Abstract: This invention provides a simple method for preparing granular ibuprofen microsphere whose surface is coated with acrylic acid resin. By this method granulation of ibuprofen and coating of its surface can be simultaneously accomplished. Namely, the method of preparation includes the steps of: (a) dissolving ibuprofen with acrylic acid resin into lower aliphatic alcohol, acetone, methylene chloride or N,N-dimethylformamide; and (b) depositing coated granular ibuprofen microsphere by mixing the solution of step (a) with water and by stirring the mixed solution.

Abstract: This invention relates to a self-microencapsulating pesticidal composition consisting essentially of a solution of a polymeric barrier material in an organic solvent system, a dissolved or dispersed pesticidal agent and a surfactant.

Abstract: A controlled absorption diltiazem formulation for oral administration comprises a pellet having a core of diltiazem or a pharmaceutically acceptable salt thereof in association with an organic acid and a lubricant, and an outer membrane which permits release of diltiazem in an aqueous medium at a controlled rate which is substantially pH independent. The pellet has a dissolution rate in vitro, which when measured according to the Paddle Method of U.S. Pharmacopoeia XX, is not more than 10% of the total diltiazem after 2 hours of measurement in a buffered medium. Not more than 30% of the total diltiazem is released after a total of 4 hours measurement and not more than 40% of the total diltiazem is released after a total of 6 hours. 100% release is achieved after 12 hours, with a maximum of 80% of the total diltiazem being released after 8 hours.

Abstract: Disclosed are coatings for protecting pellet cores from environmental conditions of predetermined pH conditions. The coatings have a pH sensitive portion and a pH insensitive portion. The pH sensitive portion allows the cores to be protected by the coating under certain pH conditions and disintegrates under other pH conditions to allow exposure of the cores.

Abstract: A controlled absorption methyldopa formulation for oral administration comprises a pellet having a core of methyldopa or a pharmaceutically acceptable salt thereof in association with an organic acid, and an outer membrane which permits release of methyldopa in an aqueous medium at a controlled rate which is substantially pH independent. The pellet has a dissolution rate in vitro, which when measured in a Basket Assembly according to U.S. Pharmacopoeia XX at 37.degree. C. and 75 r.p.m., is not more than 50% of the total methyldopa after one hour of measurement. Not more than 80% of the total methyldopa is released after a total of 3 hours of measurement and 100% release is achieved after a total of 7 hours.

Abstract: Highly potent long-acting formulation of cefaclor for treating bacterial infections in human or animals, comprising a rapid-release and a slow-release component at a ratio of about 3:7 to about 5:5 by potency of cefaclor, convenient for administration or carrying about.

Abstract: A stable emulsion of microcapsules is obtained by polymerizing at least one water-soluble vinyl monomer in an aqueous solution of an oil-soluble vinyl monomer-maleic anhydride-maleic ester multipolymer to prepare a water-soluble resin, dispersing or emulsifying discrete fine particles of a hydrophobic material in an acidic aqueous solution of the water-soluble resin, adding an amino resin precursor separately prepared to the dispersion or emulsion, and heating the mixture.

Abstract: A process for producing a microcapsule containing a liquid active material is described, comprising the steps of:(1) dissolving in an organic solvent a polymer, esp. a polysulfone and an active material which has a limited solubility of about 0.01 to about 2 parts by weight in 100 parts by weight of said polymer and which is liquid at room temperature, the amount of said liquid active material added being more than the limited solubility and being about 2 to about 250 parts by weight per 100 parts by weight of the polymer and said organic solvent being capable of dissolving the respective components and being more volatile than said active material;(2) atomizing the resulting solution through a nozzle into a gaseous atmosphere to form a mist of tiny liquid droplets; and(3) removing the solvent from the droplets by evaporation so as to provide a microcapsule having the liquid active material confined by the wall of said microcapsule made of the polymer.

Abstract: This invention concerns novel sustained release microcapsule compositions comprising water-soluble, hormonally active polypeptides and, optionally, a polymer hydrolysis modifying agent encapsulated in a biocompatible, biodegradable polymer.