Patent number: 8802701
Abstract: The present invention refers to new compounds represented by the general formula (I) where X is represented by the general formula (II) and Y is represented by the general formula (III). The relation X to Y may vary from 1:1 to 1:7. The radicals R1, R2, R3, R4, R5, and R6 in formula (II) are represented by: R1=H, CF3, CH3, OCH3, NH2, halogen; R2=H, CH3, NH2, halogen, NH—CHCH3(CH2)3N(C2H5)(CH2CH2OH), CH(OH)-2(C5H11N), NH—R7—N—(C2H5)2; R3=H, m-OC6H4CF3, NH2; R4=H, CH3, OCH3, NH2, halogen; R5=H, CH3, CF3, NH2, halogen; R6=H, CF3, CH3, NH2, halogen, NH—R8—N—(C2H5)2, NHCH(CH3)(CH2)3NH2; R7=(CH2)2, (CH2)3, CHCH3CH2, (CH2)4, (CH2)5, CHCH3(CH2)3, (CH2)6, (CH2)8, (CH2)10, (CH2)12; R8=CHCH3(CH2)3, CHCH3(CH2)CHCH3, (CH2)2, (CH2)3, (CH2)6, (CH2)3O(CH2)3. This invention also refers to a process of preparation of these compounds (formula I), and antiparasitic pharmaceutical compositions thereof.
Type:
Grant
Filed:
November 27, 2012
Date of Patent:
August 12, 2014
Assignee:
Fundação Oswaldo Cruz
Inventors:
Nubia Boechat, Marcus Vinicius Nora de Souza, Alessandra Leda Valverde, Antoniana Ursine Krettli
Publication number: 20140113934
Abstract: Disclosed are compounds of Formula 1, N-oxides, and salts thereof, wherein L is (CR13aR13b)t, CR14?CR14, C?C, CR15aR15bX, XCR15aR15b, CO, O, S(O)p, NR5, CONR5, NR5CO, NR5SO2 or SO2NR5; X is O, S, SO, SO2, or NR5; and Q, R1, R2, R3, R5, R13a, R13b, R14, R15a, R15b t, p, n and m are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for treating helminth infections comprising administration to an animal a parasiticidally effective amount of a compound or a composition of the invention.
Type:
Application
Filed:
June 19, 2012
Publication date:
April 24, 2014
Applicant:
E I DU PONT DE NEMOURS AND COMPANY
Inventors:
George Philip Lahm, Benjamin Kenneth Smith