Containing Solid Synthetic Polymers Patents (Class 424/497)
-
Patent number: 10022373Abstract: The present invention relates to a pharmaceutical composition comprising posaconazole and a carrier material, wherein the carrier material comprises a vinylpyrrolidone-vinyl acetate copolymer or a polymer containing ethylene glycol units. The present invention also relates to a method for the preparation of the pharmaceutical composition, a method for the prevention and/or treatment of fungal infections and related diseases in a mammal using the pharmaceutical composition, and a pharmaceutical formulation comprising the pharmaceutical composition.Type: GrantFiled: April 10, 2015Date of Patent: July 17, 2018Assignee: SINOTHERAPEUTICS INC.Inventors: Jiansheng Wan, Kun Li, Xiaoxi Sheng
-
Patent number: 10000447Abstract: Here described are compounds consisting of the structure (targeting molecule)m-linker-(targeting molecule)n, wherein the targeting molecule is a retinoid or a fat soluble vitamin having a specific receptor on the target cell; wherein m and n are independently 0, 1, 2 or 3; and wherein the linker comprises a polyethylene glycol (PEG) or PEG-like molecule, as well as compositions and pharmaceutical formulations including these compounds which are useful for the targeting and delivery of therapeutic agents; and methods of using these compositions and pharmaceutical formulations.Type: GrantFiled: June 8, 2016Date of Patent: June 19, 2018Assignee: Nitto Denko CorporationInventors: Yoshiro Niitsu, Joseph E. Payne, John A. Gaudette, Zheng Hou, Victor Knopov, Richard P. Witte, Mohammad Ahmadian, Loren A. Perelman, Yasunobu Tanaka, Violetta Akopian
-
Patent number: 9988517Abstract: Microsphere compositions containing a mixture of at least two materials with same or differing phases are described. The materials have differing optical dispersion curves that intersect at at least one particular wavelength exhibiting the Christiansen effect. The materials may be encompassed by a microsphere, which may also include a separation entity.Type: GrantFiled: June 5, 2012Date of Patent: June 5, 2018Assignee: EMPIRE TECHNOLOGY DEVELOPMENT LLCInventors: Sung-Wei Chen, Christopher J. Rothfuss
-
Patent number: 9982090Abstract: The present invention relates to a method for manufacturing polydioxanone particles (PDO) for a filler, more particularly to a method for manufacturing polydioxanone particles, which includes a step of mixing a solution of polydioxanone dissolved in a perfluoroalcohol with a polymer emulsion containing a polyethylene oxide-polypropylene oxide-polyethylene oxide terpolymer at a predetermined ratio to generate polydioxanone particles and then recovering the polydioxanone particles through aging and washing. The polydioxanone particles manufactured by the manufacturing method of the present invention can be favorably used as an injection for regenerating skin tissues.Type: GrantFiled: July 16, 2015Date of Patent: May 29, 2018Assignee: ULTRA V CO., LTD.Inventors: Myung Choi, Sang Jin Kim, Byeung Mo Chang, Michael Gilbert Douglas, Han Jin Kwon
-
Patent number: 9925212Abstract: The present invention generally relates to methods of treating hypertension (HTN) in patients in need thereof wherein the patient optionally further suffers from chronic kidney disease (CKD) or Type II diabetes mellitus (T2DM). The invention also relates to methods of treating hyperkalemia in a patient in need thereof, wherein the patient suffers from CKD, T2DM or HTN and are optionally being treated with an effective amount of a renin-angiotensin-aldosterone system (RAAS) agent. The invention also relates to methods of treating kidney disease in a patient in need thereof, wherein the patient is optionally being treated with an effective amount of a renin-angiotensin-aldosterone system (RAAS) agent. The methods can comprise administering an effective amount of a potassium-binding agent to the patient to lower the patient's blood pressure and/or increase or stabilize the patient's kidney function.Type: GrantFiled: October 6, 2016Date of Patent: March 27, 2018Assignee: Relypsa, Inc.Inventors: Gerrit Klaerner, Lance Berman
-
Patent number: 9907977Abstract: The present disclosure relates to the cross-linking of eye tissue. Embodiments of the disclosure relate to the activation of a photosensitizer and/or nanoparticles for the cross-linking of eye tissue.Type: GrantFiled: May 13, 2015Date of Patent: March 6, 2018Assignee: Novartis AGInventor: Katrin Skerl
-
Patent number: 9849128Abstract: Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.Type: GrantFiled: March 10, 2017Date of Patent: December 26, 2017Assignees: Unity Biotechnology, Inc., Buck Institute for Research on Aging, Mayo Foundation for Medical Education and Research, The John Hopkins UniversityInventors: Remi-Martin Laberge, Judith Campisi, Albert Davalos, Marco Demaria, Nathaniel David, Alain Philippe Vasserot, James L. Kirkland, Tamar Tchkonia, Yi Zhu, Jennifer Elisseeff, Chaekyu Kim, Okhee Jeon
-
Patent number: 9802165Abstract: This invention relates to bubble generation, in particular to microbubble generation in a microfluidic device, which bubbles may be useful as contrasting agents or drug delivery vehicles. The invention further relates to apparatuses, systems and methods for manufacturing said microbubbles, microbubbles produced by such methods and to their uses, e.g. in medical, diagnostic and other such applications. The microbubbles are preferentially formed using a microspray regime.Type: GrantFiled: June 29, 2012Date of Patent: October 31, 2017Assignee: The University of LeedsInventors: Sally Anne Peyman, Radwa Hassan Abou-Saleh, Stephen Derek Evans
-
Patent number: 9782484Abstract: The purpose of present invention is to provide a medicine which has low contamination with a fine-pulverizing medium, is safe and has improved bioavailability. A method for producing a composite organic compound powder for medical use is used which comprises: mixing a poorly water-soluble and crystalline organic compound powder, a physiologically acceptable salt, a physiologically acceptable polyol, and a carboxyvinyl polymer and fine-pulverizing the organic compound powder; and removing at least the salt and the polyol during or after fine-pulverizing.Type: GrantFiled: August 27, 2013Date of Patent: October 10, 2017Assignee: ACTIVUS PHARMA CO., LTD.Inventors: Takashi Hirokawa, Takahiro Tada, Jun Nihira
-
Patent number: 9764305Abstract: A principle is established to show that nanoscale energy deposition in water by X-rays can be greatly enhanced via the geometry of nanostructures. The calculated results show that enhancement over background water can reach over 60 times for a single nanoshell made of gold. Other geometries and nanostructures are investigated, and it is found that a shell of gold nanoparticles can generate similar enhancement. The concepts of composition, matrix, and satellite effects are established and studied, all of which can further increase the enhancement of the effect of X-rays.Type: GrantFiled: March 15, 2013Date of Patent: September 19, 2017Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventor: Ting Guo
-
Patent number: 9757331Abstract: Stable solid compositions have a first carrier and an adsorbate having at least one active component, such as, a vitamin D derivative and a hydrophobic stabilizer thereof, wherein the first carrier is a calcium phosphate or derivatives thereof having a solubility in water lower than 0.1 wt % at room temperature.Type: GrantFiled: June 24, 2011Date of Patent: September 12, 2017Assignee: PRAYON SAInventors: Khadija Tantaoui Elaraqi, Guy Broze, Audrey Leruite
-
Patent number: 9717695Abstract: The present invention features, inter alia, constructs for the delivery of therapeutic and diagnostic agents to a patient. The constructs can include a nanoparticle, a targeting agent that specifically binds a targeted tissue or cell, a therapeutic moiety, and a hydrogel. The constructs can be used in the treatment and diagnosis of bowel diseases, including inflammatory bowel disease (IBD) and colon cancer. In one embodiment, the therapeutic agent is a nucleic acid that mediates RNA inhibition (RNAi), and the invention is directed to treatments for IBD that combine the positive aspects of such agents {e.g., siRNAs) with the safety of a biodegradable polymeric delivery system to facilitate specific targeting of colonic tissues and cells. As the constructs can be formulated for oral administration, they are well tolerated and offer advantages with regard to patient compliance.Type: GrantFiled: May 18, 2013Date of Patent: August 1, 2017Assignee: Georgia State University Research Foundation, Inc.Inventors: Didier Merlin, Bo Xiao, Hamed Laroui
-
Patent number: 9709501Abstract: The present invention relates to an in vitro method for diagnosing the infectious state of an individual on the basis of a sample of white corpuscles arising from a biological specimen taken from an organ potentially infected by a pathogenic microorganism of said individual, comprising at least the following two steps: i) measuring the mean cellular intensity of the autofluorescence of said sample, and ii) comparing the intensity measured in step i) with a control value, so as to determine the infectious state of said individual. The diagnostic method of the invention uses a routine optical material making it possible to work in wavelength regions which are compatible with the cellular autofluorescence, and thus constitutes a rapid, reliable and inexpensive aid for the diagnosis or monitoring of an infection in an individual.Type: GrantFiled: March 22, 2012Date of Patent: July 18, 2017Assignees: UNIVERSITE DE NANTES, UNIVERSITE PARIS-SUD 11, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Karim Asehnoune, Marie-Pierre Fontaine-Aupart, Sandrine Lecart, Antoine Monsel, Antoine Roquilly
-
Patent number: 9707548Abstract: Provided are a polymer capsule loaded with transition metal particles having excellent water dispersibility and stability, and a method for preparing the same. Specifically, the polymer capsule loaded with transition metal particles according to the present invention includes a surface-modified polymer capsule surface-modified to thereby have a positive zeta potential in a dispersed state in water; and transition metal particles loaded on a surface of the surface-modified polymer capsule. In addition, a method for preparing a polymer capsule loaded with transition metal particles according to the present invention includes a) preparing a polymer capsule; b) surface-modifying the polymer capsule to prepare a polymer capsule having a positive zeta potential in a dispersed state in water; and c) sequentially adding a water-soluble transition metal precursor and a reducing agent to a water dispersion of the surface-modified polymer capsule obtained in step b).Type: GrantFiled: April 16, 2015Date of Patent: July 18, 2017Assignees: INSTITUTE FOR BASIC SCIENCE, POSTECH ACADEMY-INDUSTRY FOUNDATIONInventors: Kimoon Kim, Gyeongwon Yun, Zahid Hassan, Jiyeong Lee, Jeehong Kim, Nam Hoon Kim, Kangkyun Baek, Iiha Hwang
-
Patent number: 9700530Abstract: This disclosure provides an extended-release capsule dosage form of metoprolol succinate in the form of coated discrete units, wherein said capsule dosage form is bioequivalent to the marketed Toprol-XL® tablet. The extended-release capsule dosage form comprising coated discrete units can be sprinkled onto food to ease administration to patients who have difficulty swallowing tablets or capsules.Type: GrantFiled: October 28, 2016Date of Patent: July 11, 2017Assignee: SUN PHARMACEUTICAL INDUSTRIES LIMITEDInventors: Sandeep Kumar Vats, Balaram Mondal, Kalaiselvan Ramaraju, Romi Barat Singh
-
Patent number: 9687452Abstract: This invention relates to coated digestive enzyme preparations and enzyme delivery systems and pharmaceutical compositions comprising the preparations. This invention further relates to methods of preparation and use of the systems, pharmaceutical compositions and preparations to treat persons having ADD, ADHD, autism, cystic fibrosis and other behavioral and neurological disorders.Type: GrantFiled: April 22, 2015Date of Patent: June 27, 2017Assignee: Curemark, LLCInventors: Joan M. Fallon, Matthew Heil
-
Patent number: 9675711Abstract: Nanoparticles gene carriers, particularly nanoparticle gene carriers which exhibit increased rates of diffusion through cystic fibrosis (CF) mucus, as well as methods of making and using thereof, are described herein. The nanoparticle gene carriers are formed from a nucleic acid complexed to one or more biocompatible, polycationic polymers. The nanoparticle gene carriers also contain one or more mucus resistant polymers. In a particularly preferred embodiment, the nanoparticle gene carrier is a nanoparticle formed from one or more nucleic acids, PEI, and a mucus-resistant/diffusive graft copolymer composed of a PEI backbone functionalized by one or more PEG side chains. The nanoparticle gene carriers can efficiently diffuse through CF mucus, and can effectively serve as a vehicle to administer one or more nucleic acids to a patient suffering from CF.Type: GrantFiled: May 2, 2016Date of Patent: June 13, 2017Assignee: The Johns Hopkins UniversityInventors: Jung Soo Suk, Justin Scot Hanes
-
Patent number: 9622972Abstract: There is provided a sustained-release pharmaceutical composition comprising a solid, continuous network comprising an excipient with a high mechanical strength, which network also comprises pores, within which pores is interspersed a mixture of an active ingredient and a film-forming agent, characterized in that said pores are formed during the production of the composition. Compositions of the invention find particularly utility as abuse-resistant formulations comprising opioid analgesics that may be employed in the treatment of chronic pain.Type: GrantFiled: March 2, 2010Date of Patent: April 18, 2017Assignee: Emplicure ABInventors: Susanne Bredenberg, Anna Dahlgren, Anders Sågström, Håkan Engqvist
-
Patent number: 9527040Abstract: Continuous processes for depleting residuals in hollow fiber membranes comprising polysulfone or polyethersulfone and polyvinylpyrrolidone by rinsing the membranes while compressing them in a pinching device comprising grooved rollers.Type: GrantFiled: October 18, 2012Date of Patent: December 27, 2016Assignee: GAMBRO LUNDIA ABInventors: Bernd Krause, Carina Zweigart, Christof Beck, Bernd Hertzler, Steffen Wagner, Joachim Loercher
-
Patent number: 9504655Abstract: The present invention provides an extended-release capsule dosage form of metoprolol succinate in the form of coated discrete units and processes for their preparation.Type: GrantFiled: February 1, 2016Date of Patent: November 29, 2016Assignee: SUN PHARMACEUTICAL INDUSTRIES LIMITEDInventors: Sandeep Kumar Vats, Balaram Mondal, Kalaiselvan Ramaraju, Romi Barat Singh
-
Patent number: 9492476Abstract: The present invention generally relates to methods of treating hypertension (HTN) in patients in need thereof wherein the patient optionally further suffers from chronic kidney disease (CKD) or Type II diabetes mellitus (T2DM). The invention also relates to methods of treating hyperkalemia in a patient in need thereof, wherein the patient suffers from CKD, T2DM or HTN and are optionally being treated with an effective amount of a renin-angiotensin-aldosterone system (RAAS) agent. The invention also relates to methods of treating kidney disease in a patient in need thereof, wherein the patient is optionally being treated with an effective amount of a renin-angiotensin-aldosterone system (RAAS) agent. The methods can comprise administering an effective amount of a potassium-binding agent to the patient to lower the patient's blood pressure and/or increase or stabilize the patient's kidney function.Type: GrantFiled: December 23, 2014Date of Patent: November 15, 2016Assignee: Relypsa, Inc.Inventors: Gerrit Klaerner, Lance Berman
-
Patent number: 9480640Abstract: A nano freeze dry process of preparation for a cosmetic composition having a bioactive agent for providing an anti-aging effect on a skin, comprising the steps of: placing the cosmetic composition having a bioactive agent into a capsule container; and nano freeze drying the cosmetic composition by: freezing the cosmetic composition in the capsule container at ?170° C.; increasing the temperature to ?85° C. and allowing sublimation under vacuum condition; then increasing the temperature to 35° C.; and vacuum drying to obtain a final product, wherein a volume of the cosmetic composition remains unchanged after the process, a water content of less than 5% is inside the final, at least 80% of bioactivity of the cosmetic composition is retained, and significant anti-aging effect is observed after a two-day treatment.Type: GrantFiled: September 24, 2014Date of Patent: November 1, 2016Inventor: Hongkai Zhang
-
Patent number: 9457099Abstract: The instant invention relates to polyethylene glycol-based dendrons, otherwise known as PEGtide dendrons, compositions thereof and methods of use.Type: GrantFiled: November 14, 2011Date of Patent: October 4, 2016Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYInventors: Patrick J. Sinko, Jieming Gao, Yashveer Singh, Xiaoping Zhang, Matthew S. Palombo, Stanley Stein
-
Patent number: 9421246Abstract: Provided are ingestible polymeric formulations and oral dosage forms for the reduction of gastric volume in the treatment of overweight and obese patients. The formulation includes an acid-sensitive, gelatin coating over a dehydrated hydrophilic polymer. When ingested, the acid-sensitive coating is quickly dissolved by gastric secretions and the hydrophilic polymer is exposed to the aqueous environment of the gastric milieu. The polymer absorbs water and expands to the point that will not allow the polymer to pass beyond the pyloric valve, and the expanded polymer is therefore trapped in the stomach.Type: GrantFiled: February 12, 2014Date of Patent: August 23, 2016Assignee: BAROnova, Inc.Inventors: Daniel R. Burnett, Peter G. Edelman
-
Patent number: 9381156Abstract: A sprayable emulsion is provided. The emulsion can be used in the treatment of various skin conditions. The emulsion includes a hydrofluoro-based propellant, an emulsification system, an oil phase, a water phase, and active agent particles. Further, the emulsification system includes at least one nonionic emulsifier. The emulsion has a viscosity ranging from about 500 centipoise to about 10,000 centipoise and a hydrophilic to lipophilic balance (HLB) value of from about 2 to about 12. The present inventors have found that by selectively controlling the nature of the emulsification system and the viscosity of the emulsion, the active agent particles resist settling such that a substantially homogeneous distribution of the active agent particles is maintained and can be evenly sprayed onto a surface without running once applied.Type: GrantFiled: February 11, 2015Date of Patent: July 5, 2016Assignee: Mission Pharmacal CompanyInventors: Thomas Dann, Renee Nelson, Brian Wagner, Mary Walter
-
Patent number: 9346682Abstract: The present document describes a microcapsule having silica shells, processes for making the same, processes for functionalizing said microcapsules and processes for encapsulating active agent in said microcapsules.Type: GrantFiled: November 30, 2012Date of Patent: May 24, 2016Assignee: LES INNOVATIONS MATERIUMInventors: Mathilde Gosselin, Shaoyong Yu, Nabil Ghezal, Cé Guinto Gamys
-
Patent number: 9339485Abstract: The present invention provides for a method to increase the triplet yield of a photosensitizer by the coupling to metal surface plasmons which leads to increased singlet oxygen generation by electric field enhancement or enhanced energy absorption of the photosensitizer. The extent of singlet oxygen enhancement can be tuned for applications in singlet oxygen based clinical therapy by modifying plasmon coupling parameters, such as metallic nanoparticle size and shape, photosensitizer/metallic nanoparticle distance, and the excitation wavelength of the coupling photosensitizer.Type: GrantFiled: January 27, 2008Date of Patent: May 17, 2016Assignee: UNIVERSITY OF MARYLAND, BALTIMORE COUNTYInventor: Chris D. Geddes
-
Patent number: 9278070Abstract: A composition comprises a water-soluble polymer matrix in which are dispersed droplets of oil, the composition comprising an active principle. The invention includes embodiments in which the active principle is included in at least some of the oil droplets as well as embodiments in which the oil droplets are free of active principle. The oil droplets are released as the matrix containing them dissolves in an aqueous medium. In one embodiment, the oil droplets are substantially immobilized in or by the matrix and the immobilizing feature is lost as the matrix dissolves in aqueous media. In certain embodiments, the oil drops may collectively be referred to as the oil phase of the composition of the invention. The product may be in the form of mini-beads. The oil phase and/or the polymer matrix may each include a surfactant.Type: GrantFiled: May 18, 2010Date of Patent: March 8, 2016Assignee: Sigmoid Pharma LimitedInventors: Ivan Coulter, Bernard Francis McDonald, Vincenzo Aversa
-
Patent number: 9259395Abstract: A tumor-targeting gas-generating nanoparticle, a method for preparing same and a tumor-targeting nanoparticle for drug delivery using same relate to a tumor-targeting gas-generating nanoparticle including a polycarbonate core and a amphiphilic coat, a method for preparing same and a tumor-targeting nanoparticle for drug delivery using same. Since a tumor-targeting gas-generating nanoparticle according to the present disclosure is accumulated in the tumor tissue in large quantity and generates strong ultrasound wave signals, it can be usefully used as a contrast agent for ultrasonic imaging.Type: GrantFiled: May 31, 2013Date of Patent: February 16, 2016Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Ick Chan Kwon, Kwang Meyung Kim, Kuiwon Choi, Heebeom Koo, Hyun Su Min, Inchan Youn
-
Patent number: 9186640Abstract: A complex coacervate delivery system is provided which encapsulates lipophilic nutrients such as, for example, fish oils high in omega-3 fatty acids. The complex coacervate delivery system protects the lipophilic nutrient from degradation, e.g., oxidation and hydrolysis, and also reduces or eliminates the unpleasant taste and odor of the lipophilic nutrient. The complex coacervate delivery system upon ingestion is operative to substantially release the lipophilic nutrient in the lower gastrointestinal tract in a pH-controlled manner. The complex coacervate delivery system may be included in a food or beverage product having a pH value within the range of about 1.5 to about 5.0.Type: GrantFiled: August 28, 2007Date of Patent: November 17, 2015Assignee: PepsiCo, Inc.Inventors: Daniel S. Kohane, Yoon Yeo, Peter Given, Robert S. Langer
-
Synergistic combinations to reduce particle dose for targeted treatment of cancer and its metastases
Patent number: 9125835Abstract: Non-Small Cell Lung Carcinomas (NSCLCs) are treated with Gel Micro-Particles (GMPs) that passively accumulate in the lungs and contain Nano-Particles (NPs) combining one or more therapeutic agents that are cytotoxic to the NSCLC with one or more NSCLC active targeting ligands, as well as one or more other optional agents that increase cellular uptake, enhance the pro-apoptotic effect of the chemotherapeutic agent(s), and the like. NPs targeting other cancer cells are also disclosed, as well as NP-containing GMPs that reduce the occurrence of tumor metastasis.Type: GrantFiled: November 14, 2011Date of Patent: September 8, 2015Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYInventors: Patrick J. Sinko, Jieming Gao, Manjeet Deshmukh, Xiaoping Zhang, Matthew S. Palombo, Sherif Ibrahim -
Patent number: 9120125Abstract: The present invention includes systems, methods and compositions for the encapsulation of particles. In one form, the system comprises one or more particles, a rotatable reaction chamber in a plasma enhanced chemical reactor to accept one or more particles, and at least one carbonaceous compound to be used in the rotatable reaction chamber, wherein the carbonaceous compound is polymerized onto a surface of one or more particles forming a polymer film encapsulating one or more particles. Using systems, methods, and compositions of the present invention, any particle encapsulated with a degradable or nondegradable polymer film may be introduced and/or released into an environment. The polymer film as well as introduction of encapsulated particles and release therefrom into an environment are controlled by the present invention.Type: GrantFiled: October 31, 2013Date of Patent: September 1, 2015Assignee: Board of Regents, The University of Texas SystemInventors: Richard B. Timmons, Ceren Susut
-
Patent number: 9084963Abstract: A method for manufacturing an immobilized liquid membrane using a water solution and a hexane solution is provided. The method may include producing a plurality of particles having a distribution of sizes from the water solution, covering the plurality of particles in the hexane solution, creating a plurality of microcapsules each comprising a flexible wall encapsulating a respective one of the plurality of particles, and creating a gap membrane between the plurality of microcapsules, the gap membrane being formed by polymerization reaction between a second portion of the water solution and a second portion of the hexane solution. Each of the plurality of microcapsules and the gap membrane are permeable to a first gas of a mixture of gasses comprising the first gas and a second gas, each of the microcapsules and the gap membrane being substantially impermeable to the second gas.Type: GrantFiled: March 13, 2014Date of Patent: July 21, 2015Assignee: Triext, LLCInventor: Clyde F. Parrish
-
Patent number: 9084602Abstract: A surgical stapling apparatus includes a jaw assembly including a pair of jaw members and a surgical buttress positioned adjacent a tissue contacting surface of at least one of the pair of jaw members. The surgical buttress includes a hemostatic agent and is configured to release the hemostatic agent therefrom upon actuation of the surgical stapling apparatus to approximate the pair of jaw members and exert a pressure on the surgical buttress.Type: GrantFiled: January 26, 2011Date of Patent: July 21, 2015Assignee: Covidien LPInventor: Seth S. Gleiman
-
Patent number: 9078830Abstract: The invention relates to pharmaceutical compositions comprising multilayered multiple units and processes for the preparation thereof.Type: GrantFiled: July 28, 2010Date of Patent: July 14, 2015Assignee: RANBAXY LABORATORIES LIMITEDInventors: Paras Jain, Umesh Vinayakrao Barabde, Kanwarpreet Singh Bakshi, Rajan Kumar Verma, Romi Barat Singh
-
Patent number: 9066912Abstract: The present invention includes methods for the inhibition of post-operative adhesion formation between tissue surfaces in a body cavity having been subjected to a surgical procedure, which methods involve administering Tranilast, or an analog thereof, directly to tissue surfaces in the body cavity in amounts and under conditions effective to inhibit formation of adhesions, and to delivery vehicles and compositions suitable for use for local, non-systemic administration of a drug to the body and directly to tissue within a body cavity having been subjected to a surgical procedure.Type: GrantFiled: November 17, 2003Date of Patent: June 30, 2015Assignee: Ethicon, Inc.Inventors: Janel E. Young, Scott A. Wadsworth, Kevin Cooper, Joel Rosenblatt, Han Cui
-
Patent number: 9056942Abstract: A solvent-free curable epoxy resin composition including (a) at least one divinylarene dioxide; and (b) at least one hardener; wherein the solvent-free curable epoxy resin composition is substantially free of solvent and has at least two exotherm peaks and wherein the exothermic peak difference of the two exotherm peaks is sufficient to allow the curable solvent-free epoxy resin composition of being B-staged.Type: GrantFiled: July 18, 2012Date of Patent: June 16, 2015Assignee: Dow Global Technologies LLCInventors: Angela I. Padilla-Acevedo, Ludovic Valette, Michael J. Mullins, Kandathil E. Verghese, Mark B. Wilson
-
Patent number: 9056059Abstract: Cosmetic compositions include a Clostridial neurotoxin component and a microsphere component. In certain compositions, the composition includes a botulinum toxin and a plurality of swellable microspheres. The compositions are administered to individuals, by injection and the like, to treat a cosmetic defect of deficiency.Type: GrantFiled: December 30, 2013Date of Patent: June 16, 2015Assignee: Allergan, Inc.Inventor: Eric R. First
-
Patent number: 9053849Abstract: A magnetic nanosilicon material comprising silicon nanoparticles impregnated with magnetic atoms. This magnetic nanosilicon material has both luminescent and magnetic properties. In certain embodiments of the invention, magnetic nanosilicon material is encapsulated in a polymer or silica sphere to provide a supermolecule. Supermolecules can be used in applications such as but not limited to detection and imaging.Type: GrantFiled: September 20, 2011Date of Patent: June 9, 2015Assignees: NanoSi Advanced Technologies, Inc., King Fahd University of Petroleum and Minerals (KFUPM)Inventors: Munir H. Nayfeh, Zain H. Yamani
-
Publication number: 20150147402Abstract: The present invention provides an implantable device having a coating including a slow dissolving polymer or material and the methods of making and using the same.Type: ApplicationFiled: November 17, 2014Publication date: May 28, 2015Inventors: O. Mikael Trollsas, Michael H. Ngo, David J. Sherman, Syed F.A. Hossainy
-
Patent number: 9040080Abstract: The present disclosure relates to a method of melt processing an active agent. The method may include encapsulating an active agent in a first polymer material exhibiting a first processing temperature T1 and forming capsules including the active agent. The method may also include melt processing the capsules with a second polymer material exhibiting a second processing temperature T2, wherein T1>T2.Type: GrantFiled: October 21, 2008Date of Patent: May 26, 2015Assignee: SOUTHWEST RESEARCH INSTITUTEInventors: Hong Dixon, Joseph A McDonough
-
Publication number: 20150140106Abstract: An ophthalmic formulation that includes nanoparticles. Each nanoparticle includes a shell which encapsulates sulfated non-anticoagulant heparin (SNACH), with or without hydrophobic anti-angiogenesis Tyrosine Kinase inhibitors. The SNACH is ionically or covalently bonded to the shell. The shell includes a polymer selected from the group consisting of poly (lactic-co-glycolic acid) (PLGA), chitosan, chitosan-alginate, and NIPAAM-APMAH-AA, wherein NIPAAM is N-isopropyl acrylamide, APMAH is N-3-aminopropylmethacrylamide hydrochloride, and AA is acrylic acid. A method for treating an eye disease of a subject includes: administering to an eye of the subject a therapeutically effective amount of the ophthalmic formulation for treating the eye disease. The eye disease involves an ocular angiogenesis-mediated disorder.Type: ApplicationFiled: October 29, 2014Publication date: May 21, 2015Inventor: Shaker A. Mousa
-
Publication number: 20150140107Abstract: Embodiments of the invention include drug delivery coatings and devices including the same. In an embodiment, the invention includes a drug delivery coating including a polymeric layer. The polymeric layer can include a hydrophilic outer surface. The coating can also include a matrix contacting the hydrophilic outer surface. The matrix can include a particulate hydrophobic therapeutic agent and a cationic agent. The polymeric layer can further include a hydrophilic polymer having pendent photoreactive groups and a photo-crosslinker including two aryl ketone functionalities. Other embodiments are also included herein.Type: ApplicationFiled: January 29, 2015Publication date: May 21, 2015Inventors: Joram Slager, Toni M. Heyer, David E. Babcock
-
Publication number: 20150140085Abstract: Oral pharmaceutical formulations of ibrutinib and/or a pharmaceutically acceptable salt thereof, methods for their administration, process of their production, and use of these formulations for the treatment of diseases treatable by ibrutinib such as cancer, inflammatory diseases, and autoimmune diseases.Type: ApplicationFiled: June 26, 2013Publication date: May 21, 2015Applicant: Principia Biopharma Inc.Inventor: David Michael Goldstein
-
Patent number: 9034902Abstract: Therapeutic compositions and methods for treatment of attention deficit disorder (ADD) or attention deficit hyperactivity disorder (ADHD) include dosage forms that deliver a therapeutic amount of active drug in a delayed and controlled release formulation. The dosage form can be administered at night and drug release is delayed for from 4 to 6 hours or longer, followed by an ascending release rate.Type: GrantFiled: December 19, 2014Date of Patent: May 19, 2015Assignee: Ironshore Pharmaceuticals & Development, Inc.Inventors: David Lickrish, Feng Zhang
-
Publication number: 20150132397Abstract: The invention relates to the use of inhibitors of the enzyme mTOR kinase (mammalian target of rapamycin) in the treatment of neuro-oncologic diseases, in particular tuberous sclerosis, neurodegenerative diseases, in particular Alzheimer's disease, and neuroinflammatory diseases, in particular multiple sclerosis and primary progressive aphasia, via intrathecal, or preferably intraventricular, administration of said inhibitors.Type: ApplicationFiled: May 10, 2013Publication date: May 14, 2015Inventor: Diego DOLCETTA
-
Publication number: 20150132382Abstract: The present invention provides compositions comprising fosfomycin or a pharmaceutically acceptable salt, solvate or prodrug thereof (e.g., fosfomycin disodium) alone or in combination with an antibacterial agent. The present invention provides methods of treating bacterial infections, which include administering an effective amount of fosfomycin or a pharmaceutically acceptable salt, solvate or a prodrug thereof (e.g., fosfomycin disodium) alone or in combination with an antibacterial agent.Type: ApplicationFiled: November 10, 2014Publication date: May 14, 2015Inventors: Mahendra G. Dedhiya, Sisir Bhattacharya
-
Publication number: 20150125401Abstract: The present invention provides compositions and methods for the delivery of therapeutics to a cell or subject.Type: ApplicationFiled: April 15, 2013Publication date: May 7, 2015Inventors: Howard E. Gendelman, Alexander V. Kabanov, Xin-Ming Liu, Richey M. Davis, Judy Riffle
-
Publication number: 20150125539Abstract: Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and/or the back of the eye.Type: ApplicationFiled: November 2, 2013Publication date: May 7, 2015Applicant: Kala Pharmaceuticals, Inc.Inventors: Alexey Popov, Elizabeth M. Enlow, Hongming Chen, James Bourassa
-
Publication number: 20150125521Abstract: Therapeutic compositions and methods for treatment of attention deficit disorder (ADD) or attention deficit hyperactivity disorder (ADHD) include dosage forms that deliver a therapeutic amount of active drug in a delayed and controlled release formulation. The dosage form can be administered at night and drug release is delayed for from 4 to 6 hours or longer, followed by an ascending release rate.Type: ApplicationFiled: January 5, 2015Publication date: May 7, 2015Inventors: David Lickrish, Feng Zhang