With Additional Active Ingredient Patents (Class 514/171)
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Patent number: 9655883Abstract: A topical composition comprises at least 5-wt % metronidazole or a pharmacologically acceptable derivative thereof in a non-aqueous vehicle. The composition may be used in the treatment of conditions of the colon, rectum, anorectum and perianal region, in particular inflammatory bowel disease and perianal Crohn's disease. The composition also relieves pain and inflammation and promotes healing of the colon, rectum, and anorectum and perianal region following surgical operations. One advantage of the composition is that topical administration of metronidazole results in a primarily local effect and thus side effects observed from systemic administration are avoided.Type: GrantFiled: July 12, 2010Date of Patent: May 23, 2017Assignee: SLA PHARMA AGInventor: David Nigel Armstrong
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Patent number: 9642912Abstract: The present disclosure is drawn to topical formulations and related methods. In one embodiment, a topical formulation is provided that includes at least one corticosteroid, a first compound, and a second compound. The first compound and second compound are different and each is selected from the group consisting of N-lauroyl sarcosine, sodium octyl sulfate, methyl laurate, isopropyl myristate, oleic acid, glyceryl oleate, and sodium lauryl sulfoacetate.Type: GrantFiled: December 22, 2014Date of Patent: May 9, 2017Assignee: Crescita Therapeutics Inc.Inventors: Edward T. Kisak, John M. Newsam, Dominic King-Smith, Pankaj Karande, Samir Mitragotri, Wade A. Hull, Ngoc Truc-Chi Vo
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Patent number: 9636336Abstract: Compounds of formula (I) defined herein are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for treating diseases of the respiratory tract.Type: GrantFiled: May 31, 2016Date of Patent: May 2, 2017Assignee: CHIESI FARMACEUTICI S.p.A.Inventors: Gabriele Amari, Elisabetta Armani, Wesley Blackaby, Herve Van De Poeol, Charles Baker-Glenn, Naimisha Trivedi
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Patent number: 9636425Abstract: A device and method for staining the eye of a patient in need of the same includes the introduction, onto the surface of the eye, of a dry powder form at a dye suitable for staining the eye. The dry powder form of the dye is introduced onto the surface of the eye without the use of a substrate at or near the eye's surface.Type: GrantFiled: September 18, 2012Date of Patent: May 2, 2017Assignee: Focal Point Technologies, LLCInventor: Amir Sahba Jalali
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Patent number: 9629847Abstract: The present invention relates to compositions containing stimulant and anti-histamine compounds, to methods for treating symptoms related to inflammation using the combination compounds, and to a method for preparing the compositions.Type: GrantFiled: September 4, 2015Date of Patent: April 25, 2017Inventor: Michael Leighton
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Patent number: 9623000Abstract: Compositions which include a corticosteroid in combination with an additional compound active in treatment of an inflammatory disorder are provided.Type: GrantFiled: July 29, 2009Date of Patent: April 18, 2017Assignee: DEKEL PHARMACEUTICALS LTDInventors: Seth Kindler, Ascher Shmulewitz
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Patent number: 9616127Abstract: Methods and formulations are provided for the treatment of localized edema, particularly localized edema resulting from chronic venous insufficiency. A metal ion sequestrant is topically administered to a subject afflicted with localized edema in combination with a permeation enhancer selected from methylsulfonylmethane and a combination of methylsulfonylmethane and dimethylsulfoxide. Topically administrable formulations for use in the aforementioned method are also provided.Type: GrantFiled: October 19, 2009Date of Patent: April 11, 2017Assignee: Livionex Inc.Inventors: Rajiv Bhushan, Jerry B. Gin, Amit Goswamy
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Patent number: 9597323Abstract: Compounds of formula (I) defined herein are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for treating diseases of the respiratory tract.Type: GrantFiled: May 31, 2016Date of Patent: March 21, 2017Assignee: CHIESI FARMACEUTICI S.p.A.Inventors: Gabriele Amari, Elisabetta Armani, Herve Van De Poeol, Charles Baker-Glenn, Naimisha Trivedi
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Patent number: 9597297Abstract: The present invention relates to compositions and methods for the treatment of the Charcot-Marie-Tooth disease and related peripheral neuropathies. More particularly, the invention relates to combined therapies for treating said disease by affecting simultaneously muscarinic receptor signalling and thyroid hormone pathway in a subject.Type: GrantFiled: May 5, 2014Date of Patent: March 21, 2017Assignee: PHARNEXTInventors: Daniel Cohen, Ilya Chumakov, Serguei Nabirochkin, Oxana Guerassimenko
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Patent number: 9579316Abstract: The present invention is directed to crystalline addition salts of (i) 8-hydroxyquinolin-2(1H)-one derivatives and (ii) a dicarboxylic acid or a sulfimide, or a pharmaceutically acceptable solvates thereof.Type: GrantFiled: July 24, 2014Date of Patent: February 28, 2017Assignee: Almirall, S.A.Inventors: Montserrat Julia Jane, Francesc Carrera Carrera, Maria Prat Quiñones, Carlos Puig Duran, Francesca Pajuelo Lorenzo, Juan Antonio Perez Andres
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Patent number: 9556185Abstract: The present invention relates to optionally substituted 4,5,7,8-tetrahydro-(optionally 4-oxo, 4-thioxo or 4-imino)-(1H or 2H)-imidazo[1,2-a]pyrazolo[4,3-e]pyrimidine or 4,5,7,8,9-pentahydro-(optionally 4-oxo, 4-thioxo or 4-imino)-(1H or 2H)-pyrimido[1,2-a]pyrazolo[4,3-e]pyrimidine compounds, and methods of using said compound, e.g., wherein the treatment relates to diseases involving disorders of the dopamine D1 receptor intracellular pathway, such as, among others, Parkinson's disease, depression, narcolepsy, damage to cognitive function, e.g., in schizophrenia.Type: GrantFiled: May 31, 2011Date of Patent: January 31, 2017Assignee: INTRA-CELLULAR THERAPIES, INC.Inventors: Peng Li, Hailin Zheng, Jun Zhao, Lawrence P. Wennogle
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Patent number: 9546175Abstract: The invention relates to novel inhibitors of phosphodiesterase 1 (PDE1), useful for the treatment of diseases or disorders characterized by disruption of or damage to certain cGMP/PKG mediated pathways (e.g., in cardiac tissue). The invention further relates to pharmaceutical composition comprising the same and methods of treatment of cardiovascular disease and related disorders, e.g., congestive heart disease, atherosclerosis, myocardial infarction, and stroke.Type: GrantFiled: August 6, 2015Date of Patent: January 17, 2017Assignee: INTRA-CELLULAR THERAPIES, INC.Inventors: Peng Li, Hailin Zheng, Jun Zhao, Lawrence P. Wennogle
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Patent number: 9545406Abstract: The subject matter generally relates to methods of treatment and/or prophylaxis of CNS diseases, disorders, and/or injuries. In one aspect, the subject matter relates to inhibitors of phosphodiesterase 1 (PDE1) as neuroprotective agents and/or neural regenerative agents. In a further aspect, the subject matter relates to individuals that are at risk for the development of CNS disease or disorder.Type: GrantFiled: March 17, 2014Date of Patent: January 17, 2017Assignee: INTRA-CELLULAR THERAPIES, INC.Inventor: Lawrence Wennogle
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Patent number: 9511045Abstract: This invention relates to riluzole for use in the treatment or prevention of adverse effects associated with the administration of anticancer agents having neurotoxic effects, such as, for example, platinum salts, taxanes and periwinkle alkaloids.Type: GrantFiled: March 2, 2011Date of Patent: December 6, 2016Assignee: UNIVERSITE D'AUVERGNE CLERMONT IInventors: Jérôme Busserolles, Abdelkrim Alloui, Michel Lazdunski, Alain Eschalier
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Patent number: 9512083Abstract: This invention relates to methods for treating bone disease associated with osteoclast activation using HDAC6 selective inhibitors, e.g., small molecule inhibitors such as reverse amide compounds.Type: GrantFiled: July 20, 2012Date of Patent: December 6, 2016Assignee: The General Hospital CorporationInventors: Noopur Raje, Loredana Santo
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Patent number: 9469669Abstract: Glucocorticosteroids that are derivatives of isoxazolidine are useful as anti-inflammatory and antiallergic compounds of the glucocorticosteroid series.Type: GrantFiled: September 3, 2015Date of Patent: October 18, 2016Assignee: Chiesi Farmaceutici S.p.A.Inventor: Eleonora Ghidini
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Patent number: 9456970Abstract: Dermatological compositions (methods of making and using) that include one or more anesthetic agents and/or one or more anti-inflammatory agents and/or a combination of ammonium, sodium, and potassium salts, preferably of an alpha-hydroxy acid.Type: GrantFiled: September 11, 2015Date of Patent: October 4, 2016Assignee: Upsher-Smith Laboratories, Inc.Inventors: Gloria A. Rood, Kenneth L. Evenstad, Victoria A. O'Neill
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Patent number: 9452175Abstract: The present invention relates to pregnancy hormone combinations and methods of treatment for autoimmune diseases having at least two hormonal components, a pregnancy hormone (such as estriol), and a gestagen (such as levonorgestrel or norethindrone) thereby providing for the continuous, uninterrupted administration of pregnancy hormones for the treatment for autoimmune disorders, such as multiple sclerosis.Type: GrantFiled: October 27, 2014Date of Patent: September 27, 2016Assignee: The Regents of the University of CaliforniaInventor: Rhonda Voskuhl
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Patent number: 9452147Abstract: Compositions, formulations, methods, and systems for treating regional fat deposits comprise contacting a targeted fat deposit with a composition comprising long acting beta-2 adrenergic receptor agonist and a compound that reduces desensitization of the target tissue to the long acting beta-2 adrenergic receptor agonist, for example, glucocorticosteroids and/or ketotifen. Embodiments of the composition are administered, for example, by injection, and/or transdermally.Type: GrantFiled: August 25, 2015Date of Patent: September 27, 2016Assignee: NEOTHETICS, INC.Inventor: John Daniel Dobak
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Patent number: 9446052Abstract: Provided is a composition for preventing nausea or vomiting, including a 5-HT3 receptor antagonist and a corticosteroid, and having a pH adjusted to 3.0-6.0. Provided also is a method for preparing a composition for preventing nausea or vomiting, including: mixing a 5-HT3 receptor antagonist with a corticosteroid; and adjusting pH of the mixture obtained from the preceding operation to 3.0-6.0.Type: GrantFiled: December 21, 2011Date of Patent: September 20, 2016Assignee: SAMYANG BIOPHARMACEUTICALS CORPORATIONInventors: Min Hyo Seo, Sa Won Lee, Do Hoon Kim
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Patent number: 9433570Abstract: A composition including 0.5-40 weight % vegetable extract, 30-90 weight % sugar and 0.5-30 weight % phospholipid for cosmetic, pharmaceutical or dietary uses.Type: GrantFiled: December 27, 2013Date of Patent: September 6, 2016Assignee: LIPOID GMBHInventor: Herbert Rebmann
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Patent number: 9415008Abstract: This invention provides a dry powder inhaler comprising: a dry powder medicament comprising fluticasone propionate, salmeterol xinafoate and a lactose carrier; wherein, the delivered dose of fluticasone propionate per actuation is less than 100 ?g; and wherein the dose provides a baseline-adjusted FEV1 in a patient of more than 150 mL within 30 minutes of receiving the dose. A method of treating a patient includes administering to a patient a dry powder medicament having fluticasone propionate, salmeterol xinafoate and a lactose carrier; wherein, the delivered dose of fluticasone propionate per actuation is less than 100 ?g; and wherein the dose provides a baseline-adjusted FEV1 in a patient of more than 150 mL within 30 minutes of receiving the dose.Type: GrantFiled: January 20, 2016Date of Patent: August 16, 2016Assignee: Teva Branded Pharmaceutical Products R&D, Inc.Inventors: Mukul Dalvi, Seah Kee Tee
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Patent number: 9409890Abstract: The present invention relates to novel pyrimidine hydroxy amide compounds, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.Type: GrantFiled: November 18, 2013Date of Patent: August 9, 2016Assignee: ACETYLON PHARAMCEUTICALS, INC.Inventors: John H. van Duzer, Ralph Mazitschek, Yanbing Ding, Nan Yu, Yun Cao, Yong Liu
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Patent number: 9403801Abstract: The present invention provides novel heteroaryl compounds, pharmaceutical acceptable salts and formulations thereof useful in preventing, treating or lessening the severity of a protein kinase-mediated disease. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of protein kinase-mediated disease.Type: GrantFiled: March 27, 2015Date of Patent: August 2, 2016Assignees: CALITOR SCIENCES, LLC, SUNSHINE LAKE PHARMA CO., LTD.Inventors: Ning Xi, Minxiong Li, Haiyang Hu, Weilong Dai
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Patent number: 9402805Abstract: Aqueous suspension formulations containing dexamethasone and ciprofloxacin are disclosed for the treatment of middle ear infections in human patients having an open tympanic membrane.Type: GrantFiled: April 29, 2016Date of Patent: August 2, 2016Assignee: Alcon Pharmaceuticals Ltd.Inventors: G. Michael Wall, Peter J. Conroy
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Patent number: 9399637Abstract: The present invention provides novel heteroaryl compounds, pharmaceutical acceptable salts and formulations thereof useful in preventing, treating or lessening the severity of a protein-mediated disease. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of protein kinase-mediated disease.Type: GrantFiled: March 27, 2015Date of Patent: July 26, 2016Assignees: CALITOR SCIENCES, LLC, SUNSHINE LAKE PHARMA CO., LTD.Inventors: Ning Xi, Minxiong Li, Xiaobo Li, Tao Zhang, Yanjun Wu
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Patent number: 9394281Abstract: The present invention provides novel heteroaryl compounds, pharmaceutical acceptable salts and formulations thereof useful in preventing, treating or lessening the severity of a protein kinase-mediated disease. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of protein kinase-mediated disease.Type: GrantFiled: March 27, 2015Date of Patent: July 19, 2016Assignees: CALITOR SCIENCES, LLC, SUNSHINE LAKE PHARMA CO., LTD.Inventors: Ning Xi, Minxiong Li, Xiaobo Li, Weilong Dai, Tingjin Wang
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Patent number: 9387167Abstract: The present invention is directed to orally administered corticosteroid compositions. The present invention also provides a method for treating a condition associated with inflammation of the gastrointestinal tract in an individual. The method comprises administering to an individual in need thereof a pharmaceutical composition of the present invention.Type: GrantFiled: June 23, 2014Date of Patent: July 12, 2016Assignee: ADARE PHARMACEUTICALS, INC.Inventors: Stephen Perrett, Fredric Jay Cohen, Gopi Venkatesh
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Patent number: 9381188Abstract: The invention relates to methods for treating pruritus with NK-1 receptor antagonists such as serlopitant. The invention further relates to pharmaceutical compositions comprising NK-1 receptor antagonists such as serlopitant. In addition, the invention encompasses treatment of a pruritus-associated condition with serlopitant and an additional antipruritic agent, and the use of serlopitant as a sleep aid, optionally in combination with an additional sleep-aiding agent.Type: GrantFiled: October 26, 2015Date of Patent: July 5, 2016Assignee: TIGERCAT PHARMA, INC.Inventors: Xiaoming Zhang, Edward F. Schnipper, Andrew J. Perlman, James W. Larrick
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Patent number: 9365577Abstract: Pyrimidinone compounds defined herein exhibit human neutrophil elastase inhibitory properties and are useful for treating diseases and conditions in which HINE is implicated.Type: GrantFiled: December 17, 2013Date of Patent: June 14, 2016Assignee: Chiesi Farmaceutici S.p.A.Inventors: Lilian Alcaraz, Robert Andrew Heald, Jonathan Mark Sutton, Elisabetta Armani, Carmelida Capaldi
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Patent number: 9353143Abstract: An ecdysterone compound is described. An ecdysterone compound may include ecdysterone and decanoic acid. An ecdysterone compound may further include ecdysterone and isobutyric acid. An ecdysterone compound may comprise a physiologically active salt or ester of ecdysterone. An ecdysterone compound may further comprise a physiologically active salt or ester of decanoic acid. Alternatively, an ecdysterone compound may include a physiologically active salt or ester of isobutyric acid.Type: GrantFiled: December 31, 2012Date of Patent: May 31, 2016Inventors: Ronald Kramer, Alexander Nikolaidis
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Patent number: 9351977Abstract: The present disclosure is directed to generally methods for treating mammographic breast density and/or breast stiffness in a patient in need thereof, such as a premenopausal or perimenopausal patient, comprising the administration of an effective amount of androgenic agent and an effective amount of an aromatase inhibitor. These methods may also be useful in post-menopausal woman.Type: GrantFiled: October 22, 2015Date of Patent: May 31, 2016Assignee: CHAVAH PTY LTD.Inventor: Stephen Nigel Birrell
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Patent number: 9351958Abstract: Provided is a composition for use in treating a skin condition, the composition comprising: (a) a first component comprising a substituted or unsubstituted diindolylmethane compound; and (b) a second component comprising a substituted or unsubstituted retinoid compound.Type: GrantFiled: September 24, 2015Date of Patent: May 31, 2016Assignee: SKINTECH LIFE SCIENCE LIMITEDInventor: David Alpert
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Patent number: 9314469Abstract: A method of treating corticosteroid-induced cognitive impairment comprises administering an effective amount of at least one compound of formula I, or pharmaceutically acceptable salts thereof, to a subject in need of such treatment. Formula I is: wherein: A is a bridge selected from the following radicals: —(CH2)m—, —CH?CH—, —(CH2)p—O—, —(CH2)p—S—, —(CH2)p—SO2—, —(CH2)p—NR1— and —SO2—NR2—, and wherein: m is an integer of from 1 to 3 inclusive; p is an integer selected from 1 and 2; R1 is selected from the group consisting of hydrogen and C1-C5 alkyl; and R2 is C1-C5 alkyl; X and Y are independently selected from the group consisting of hydrogen and halogen; R and R? are independently selected from the group consisting of hydrogen and C1-C5 alkyl; n is an integer from 1 to 12 inclusive; and * denotes an asymmetric carbon.Type: GrantFiled: May 5, 2008Date of Patent: April 19, 2016Assignee: Tonix Pharma Holdings LimitedInventor: Gregory M. Sullivan
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Patent number: 9295676Abstract: This invention is in the fields of cancer therapy. More particularly it concerns compounds which are useful agents for treating cell proliferative disorders, especially those disorders characterized by over activity and/or inappropriate activity of a EGFR, including EGFR-related cancers, particularly for expanding the efficacy of drugs previously developed for this purpose, and for methods of treatments using the compounds for this purpose.Type: GrantFiled: March 16, 2012Date of Patent: March 29, 2016Assignee: The Trustees Of The University of PennsylvaniaInventors: Alan Berezov, Mark I. Greene, Natalie Minkovsky, Zheng Cai, Hongtao Zhang
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Patent number: 9289399Abstract: The invention concerns a pharmaceutical composition characterized in that it contains a combination of a parasympatholytic agent, a sympathomimetic agent and a local anaesthetic. Such a composition may be injected into the anterior chamber of the eye before a cataract operation or instilled on the eye before laser treatment.Type: GrantFiled: May 4, 2012Date of Patent: March 22, 2016Assignee: LABORATOIRES THEAInventor: Walid Khatib
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Patent number: 9289442Abstract: Provided herein are anhydrous compositions that include at least one viscosity increasing agent, at least one organic solvent and at least one humectant. Such compositions may also include at least one active pharmaceutical ingredient (API) and/or at least one water repellant. Related compositions, methods and kits are also provided.Type: GrantFiled: December 19, 2013Date of Patent: March 22, 2016Assignee: Novan, Inc.Inventors: Ryan Doxey, Nathan Stasko
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Patent number: 9241944Abstract: The present invention relates to methods and compositions for stimulating reepithelialization during wound healing. More particularly, the present invention relates to a mmeralocorticoid receptor antagonist or an inhibitor of mineralocorticoid receptor gene expression for use in a method for stimulating reepithelialization of the skin or of the cornea during wound healing.Type: GrantFiled: June 16, 2011Date of Patent: January 26, 2016Assignees: Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance Publique Hopitaux de Paris, Universite Paris DescartesInventors: Nicolette Farman, Francine Behar-Cohen, Frédéric Jaisser
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Patent number: 9233973Abstract: Pharmaceutical compositions that bind to a predicted FK506 Binding Protein 52 (FKBP52) interaction surface on the androgen receptor hormone binding domain, otherwise known as FKBP52 Targeting Agents (FTAs) are provided. These compositions of the present invention are found to specifically recognize the FKBP52 regulatory surface on the androgen receptor and inhibit FKBP52 from functionally interacting with the androgen receptor. Compositions comprising the pharmaceutical composition, as well as methods of use, treatment and screening are also provided.Type: GrantFiled: July 21, 2014Date of Patent: January 12, 2016Assignees: The United States of America, as represented by The Secretary, Department of Health and Human Services, The Regents of the University of California, a California Corporation, Board of Regents, The University of Texas SystemInventors: Leonard M. Neckers, Marc B. Cox, Jane B. Neckers, Yeong Sang Kim, Aki Iwai, Yangmin Ning, Johanny Kugelman-Tonos, Heather A. Balsiger, Robert Fletterick
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Patent number: 9199937Abstract: Disclosed are substituted quinolines of formula 1 wherein R1 and R2 are defined herein, the processing of making and using the same.Type: GrantFiled: October 30, 2014Date of Patent: December 1, 2015Assignee: Boehringer Ingelheim International GmbHInventors: Matthias Hoffmann, Daniel Bischoff, Georg Dahmann, Jasna Klicic, Gerhard Schaenzle, Stefan Ludwig Michael Wollin, Serge Gaston Convers-Reignier, Stephen Peter East, Frederic Jacques Marlin, Clive McCarthy, John Scott
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Patent number: 9198885Abstract: Compositions, formulations, methods, and systems for treating regional fat deposits comprise contacting a targeted fat deposit with a composition comprising long acting beta-2 adrenergic receptor agonist and a compound that reduces desensitization of the target tissue to the long acting beta-2 adrenergic receptor agonist, for example, glucocorticosteroids and/or ketotifen. Embodiments of the composition are administered, for example, by injection, and/or transdermally.Type: GrantFiled: August 5, 2011Date of Patent: December 1, 2015Assignee: NEOTHETICS, INC.Inventor: John Daniel Dobak
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Patent number: 9198921Abstract: The present invention relates to compounds and methods which may be useful as treatments of neuromuscular diseases such as muscular dystrophy, and as inhibitors of NF-?B for the treatment or prevention of muscular wasting disease, including muscular dystrophy.Type: GrantFiled: April 5, 2011Date of Patent: December 1, 2015Assignee: ReveraGen BioPharma, Inc.Inventors: John M. McCall, Eric Hoffman, Kanneboyina Nagaraju
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Patent number: 9187518Abstract: A method of treating a solid tumor in a mammal by inhibiting angiogenesis, including administering to the mammal which has a solid tumor selected from the group consisting of breast carcinoma, lung carcinoma, prostate carcinoma, colon carcinoma, ovarian carcinoma, neuroblastoma, central nervous system tumor, multiform glioblastoma and melanoma; a composition including brassinosteroids of general formula (I) wherein can be a single or double bond and the configurations of carbon atoms C22 and C23 respectively linked to the substituents HO are S for both carbon atoms and a pharmaceutically acceptable additive.Type: GrantFiled: December 14, 2012Date of Patent: November 17, 2015Assignees: CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET), INIS BIOTECH LLCInventors: Javier Alberto Ramirez, Flavia Mariana Michelini, Lydia Raquel Galagovsky, Alejandro Berra, Laura Edith Alche
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Patent number: 9149485Abstract: Embodiments of the invention are directed to methods of determining the prognosis of a breast cancer patient by evaluating the activity of the glucocorticoid receptor in tumor cells. Other embodiment include methods of treating breast cancer cells, particularly, chemo-resistant cells, with a glucocorticoid receptor antagonist and an anticancer agent or compound.Type: GrantFiled: February 4, 2014Date of Patent: October 6, 2015Assignee: The University of ChicagoInventors: Deng Pan, Masha Kocherginsky, Suzanne D. Conzen
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Patent number: 9149486Abstract: Aqueous suspension formulations containing dexamethasone and ciprofloxacin are disclosed for the treatment of middle ear infections in human patients having an open tympanic membrane.Type: GrantFiled: August 25, 2014Date of Patent: October 6, 2015Assignee: ALCON PHARMACEUTICALS LTDInventors: G. Michael Wall, Peter J. Conroy
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Patent number: 9144565Abstract: A method of treating hearing loss includes the step administering a composition to the mammal, wherein the composition consists essentially of a biologically effective amount of vitamin A, vitamin E, vitamin C, a vasodilator comprising magnesium, and, optionally, a withanolide, and/or resveratrol.Type: GrantFiled: March 15, 2013Date of Patent: September 29, 2015Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Josef M. Miller, Glenn E. Green, Colleen G. LePrell
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Patent number: 9144555Abstract: Compositions comprising hydroxytyrosol-containing formulations and treatment regiments comprising hydroxytyrosol and/or oleuropein and chemotherapeutic agents are disclosed. Compositions and/or regiments may optionally include the administration of vitamins, minerals, and anti-oxidants. Methods for using these compositions and treatment regimens for treating subjects for diseases, such as a malignancy, and for inducing or enhancing angiogenesis, treating or preventing oxidative stress, for treating or preventing high glucose-induced dysfunction, treating or preventing chemotherapy-induced dysfunction, and for improving cell viability are provided. Various methods for use of the hydroxytyrosol compositions for inhibition of lysine specific demethylase 1 (LSD1) in various cancers are also provided.Type: GrantFiled: November 27, 2013Date of Patent: September 29, 2015Inventors: Darlene E. McCord, Thomas Karagiannis
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Patent number: 9144558Abstract: The present invention relates to combinations and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid ? toxicity. More specifically, the present invention relates to novel combinatorial therapies of Alzheimer's disease, Alzheimer's disease related disorders, amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury, based on baclofen and acamprosate combination.Type: GrantFiled: September 8, 2014Date of Patent: September 29, 2015Assignee: PHARNEXTInventors: Daniel Cohen, Ilya Chumakov, Serguei Nabirochkin, Emmanuel Vial, Mickael Guedj
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Patent number: 9127024Abstract: The present disclosure provides boron-containing diacylhydrazines having Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, and R5 are defined as set forth in the specification. The present disclosure also provides the use of boron-containing diacylhydrazines is ecdysone receptor-based inducible gene expression systems. Thus, the present disclosure is useful for applications such as gene therapy, treatment of disease, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable.Type: GrantFiled: March 14, 2014Date of Patent: September 8, 2015Assignee: Intrexon CorporationInventors: Sheela K. Chellappan, Robert E. Hormann, Inna Shulman
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Patent number: 9119863Abstract: Provided herein are methods for preventing or alleviating the symptoms of and inflammation associated with inflammatory diseases and conditions of the gastrointestinal tract, for example, those involving the esophagus. Also provided herein are pharmaceutical compositions useful for the methods of the present invention.Type: GrantFiled: July 8, 2013Date of Patent: September 1, 2015Assignee: The Regents of the University of CaliforniaInventors: Ranjan Dohil, John Bastian, Seema S. Aceves, Elaine Phillips, Malcolm Hill