Oxygen Of The Saccharide Radical Bonded Directly To A Nonsaccharide Hetero Ring Or A Polycyclo Ring System Which Contains A Nonsaccharide Hetero Ring Patents (Class 514/27)
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Patent number: 10555982Abstract: Disclosed are the compositions comprising bioactive components Oroxylin A, Baicalein, Chrysin, and their glucuronides Oroxylin A-7-glucuronide, Baicalein-7-glucuronide and Chrysin-7-glucuronide, isolated from the bark of Oroxylum indicum, and the process of isolating the said bioactives.Type: GrantFiled: November 7, 2017Date of Patent: February 11, 2020Assignee: SAMI LABS LIMITEDInventors: Muhammed Majeed, Kalyanam Nagabhushanam, Beena Bhat, Anurag Pande
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Method of isolating anti-viral ingredients from , compositions comprising them and their medical use
Patent number: 10537601Abstract: The present invention provides a method of isolating at least one ingredient with anti-viral efficacy from Baphicacanthus cusia. The ingredient can be an alkaloid, a triterpenoid, a lignan, a phenylethanoid, a sesquiterpene lactone, or a flavonoid. Two new alkaloids are produced, which have not been previously reported. Moreover, the method isolates 12 compounds which could not or have not been previously isolated. A pharmaceutical composition includes the at least one ingredient and at least one pharmaceutical tolerable excipient. A method of treating a subject suffering from a viral disease includes administering at least one ingredient isolated from Baphicacanthus cusia.Type: GrantFiled: April 4, 2016Date of Patent: January 21, 2020Assignee: MACAU UNIVERSITY OF SCIENCE AND TECHNOLOGYInventors: Jing-Rong Wang, Zhi-Hong Jiang, Qi-Tong Feng, Guo-Yuan Zhu, Wei-Na Gao, Zifeng Yang, Nanshan Zhong -
Patent number: 10493021Abstract: The present invention provides stable antioxidant cosmetic formulations for topical use comprising green tea extract in combination with additional active compounds having the surprising ability to exert antioxidant effect on the skin, the use stable antioxidant cosmetic formulations, as well as a method for reducing and/or preventing oxidative stress in keratinous tissues.Type: GrantFiled: March 4, 2016Date of Patent: December 3, 2019Assignee: NATURA COSMÉTICOS S.A.Inventors: Ana Paula Pedroso De Oliveira, Cristiane Calvo De Santi, Gabriela Placoná Diniz, Jenny Chu Yan Ling Okuda, Juliana Carvalhães Lago, Kelen Fabíola Arroteia
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Patent number: 10420756Abstract: The present invention relates to a method of reducing or preventing the symptoms associated with the intake of alcohol. The method comprises administering to a subject an effective amount of a pharmaceutical composition prior to alcohol intake. The pharmaceutical composition comprises a non-steroidal anti-inflammatory drug and a H1-antihistamine.Type: GrantFiled: March 18, 2016Date of Patent: September 24, 2019Assignee: SEN-JAM PHARMACEUTICAL LLC.Inventors: Jacqueline M. Iversen, James M. Iversen
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Patent number: 10383842Abstract: A method and composition for treating viral infections using a combination of naturally occurring compounds is provided. The method includes administering to a patient at risk of or diagnosed with a viral infection a composition including therapeutically effective amounts of a helicase ATPase inhibitor, a sialidase enzyme inhibitor, and ICAM-1 inhibitor which each also down regulate the immune response. The composition may further include a permeation enhancer.Type: GrantFiled: February 12, 2016Date of Patent: August 20, 2019Assignee: GLOBAL BIOLIFE INC.Inventor: Daryl Thompson
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Patent number: 10376465Abstract: The present invention is directed toward respirable dry powders and particles for systemic delivery of pharmaceutically active agents or delivery to the respiratory tract. The dry powders contain one or more monovalent metal cations (such as Na+), are small and dispersible.Type: GrantFiled: September 27, 2016Date of Patent: August 13, 2019Assignee: Pulmatrix Operating Company, Inc.Inventors: Michael M. Lipp, Jean C. Sung
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Patent number: 10350230Abstract: Disclosed is a use of albiflorin or a pharmaceutically acceptable salt for the prevention and/or treatment of irritable bowel syndrome. The experimental results demonstrate that the prevention, remission and/or treatment of irritable bowel syndrome with albiflorin or a pharmaceutically acceptable salt has significant effects and few side effects. This is a preparation derived from a natural plant for the safe, effective and multi-targeted prevention, remission and/or treatment of irritable bowel syndrome.Type: GrantFiled: April 27, 2015Date of Patent: July 16, 2019Inventor: Zuoguang Zhang
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Patent number: 10335356Abstract: The present invention discloses a use of neohesperidin or a neohesperidin-containing plant extract in the manufacture of a product for improving and/or promoting skin microcirculation, or for eliminating and/or alleviating diseases or conditions associated with poor skin microcirculation. The present invention also discloses a composition comprising an effective amount of neohesperidin or a neohesperidin-containing plant extract, and to a method for improving and/or promoting skin microcirculation, or eliminating and/or alleviating diseases or conditions associated with poor skin microcirculation, by using neohesperidin. The skin microcirculation of the present invention is preferably eye skin microcirculation.Type: GrantFiled: November 25, 2011Date of Patent: July 2, 2019Assignee: Natural Medicine Institute of Zhejiang Yangshengtang Co., Ltd.Inventors: Liu Hu, Hongying Lan
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Patent number: 10328183Abstract: Various aspects of the present invention provide compositions and implantable devices including a water-insoluble therapeutic agent solubilized in a matrix of a gallate-containing compound. Other aspects provide methods of manufacturing and using such compositions and devices.Type: GrantFiled: June 6, 2018Date of Patent: June 25, 2019Assignee: COOK MEDICAL TECHNOLOGIES LLCInventors: John Jackson, Lindsay Stuart Machan, Kevin Letchford
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Patent number: 10286068Abstract: A vaccine composition is disclosed that contains a vaccine antigen and a neutrophil inhibitor in amounts effective to promote an IgA response to the antigen in a subject. Also disclosed is a method for enhancing immune response to a vaccine antigen in a subject that involves co-administering to the subject the vaccine antigen and an adjuvant composition comprising a neutrophil inhibitor in an amount effective to promote an IgA response to the vaccine antigen in the subject.Type: GrantFiled: April 15, 2016Date of Patent: May 14, 2019Assignee: Ohio State Innovation FoundationInventor: Prosper Boyaka
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Patent number: 10285976Abstract: Compositions for treating autoimmune, allergic, or atopic disease comprising a compound that inhibits hyaluronan synthesis and a pharmaceutically acceptable carrier are described. In some embodiments, the compound that inhibits hyaluronan synthesis is 4-methylumbelliferone or a metabolite of 4-methylumbelliferone. Methods for treating autoimmune diabetes, multiple sclerosis and/or autoimmune demyelination, including administering to the subject a composition having a compound in an amount effective to inhibit hyaluronan synthesis in a mammalian subject, are also described.Type: GrantFiled: August 12, 2014Date of Patent: May 14, 2019Assignees: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASONInventors: Paul L. Bollyky, Nadine Nagy, Thomas Wight, Hedwich F. Kuipers
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Patent number: 10278949Abstract: A biotechnology process that employs membrane technology for obtaining an extract rich in tannins of ellagic acid from blackberries (Rubus spp.) and from other fruits that contain these compounds, as well as to the extract obtained using this method. The method is essentially based on baromembrane technologies that allow mechanical separation and effective fractionation between the polyphenol compounds, by interactions between the physico-chemical properties thereof, the material of the membrane and the molar mass of same, thereby allowing enrichment of a fraction of the natural extract with ellagic acid tannins and modification of the content thereof in terms of anthocyanins and other compounds such as sugars and acids.Type: GrantFiled: May 11, 2012Date of Patent: May 7, 2019Assignees: UNIVERSIDAD DE COSTA RICA, CENTRO INTERNACIONAL DE COOPERACION EN INVESTIGACION AGRICOLA PARA EL DESARROLLO, CIRAD, CENTRO INTERNACIONAL DE ESTUDIOS SUPERIORES EN CIENCIAS AGRONOMICAS, SUPAGROInventors: Oscar Gerardo Acosta Montoya, Ana Mercedes Perez Carvajal, Manuel Dornier, Fabrice Vaillant
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Patent number: 10272099Abstract: The therapies described herein can be selectively lethal toward a variety of different cancer cell types and cancer conditions in a subject. The combination therapies described herein can be useful for the management, treatment, control, or adjunct treatment of diseases, where the selective lethality is beneficial in chemotherapeutic therapy, particularly where the disease is accompanied by elevated levels of NQO1.Type: GrantFiled: April 8, 2014Date of Patent: April 30, 2019Assignees: The Board of Regents of the University of Texas System, The Board of Trustees of the University of Illinois.Inventors: Paul J. Hergenrother, David A. Boothman, Joseph S. Bair, Lifen Cao, Jinming Gao, Xiumei Huang, Xiuquan Luo, Xinpeng Ma, Zachary R. Moore, Elizabeth I. Parkinson
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Patent number: 10196417Abstract: A baicalin magnesium compound and methods for preparing and extracting the same. The method for preparing the baicalin magnesium compound includes steps of preparation of a baicalin suspension, preparation of a magnesium ion-containing suspension, reaction and drying. The method for extracting the baicalin magnesium compound includes steps of pretreatment of macroporous resin, extraction, adsorption and elution, concentration and drying and purification. The methods restores the baicalin to the original form as found in radix scutellariae, and the baicalin magnesium compound may be used as a substitute for the baicalin in pharmaceutical applications. As compared to the baicalin, the baicalin magnesium has a greatly increased solubility, faster adsorption rate and higher oral bioavailability. The baicalin magnesium compound may also be easily formulated as a water-soluble injection or a powder injection.Type: GrantFiled: August 1, 2018Date of Patent: February 5, 2019Assignee: CHENGDE MEDCIAL UNIVERSITYInventors: Cuizhe Liu, Zhixuan Wang, Ceyu Miao, Liyan Liu, Hefei Xue, Xigang Liu, Wenshan Du, Yixin Liu, Lin Zhang, Xiaoxia Mao, Jinjun Liu, Guiqin Zhao
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Methods and compositions comprising ursolic acid and/or resveratrol for treating diabetes, or cancer
Patent number: 10155003Abstract: Certain embodiments are directed to methods and compositions for treating obesity, diabetes, and/or cancer with a combination of ursolic acid and resveratrol.Type: GrantFiled: May 5, 2015Date of Patent: December 18, 2018Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEMInventors: Thomas J. Slaga, Jacob Junco, Huiyun Liang, Sara Reyna -
Patent number: 10149877Abstract: The present invention relates to combinations of an agent that stimulates cell proliferation and an anti-inflammatory/analgesic, which are useful in the treatment of peripheral ulcers of various origins, such as radiation dermatitis, diabetic ulcers, ulcers caused by venous stasis of the limbs, bedsores, and the associated skin infections, proctitis, vulvovaginitis and haemorrhoids with vascular lesions. These combinations can be presented as formulations for topical use.Type: GrantFiled: October 18, 2016Date of Patent: December 11, 2018Assignee: INDENA S.P.A.Inventor: Ezio Bombardelli
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Patent number: 10137136Abstract: In one aspect, the invention relates to methods for treating muscle atrophy by providing to an animal in need thereof an effective amount of a compound. The compound can modulate the expression levels of multiple mRNA of a muscle atrophy signature. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: February 23, 2016Date of Patent: November 27, 2018Assignees: UNIVERSITY OF IOWA RESEARCH FOUNDATION, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF VETERANS AFFAIRSInventors: Christopher M. Adams, Steven D. Kunkel, Michael Welsh
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Patent number: 10131727Abstract: The present invention relates to a process for the development of a highly efficient solid state matrix by the activation of acrylate based polymer resin having specialized functional groups with 1,1-Carboxyl diimidazole for immobilizing biologically active macromeloecules such as oxidases, in particular plant oxidases and the most preferred being tea polyphenol oxidase through indirect covalent bonding/cross linking on such activated polymer resin support, are thermally stable, gives very high number of turnovers in vitro (“n” times) with tea substrate forming exclusive product Theaflavins without any loss of biological activity and leaving the product remaining in vitro with adherence to matrix rendering the matrix safe towards product poisoning and subsequent partial or complete loss of biological activity of the matrix bound enzyme system and thus well adapted to and well suited biorectors based on such systems.Type: GrantFiled: March 21, 2007Date of Patent: November 20, 2018Assignee: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCHInventors: Harsh Pratap Singh, Kapil Sharma
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Patent number: 10123992Abstract: The invention provides compounds, methods, pharmaceutical compositions, and kits for the treatment of proliferative disorders such as cancer. In one aspect, the methods comprise compounds that inhibit the activity of protein kinases, such as cell division cycle (Cdc) kinase. In another aspect, the methods comprise compounds that inhibit Cdc7 and/or Dbf4 activity. In another aspect, the methods comprise compounds that exhibit anti-proliferative properties useful in treating diseases such as cancer. Compounds useful for any of the methods include compounds of the Formula (A) or (B): or pharmaceutically acceptable salts thereof. Exemplary compounds of Formula (A) or (B) include granaticin A, granaticin B, dihydrogranaticin A, dihydrogranaticin B, medermycin, and actinorhodin.Type: GrantFiled: October 10, 2017Date of Patent: November 13, 2018Assignee: SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCHInventors: Mark G. Frattini, Hakim Djaballah, Thomas J. Kelly
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Patent number: 10111854Abstract: The present invention relates to novel series of amine-containing flavonoids and compositions containing the compounds, as well as the synthesis and the use of the same. The invention also relates to methods of treatment and prevention of diseases, in particular, parasitic infections including Leishmaniasis, comprising administration of the compounds.Type: GrantFiled: February 6, 2017Date of Patent: October 30, 2018Assignee: The Hong Kong Polytechnic UniversityInventors: Larry Ming-Cheung Chow, Tak Hang William Chan, Kin-Fai Chan, Iris Lai King Wong, Wing-Yiu Kan
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Patent number: 10098838Abstract: The invention relates to water-soluble granules for preparing a drinkable solution, in particular for preventing or treating symptoms associated with mild to moderate chronic venous insufficiency of the lower extremities, containing at least 20 percent by weight of a concentrated extract of red wine leaves, and to a ready-to-use packaging unit comprising one or more portion sachets which contain the granules according to the invention.Type: GrantFiled: July 21, 2015Date of Patent: October 16, 2018Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBHInventors: Sandra Sauerland, Sonja Heigenhauser, Uwe Scheuring, Oliver Timm
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Patent number: 10076513Abstract: A pharmaceutical composition comprising Compound 1, (3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid), and at least one excipient selected from: a filler, a diluent, a disintegrant, a surfactant, a binder, a glidant and a lubricant, the composition being suitable for oral administration to a patient in need thereof to treat a CFTR mediated disease such as Cystic Fibrosis. Methods for treating a patient in need thereof include administering an oral pharmaceutical formulation of Compound 1 to the patient.Type: GrantFiled: January 19, 2016Date of Patent: September 18, 2018Assignee: Vertex Pharmaceuticals IncorporatedInventors: Marinus Jacobus Verwijs, Rossitza Gueorguieva Alargova, Ritu Rohit Kaushik, Irina Nikolaevna Kadiyala, Christopher Young
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Patent number: 10058579Abstract: A dietary supplement composition is provided for enhancing the expression of a sirtuin gene or protein. An inventive supplement composition includes at least one cinnamon extract containing at least 0.5% doubly linked Type-A polymers by dry weight. The cinnamon extract is derived from the Cinnamonum aromaticum, Cinnamonum verum or Cinnamonum burmannii plant. In some embodiments, the cinnamon extract is present at approximately 20%-50% of the dry weight of the composition. A vitamin, weight loss agent, or antioxidant is optionally provided in the composition. The dietary supplement composition is administered orally to promote expression or enhanced expression of a sirtuin gene or protein.Type: GrantFiled: May 26, 2011Date of Patent: August 28, 2018Assignee: IN Ingredients, Inc.Inventors: Peter J. Miller, Tim Romero, Bolin Qin, Augustin T. Romero
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Patent number: 10016421Abstract: Disclosed are methods whereby an effective amount of a HDAC6 inhibitor is used to activate a subjects T-cell response to tumor or tumor vaccine. Methods of using HDAC6 inhibitors to increase a subjects anti-tumor immune response, alone or in conjunction with other tumor treatments, are also disclosed.Type: GrantFiled: April 6, 2015Date of Patent: July 10, 2018Assignee: H. Lee Moffitt Cancer Center and Research Institute, Inc.Inventors: Eduardo M. Sotomayor, Alejandro V. Villagra
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Patent number: 9987214Abstract: A composition having a pH in the range of from 3 to 8.5, comprising: (a) in the range of from 0.1% to <10% w/w (based on the total weight of the composition) of a stock solution comprising a mixture of bioflavonoids and fruit acids or salts thereof; (b) sodium hyaluronate; and (c) water; and, optionally, (d) a pharmaceutically acceptable carrier therefor; wherein the sodium hyaluronate has an average molecular weight of between 800,000 and 4,000,000.Type: GrantFiled: August 25, 2016Date of Patent: June 5, 2018Assignees: Oraldent Limited, Ricerfarma S.R.L.Inventors: Ian Ripley, Howard Thomas
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Patent number: 9956242Abstract: The pharmaceutical composition of the present invention, which comprises spinosin or a spinosin-containing herbal extract, is a composition for preventing and treating cognitive function disorders, and can effectively improve memory and learning ability, and effectively treat and prevent cognitive function disorders such as dementia and amnesia.Type: GrantFiled: November 3, 2016Date of Patent: May 1, 2018Assignees: MINISTRY OF FOOD AND DRUG SAFETY, DAE HWA PHARMA, CO., LTD.Inventors: Jong Hoon Ryu, Hyung Eun Lee, Sam Sik Kang, Ju Sun Kim, So Young Lee, Do Hoon Kim, Dong Sup Kim, Seung Hee Kim
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Patent number: 9925152Abstract: This disclosure provides generally for antimicrobial compositions and methods of use comprising an anthocyanin, an anthocyanidin or metabolites thereof. Methods for promoting healing of a wound using these compositions are also disclosed. These compositions have broad spectrum antimicrobial activity and are safe for human and animal uses. Further, these compositions are safe for medical uses and industrial uses as antiseptic preparations to reduce or prevent microbial growth.Type: GrantFiled: June 22, 2016Date of Patent: March 27, 2018Inventor: Lanny Leo Johnson
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Patent number: 9895390Abstract: The technology described herein is directed to the treatment of cancer, e.g. methods and assays relating to selecting and administering a chemotherapy with or without an EZH2 inhibitor.Type: GrantFiled: November 12, 2013Date of Patent: February 20, 2018Assignee: Children's Medical Center CorporationInventors: Christine M. Fillmore, Carla F. Kim
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Salacia compositions, methods of treatment by their administration, and methods of their preparation
Patent number: 9849151Abstract: A Salacia composition described herein significantly reduces appetite, activates Hormone Sensitive Lipase, and manages a healthy lipid profile through inhibition of HMG-CoA Reductase enzyme. Salacia compositions described herein include of at least 12% of polyphenols, 2% of mangiferin and 1% of 25,26-oxidofriedelane-1,3-dione by weight of the composition in the form of extract. The composition is obtained by continuous solvent extraction, employing non-aqueous food grade solvents. Salacia compositions herein reduce appetite by about 18% of routine diet, when effective amounts are administered to a subject in need thereof. Effective management of a healthy lipid profile is thus possible with synergistic combination of reduction in energy intake, activation of Hormone Sensitive Lipase, and inhibition of HMG-CoA Reductase enzyme responsible for cholesterol metabolism.Type: GrantFiled: November 19, 2014Date of Patent: December 26, 2017Assignee: OmniActive Health Technologies (Canada) LimitedInventors: Jayant Deshpande, Khadija Ghanam, Stephen Ewart, Vijaya Juturu -
Patent number: 9801850Abstract: The present invention provides an epigallocatechin gallate derivative (EGCG derivative) that has excellent safety and antibacterial properties. An epigallocatechin gallate derivative represented by the following chemical formula (1), an isomer thereof, or a salt thereof is used as an antibacterial agent. In the formula, R1 to R6 are each a hydrogen atom, halogen, sodium, potassium, or a straight-chain or branched, saturated or unsaturated acyl group and may be identical to or different from one another. The acyl group may be substituted further with one or more substituents. At least one of the R1 to R6 is the acyl group. R7 to R16 are each a hydrogen atom, halogen, sodium, or potassium and may be identical to or different from one another.Type: GrantFiled: July 30, 2010Date of Patent: October 31, 2017Assignee: OSAKA UNIVERSITYInventors: Kunihiro Kaihatsu, Yoshimi Matsumoto
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Patent number: 9782386Abstract: The invention provides compounds, methods, pharmaceutical compositions, and kits for the treatment of proliferative disorders such as cancer. In one aspect, the methods comprise compounds that inhibit the activity of protein kinases, such as cell division cycle (Cdc) kinase. In another aspect, the methods comprise compounds that inhibit Cdc7 and/or Dbf4 activity. In another aspect, the methods comprise compounds that exhibit anti-proliferative properties useful in treating diseases such as cancer. Compounds useful for any of the methods include compounds of the Formula (A) or (B): or pharmaceutically acceptable salts thereof. Exemplary compounds of Formula (A) or (B) include granaticin A, granaticin B, dihydrogranaticin A, dihydrogranaticin B, medermycin, and actinorhodin.Type: GrantFiled: November 11, 2016Date of Patent: October 10, 2017Assignee: Sloan-Kettering Institute for Cancer ResearchInventors: Mark G. Frattini, Hakim Djaballah, Thomas J. Kelly
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Patent number: 9757424Abstract: The present invention provides, inter alia, methods for treating or ameliorating the effects of a glioma. Methods of this invention include administering to a subject in need thereof an effective amount of a first active agent, such as e.g., an angiotensin receptor blocker, an antifungal agent, a bisphosphonate, an oxytocin inhibitor, an interleukin-1 (IL-1) inhibitor, a cyclooxygenase inhibitor, an ?2? voltage-dependent calcium channel (VDCC) inhibitor, a dihydroorotate dehydrogenase inhibitor, a calcium channel blocker, a renal sodium-chloride symporter inhibitor, an a2 adrenergic agonist, a phenothiazine antipsychotic, a calcineurin inhibitor, a 5-HT agonist, an angiotensin-converting enzyme (ACE) inhibitor, a direct rennin inhibitor, or combinations thereof, and a second active agent, which is a chemotherapeutic agent. Compositions for treating or ameliorating the effects of a glioma are also provided.Type: GrantFiled: September 25, 2012Date of Patent: September 12, 2017Assignee: Biomed Valley Discoveries, Inc.Inventors: Reza Halse, Saurabh Saha, Jeffrey James Roix
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Patent number: 9737515Abstract: The present invention relates to compositions and methods for preventing and treating cell proliferation in cancer. More specifically, the present invention relates to compositions and methods for inhibiting tumor growth, and for treating proliferative diseases, particularly colon and breast cancer, with a combined pharmacological approach. Yet more specifically, the compositions for inhibiting tumor growth comprise a combination of: i) a first component which is an ACSL4 inhibitor; and ii) a second component selected from the group consisting of mTOR inhibitor and ER inhibitor.Type: GrantFiled: March 2, 2016Date of Patent: August 22, 2017Assignee: Consejo Nacional De Investigaciones Cientificas Y Tecnicas (CONICET)Inventors: Ernesto Jorge Podesta, Paula Mariana Maloberti, Ulises Daniel Orlando, Melina Andrea Dattilo, Ana Fernanda Castillo, Angela Rosaria Solano
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Patent number: 9724361Abstract: The present invention relates to a pharmaceutical composition for treating liver diseases, containing a narirutin extract of citrus peel extract or narirutin as an active ingredient. The extract or narirutin decreases cholesterol levels and fat levels in liver tissue, and thus can be utilized as a composition or food for preventing and treating liver diseases. In addition, the present invention relates to a method for extracting narirutin from citrus peel, and a method for preparing citrus fermented milk using the same.Type: GrantFiled: March 28, 2014Date of Patent: August 8, 2017Assignee: Korea Food Research InstituteInventors: In Wook Choi, Yong Kon Park, Yoon Sook Kim, Hee Don Choi, Ho Young Park
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Patent number: 9688711Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R8 and R9 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.Type: GrantFiled: January 20, 2016Date of Patent: June 27, 2017Assignee: Achaogen, Inc.Inventors: James Bradley Aggen, Adam Aaron Goldblum, Martin Sheringham Linsell, Paola Dozzo, Heinz Ernst Moser, Darin James Hildebrandt, Micah James Gliedt
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Patent number: 9609884Abstract: Anti-fatigue agents containing dioxabicyclo[3.3.0]octane derivatives such as sesamin which is an ingredient contained in sesame, as well as pharmaceutical compositions and physiologically functional foods that contain such anti-fatigue agents are disclosed. These compounds can safely be administered to humans and animals alike and hence allow for continued ingestion while proving effective in promoting an improvement of stamina, an increase of body strength, a relief of fatigue, and recovery from fatigue.Type: GrantFiled: March 12, 2008Date of Patent: April 4, 2017Assignee: Suntory Holdings LimitedInventors: Yoshiko Ono, Kayo Saito, Norifumi Tateishi, Akifumi Maeda
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Patent number: 9610276Abstract: Compositions and methods for providing anti-diabetic and anti-hyperlipidemia benefits to diabetic subjects currently on medication but not meeting recommended targets for blood glucose, HbA1c, blood pressure and total cholesterol.Type: GrantFiled: July 29, 2015Date of Patent: April 4, 2017Assignee: KGK Synergize, Inc.Inventor: Najla Guthrie
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Patent number: 9603862Abstract: The invention provides a method of increasing a deacetylase activity of SIRT5 by contacting SIRT5 with an agent that binds SIRT5 and reduces the Km of SIRT5 for a substrate, thereby increasing the deacetylase activity of SIRT5. The invention also provides a method for treating a urea cycle disorder in a mammal, as well as a method of assaying a sirtuin modulator.Type: GrantFiled: December 14, 2010Date of Patent: March 28, 2017Assignee: CORNELL UNIVERSITYInventors: Anthony Sauve, Yana Cen
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Patent number: 9562037Abstract: The present invention relates to novel series of amine-containing flavonoids and compositions containing the compounds, as well as the synthesis and the use of the same. The invention also relates to methods of treatment and prevention of diseases, in particular, parasitic infections including Leishmaniasis, comprising administration of the compounds.Type: GrantFiled: February 26, 2015Date of Patent: February 7, 2017Assignee: The Hong Kong Polytechnic UniversityInventors: Larry Ming-Cheung Chow, William Tak Hang Chan, Kin-Fai Chan, Iris Lai King Wong, Wing-Yiu Kan
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Patent number: 9549883Abstract: Cosmetic antiperspirants for nonaerosol use, having a content of methanesulfonic acid and/or at least one physiologically acceptable salt of methanesulfonic acid, which exhibit less textile staining than known antiperspirants.Type: GrantFiled: December 16, 2013Date of Patent: January 24, 2017Assignee: Henkel AG & Co. KGaAInventors: Bernhard Banowski, Marcus Claas
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Patent number: 9498413Abstract: This disclosure provides generally for antimicrobial compositions and methods of use comprising an anthocyanin, an anthocyanidin or metabolites thereof. Methods for promoting healing of a wound using these compositions are also disclosed. These compositions have broad spectrum antimicrobial activity and are safe for human and animal uses. Further, these compositions are safe for medical uses and industrial uses as antiseptic preparations to reduce or prevent microbial growth.Type: GrantFiled: April 29, 2014Date of Patent: November 22, 2016Inventor: Lanny Leo Johnson
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Patent number: 9492427Abstract: The invention provides compounds, methods, pharmaceutical compositions, and kits for the treatment of proliferative disorders such as cancer. In one aspect, the methods comprise compounds that inhibit the activity of protein kinases, such as cell division cycle (Cdc) kinase. In another aspect, the methods comprise compounds that inhibit Cdc7 and/or Dbf4 activity. In another aspect, the methods comprise compounds that exhibit anti-proliferative properties useful in treating diseases such as cancer. Compounds useful for any of the methods include compounds of the Formula (A) or (B): or pharmaceutically acceptable salts thereof. Exemplary compounds of Formula (A) or (B) include granaticin A, granaticin B, dihydrogranaticin A, dihydrogranaticin B, medermycin, and actinorhodin.Type: GrantFiled: November 9, 2015Date of Patent: November 15, 2016Assignee: Sloan-Kettering Institute for Cancer ResearchInventors: Mark G. Frattini, Hakim Djaballah, Thomas J. Kelly
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Patent number: 9452192Abstract: Disclosed is a composition for preventing or improving metabolic syndrome, including a tea plant leaf extract, a tea plant flower extract and a tea plant seed extract as active ingredients.Type: GrantFiled: December 20, 2012Date of Patent: September 27, 2016Assignee: AMOREPACIFIC CORPORATIONInventors: Su Kyung Kim, Hyun Jung Shin, Chan Su Rha, Seung Hun Kim, Bum Jin Lee, Young Kyung Kim, Dae Bang Seo, Wan Gi Kim, Jin Oh Chung, Sang Jun Lee
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Patent number: 9440942Abstract: Methods for the prevention and/or alleviation of androgen-mediated disorders treatable by administering a chroman-derived anti-androgen compound are provided by the present invention. The invention further provides pharmaceutical and nutraceutical compositions containing chroman-derived anti-androgen compounds useful in the prevention and/or alleviation of androgen-mediated disorders, particularly prostate cancer.Type: GrantFiled: July 10, 2014Date of Patent: September 13, 2016Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATIONInventors: Todd A. Thompson, George Wilding
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Patent number: 9434900Abstract: A liquid fuel composition containing: (a) a gasoline base fuel suitable for use in an internal combustion engine; and (b) one or more organic sunscreen compounds.Type: GrantFiled: August 26, 2015Date of Patent: September 6, 2016Assignee: Shell Oil CompanyInventors: Mark Lawrence Brewer, Michael William Howe
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Patent number: 9428716Abstract: The present invention relates to the use of oligohydroxybenzoic acid derivatives in washing and cleaning agents in order to improve washing or cleaning performance with respect to bleachable stains.Type: GrantFiled: June 18, 2014Date of Patent: August 30, 2016Assignee: Henkel AG & Co. KGaAInventors: Christian Kropf, Mareile Job, Christian Umbreit, Siglinde Erpenbach
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Patent number: 9427002Abstract: Edible compositions useful for weight management in male animals are disclosed. The compositions comprise one or more isoflavones or isoflavone metabolites and are particularly useful for reducing or preventing the accumulation of body fat. Also disclosed are methods useful for weight management in an animal utilizing compositions comprising one or more isoflavones. The compositions and methods are particularly useful for the reduction or prevention of body fat accumulation during periods of excess caloric intake, and preferably have a sparing effect on lean body mass.Type: GrantFiled: February 3, 2012Date of Patent: August 30, 2016Assignee: Nestec S.A.Inventor: Yuanlong Pan
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Patent number: 9428533Abstract: The present invention provides compounds of the formula, wherein A, B, G, R2, R6, and X are defined herein, pharmaceutical compositions of the same, and methods for treating or inhibiting development of AGE- and/or ALE-associated complications in subjects in need thereof.Type: GrantFiled: February 20, 2014Date of Patent: August 30, 2016Assignee: Nephrogenex, IncInventors: Raja G. Khalifah, Roger E. Marti
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Patent number: 9393276Abstract: The present invention provides relates to an edible composition for anti-diabetic benefit. Diabetes is one of the major and commonly occurring health problems in today's world. Pharmaceuticals companies are very active in this field to develop new medicines for preventing and controlling diabetes. There are several medicines available in the market for the treatment of type 2 diabetes. There are also prior arts which describes composition for the prevention of glucose intolerance and/or diabetes. We have found that though prior that discloses compositions for prevention of glucose intolerance and/or diabetes, it is not that effective for preventing diabetes. The present inventors while working extensively for providing an edible composition for preventing diabetes have surprisingly found that a particular combination of Inula racemosa and theobromine is effective for controlling and/or preventive diabetes thereby satisfying one or more of the aforesaid objects.Type: GrantFiled: November 18, 2013Date of Patent: July 19, 2016Assignee: Conopco, Inc.Inventors: Gautam Banerjee, Vinitha Kadamkode, Ramitha Kalathil, Suman Majumder
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Patent number: RE47741Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R11 and R12 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.Type: GrantFiled: June 14, 2018Date of Patent: November 26, 2019Assignee: Achaogen, Inc.Inventors: Paola Dozzo, Adam Aaron Goldblum, James Bradley Aggen, Martin Sheringham Linsell