Polycyclo Ring System Having The Seven-membered Hetero Ring As One Of The Cyclos Patents (Class 514/212.04)
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Patent number: 10865188Abstract: The present disclosure provides crystalline Compound I and crystalline Compound II, pharmaceutical compositions comprising one of said crystalline compounds suitable for intratympanic administration, and methods for treating otic disorders using the crystalline compounds and the pharmaceutical compositions.Type: GrantFiled: March 4, 2019Date of Patent: December 15, 2020Assignee: Pipeline Therapeutics, Inc.Inventors: Thomas Jon Seiders, Catherine Yuling Lee, Yiwei Li
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Patent number: 10301266Abstract: The present disclosure provides crystalline Compound I and crystalline Compound II, pharmaceutical compositions comprising one of said crystalline compounds suitable for intratympanic administration, and methods for treating otic disorders using the crystalline compounds and the pharmaceutical compositions.Type: GrantFiled: April 10, 2018Date of Patent: May 28, 2019Assignee: Inception 3, Inc.Inventors: Thomas Jon Seiders, Catherine Yuling Lee, Yiwei Li
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Patent number: 9913848Abstract: The present invention relates to methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells. Specifically, the invention relates to methods of using compounds comprising a 1,2,3,4-tetrahydro-[1,4]diazepino[6,7, 1-hi]indole moiety having a Formula I and pharmaceutically acceptable salts thereof.Type: GrantFiled: March 2, 2017Date of Patent: March 13, 2018Assignee: Frequency Therapeutics, Inc.Inventors: Christopher Loose, Will McLean, Melissa Hill-Drzewi
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Patent number: 9144543Abstract: Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants may be placed in an eye to prevent the occurrence of one or more ocular conditions, or to reduce one or more symptoms of an ocular condition, such as an ocular neurosensory disorder and the like.Type: GrantFiled: April 22, 2013Date of Patent: September 29, 2015Assignee: Allergan, Inc.Inventors: Glenn T. Huang, James A. Burke, Patrick M. Hughes, Kai-Ming Zhang, Ton Lin, Larry A. Wheeler, Rosy Sheng
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Publication number: 20140364402Abstract: The present invention provides, inter alia, a method for identifying an agent that selectively decreases the number of cancer stem cells (CSCs). This method includes (a) contacting a CSC from a population of cells with a candidate agent; and (b) determining whether the candidate agent reduces the survival or growth of the CSC or increases differentiation of the CSC relative to a CSC that has not been contacted with the candidate agent. The method may be used as a high throughput screen.Type: ApplicationFiled: March 22, 2012Publication date: December 11, 2014Applicant: THE ROGOSIN INSTITUTEInventors: Barry Smith, Carlos Cordon-Cardo, Daniel Petrylak, Josep Domenech, Mireia Castilla Martin
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Publication number: 20140357620Abstract: There are provided a new dosage regimens for the gamma secretase inhibitor 2,2-Dimethyl-N-((S)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-N-(2,2,3,3,3-pentafluoro-propyl)-malonamide which maximizes anti-tumor activity while maintaining acceptable toxicity levels.Type: ApplicationFiled: August 20, 2014Publication date: December 4, 2014Inventors: John Frederick Boylan, Stanislaw M. Mikulski
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Publication number: 20140248378Abstract: The present invention provides compounds of formula (1) and pharmaceutically acceptable salts thereof, wherein R1, R2, Y and Z are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.Type: ApplicationFiled: July 5, 2012Publication date: September 4, 2014Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Xiao-Ling Fan Cockcroft, William Farnaby, Natasha Kinsella, Kevin Merchant, David Miller
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Publication number: 20140187495Abstract: Described are methods for treating cancers, e.g., glioblastoma, including administering an inhibitor of Notch signalling, e.g., a gamma secretase inhibitor, in combination with a chemotherapeutic agent.Type: ApplicationFiled: December 20, 2013Publication date: July 3, 2014Applicant: University of MassachusettsInventors: Alonzo H. Ross, Candace Gilbert, Richard Moser
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Patent number: 8741889Abstract: The present invention provides a method for treating a patient having cancer comprising administering to the patient a therapeutically effective amount of compound (1), or a pharmaceutically acceptable salt thereof, having the formula: The present invention also provides a kit containing the above compound.Type: GrantFiled: April 19, 2012Date of Patent: June 3, 2014Assignee: Hoffmann-La Roche IncInventors: John Frederick Boylan, Leopoldo Ladores Luistro, Kathryn Elizabeth Packman
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Publication number: 20140128357Abstract: The disclosure relates to methods of using brassinosteroid compounds, including those defined by formula I or a derivative thereof, for inducing an anabolically favorable state for growth, repair, and maintenance of skeletal muscle and skin.Type: ApplicationFiled: December 13, 2011Publication date: May 8, 2014Applicant: Rutgers UniversityInventors: Ilya Raskin, Debora Esposito, Slavko Komarnytsky, Thirumurugan Rathinasabapathy, Leonel Rojo Castillo
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Patent number: 8691808Abstract: The present disclosure provides compounds having affinity for the M2 proton channel, useful for the treatment of viral infections such as influenza, which are of the Formula (I): wherein R1, R2, and Y are as defined herein. Methods of preparing the compounds, pharmaceutical compositions containing the compounds, and methods of using the compounds in the treatment of viral infections such as influenza are also provided.Type: GrantFiled: May 18, 2012Date of Patent: April 8, 2014Assignee: Influmedix, Inc.Inventors: Jizhou Wang, Xiaodong Fan, Lidia Cristian
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Publication number: 20130281437Abstract: The present invention provides a method for treating a patient having cancer comprising administering to the patient a therapeutically effective amount of compound (1), or a pharmaceutically acceptable salt thereof, having the formula: The present invention also provides a kit containing the above compound.Type: ApplicationFiled: April 19, 2012Publication date: October 24, 2013Inventors: John Frederick Boylan, Leopoldo Ladores Luistro, III, Kathyrn Elizabeth Packman
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Publication number: 20130252930Abstract: Provided herein are inhibitors of CYP11B, CYP17, and/or CYP21 enzymes of Formula (Z), (IX), (X), (XI), (XII), (XIII), (XIV), (XV), (XVI), or (XVII). Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat androgen-dependent diseases, disorders and conditions.Type: ApplicationFiled: December 16, 2011Publication date: September 26, 2013Applicant: BIOMARIN PHARMACEUTICAL INC.Inventors: Daniel Chu, Bing Wang, Tao Ye
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Patent number: 8524701Abstract: The present invention provides the use in a pharmaceutical composition of a specific cyclic amine derivative, or its pharmaceutically acceptable salts, for the treatment of heart failure of any aetiology.Type: GrantFiled: June 13, 2008Date of Patent: September 3, 2013Assignee: Boehringer Ingelheim Pharma GmbH & Co. KGInventors: Brian Guth, Randolph Seidler, Juergen Daemmgen
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Publication number: 20130217674Abstract: Compounds of structure (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2 and A are as defined herein are disclosed. Such compounds have enhanced water solubility and have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Enantioselective methods for preparation of compounds of structure (I), compositions comprising a compound of structure (I) in combination with a pharmaceutically acceptable carrier or diluents and methods of SHIP1 modulation by administration of such compounds to an animal in need thereof are also disclosed.Type: ApplicationFiled: August 22, 2011Publication date: August 22, 2013Applicant: THE UNIVERSITY OF BRITISH COLUMBIAInventors: Xiaoxia Wang, Labros George Meimetis, Matthew Bruce Nodwell, Raymond Andersen
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Publication number: 20130196976Abstract: Disclosed are a composition for reducing beta amyloid-induced neurotoxicity by inhibiting ?-secretase activity, comprising a dibenzofuran derivative, and a method for preparing the same. Further disclosed is that the combination of the dibenzofuran derivative with a ?-secretase inhibitor or an anti-inflammatory agent shows higher activity with respect to reducing beta amyloid-induced neurotoxicity.Type: ApplicationFiled: March 12, 2013Publication date: August 1, 2013Applicant: PHLORONOL, INC.Inventor: PHLORONOL, INC.
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Publication number: 20130102538Abstract: The present invention relates to a method for treating an individual having Alzheimer's Disease by using pharmacological chaperones that bind presenelin and thereby increase ?-secretase activity.Type: ApplicationFiled: May 4, 2011Publication date: April 25, 2013Applicant: AMICUS THERAPEUTICS, INC.Inventors: Brandon Wustman, Anthony Stevens
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Patent number: 8377886Abstract: Methods are provided for treating and preventing renal disease in a subject by administering a gamma secretase inhibitor or a Notch pathway inhibitor to the subject.Type: GrantFiled: September 4, 2008Date of Patent: February 19, 2013Assignee: Albert Einstein College of Medicine of Yeshiva UniversityInventors: Katalin Susztak, Bernhard Bielesz, Thiruvur G. Niranjan
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Publication number: 20120295886Abstract: The present disclosure provides compounds having affinity for the M2 proton channel, useful for the treatment of viral infections such as influenza, which are of the Formula (I): wherein R1, R2, and Y are as defined herein. Methods of preparing the compounds, pharmaceutical compositions containing the compounds, and methods of using the compounds in the treatment of viral infections such as influenza are also provided.Type: ApplicationFiled: May 18, 2012Publication date: November 22, 2012Applicant: INFLUMEDIX, INC.Inventors: Jizhou Wang, Xiaodong Fan, Lidia Cristian
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Publication number: 20120238549Abstract: The invention provides a compound of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.Type: ApplicationFiled: March 15, 2012Publication date: September 20, 2012Applicant: ABBOTT LABORATORIESInventors: Kevin P. Cusack, Thomas D. Gordon, David C. Ihle, Martin E. Hayes, Eric C. Breinlinger, Anna M. Ericsson, Bin Li, Lei Wang, Gloria Y. Martinez, Andrew Burchat, Adrian D. Hobson, Kelly D. Mullen, Michael Friedman, Michael J. Morytko
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Publication number: 20120230951Abstract: The present invention provides compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.Type: ApplicationFiled: March 8, 2012Publication date: September 13, 2012Inventors: Muzaffar Alam, Steven Joseph Berthel, John A. Brinkman, Ronald Charles Hawley, Hongju Li, Wylie Solang Palmer, Sherrie Pietranico-Cole, Ramakanth Sarabu, Mark Smith, Sung-Sau So, Lin Yi, Yansheng Zhai, Qiang Zhang, Shu-Hai Zhao
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Publication number: 20120225860Abstract: There are provided a new dosage regimens for the gamma secretase inhibitor 2,2-Dimethyl-N-((S)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-N?-(2,2,3,3,3-pentafluoro-propyl)-malonamide which maximizes anti-tumor activity while maintaining acceptable toxicity levels.Type: ApplicationFiled: February 20, 2012Publication date: September 6, 2012Inventors: John Frederick Boylan, Stanislaw Mikulski
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Publication number: 20120184529Abstract: The present invention relates to a combination therapy of 2-Chloro-N-(4-chloro-pyridin-2-yl-phenyl)-4-methanesulfonyl-benzamide and 2,2-Dimethyl-N-((S)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-N?-(2,2,3,3,3-pentafluoro-propyl)-malonamide for treating a patient suffering from a proliferative disorder.Type: ApplicationFiled: January 3, 2012Publication date: July 19, 2012Inventors: Mark D. DeMario, Stanislaw M. Mikulski
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Patent number: 8217030Abstract: Association of a sinus node If current inhibitor and a ?-blocker and also pharmaceutical compositions containing it. Medicinal products containing the same which are useful in treating angina pectoris, ischaemia, and heart failure.Type: GrantFiled: February 11, 2009Date of Patent: July 10, 2012Assignee: Les Laboratoires ServierInventors: Guy Lerebours-Pegeonniere, Jean-Henri Calvet
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Publication number: 20110287025Abstract: The present invention relates to a method for determining a subject's resistance to treatment with 2,2-dimethyl-N—((S)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-N?-(2,2,3,3,3-pentafluoro-propyl)-malonamide by measuring the levels a biomarker or biomarkers present in a biological sample obtained from the subject, the biomarker being IL6 and/or IL8. The present invention also relates to a combination therapy for a patient suffering from a proliferative disorder comprising administering to the patient 2,2-Dimethyl-N—((S)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-N?-(2,2,3,3,3-pentafluoro-propyl)-malonamide and an anti-IL6 and/or an anti-IL8 agent.Type: ApplicationFiled: May 2, 2011Publication date: November 24, 2011Inventors: John Frederick Boylan, Wei He
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Publication number: 20110245233Abstract: This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.Type: ApplicationFiled: February 23, 2011Publication date: October 6, 2011Inventors: Eric Anderson, Xin Jiang, Xiaofeng Liu, Melean Visnick
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Patent number: 8022203Abstract: New aminoalkoxyimino derivatives at position 3 of substituted B-homoandrostanes and B-heteroandrostanes, processes for their preparation, and to pharmaceutical compositions containing them for the treatment of cardiovascular disorders, such as heart failure and hypertension. In particular compounds having the general formula (I) are described, where the radicals have the meanings described in detail in the application.Type: GrantFiled: May 31, 2007Date of Patent: September 20, 2011Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.Inventors: Alberto Cerri, Barbara Moro, Maco Torri, Giulio Carzana, Giuseppe Bianchi, Mara Ferrandi, Patrizia Ferrari, Maria Pia Zappavigna, Leonardo Banfi, Giuseppe Giacalone
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Publication number: 20110178065Abstract: Provided herein are inhibitors of CYP17 enzyme. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat androgen-dependent diseases, disorders and conditions.Type: ApplicationFiled: January 13, 2011Publication date: July 21, 2011Applicant: BIOMARIN PHARMACEUTICAL INC.Inventors: Daniel Chu, Bing Wang, Tao Ye
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Publication number: 20110150835Abstract: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.Type: ApplicationFiled: October 31, 2007Publication date: June 23, 2011Inventors: Srikanth Venkatraman, F. George Njoroge, Wanli Wu, Viyyoor M. Girijavallabhan, Brian A. McKittrick, Jing Su, Francisco Velazquez, Patrick A. Pinto
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Patent number: 7915280Abstract: This invention relates to compounds, pharmaceutical compositions, and methods of using the disclosed compounds for inhibiting PARP.Type: GrantFiled: August 30, 2005Date of Patent: March 29, 2011Assignee: Eisai Inc.Inventors: Dana Victor Ferraris, Jia-He Li, Vincent Kalish, Jie Zhang
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Publication number: 20110033463Abstract: A device is configured to remove a target molecule from a bodily fluid of a subject and to deliver a therapeutic agent to the subject. Such a device may be used for treatment of a disease associated with amyloid beta accumulation in the subject. Agents selected from the group consisting of an ApoE-modulating agent; a RAGE inhibitor; a ?-secretase 1 (BACE1) inhibitor; a ?-secretase inhibitor; a muscarinic receptor subtype 1 (M1) agonists; a growth factor; an enzyme capable of degrading amyloid beta; a mitochondrial antioxidant; insulin; and an inhibitor of tumor necrosis factor (TNF) may be administered directly to the central nervous system of a subject for treatment of a disease associated with amyloid beta accumulation.Type: ApplicationFiled: August 6, 2010Publication date: February 10, 2011Applicant: MEDTRONIC, INC.Inventors: Deepak R. Thakker, Lisa L. Shafer
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Publication number: 20100292157Abstract: The invention relates generally to novel compositions and methods comprising a cyclohexanehexol and a secretase inhibitor. The compositions and methods provide beneficial effects, in particular sustained beneficial effects, in the treatment of diseases involving a disorder in protein folding and/or aggregation, and/or amyloid formation, deposition, accumulation, or persistence, such as Alzheimer's disease and related neurodegenerative disorders.Type: ApplicationFiled: November 22, 2007Publication date: November 18, 2010Inventor: Antonio Cruz
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Publication number: 20100226944Abstract: The present invention relates to a process for the preparation of controlled-release solid oral pharmaceutical formulations of oxcarbazepine, and the pharmaceutical formulations obtainable by said process.Type: ApplicationFiled: July 23, 2008Publication date: September 9, 2010Applicant: ARCHIMICA S.R.L.Inventors: Giovanni Sanso', Aldo Banfi, Giorgio Bertolini, Claudio Silva
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Publication number: 20100222283Abstract: Methods are provided for treating and preventing renal disease in a subject by administering a gamma secretase inhibitor or a Notch pathway inhibitor to the subject.Type: ApplicationFiled: September 4, 2008Publication date: September 2, 2010Inventors: Katalin Susztak, Bernhard Bielesz, Thiruvur G. Niranjan
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Publication number: 20100216772Abstract: The present invention relates to compounds of the general formula (IV) and (II) and salts and physiologically functional derivatives thereof, wherein X is C—R8 or N; and Z is independently one of the following groups:Type: ApplicationFiled: October 5, 2004Publication date: August 26, 2010Inventors: Stefano Pegoraro, Martin Lang, Juliane Feurle, Jürgen Krauss
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Patent number: 7767664Abstract: The present invention relates to a new class of plant growth regulators. In particular, the invention relates to fused azepinone derivative of general formula (I) or an agriculturally acceptable salt thereof wherein X is CO2R2 or H; Y is OH; NHNR3R4, NHNHC(?Z)NR5R6 or NHNHC(?Z)CR7R8R9; or X and Y together with the two carbon atoms to which they are attached form a ring of formula (A) and a method for treatment of plants with such compounds in order to induce growth regulating responses.Type: GrantFiled: April 30, 2005Date of Patent: August 3, 2010Assignee: Bayer CropScience AGInventors: Henricus M. M. Bastiaans, Günter Donn, Nathalie Knittel, Arianna Martelletti, Richard Rees, Michael Schwall, Ryan Whitford
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Publication number: 20100190688Abstract: Compounds, compositions and methods for treatment of hyperproliferative diseases, such as cancer are provided.Type: ApplicationFiled: July 12, 2005Publication date: July 29, 2010Inventors: Bin Chao, Thomas L. Deckwerth, Paul S. Furth, Steven D. Linton, Alfred P. Spada, Brett R. Ullman, Michael I. Weinhouse
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Publication number: 20100190752Abstract: A composition of matter comprising in combination as component (a) at least one 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol compound, and as component (b) at least one antiepileptic, a pharmaceutical formulation and a dosage form comprising said composition of matter, and a method of treating pain, e.g. neuropathic pain, in which components (a) and (b) are administered simultaneously or sequentially to a mammal, whereby component (a) may be administered before or after component (b) and whereby components (a) or (b) are administered to the mammal either via the same or a different pathway of administration.Type: ApplicationFiled: January 26, 2010Publication date: July 29, 2010Applicant: Gruenenthal GmbHInventors: Klaus Schiene, Petra Bloms-Funke, Thomas Christoph
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Publication number: 20100069359Abstract: Compounds of formula I: (wherein variables A1, A2, A3, G1, G2, G3, J, m, n, p, R1, R2, R3, R4 and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.Type: ApplicationFiled: December 5, 2007Publication date: March 18, 2010Inventors: Ian M. Bell, Harold G. Selnick
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Publication number: 20100041639Abstract: This invention relates to novel cyclic malonamides having the formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A?-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to ?-amyloid production such as Alzheimer's disease and Down's Syndrome.Type: ApplicationFiled: October 21, 2009Publication date: February 18, 2010Applicant: BRISTOL-MYERS SQIBB PHARMA COMAPNYInventors: Richard E. Olson, Michael G. Yang
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Publication number: 20100009966Abstract: This invention relates to novel lactams of Formula (I): having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A?-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to ?-amyloid production such as Alzheimer's disease and Down's Syndrome.Type: ApplicationFiled: September 15, 2009Publication date: January 14, 2010Applicant: BRISTOL-MYERS SQUIBB PHARMA COMPANYInventors: Qi HAN, Hong Liu, Richard E. Olson, Michael G. Yang
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Publication number: 20090281081Abstract: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.Type: ApplicationFiled: May 6, 2009Publication date: November 12, 2009Inventors: Jay R. Luly, Yoshisuke Nakasato, Etsuo Ohshima, Geraldine C. B. Harriman, Kenneth G. Carson, Shomir Ghosh, Amy M. Elder, Karen M. Mattia
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Publication number: 20090192140Abstract: Disclosed herein is an isomer, enantiomer, diastereoisomer or tautomer of a compound represented by Formula I: or a prodrug, or a pharmaceutically acceptable salt, or labeled with a detectable label or an affinity tag thereof; wherein R1, R1a, R100, R100a, R2, R200, W, B, and W1 are defined herein. Also disclosed are methods of using compounds of Formula I to treat proliferative disorders such as cancer.Type: ApplicationFiled: May 16, 2007Publication date: July 30, 2009Applicant: Aegera Therapeutics Inc.Inventors: Alain Laurent, Scott Jarvis, Patrick Bureau, Alain Boudreault, James Jaquith
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Patent number: 7550453Abstract: The invention relates particularly to 2-alkoxy-3,4,5-trihydroxy-alkylamides, preparation thereof, compositions containing them and use thereof as a medicament, particularly as anti-cancer agents.Type: GrantFiled: May 24, 2007Date of Patent: June 23, 2009Assignee: Aventis Pharma SAInventors: Jidong Zhang, Neerja Bhatnagar, Jean-Marie Ruxer
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Patent number: 7544679Abstract: The invention relates to 6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl derivatives of formula I wherein R1, R2 and R3 are as defined herein. The compounds are ?-secretase inhibitors useful in the treatment of Alzheimer's disease or common cancer, including, but not limited to, cervical carcinomas and breast carcinomas and malignancies of the hematopoietic system.Type: GrantFiled: January 25, 2008Date of Patent: June 9, 2009Assignee: Hoffman-La Roche Inc.Inventors: Alexander Flohr, Roland Jakob-Roetne, Wolfgang Wostl
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Publication number: 20090111793Abstract: This invention relates to novel lactams having the formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A?-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to ?-amyloid production such as Alzheimer's disease and Down's Syndrome.Type: ApplicationFiled: September 9, 2008Publication date: April 30, 2009Applicant: BRISTOL-MYERS SQUIBB PHARMA COMPANYInventors: Richard E. Olson, Hong Liu, Lorin A. Thompson
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Publication number: 20090069293Abstract: This invention relates to novel lactams having the formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A?-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to ?-amyloid production such as Alzheimer's disease and Down's Syndrome.Type: ApplicationFiled: October 20, 2008Publication date: March 12, 2009Applicant: Bristol-Myers Squibb Pharma CompanyInventor: Richard E. Olson
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Patent number: 7501405Abstract: Combination therapy comprising the administration of an 11?-hydroxysteroid dehydrogenase type 1 inhibitor and an antihypertensive agent useful for treating, preventing and reducing the risk of developing insulin resistance, dyslipidemia, obesity, hypertension and other related diseases and disorders.Type: GrantFiled: October 11, 2005Date of Patent: March 10, 2009Assignee: High Point Pharmaceuticals, LLCInventors: Gita Camilla Tejlgaard Kampen, Henrik Sune Andersen
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Publication number: 20090062256Abstract: This invention relates to novel lactams having the Formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A?-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to ?-amyloid production such as Alzheimer's disease and Down's Syndrome.Type: ApplicationFiled: October 24, 2008Publication date: March 5, 2009Applicant: BRISTOL-MYERS SQUIBB PHARMA COMPANYInventor: Richard E. Olson
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Publication number: 20080312210Abstract: The present invention provides the use in a pharmaceutical composition of a specific cyclic amine derivative, or its pharmaceutically acceptable salts, for the treatment of heart failure of any aetiology.Type: ApplicationFiled: June 13, 2008Publication date: December 18, 2008Applicant: Boehringer Ingelheim Pharma GmbH & Co. KGInventors: Brian GUTH, Randolph SEIDLER, Juergen DAEMMGEN