Process for producing 5,6-dihydro-1,3-oxazines
There has been found a new process for the preparation of 5,6-dihydro-1,3-oxazines, some of which are known, of the formula (I) ##STR1## in which A represents substituted phenyl, or represents in each case optionally substituted naphthyl, pyridyl, thienyl or pyrazolyl, andB represents hydrogen, alkyl, alkoxyalkyl, alkylthioalkyl, halogenoalkyl, alkenyl, optionally substituted cycloalkyl, or in each case optionally substituted phenyl, phenylalkyl, phenylalkenyl, phenoxyalkyl, phenylthioalkyl, pyridyl or 2- or 3-pyrrolylby reacting amide derivatives of the formula (II) ##STR2## with ethylene in the presence of hydrogen chloride gas and of a catalyst. The new 5,6-dihydro-1,3-oxazines can be used for combatting animal pests.
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Claims
1. Process for the preparation of compounds of the formula (I) ##STR334## in which A represents substituted phenyl, or represents in each case optionally substituted naphthyl, pyridyl, thienyl or pyrazolyl, and
- B represents hydrogen, alkyl, alkoxyalkyl, alkylthioalkyl, halogenoalkyl, alkenyl, optionally substituted cycloalkyl, or in each case optionally substituted phenyl, phenylalkyl, phenylalkenyl, phenoxyalkyl, phenylthioalkyl, pyridyl or 2- or 3-pyrrolyl
- R.sup.1 and R.sup.2 are identical or different and in each case represent alkyl, or together with the N atom to which they are bonded represent an optionally substituted heterocycle
| 5538967 | July 23, 1996 | Long et al. |
| 394850 | October 1990 | EPX |
| 1545671 | August 1969 | DEX |
| 1670475 | January 1971 | DEX |
| 2049160 | April 1972 | DEX |
| 93/2296 | November 1993 | WOX |
| WO 94/14783 | July 1994 | WOX |
- Schmidt et al., Agnew. Chem., 77, 5, 1965, 218 pp. W. Seeliger et al., Liebigs Annalen, 697, 1966, 171pp. Schmidt et al., Agnew. Chem., 81, 15, 1969, 576pp. Schmidt et al., Chem. Ber. 103, 1970, 3242pp. Giordano et al., Synthesis, 1971, 92pp. Giordano et al., Synthesis, 1972, 34pp. Giordano et al., JCS Perkin Trans. I, 1973, 771pp. Foglia et al., J. of the Am. Oil Chemists Soc., 50, 1973, p. 9/10. Giordano et al., Gazz. Chim. Ital., 104, 1974, 181pp. Zaugg et al., Synthesis, 1984, 85pp. Zaugg et al., Synthesis, 1984, 1181pp. Hans Bundgaard et al., Int. J. of Pharmaceuttics. 22, 1984, 44pp. Katritzky et al., Tetr. 49, 19, 1993, 3907pp.
Type: Grant
Filed: Nov 14, 1997
Date of Patent: Apr 6, 1999
Assignee: Bayer Aktiengesellschaft (Leverkusen)
Inventor: Bernd Alig (Konigswinter)
Primary Examiner: Richard L. Raymond
Law Firm: Sprung Kramer Schaefer & Briscoe
Application Number: 8/930,051
International Classification: C07D26508; C07D295125;
