Contains Proteins Or Derivative Or Polysaccharides Or Derivative Patents (Class 424/499)
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Patent number: 8945602Abstract: A minimally invasive controlled drug delivery system for delivering a particular drug or drugs to a particular location of the eye, the system including a porous film template having pores configured and dimensioned to at least partially receive at least one drug therein, and wherein the template is dimensioned to be delivered into or onto the eye.Type: GrantFiled: March 29, 2013Date of Patent: February 3, 2015Assignee: The Regents of the University of CaliforniaInventors: William Freeman, Michael J. Sailor, Lingyun Cheng, Frederique Cunin, Emily Anglin, Yang Yang Li
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Publication number: 20150030685Abstract: A sugar-free, pharmaceutical composition comprising an oral transmucosal solid dosage form which includes an adherent carrier preblend mixture of a highly potent pharmaceutical agent, and dextrates, hydrated the composition further including a pharmaceutically acceptable sugar-free excipient.Type: ApplicationFiled: July 23, 2013Publication date: January 29, 2015Inventors: Lynn J. Maland, Brian I. Hague
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Patent number: 8936811Abstract: Embodiments of the invention include particles with nucleic acid complexes, medical devices including the same and related methods. In an embodiment, the invention can include a method of making a medical device. The method can include contacting nucleic acids with cationic carrier agents to form nucleic acid complexes, adsorbing the nucleic acid complexes to porous particles to form nucleic acid complex containing particles, mixing the nucleic acid complex containing particles with a polymer solution to form a coating mixture, and applying the coating mixture to a substrate. In an embodiment, the method can include contacting nucleic acids with cationic carrier agents to form nucleic acid complexes, combining the nucleic acid complexes with a material to form nucleic acid complex containing particles in situ, mixing the nucleic acid complex particles with a polymer solution to form a coating mixture, and applying the coating mixture to a substrate.Type: GrantFiled: May 7, 2009Date of Patent: January 20, 2015Assignee: SurModics, Inc.Inventors: Joram Slager, Joseph Schmidt McGonigle
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Patent number: 8936813Abstract: A method and apparatus are provided for atomizing a liquid under dispersal conditions suitable for spray drying at a commercial plant scale. In one embodiment, a liquid atomizer has a structural body adapted for connection with a spray dryer and a plurality of atomizing nozzles. Each of the atomizing nozzles includes a liquid nozzle adapted to disperse a supply of liquid and a gas nozzle adapted to disperse a supply of gas. In another embodiment, a process for producing a powder blend of at least two target substances in a single processing step is provided.Type: GrantFiled: October 21, 2011Date of Patent: January 20, 2015Assignee: Novartis AGInventors: Herman E Snyder, Michael J Vosberg, Christopher M Varga
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Publication number: 20150018906Abstract: Disclosed are methods and preparations useful for reducing fat at a targeted area(s) on a human. The preparations comprise as an active ingredient an adipolysis enhancing (i.e., fat-melting) amount of an active ingredient, paeoniflorin (PF). The preparations may be provided as an injectable preparation or as a topically applied preparation, such as in the form of a crème or lotion. In topical preparations, the active ingredient paeoniflorin may be contained within nanospheres, such as albumin nanospheres. The PF-containing preparations may also include a permeant, such as azone. The method may be accompanied by the application of ultrasound to the area being treated prior to, during or after, or prior to, during, and after application of the paeoniflorin preparation to an area of the body in which fat reduction is desired.Type: ApplicationFiled: July 10, 2013Publication date: January 15, 2015Inventor: Bakr Rabie
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Patent number: 8932633Abstract: A method of preparing polysaccharide glassy microparticles which are less than 10 ?um in diameter and contain structurally delicate agents, such as proteins, peptides, gene materials, vaccines, antibodies, viruses and liposomes using low-temperature aqueous-aqueous emulsification (free of polyelectrolytes) and freezing-induced phase separation. When delicate agents are added to a polysaccharide-PEG two phase system followed by homogenization (or other shear adding process), the agents partition into the polysaccharide dispersed phase preferentially. These processes help to avoid aggregation of proteins caused by interaction with charged polyelectrolytes used for stabilizing the polysaccharide dispersed phase in our previously reported aqueous-aqueous emulsion. When this system is frozen and lyophilized, glassy particles less than 10 ?m in diameter containing delicate agents can be formed.Type: GrantFiled: July 20, 2006Date of Patent: January 13, 2015Assignee: Biopharm Solutions Inc.Inventors: Tuo Jin, Fei Wu, Weien Yuan
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Patent number: 8932640Abstract: A process for preparing a particle comprising a biological molecule typically a DNA plasmid, and a carrier polymer, typically poly-lactic acid (PLA), in which an organic solvent solution of the biological molecule and the carrier polymer in an organic solvent medium, nearly saturated with the biological molecule, is prepared, then this solution is contacted with an antisolvent substance, typically supercritical carbon dioxide to separate a particle comprising the biological molecule and the carrier polymer. High loadings of the biological molecule in the particle can be achieved.Type: GrantFiled: February 8, 2007Date of Patent: January 13, 2015Assignee: Glaxo Group LimitedInventors: John Robertson, Kenneth Baird Smith
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Publication number: 20150010642Abstract: A composition of a bone repair mixture has a quantity of allograft particulate bone having a bone particle distribution of particle sizes less than 700 micron and a quantity of biologic carrier material intermixed with the particulate bone. The biologic carrier material is one of collagen, porous collagen or a collagen mixture. Preferably, the carrier material is exclusively collagen.Type: ApplicationFiled: June 10, 2014Publication date: January 8, 2015Applicant: Vivex Biomedical, Inc.Inventors: Tracy Scott Anderson, Timothy E. Taylor
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Publication number: 20150004242Abstract: Disclosed are nanoparticle compositions comprising nanoparticles prepared from denatured, cross-linked albumin and a therapeutic agent for treating a neutrophil-mediated inflammation, and methods of treating neutrophil-mediated inflammation using the compositions.Type: ApplicationFiled: June 26, 2014Publication date: January 1, 2015Inventors: Zhenjia Wang, Jaehyung Cho, Asrar Malik
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Patent number: 8920781Abstract: A powder for use in a dry powder inhaler includes active particles and carrier particles for carrying the active particles. The powder further includes additive material on the surfaces of the carrier particles to promote the release of the active particles from the carrier particles on actuation of the inhaler. The powder is such that the active particles are not liable to be released from the carrier particles before actuation of the inhaler. The inclusion of additive material in the powder has been found to give an increased respirable fraction of the active material.Type: GrantFiled: March 26, 2010Date of Patent: December 30, 2014Assignee: Vectura LimitedInventor: John Nicholas Staniforth
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Publication number: 20140377366Abstract: Methods, processes, systems, and compositions for treating disease are disclosed. In some cases, the present disclosure provides for delivery of therapeutic agents, in an active form, to a localized area, over an extended period of time. In one embodiment, the disclosed composition may comprise a therapeutic agent and a biodegradable polymer and/or a biodegradable polymer microsphere.Type: ApplicationFiled: June 24, 2014Publication date: December 25, 2014Inventor: Melissa D. Krebs
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Publication number: 20140377367Abstract: This invention relates to a chimaeric human papillomavirus (HPV) virus like particle (VLP) having a diameter of about 30 nm. The invention further relates to methods of treatment and/or prophylaxis of HPV infection and/or cervical cancer by administration of the chimaeric HPV VLP of the invention to a subject.Type: ApplicationFiled: December 3, 2012Publication date: December 25, 2014Applicant: University of Cape TownInventors: Edward Peter Rybicki, Inga Isabel Hitzeroth
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Publication number: 20140377368Abstract: The present invention pertains to chitosan beads consisting of chitosan cross-linked with citrate ions. The present invention furthermore pertains to a filler comprising such chitosan-citrate beads. In one embodiment of the instant invention the filler is a dermal filler. In one further embodiment of the present invention the dermal filler is for the treatment of wrinkles and/or folds. In another embodiment of the instant invention the filler is for use in the treatment of a medical condition. The filler provided in the present invention may further comprise one or more active pharmaceutical ingredients. Further, the present invention pertains to a process for preparing the filler as claimed herein.Type: ApplicationFiled: September 9, 2014Publication date: December 25, 2014Inventors: Kevin Kiehm, Bernhard Hauptmeier, Peter Boderke
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Patent number: 8916143Abstract: The present disclosure provides injectable synthetic and biodegradable polymeric biomaterials that effectively prevent seroma, a common postoperative complication following ablative and reconstructive surgeries. Provided biomaterials include physically crosslinked hydrogels that are thixotropic, display rapid chain relaxation, are easily extruded through narrow gauge needles, biodegrade into inert products, are well tolerated by soft tissues, and effectively prevent seroma in a radical breast mastectomy animal model.Type: GrantFiled: November 3, 2009Date of Patent: December 23, 2014Assignee: Cornell UniversityInventors: David Putnam, Peter Zaweneh, Jason Spector
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Publication number: 20140370111Abstract: Disclosed are methods and compositions of microbead carriers for delivery of cells and other biologically active substances to diseased or damaged tissue in a subject in need thereof.Type: ApplicationFiled: November 23, 2011Publication date: December 18, 2014Inventors: Barbara Dale Boyan, Zvi Schwartz, Christopher S.D. Lee, Shirae Kerisha Leslie, Ramsey C. Kinney
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Patent number: 8911789Abstract: Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.Type: GrantFiled: March 11, 2013Date of Patent: December 16, 2014Assignees: Carnegie Mellon University, Allegheny-Singer Research Institute, Carmell Therapeutics CorporationInventors: Phil G. Campbell, James E. Burgess, Lee E. Weiss, Jason Smith
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Publication number: 20140356442Abstract: Sustained release triptorelin microspheres include triptorelin or a salt of triptorelin, a copolymer of lactide and glycolide, and glucose or mannitol. The sustained release triptorelin microspheres have a relatively high initial release after administration, which allows the drug to produce its pharmaceutical effects immediately and to maintain long-term steady pharmaceutical effects.Type: ApplicationFiled: December 18, 2012Publication date: December 4, 2014Applicant: Shangdong Luye Pharmaceutical Co., Ltd.Inventors: Kaoxiang Sun, Tao Song, Qilin Wang, Jie Han, Tao Wang, Jiangbin Han, Jianzhao Zhang, Shujiang Wang
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Publication number: 20140356443Abstract: The present invention relates to the field of methods for providing pharmaceutical compositions comprising poorly water-soluble drugs. In particular the present invention relates to compositions comprising stable, amorphous hybrid nanoparticles, comprising at least one protein kinase inhibitor and at least one polymeric stabilizing and matrix-forming component, useful in pharmaceutical compositions and in therapy.Type: ApplicationFiled: January 11, 2013Publication date: December 4, 2014Applicant: XSPRAY MICROPARTICLES ABInventors: Magnus Brisander, Mustafa Demirbüker, Gérald Jesson, Martin Malmsten, Helene Dérand
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Patent number: 8900594Abstract: The invention relates to a recombinant protein used for immunoprophylaxis of human Helicobacter pylori infection and a degradable slow-releasing microsphere-encapsulated oral vaccine preparation prepared from the same, and the preparation method thereof. Said recombinant protein is composed of A2 subunit and B subunit of the LT of enterotoxigenic Escherichia coli and urease B subunit. The vaccine provided in the invention used in human Helicobacter pylori infection is safe and effective and convenient for oral intake.Type: GrantFiled: September 5, 2007Date of Patent: December 2, 2014Assignee: Wuhu Kangwei Biotechnology Co., LtdInventors: Quanming Zou, Wende Tong, Xuhu Mao, Gang Guo, Dongshui Lu, Chao Wu, Hao Zeng, Yichao Wang, Jun Yang, Weijun Zhang, Kaiyun Liu, Ping Luo
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Patent number: 8900638Abstract: The present invention provides a solid preparation containing compound (I) [compound (I) is as defined in the specification] or a salt thereof, and metformin hydrochloride, which is useful as a therapeutic drug for diabetes and the like, and superior in the preservation stability. A solid preparation having a first part and a second part: a first part: a part containing compound (I) or a salt thereof and substantially free of metformin hydrochloride a second part: a part containing metformin hydrochloride and substantially free of compound (I) and a salt thereof.Type: GrantFiled: July 16, 2008Date of Patent: December 2, 2014Assignee: Takeda Pharmaceutical Company LimitedInventors: Kazumichi Yamamoto, Hiroyoshi Koyama
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Publication number: 20140348935Abstract: A process is provided for inhibiting symptoms of food allergy or food intolerance in a subject that includes the oral adminstration to the subject suffering from food allergy or food intolerance an IgM. When administered in a therapeutic quantity based on the subject characteristics and the type of IgM, symptoms of food allergy or food intolerance in that subject are inhibited. Even non-secretory forms of IgM are effective when administered orally.Type: ApplicationFiled: April 28, 2014Publication date: November 27, 2014Inventor: Michael R. Simon
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Publication number: 20140342007Abstract: The present invention is directed to methods of manufacturing bioactive gels from ECM material, i.e., gels which retain bioactivity, and can serve as scaffolds for preclinical and clinical tissue engineering and regenerative medicine approaches to tissue reconstruction. The manufacturing methods take advantage of a new recognition that bioactive gels from ECM material can be created by digesting particularized ECM material in an alkaline environment and neutralizing to provide bioactive gels.Type: ApplicationFiled: July 16, 2014Publication date: November 20, 2014Inventors: Kimberly A. Kentner, Katherine A. Stuart, Abram D. Janis
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Publication number: 20140342006Abstract: A method for preparing a microparticle suspension, which comprises: (a) providing protein microparticles having a median diameter between 5 and 13 microns and a GSD less than 2.5; (b) combining the microparticles with a liquid, pharmaceutically acceptable, water miscible media to create a first mixture; (c) adding an aqueous media to the first mixture to create second mixture; and (d) mixing the second mixture to create a microparticle suspension is described. The suspension are injectable even when they contain a relatively high concentration of protein.Type: ApplicationFiled: March 13, 2014Publication date: November 20, 2014Applicant: Ansun Biopharma, Inc.Inventor: Tiejun Li
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Patent number: 8889105Abstract: A respirable composition for treatment of a bacterial infection includes one or more active bacteriophages in combination with a pharmaceutically acceptable respirable carrier. The composition includes a carbohydrate carrier, and is prepared as fine powder. In another aspect, bacteriophages are provided in a liquid carrier for administration by nebulization. In one aspect, the bacteriophages have anti-bacterial activity against one or more species or strains of Burkholderia cepacia complex (BCC) bacteria. The invention further relates to the use of a BCC bacteriophage to treat a BCC infection, in particular in an individual suffering from cystic fibrosis.Type: GrantFiled: November 26, 2009Date of Patent: November 18, 2014Inventors: Warren H. Finlay, Jonathan J. Dennis, Helena Orszanska, Kimberley D. Seed, Karlene Heather Lynch
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Patent number: 8889189Abstract: There are described solid compositions or examining drug solubility comprising bile salts and phospholipids, optionally containing buffer components suitable for preparation of intestinal media that simulate the composition of the intestinal fluids in fasted and fed states.Type: GrantFiled: October 16, 2012Date of Patent: November 18, 2014Assignee: Phares Pharmaceutical Research, N.V.Inventors: Steve Leigh, Mathew Louis Steven Leigh, Peter Van Hoogevest, Daniel Streich, Jacques Quinton
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Patent number: 8889902Abstract: Novel betaine salts of acetylsalicylic acid, namely 4-trimethylammoniobutanoate acetylsalicylic acid addition salt (gamma-butyrobetaine acetylsalicylate), L-carnitine acetylsalicylic acid addition salt and 3-(trimethylammonioamino)propanoate (meldonium) acetylsalicylic acid addition salt. Use of meldonium acetylsalicylate as antiplatelet agent for treating various pathologies induced by platelet aggregation, anti-inflammatory and antihyperlipidemic agent.Type: GrantFiled: June 21, 2010Date of Patent: November 18, 2014Assignee: Tetra, SIAInventors: Ivars Kalvins, Anatolijs Birmans, Maris Veveris, Antons Lebedevs, Anatolijs Misnovs
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Publication number: 20140335192Abstract: Provided are compositions for the delivery of biomolecules, such as nucleic acids into target cells, and methods of making and using same. The compositions comprise nucleic acid delivery complexes that include a nucleic acid, such as an RNA interfering agent, an RNA neutralization domain, a double stranded RNA binding domain, and a protein transduction domain.Type: ApplicationFiled: May 9, 2014Publication date: November 13, 2014Inventors: Gary H. WARD, Curt W. BRADSHAW
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Patent number: 8883220Abstract: The disclosure describes nanocarried and/or microcarried jasmonate compounds and their pharmaceutical compositions, as well as use thereof for treating or preventing angiogenesis-related or NF-?B-related disorders. Also disclosed are methods of making the nanocarried and/or microcarried compounds and their compositions.Type: GrantFiled: September 17, 2012Date of Patent: November 11, 2014Assignee: NanoCare Technologies, Inc.Inventor: José E. Fehr Pereira Lopes
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Publication number: 20140328936Abstract: The invention relates to a pharmaceutical composition, comprising or consisting of: 10 to 30 weight percent of at least a pharmaceutically active amount of a pharmaceutical substance selected from the group comprising statins, in particular water-insoluble, oxidatively degradable statins, preferably cerivastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, simvastatin, or combinations thereof, 30 to 70 weight percent of lactose hydrate, 2 to 15 weight percent of microcrystalline cellulose, 5 to 25 weight percent of a partially water-soluble starch, 0.2 to 4 weight percent of at least one alkali and/or alkaline-earth salt of stearic acid and/or stearyl fumaric acid, wherein the composition contains no antioxidatively active substances such as chain terminators, reductants, free-radical scavengers, and complexing agents.Type: ApplicationFiled: December 6, 2012Publication date: November 6, 2014Applicant: HEXAL AGInventors: Theresa Taeubrich, Patrick Rother
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Publication number: 20140328935Abstract: The present invention discloses a codon-optimized gene encoding major capsid protein L1 of human papilloma virus, which is capable, after transduced into a yeast cell, of efficiently expressing the major capsid protein L1 of human papilloma virus. The present invention also discloses an immunogenic macromolecule which is essentially produced by expression of said codon-optimized gene encoding the major capsid protein L1 of human papilloma virus in a yeast cell. The present invention further discloses the use of said immunogenic macromolecule and a composition comprising said immunogenic macromolecule.Type: ApplicationFiled: June 5, 2014Publication date: November 6, 2014Inventors: Goaxia Zhang, Qiong Shen, Jianqiang Lei, Jingyu Yuan, Menghua Zhang, Qianli Zhang, Yinghua Xiong, Roger Wei, Ke Wu
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Patent number: 8877240Abstract: Provided are tablet binding compositions for binding cleaning and/or disinfecting formulation components into tablets. The tablet binding compositions are suitable replacements for traditional tablet binder compounds, such as boric acid or zeolites. The tablet binding compositions provided herein can produce tablets of increased hardness at lower compression forces and, when dissolved, yield solutions of increased clarity compared to some traditional binder compounds. Also provided are processes for preparing the tablet binding compositions and methods for formation of tablets containing the tablet binding compositions.Type: GrantFiled: January 9, 2014Date of Patent: November 4, 2014Assignee: ChemLink Laboratories, LLCInventor: Ryan Giffin Moore
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Patent number: 8877252Abstract: This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar.Type: GrantFiled: November 22, 2013Date of Patent: November 4, 2014Assignee: Alkermes Pharma Ireland LimitedInventors: Steven G. Wright, Troy Christensen, Thean Yeoh, Michael E. Rickey, Joyce M. Hotz, Rajesh Kumar, Henry R. Costantino
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Publication number: 20140322344Abstract: A vaccine preparation for treating cancer includes a complex of a hydrophobized polysaccharide and at least one synthetic long peptide derived from a tumor-specific antigenic protein and/or a pathogen-derived antigenic protein. The at least one synthetic long peptide contains at least one CD8+ cytotoxic T-cell recognition epitope and at least one CD4+ helper T-cell recognition epitope. The complex is simultaneously administered to the patient with at least one immunopotentiating agent.Type: ApplicationFiled: August 30, 2012Publication date: October 30, 2014Applicants: National University Corporation Tokyo Medical and Dental University, MIE UniversityInventors: Hiroshi Shiku, Naozumi Harada, Daisuke Muraoka, Kazunari Akiyoshi
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Publication number: 20140322345Abstract: The present invention provides novel slow-releasing ophthalmic compositions containing Povidone Iodine (PVP-I) and uses thereof in the treatment of acute infections of at least one eye tissue from bacterial, mycobacterial, viral, fungal, or amoebic causes and for preventing such infections in appropriate clinical settings. Each of the ophthalmic compositions contains povidone iodine, osmotic pressure regulator, suspending agent and EDTA-Na, wherein povidone iodine exists as microsphere particles formed by PVP-I and sodium alginate.Type: ApplicationFiled: November 28, 2012Publication date: October 30, 2014Inventors: Bo Liang, John J. Baldwin, Yong Lu
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Patent number: 8871276Abstract: The present invention discloses a dried composition comprising ?-casein micelles, assemblies and complexes thereof. The dried composition is stable in the dried state as well as upon re-suspension The dried composition retains the biological activity, drug load capacity, particle size and particle size distribution of the ?-casein micelles, assemblies and complexes comprising the active pharmaceutical ingredient, within the dried state and upon resuspension in a buffer or an aqueous pharmaceutical carrier.Type: GrantFiled: August 18, 2011Date of Patent: October 28, 2014Assignee: Technion Research and Development Foundation Ltd.Inventors: Yechezkel Barenholz, Dganit Danino
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Patent number: 8865222Abstract: The invention relates to a composition for the enrichment of food and/or beverage and to a method of preparing such composition. The composition comprises additive loaded beta-casein micelles which are of a diameter of about 100 nm or less. These nano-sized beta-casein assemblies are formed at pH values which are preferably one or more pH units above or below the pI of the protein (pI=5.3). More preferably the beta-casein nano-assemblies are formed at a pH range between about 6.0 and about 8, or between about 2.0 and about 4.2. The invention provides vehicles for delivery of additives via transparent beverages and other foods and drinks and/or acidic foods and drinks and/or non fat foods and drinks.Type: GrantFiled: February 11, 2009Date of Patent: October 21, 2014Assignee: Technion Research and Development Foundation Ltd.Inventors: Dganit Danino, Yoav D. Livney, Ory Ramon, Irina Portnoy, Uri Cogan
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Patent number: 8865223Abstract: Nanoparticulate assemblies of isolated beta-casein, are useful for encapsulation of bioactive therapeutic substances, particularly therapeutic agents with poor bioavailability. These nano-sized beta-casein assemblies are preferably formed at pH values which are at least one or more pH units below or above the pI of the protein. Pharmaceutical compositions comprising the beta-casein micelles may be used to administer the agents to the GI tract for treatment of local or systemic conditions. These carriers are stable over a wide temperature range (optionally at least from about 1° C. to at least about 45° C.).Type: GrantFiled: February 11, 2009Date of Patent: October 21, 2014Assignee: Technion Research and Development Foundation Ltd.Inventors: Yechezkel Barenholz, Dganit Danino
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Publication number: 20140308362Abstract: The inventions provided herein relate to compositions, methods, delivery devices and kits for repairing or augmenting a tissue in a subject. The compositions described herein are injectable such that they can be placed in a tissue to be treated with a minimally-invasive procedure (e.g., by injection) and/or be molded flexibly into a tissue void of any shape and/or size. In some embodiments, the composition described herein comprises a plurality of silk fibroin particles, which can retain their original volume within the tissue for a period of time. The compositions can be used as a filler to replace a tissue void, e.g., for tissue repair and/or augmentation, or as a scaffold to support tissue regeneration and/or reconstruction. In some embodiments, the compositions described herein can be used for soft tissue repair or augmentation.Type: ApplicationFiled: November 9, 2012Publication date: October 16, 2014Applicant: University of Pittsburgh of the Commonweathl SysteInventors: Evangelia Bellas, Kacey Marra, Peter J. Rubin, David L. Kaplan
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Publication number: 20140308361Abstract: The composition for management of periodontal diseases includes a gel matrix having a polymer system and a plurality of microspheres dispersed in the polymer system. The polymer system contains about one-half a dose of medicament, while the micro spheres contain the remainder. Upon administration of the composition into the periodontal cavity, the medicament in the polymer system provides an initial therapeutic benefit, while the remainder of the medication is released over time via degradation of the microspheres. This biphasic pattern of medicament delivery provides increased efficacy of the medicament through sustained delivery of the same.Type: ApplicationFiled: June 27, 2014Publication date: October 16, 2014Inventors: NOHA MOHAMED ZAKI RAYAD, Ibrahim Maghrabi, Mohamed Mostafa Hafez Mahmoud
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Patent number: 8858917Abstract: Formulations have been developed for pulmonary delivery to treat or reduce the infectivity of diseases such as vital infections, especially tuberculosis, SARS, influenza and respiratory synticial virus in humans and hoof and mouth disease in animals. Formulations for pulmonary administration include a material that significantly alters physical properties such as surface tension and surface elasticity of lung mucus lining fluid, which may be a surfactant and, optionally, a carrier. The formulation may be administered as a powder where the particles consist basically of the material altering surface tension. The carrier may be a solution, such as an alcohol, although an aqueous solution may be utilized, or a material mixed with the material altering surface tension to form particles.Type: GrantFiled: January 9, 2009Date of Patent: October 14, 2014Assignee: President and Fellows of Harvard CollegeInventors: David A. Edwards, Howard A. Stone
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Publication number: 20140302157Abstract: The present invention provides compositions comprising nanoparticles comprising: 1) a drug, such as a hydrophobic drug derivative; and 2) a carrier protein. Also provided are methods of treating diseases (such as cancer) using the compositions, as well as kits and unit dosages.Type: ApplicationFiled: February 28, 2014Publication date: October 9, 2014Applicant: Abraxis BioScience, LLCInventors: Neil P. DESAI, Chunlin TAO, Tapas DE, Sherry Xiaopei CI, Vuong TRIEU
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Publication number: 20140302158Abstract: The present invention relates to a composition or composition of bilayer lipid vesicles displaying an influenza virus antigen and carbohydrate, and the production thereof in Nicotiana tabacum plants. Also disclosed herein are pharmaceutical compositions comprising said lipid vesicles for use in the treatment or prophylaxis of viral infections.Type: ApplicationFiled: November 12, 2012Publication date: October 9, 2014Applicant: Phillip Morris Products S.A.Inventors: Rosa Cabrera, Karen Oishi, Laurent Perez, Fabio Talamo
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Publication number: 20140294985Abstract: The invention provides injectable, biofunctional agent-containing calcium phosphate cement bone pastes for bone tissue engineering, and methods of making and using the same.Type: ApplicationFiled: October 12, 2012Publication date: October 2, 2014Applicant: UNIVERSITY OF MARYLAND,BALTIMOREInventor: Huakun Xu
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Publication number: 20140294983Abstract: A nanoparticulate composition for the targeted therapeutic treatment of tumours. The stable self assembled nanocomposition according to the invention comprises (i) a carrier and targeting system comprising an optionally modified polyanion, and optionally a polycation, which may also be modified; at least one targeting agent which is linked to either the polycation/modified polycation or the polyanion/modified polyanion, or both, or to the surface of the nanoparticle; (ii) an active compound selected from the group of doxorubicin and its pharmaceutically acceptable salts, especially hydrochloride; and optionally (iii) at least one complexing agent, a metal ion, a stabilizer/formulating agent, or a PEGylating agent. The present invention furthermore relates to a process for the preparation of the above-mentioned composition, the therapeutic uses thereof, and pharmaceutical compositions containing the nanocomposition according to the invention.Type: ApplicationFiled: December 19, 2013Publication date: October 2, 2014Applicant: BBS NANOTECHNOLOGY LTD.Inventors: János BORBÉLY, Zsuzsanna CSIKÓS, Ildikó SCHRIFFERTNE DENYICSKA
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Patent number: 8846771Abstract: The present invention relates to a pharmaceutical composition comprising a pharmaceutical agent and a pharmaceutically acceptable carrier, which carrier comprises a protein, for example, human serum albumin and/or deferoxamine. He human serum albumin is present in an amount effective to reduce one or more side effects associated with administration of the pharmaceutical composition. The inventor also provides methods for reducing on or more side effects of administration of the pharmaceutical composition, and methods for enhancing transport and binding of a pharmaceutical agent to a cell.Type: GrantFiled: October 11, 2012Date of Patent: September 30, 2014Assignee: Abraxis BioScience, LLCInventors: Neil P. Desai, Patrick Soon-Shiong, Vuong Trieu
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Patent number: 8846105Abstract: The present invention relates to a dry powder fibrin sealant which comprises a mixture of fibrinogen and thrombin for use in surgery, trauma and other wounds or injuries. It further relates to novel formulations comprising said dry powder fibrin sealant for use in the treatment of wounds or for surgical intervention or as a topical hemostat.Type: GrantFiled: January 7, 2011Date of Patent: September 30, 2014Assignee: Profibrix, B.V.Inventors: Jacob Koopman, Glen Martyn
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Publication number: 20140271900Abstract: Silica materials having high cleaning and low abrasion properties are described, together with methods of making such materials and dentifrice compositions comprising the silica materials.Type: ApplicationFiled: March 7, 2014Publication date: September 18, 2014Inventor: Fitzgerald A. Sinclair
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Publication number: 20140271901Abstract: Methods and compositions are provided here to manage tractional membranes, as well as other diseases and disorders of the eye. Compositions comprising microbubbles associated with enzymes or vitreolytic agents, are provided. The method of the present invention involves administration of the microbubble and an enzyme or vitreolytic agent to a subject in need thereof, followed by application of ultrasound.Type: ApplicationFiled: March 18, 2014Publication date: September 18, 2014Inventor: Mark Humayun
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Publication number: 20140271902Abstract: There is presently provided a suspension of immiscible particles in a solution, wherein the particles comprise an agglomeration of a bioactive agent; and a plurality of conjugates of a hyaluronic acid and a flavonoid wherein the particles are on average from about 15 nm to about 300 nm in diameter and wherein the bioactive agent is releasably retained in the particles by the flavonoid. There is also provided a therapeutic formulation comprising such a suspension and methods for using the suspension and therapeutic formulation, including for delivery of a bioactive agent to a cell and for treating a disease, including cancer.Type: ApplicationFiled: May 30, 2014Publication date: September 18, 2014Inventors: Motoichi KURISAWA, Shengyong NG, Joo Eun CHUNG
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Publication number: 20140276632Abstract: The present invention provides a process for the preparation of a stable and homogeneous liquid composition that is suitable for enteral administration comprising a digestive enzyme product and nutrients from a nutritional formula having specific amount of nutrients. The invention further provides a method for efficiently and effectively administering a therapeutically effective dose of the stable and homogeneous liquid composition by means of an enteral tube.Type: ApplicationFiled: March 13, 2014Publication date: September 18, 2014Applicant: Aptalis Pharma Ltd.Inventors: Vincenza PIRONTI, Emanuela RONDA, Luigi BOLTRI