazole derivatives, for example, of Formula I, and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a proliferative disease.